Our Alumni Publications | Gerstner Sloan Kettering Graduate School of Biomedical Sciences

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Jennifer E. (Nnoli) Adeleye

Sansone P, Ceccarelli C, Berishaj M, Chang Q, Rajasekhar VK, Perna F, Bowman RL, Vidone M, Daly L, Nnoli J, Santini D, Taffurelli M, Shih NN, Feldman M, Mao JJ, Colameco C, Chen J, DeMichele A, Fabbri N, Healey JH, Cricca M, Gasparre G, Lyden D, Bonafé M, Bromberg J. (2016) Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer. Nat Commun., 7, 10442. PMCID: PMC4748123.

Gholami S, Chen CH, Gao S, Lou E, Fujisawa S, Carson J, Nnoli JE, Chou TC, Bromberg J, Fong Y. (2014) Role of MAPK in oncolytic herpes viral therapy in triple-negative breast cancer. Cancer Gene Ther., 21, 283-9.

Azare J, Doane A, Leslie K, Chang Q, Berishaj M, Nnoli J, Mark K, Al-Ahmadie H, Gerald W, Hassimi M, Viale A, Stracke M, Lyden D, Bromberg J. (2011) Stat3 mediates expression of autotoxin in breast cancer. PLoS, 6, 1-11.

Eric S. Alonzo

Alonzo E, Sant’angelo D. (2011) Development of PLZF-expressing innate T cells. Curr Opin Immunol, 23, 220-227.

Gordon S, Carty S, Kim J, Zou T, Smith-Garvin J, Alonzo E, Haimm E, Sant’Angelo D, Koretzky G, Reiner S, Jordan M. (2011) Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. J Immunol, 186, 4573-4578.

Amrani Y, Gill J, Matevossian A, Alonzo E, Yang C, Shieh J, Moore M, Park C, Sant’Angelo D, Denzin L. (2011) The Paf oncogene is essential for hematopoietic stem cell function and development. J Exp Med, 208, 1757-1765.

Alonzo E, Gottschalk R, Das J, Egawa T, Hobbs R, Pandolfi P, Pereira P, Nichols K, Koretzky G, Jordan M, Sant’Angelo D. (2010) Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. J Immunol, 184, 1268-1279.

Kovalovsky D, Alonzo E, Uche O, Eidson M, Nichols K, Sant’Angelo D. (2010) PLZF Induces the Spontaneous Acquisition of Memory/Effector Functions in T Cells Independently of NKT Cell-Related Signals. J Immunol, 184, 6746-6755.

Kim H, Alonzo E, Dorothee G, Pollard J, Sant’Angelo D. (2010) Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus. PLoS One, 5, 1-15.

Kovalovsky D, Uche O, Eladad S, Hobbs R, Woelsung Y, Alonzo E, Chua K, Eidson M, Kim H, Im J, Pandolfi P, Sant’Angelo D. (2008) The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol, 9, 1055-1064.

Minna Balbas

Balbas MD, Burgess MR, Murali R, Wongvipat J, Skaggs BJ, Mundel P, Weins A, Sawyers CL. (2014) MAGI-2 scaffold protein is critical for kidney barrier function. Proc Natl Acad Sci U S A., 111, 14876-81. PMCID: PMC4205655.

Arora V, Schenkein E, Murali R, Subudhi S, Wongvipat J, Balbas M, Shah N, Cai L, Efstathiou E, Logothetis C, Cheng D, Sawyers C. (2013) Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade. Cell, 155, 1309-1322.

Balbas M, Evans M, Hosfield D, Wongvipat J, Arora V, Watson P, Chen Y, Greene G, Shen Y, Sawyers C. (2013) Overcoming mutation-based resistance to antiandrogens with rational drug design. Elife, 2, 1-21.

Watson P, Chen Y, Balbas M, Wongvipat J, Socci N, Viale A, Kim K, Sawyers C. (2010) Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci U S A, 107, 16759-16765.

Shah NP, Kasap C, Weier C, Balbas M, Nicoll JM, Bleickardt E, Nicaise C, Sawyers CL. (2008) Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis. Cancer Cell 14, 485-93.

Neha Bhagwat

Kleppe M, Kwak M, Koppikar P, Riester M, Keller M, Bastian L, Hricik T, Bhagwat N, McKenney AS, Papalexi E, Abdel-Wahab O, Rampal R, Marubayashi S, Chen JJ, Romanet V, Fridman JS, Bromberg J, Teruya-Feldstein J, Murakami M, Radimerski T, Michor F, Fan R, Levine RL. (2015) JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response. Cancer discovery, 5, 316-31. PMCID: PMC4355105.

Kucine N, Marubayashi S, Bhagwat N, Papalexi E, Koppikar P, Sanchez Martin M, Dong L, Tallman MS, Paietta E, Wang K, He J, Lipson D, Stephens P, Miller V, Rowe JM, Teruya-Feldstein J, Mullighan CG, Ferrando AA, Krivtsov A, Armstrong S, Leung L, Ochiana SO, Chiosis G, Levine RL, Kleppe . (2015) Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias. Blood, 126, 2479-83. PMCID: PMC4661170.

Grundschober E, Hoelbl-Kovacic A, Bhagwat N, Kovacic B, Scheicher R, Eckelhart E, Kollmann K, Keller M, Grebien F, Wagner KU, Levine RL, Sexl V. (2014) Acceleration of Bcr-Abl+ leukemia induced by deletion of JAK2. Leukemia, 28, 1918-22. PMCID: PMC4158830.

Meyer SC, Keller MD, Woods BA, LaFave LM, Bastian L, Kleppe M, Bhagwat N, Marubayashi S, Levine RL. (2014) Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis. Blood, 124, 2280-4. PMCID: PMC4183987.

Bhagwat N, Koppikar P, Keller M, Marubayashi S, Shank K, Rampal R, Qi J, Kleppe M, Patel H, Shah S, Taldone T, Bradner J, Chiosis G, Levine R. (2014) Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms. Blood, 123, 2075-2083.

Murphy A, Bijl N, Yvan-Charvet L, Welch C, Bhagwat N, Reheman A, Wang Y, Shaw J, Levine R, Ni H, Tall A, Wang N. (2013) Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med, 19, 586-594.

Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel-Wahab O, Lütjohann D, Randolph G, Levine R, Tall A, Tvan-Charvet L. (2013) HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. J Exp Med, 210, 339-353.

Bhagwat N, Levine R, Koppikar P. (2013) Sensitivity and resistance of JAK2 inhibitors to myeloproliferative neoplasms. Int J Hematol, 97, 695-702.

Koppikar P, Bhagwat N, Kilpivaara O, Manshouri T, Adli M, Hricik T, Liu F, Saunders L, Mullally A, Abdel-Wahab O, Leung L, Weinstein A, Marubayashi S, Goel A, Gönen M, Estrov Z, Ebert B, Chiosis G, Nimer S, Bernstein B, Verstovsek S, Levine R. (2012) Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature, 489, 155-159.

Andraos R, Qian Z, Bonenfant D, Rubert J, Vangrevelinghe E, Scheufler C, Marque F, Régnier C, De Pover A, Ryckelynck H, Bhagwat N, Koppikar P, Goel A, Wyder L, Tavares G, Baffert F, Pissot-Soldermann C, Manley P, Gaul C, Voshol H, Levine R, Sellers W, Hofmann F, Radimerski T. (2012) Modulation of activation-loop phosphorylation by JAK inhibitors is binding more dependent. Cancer Discov, 2, 512-523.

Marubayashi S, Koppikar P, Taydone T, Abdel-Wahab O, West N, Bhagwat N, Caldas-Lopes R, Ross K, Gönen M, Gozman A, Ahn, J, Rodina A, Ouerfelli O, Yang G, Hedvat C, Bradner J, Chiosis G, Levine R. (2010) HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans. J Clin Invest, 120, 3578-3593.

Figueroa M, Abdel-Wahab O, Lu C, Ward P, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez H, Tallman M, Sun Z, Wolniak K, Peeters J, Liu W, Chloe S, Fantin V, Paietta E, Löwenberg B, Licht J, Godley L, Delwel R, Valk P, Thompson C, Levine R, Melnick A. (2010) Leukemia IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell, 18, 553-567.

Bhagwat N, Levine R. (2010) Metabolic syndromes and malignant transformation: where the twain shall meet. Sci Transl Med, 2, 1-3.

Robert Bowman

Sansone P, Berishaj M, Rajasekhar VK, Ceccarelli C, Chang Q, Strillacci A, Savini C, Shapiro L, Bowman R, Mastroleo C, De Carolis S, Daly L, Benito-Martin A, Perna F, Fabbri N, Healey JH, Spisni E, Cricca M, Lyden D, Bonafé M, Bromberg J. (2017) Evolution of cancer stem-like cells in endocrine-resistant metastatic breast cancers is mediated by stromal microvesicles. Cancer Res. [Epub ahead of print]

Bowman RL, Wang Q, Carro A, Verhaak RG, Squatrito M. (2017) GlioVis data portal for visualization and analysis of brain tumor expression datasets. Neuro Oncol. 19, 139-141. PMCID: PMC5193031 [Available on 2018-01-01]

Kim IS, Heilmann S, Kansler ER, Zhang Y, Zimmer M, Ratnakumar K, Bowman RL, Simon-Vermot T, Fennell M, Garippa R, Lu L, Lee W, Hollmann T, Xavier JB, White RM. (2017) Microenvironment-derived factors driving metastatic plasticity in melanoma. Nat Commun. 8, 14343. PMCID: PMC5309794

Akkari L, Gocheva V, Quick ML, Kester JC, Spencer AK, Garfall AL, Bowman RL, Joyce JA. (2016) Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer. Genes Dev., 30, 220-32. PMCID: PMC4719311.

Alidori S, Bowman RL, Yarilin D, Romin Y, Barlas A, Mulvey JJ, Fujisawa S, Xu K, Ruggiero A, Riabov V, Thorek DL, Ulmert HD, Brea EJ, Behling K, Kzhyshkowska J, Manova-Todorova K, Scheinberg DA, McDevitt MR. (2016) Deconvoluting hepatic processing of carbon nanotubes. Nat Commun. 7,12343. PMCID: PMC4974572

Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue CA, Brennan CW, Tabar V, Gutin PH, Joyce JA. (2016) Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies. Cell Rep. 17, 2445-2459.

Sansone P, Ceccarelli C, Berishaj M, Chang Q, Rajasekhar VK, Perna F, Bowman RL, Vidone M, Daly L, Nnoli J, Santini D, Taffurelli M, Shih NN, Feldman M, Mao JJ, Colameco C, Chen J, DeMichele A, Fabbri N, Healey JH, Cricca M, Gasparre G, Lyden D, Bonafé M, Bromberg J. (2016) Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer. Nat Commun., 7, 10442. PMCID: PMC4748123.

Yan D, Wang HW, Bowman RL, Joyce JA. (2016) STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation. Cell Rep. 16, 2914-27

Quail DF, Bowman RL, Akkari L, Quick ML, Schuhmacher AJ, Huse JT, Holland EC, Sutton JC, Joyce JA. (2016) The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science, 352, aad3018.

Sevenich L, Bowman R, Mason S, Quail D, Rapaport F, Elie B, Brogi E, Brastianos P, Hahn W, Holsinger L, Massagué J, Leslie C, Joyce J. (2014) Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. Nat Cell Biol., 16, 876-88. PMCID: PMC4249762.

Bowman R, Joyce J. (2014) Therapeutic targeting of tumor-associated macrophages and microglia in glioblastoma. Immunotherapy, 6, 663-666.

Pyonteck S, Akkari L, Schuhmacher A, Bowman R, Sevenich L, Quail D, Olson O, Quick M, Huse J, Teijeiro V, Setty M, Leslie C, Oei Y, Pedraza A, Zhang J, Brennan C, Sutton J, Holland E, Daniel D, and Joyce J. (2013) CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 19, 1264-1272. PMCID: PMC38440724.

Miller J, Ganat Y, Kishinevsky S, Bowman R, Liu B, Tu E, Mandal P, Vera E, Shim J, Kriks S, Taldone T, Fusaki N, Tomishima M, Krainc D, Milner T, Rossi D, and Studer L. (2013) Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging. Cell Stem Cell, 13, 691-705.

Emily C. Casey

Casey E, Bournazos S, Mo G, Mondello P, Tan KS, Ravetch JV, Scheinberg DA. (2018). A new mouse expressing human Fcγ receptors to better predict therapeutic efficacy of human anti-cancer antibodies. Leukemia. 32, 547-549. PMCID: PMC5803448

Thorek DL, Watson PA, Lee SG, Ku AT, Bournazos S, Braun K, Kim K, Sjöström K, Doran MG, Lamminmäki U, Santos E, Veach D, Turkekul M, Casey E, Lewis JS, Abou DS, van Voss MR, Scardino PT, Strand SE, Alpaugh ML, Scher HI, Lilja H, Larson SM, Ulmert D. (2016) Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis. Sci Transl Med. 8, 367ra167.

Dubrovsky L, Brea EJ, Pankov D, Casey E, Dao T, Liu C, Scheinberg DA. (2016) Mechanisms of leukemia resistance to antibody dependent cellular cytotoxicity. Oncoimmunology 5, e1211221. PMCID: PMC5048777 [Available on 2017-08-03]

Chang AY, Gejman RS, Brea EJ, Oh CY, Mathias MD, Pankov D, Casey E, Dao T, Scheinberg DA. (2016). Opportunities and challenges for TCR mimic antibodies in cancer therapy. Expert Opin Biol Ther. 16, 979-87. PMCID: PMC4936943 [Available on 2017-08-01]

Dubrovsky L, Dao T, Gejman RS, Brea EJ, Chang AY, Oh CY, Casey E, Pankov D, Scheinberg DA. (2015) T cell receptor mimic antibodies for cancer therapy. Oncoimmunology 5, e1049803. PMCID: PMC4760335

Veomett, N., Dao, T., Liu, H., Xiang, J., Pankov, D., Dubrovsky, L., Whitten, J., Park, S., Korontsvit, T., Zakhaleva, V., Casey, E., Curcio, M., Kharas, M., O’Reilly, R., Liu, C., and Scheinberg, D. (2014) Therapeutic Efficacy of an Fc-Enhanced TCR-Like Antibody to the Intracellular WT1 Oncoprotein. Clin Cancer Res, 20, OF1-OF11. PMID: 24850840.

Dao, T., Yan, S., Veomett, N., Pankov, D., Zhou, L., Korontzvit, T., Scott, A., Whitten, J., Maslak, P., Casey, E., Tan, T., Liu, H., Zakhaleva, V., Curcio, M., Doubrovina, E., O’Reilly, R., Liu, C., and Scheinberg, D. (2013) Targeting the intracellular WT1 oncogene product with a therapeutic human antibody. Sci Transl Med, 5, 1-11. PMID: 23486779; PMCID: PMC3963696.

Mulvey, J., Villa, C., McDevitt, M., Escorcia, F., Casey, E., and Scheinberg, D. (2013) Self-assembly of carbon nanotubes and antibodies on tumours for targeted amplified delivery. Nat Nanotechnol, 8, 763-771. PMID: 24077028; PMCID: PMC3798027.

Villa, C., Dao, T., Ahearn, I., Fehrenbacher, N., Casey, E., Rey, D., Korontsvit, T., Zakhaleva, V., Batt, C., Philips, M., and Scheinberg, D. (2011) Single-walled carbon nanotubes deliver peptide antigen into dendritic cells and enhance IgG responses to tumor-associated antigens. ACS Nano, 5, 5300-5311. PMID: 21682329; PMCID: PMC3143710.

Han L, Witmer PD, Casey E, Valle D, Sukumar S. (2007) DNA methylation regulates MicroRNA expression. (2007) Cancer Biol Ther., 6, 1284-8.

James Dowdle

Liu H, Dowdle JA, Khurshid S, Sullivan NJ, Bertos N, Rambani K, Mair M, Daniel P, Wheeler E, Tang X, Toth K, Lause M, Harrigan ME, Eiring K, Sullivan C, Sullivan MJ, Chang SW, Srivastava S, Conway JS, Kladney R, McElroy J, Bae S, Lu Y, Tofigh A, Saleh SMI, Fernandez SA, Parvin JD, Coppola V, Macrae ER, Majumder S, Shapiro CL, Yee LD, Ramaswamy B, Hallett M, Ostrowski MC, Park M, Chamberlin HM, Leone G. (2017) Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. Dev. Cell, 41, 392-407.

Dowdle J, Mehta M, Kass E, Vuong B, Inagaki A, Egli D, Jasin M, Keeney S. (2013) Mouse BAZ1A (ACF1) Is Dispensable for Double-Strand Break Repair but Is Essential for Averting Improper Gene Expression During Spermatogenesis. PLoS Genet, 9, 1-21.

Roig I, Dowdle J, Toth A, de Rooij D, Jasin M, Keeney S. (2010) Mouse TRIP13/PCH2 Is Required for Recombination and Normal Higher-Order Chromosome Structure during Meiosis. PLoS Genet, 6, 1-19.

Weiran Feng

Feng W, Jasin M. (2018) Homologous Recombination and Replication Fork Protection: BRCA2 and More! Cold Spring Harb Symp Quant Biol. pii: 035006.

Feng W, Jasin M. (2017) BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination. Nat Commun. 8, 525. PMCID: PMC5597640

Vanoli F, Tomishima M, Feng W, Lamribet K, Babin L, Brunet E, Jasin M. (2017) CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells. Proc Natl Acad Sci U S A. 114, 3696-3701. PMCID: PMC5389291 [Available on 2017-10-04]

Prakash R, Zhang Y, Feng W, Jasin M. (2015) Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. Cold Spring Harb Perspect Biol., 7, a016600. PMCID: PMC4382744.

Reviews

Chen CC, Feng W, Lim PX, Kass EM, Jasin M. (2018) Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer. Annu. Rev. Cancer Biol., in press. https://www.annualreviews.org/doi/full/10.1146/annurev-cancerbio-030617-050502

Kinisha Gala

Gala K, Li Q, Sinha A, Razavi P, Dorso M, Sanchez-Vega F, Chung YR, Hendrickson R, Hsieh J, Berger M, Schultz N, Pastore A, Abdel-Wahab O, Chandarlapaty S. (2018) KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function. Oncogene.

Gala, K. and Chandarlapaty, S. (2014) Molecular pathways: HER3 targeted therapy. Clin Cancer Res, 20, 1410-1416. PMCID: PMC3977203.

Toy, W., Shen, Y., Won, H., Green, B., Sakr, R., Will, M., Li, Z., Gala, K., Fanning, S., King, T., Hudis, C., Chen, D., Taran, T., Hortobagyi, G., Greene, G., Berger, M., Baselga, J., and Chandarlapaty, S. (2013) ESR1 ligand-binding domain mutations in hormone- resistant breast cancer. Nat Genet, 45, 1439-1445. PMCID: PMC3903423.

Scaglione BJ, Salerno E, Gala K, Pan M, Langer JA, Mostowski HS, Bauer S, Marti G, Li Y, Tsiagbe VK, Raveche ES. (2009) Regulatory T cells as central regulators of both autoimmunity and B cell malignancy in New Zealand Black mice. J Autoimmun., 32, 14-23.

Nicholas Paul Gauthier

Gauthier NP, Reznik E, Gao J, Sumer SO, Schultz N, Sander C, Miller ML. (2016) MutationAligner: a resource of recurrent mutation hotspots in protein domains in cancer. Nucleic Acids Res., 44, D986-91. PMCID: PMC4702822.

Miller ML, Reznik E, Gauthier NP, Aksoy BA, Korkut A, Gao J, Ciriello G, Schultz N, Sander C. (2015) Pan-Cancer Analysis of Mutation Hotspots in Protein Domains. Cell Syst., 1, 197-209.

Liu Y, Raheja R, Yeh N, Ciznadija D, Pedraza A, Ozawa T, Hukkelhoven E, Erdjument-Bromage H, Tempst P, Gauthier N, Brennan C, Hollan E, Koff A. (2014) TRIM3, a tumor suppressor linked to regulation of p21 (Waf1/Cip1.). Oncogene, 33, 308-315.

Gauthier N, Soufi B, Walkowicz W, Pedicord V, Mavrakis K, Macek B, Gin D, Sander C, Miller M. (2013) Cell-selective labeling using amino acid precursors for proteomic studies of multicellular environment. Nat Methods, 10, 768-773.

Molinelli E, Korkut A, Wang W, Miller M, Gauthier N, Jing X, Kaushik P, He Q, Mills G, Solit D, Pratilas C, Weigt M, Braunstein A, Pagnani A, Zecchina R, Sander C. (2013) Perturbation biology: inferring signaling networks in cellular systems. PLoS Comput Biol, 9, 1-23.

Gauthier N, Jensen L, Wernersson R, Brunak S, Jensen T. (2010) Cyclebase.org: version 2.0, an updated comprehensive, multi-species repository of cell cycle experiments and derived analysis results. Nucleic Acids Res., 38, D669-D702.

Gauthier NP, Larsen ME, Wernersson R, de Lichtenberg U, Jensen LJ, Brunak S, Jensen TS. (2008) Cyclebase.org—a comprehensive multi-organism online databse of cell-cycle experiments. Necleic Acids Res., 36, D854-9.

Theresa L. Geiger

O’Sullivan TE, Geary CD, Weizman OE, Geiger TL, Rapp M, Dorn GW, Overholtzer M, Sun JC. (2016) Atg5 Is Essential for the Development and Survival of Innate Lymphocytes. Cell Rep, 15, 1910-9. PMCID: PMC4889506.

Cortez VS, Cervantes-Barragan L, Robinette ML, Bando JK, Wang Y, Geiger TL, Gilfillan S, Fuchs A, Vivier E, Sun JC, Cella M, Colonna M. Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands. (2016) Immunity, 44, 1127-39.

Geiger TL, Sun JC. (2016) Development and Maturation of Natural Killer Cells. Curr Opin Immunol., 39, 82-9. PMCID: PMC4801705.

Geiger TL, Abt MC, Gasteiger G, Firth MA, O’Connor MH, Geary CD, O’Sullivan TE, van den Brink MR, Pamer EG, Hanash AM, Sun JC. (2014) Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. J Exp Med., 211, 1723-31. PMCID: PMC4144732.

Curran, M., Geiger, T., Montalvo, W., Kim, M., Reiner, S., Al-Shamkhani, A., Sun, J., and Allison, J. (2013) Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin. J Exp Med, 210, 743-755. PMID: 23547098; PMCID: PMC3620352.

Yvonne Gruber Mica

Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W, Zhao H, de Stanchina E, Gershon MD, Grikscheit TC, Chen S, Studer L. (2016) Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature. 531, 105-9. PMCID: PMC4846424

Callahan SJ, Mica Y, Studer L. (2016) Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells. J Vis Exp., 109.

Chambers S, Mica Y, Lee G, Studer L, Tomishima M. (2013) Dual-SMAD Inhibition/WNT Activation-Based Methods to Induce Neural Crest and Derivatives from Human Pluripotent Stem Cells. Methods Mol Biol.

Mica Y, Lee G, Chambers S, Tomishima M, Studer L. (2013) Modeling Neural Crest Induction, Melanocyte Specification, and Disease-Related Pigmentation Defects in hESCs and Patient-Specific iPSCs. Cell Rep, 3, 1140-1152.

Chambers S, Qi Y, Mica Y, Lee G, Zhang X, Niu L, Bilsland J, Cao L, Stevens E, Whiting P, Shi S, Studer L. (2012) Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat Biotechnol, 30, 715-720.

Chambers S, Mica Y, Studer L, Tomishima M. (2011) Converting human pluripotent stem cells to neural tissue and neurons to model neurodegeneration. Methods Mol Biol, 793, 87-97.

Papapetrou E, Tomishima M, Chambers S, Mica Y, Reed E, Menon J, Tabar V, Mo Q, Studer L, Sadelain M. (2009) Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci U S A, 106, 12759-12764.

John Halliday

Halliday J, Helmy K, Pattwell SS, Pitter KL, LaPlant Q, Ozawa T, Holland EC. (2014) In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift. Proc Natl Acad Sci U S A., 111, 5248-53. PMCID: PMC3986190.

Pietras A, Katz A, Ekström E, Wee B, Halliday J, Pitter K, Werbeck J, Amankulor N, Huse J, Holland E. (2014) Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth. Cell Stem Cell, 14, 357-369.

Huse JT, Edgar M, Halliday J, Mikolaenko I, Lavi E, Rosenblum MK. (2013) Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure-associated lesion. Brain Pathol. 23, 515-24.

Helmy K, Halliday J, Fomchenko E, Setty M, Pitter K, Hafemeister C, Holland E. (2012) Identification of global alteration of translational regulation in glioma in vivo. PLoS One 7, e46965. PMCID: PMC3463531

Halliday J, Holland E. (2011) Connective tissue growth factor and the parallels between brain injury and brain tumors. J Natl Cancer Inst, 103, 1141-1143.

Jens C. Hamann

Hamann JC, Kim SE, Overholtzer M. (2019) Methods for the Study of Entotic Cell Death. Methods Mol Biol. 1880, 447-454.

Hawk MA, Gorsuch CL, Fagan P, Lee C, Kim SE, Hamann JC, Mason JA, Weigel KJ, Tsegaye MA, Shen L, Shuff S, Zuo J, Hu S, Jiang L, Chapman S, Leevy WM, DeBerardinis RJ, Overholtzer M, Schafer ZT. (2018) RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells. Nat Cell Biol. 20, 272-284.

Hamann JC, Overholtzer M. (2017) Entosis enables a population response to starvation. Oncotarget 8, 57934-57935. PMCID: PMC5601622

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Yun-Han Huang

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Ellen Hukkelhoven

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Karen Hunter Cohn

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Jenny M. Karo Leeds

Adams NM, O’Sullivan TE, Geary CD, Karo JM, Amezquita RA, Joshi NS, Kaech SM, Sun JC. (2016) NK Cell Responses Redefine Immunological Memory. J Immunol. 197, 2963-2970. PMCID: PMC5108457

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Mary Klein Dooley

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Catherine Konopacki

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Marta Kovatcheva

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Shefali Krishna

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Krishna S, Overholtzer M. (2014) Milk makes lysosomes lethal. Nat Cell Biol, 16, 1029-31.

Krajcovic, M., Krishna, S., Akkari, L., Joyce, J., and Overholtzer, M. (2013) mTOR regulates phagosome and entotic vacuole fission. Mol Biol Cell, 24, 3736-3745. PMID: 24088573; PMCID: PMC3842999.

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Isabel Lam

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Lam I, Keeney S. (2015) Non-paradoxical evolutionary stability of the meiotic recombination initiation landscape in yeasts. Science, 350, 932–937. PMCID: PMC4656144.

Vincenten N, Kuhl LM, Lam I, Oke A, Kerr A, Hochwagen A, Fung J, Keeney S, Vader G, Marston AL. (2015) The kinetochore prevents centromere-proximal crossover recombination during meiosis. eLife, 4, e10850. PMCID: PMC4749563.

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Chi, P., Kwon, Y., Visnapuu, M., Lam, I., Santa Maria, S., Zheng, X., Epshtein, A., Greene, E., Sung, P., Klein, H. (2011). Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors. Nucleic Acids Res, 39, 6511-6522. PMID: 21558173; PMCID: PMC3159464.

Thacker, D., Lam, I., Knop, M., Keeney, S. (2011) Exploiting Spore-Autonomous Fluorescent Protein Expression to Quantify Meiotic Chromosome Behaviors in Saccharomyces cerevisiae. Genetics, 189, 423-439. PMID: 21840861; PMCID: PMC3189805.

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Chong Luo

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Luo C, Li M. (2013) Transcriptional control of regulatory T cell development and function. Trends Immunol, 34, 531-539.

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Danilo G. Macalinao

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John Maciejowski

Maciejowski J, Drechsler H, Grundner-Culemann K, Ballister ER, Rodriguez-Rodriguez JA, Rodriguez-Bravo V, Jones MJK, Foley E, Lampson MA, Daub H, McAinsh AD, Jallepalli PV. (2017) Mps1 Regulates Kinetochore-Microtubule Attachment Stability via the Ska Complex to Ensure Error-Free Chromosome Segregation. Dev Cell. 41, 143-156. PMCID: PMC5477644.

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Maciejowski J, George K, Terret M, Zhang C, Shokat K, Jallepalli P. (2010) Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol, 190, 89-100.

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James P. Mahaffey

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Daniel H. Marks

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Armine Matevossian

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Gregory Mazo

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Mazo G, Soplop N, Wang WJ, Uryu K, Tsou MB.(2016) Spatial Control of Primary Ciliogenesis by Subdistal Appendages Alters Sensation-Associated Properties of Cilia. Dev Cell. 39, 424-437. PMCID: PMC5125554 [Available on 2017-11-21]

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Anna Sophia McKenney

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Francis ER, Goodsmith N, Michelow M, Kulkarni A, McKenney AS, Kishore SP, Bertelsen N, Fein O, Balsari S, Lemery J, Fitzgerald D, Johnson W, Finkel ML. (2012) The global health curriculum of Weill Cornell Medical College: how one school developed a global health program. Acad Med., 87, 1296-302.

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Justine D. Miller

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Miller J, Ganat Y, Kishinevsky S, Bowman R, Liu B, Tu E, Mandal P, Vera E, Shim J, Kriks S, Taldone T, Fusaki N, Tomishima M, Krainc D, Milner T, Rossi D, Studer L. (2013) Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Again. Cell Stem Cell, 13, 691-705.

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Prashant Monian

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Semanti Mukherjee

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Brandon Nemieboka

Rao TD, Fernández-Tejada A, Axelrod A, Rosales N, Yan X, Thapi S, Wang A, Park KJ, Nemieboka B, Xiang J, Lewis JS, Olvera N, Levine DA, Danishefsky SJ, Spriggs DR. (2017) Antibodies Against Specific MUC16 Glycosylation Sites Inhibit Ovarian Cancer Growth. ACS Chem Biol. 12, 2085-2096. PMCID: PMC5603915 [Available on 2018-08-18]

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Berenice Ortiz Thompson

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Joseph N. Pucella

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Cindy Puente

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Sadia Rahman

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Leili Ran

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Jessica Rios-Esteves

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Piero Sanfilippo

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Neel Shah

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Alison K. Spencer

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Kelsey Temprine

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York AG, Parekh SH, Dalle Nogare D, Fischer RS, Temprine K, Mione M, Chitnis AB, Combs CA, Shroff H. (2012) Resolution doubling in live, multicellular organisms via multifocal structured illumination microscopy. Nat Methods., 9, 749-54. PMCID: PMC3462167.

George Vaisey

Miller AN, Vaisey G, Long SB. (2019) Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin. eLife. 8. pii: e43231. PMCID: PMC6342527

Vaisey G, Long SB. (2018) An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1. J Gen Physiol. pii: jgp.201812190.

Vaisey G, Miller AN, Long SB. (2016) Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel. Proc Natl Acad Sci U S A.113, 7399-7408. PMCID: PMC5127342 [Available on 2017-05-22]

Ly Vu

Taggart J, Ho TC, Amin E, Xu H, Barlowe TS, Perez AR, Durham BH, Tivnan P, Okabe R, Chow A, Vu L, Park SM, Prieto C, Famulare C, Patel M, Lengner CJ, Verma A, Roboz G, Guzman M, Klimek VM, Abdel-Wahab O, Leslie C, Nimer SD, Kharas MG. (2016) MSI2 is required for maintaining activated myelodysplastic syndrome stem cells. Nat Commun., 7, 10739. PMCID: PMC4764878.

Perna F, Vu LP, Themeli M, Kriks S, Hoya-Arias R, Khanin R, Hricik T, Mansilla-Soto J, Papapetrou EP, Levine RL, Studer L, Sadelain M, Nimer SD. (2015) The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells. Stem Cell Reports, 4, 658-69. PMCID: PMC4400644.

Park SM, Gönen M, Vu L, Minuesa G, Tivnan P, Barlowe TS, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa ME, Paietta E, Fernandez HF, Tallman MS, Melnick A, Levine R, Leslie C, Lengner CJ, Kharas MG. (2015) Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program. J Clin Invest. 125, 1286-98. PMCID: PMC4362230

Vu L, Luciani L, Nimer S. (2013) Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential. Int J Hematol, 97, 198-209.

Vu L, Perna F, Wang L, Voza F, Figueroa M, Tempst P, Erdjument-Bromage H, Gao R, Chen S, Paietta E, Deblasio T, Melnick A, Liu Y, Zhao X, Nimer S. (2013) PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex. Cell Rep, 5, 1625-1638.

Moulick K, Ahn J, Zong H, Rodina A, Cerchietti L, Gomes Dagama E, Caldas-Lopes E, Beebe K, Perna F, Hatzi K, Vu L, Zhao X, Zatorska D, Taldone T, Smith-Jones P, Alpaugh M, Gross S, Pillarsetty N, Ku T, Lewis J, Larson S, Levine R, Erdjument-Bromage H, Guzman M, Nimer S, Melnick A, Neckers L, Chiosis G. (2011) Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nat Chem Biol, 7, 818-826.

Wang L, Gural A, Sun X, Zhao X, Perna X, Huang G, Hatlen M, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole P, Zhang J, Melnick A, Roeder R, Nimer S. (2011). The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science, 333, 765-769.

Wang L, Huang G, Zhao X, Hatlen M, Vu L, Liu F, Nimer S. (2009) Post-translational modifications of Runx1 regulate its activity in the cell. Blood Cells Mol Dis, 43, 30-34.

William Walkowicz

Fernández-Tejada A, Walkowicz WE, Tan DS, Gin DY. (2017) Semisynthesis of Analogues of the Saponin Immunoadjuvant QS-21. Methods Mol Biol. 1494, 45-71. PMCID: PMC5120590

Walkowicz WE, Fernández-Tejada A, George C, Corzana F, Jiménez-Barbero J, Ragupathi G, Tan DS, Gin DY. (2016) Quillaja Saponin Variants with Central Glycosidic Linkage Modifications Exhibit Distinct Conformations and Adjuvant Activities. Chem Sci, 7, 2371-2380. PMCID: PMC4800320.

Gauthier N, Soufi B, Walkowicz W, Pedicord V, Mavrakis K, Macek B, Gin D, Sander C, Miller M. (2013) Cell-selective labeling using amino acid precursors for proteomic studies of multicellular environments. Nat Methods, 10, 768-773.

Elizabeth Wasmuth

Bose R, Karthaus WR, Armenia J, Abida W, Iaquinta PJ, Zhang Z, Wongvipat J, Wasmuth EV, Shah N, Sullivan PS, Doran MG, Wang P, Patruno A, Zhao Y, International SU2C/PCF Prostate Cancer Dream Team, Zheng D, Schultz N, Sawyers CL. (2017) ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis. Nature 546, 671-675. PMCID: PMC5576182 [Available on 2018-06-29]

Wasmuth EV, Zinder JC, Zattas D, Das M, Lima CD. (2017) Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. Elife 6, pii: e29062. PMCID: PMC5553935

Wasmuth EV, Lima CD. (2017) The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome. Nucleic Acids Res. 45, 846-860. PMCID: PMC5314766

Zinder JC, Wasmuth EV, Lima CD. (2016) Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3. Mol Cell. 64, 734-745. PMCID: PMC5115963

Wasmuth E, Januszyk K, Lima C. (2014) Structure of an Rrp6-RNA exosome complex bound to polyA RNA. Nature,511, 435-9. PMCID: PMC4310248.

Wasmuth E, Lima C. (2012) Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel. Mol Cell, 48, 133-144. PMCID: PMC3472098.

Wasmuth E, Lima C. (2012) Structure and activities of the eukaryotic RNA exosome. Chapter in the book “The Enzymes” 31, 53-75. ISBN: 18746047. Publisher: Elsevier, Editors: Guillaume F. Chanfreau, Fuyuhiko Tamanoi.

Lei Wei

Wei L, Zhao X. (2016). A new MCM modification cycle regulates DNA replication initiation. Nature Structural & Molecular Biology, 23, 209–216.

Bonner JN1 Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X. (2016) Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates. Cell Rep., 16, 368-78. PMCID: PMC5051638

Hang LE, Lopez CR, Liu X, Williams JM, Chung I, Wei L, Bertuch AA, Zhao X. (2014). Regulation of Ku-DNA association by Yku70 C-terminal tail and SUMO modification. The Journal of Biological Chemistry, 289, 10308-10317.

Raymond Wu

Li X, Wu R, Ventura A. (2016) The present and future of genome editing in cancer research. Hum. Genet. 135, 1083-92.

Shannon Yu

Yu S, Baylies M. (2013) Cell biology: Death brings new life to muscle. Nature, 497, 196-197.

Rochlin K, Yu S, Roy S, Baylies M. (2010) Myoblast fusion: when it takes more to make one. Dev Biol, 341, 66-83.

Yilong Zou

Malladi S, Macalinao DG, Jin X, He L, Basnet H, Zou Y, de Stanchina E, Massagué J. (2016) Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT. Cell, 165, 45-60. PMCID: PMC4808520.

David CJ, Huang YH, Chen M, Su J, Zou Y, Bardeesy N, Iacobuzio-Donahue CA, Massagué J. (2016) TGF-β Tumor Suppression through a Lethal EMT. Cell, 164, 1015-30. PMCID: PMC4801341

Obenauf AC, Zou Y, Ji AL, Vanharanta S, Shu W, Shi H, Kong X, Bosenberg MC, Wiesner T, Rosen N, Lo RS, Massagué J. (2015) Therapy-induced tumour secretomes promote resistance and tumour progression. Nature, 520, 368-72. PMCID: PMC4507807

Vanharanta S, Marney C, Shu W, Valiente M, Zou Y, Mele A, Darnell R, and Massagué J. (2014) Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. Elife, 3, 1-24.

Morris L, Kaufman A, Gong Y, Ramaswami D, Walsh L, Turcan Ş, Eng S, Kannan K, Zou Y, Peng L, Banuchi V, Paty P, Zeng Z, Vakiani E, Solit D, Singh B, Ganly I, Liau L, Cloughesy T, Mischel P, Mellinghoff I, Chan T. (2013) Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat Genet, 45, 253-261. PMCID:PMC3729040.

Zhang X, Jin X, Malladi S, Zou Y, Wen Y, Brogi E, Smid M, Foekens J, and Massagué J. (2013) Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell, 154, 1060-1073. PMCID: PMC3974915.