Human Oncology & Pathogenesis Program
The Christine Iacobuzio-Donahue Lab
Research

Professor
Our lab investigates the fundamental evolutionary mechanisms underlying metastasis using pancreatic cancer as our model tumor type. Metastasis is the result of a series of biological hurdles subject to Darwinian selection including the birth of metastasis-enabled cells within a heterogeneous primary tumor microenvironment, intravasation of these cells into a functional vascular bed, survival in the circulation, extravasation from the vasculature, and establishment of an autonomous cell population within the newly encountered foreign microenvironment.

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Christine A. Iacobuzio-Donahue, MD, PhD
David M. Rubenstein Center Chair for Pancreatic Cancer Research; Director, Center for Pancreatic Cancer Research
Professor
- Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.
- MD, PhD, Boston University
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- Physician profile
Members







- BS, University of Massachusetts Amherst






Assistant Attending

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Graduate Research Assistant

Lab Manager

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Morgue Attendant

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Research Associate

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Lab Alumni

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Visiting Investigator

Assistant Attending Radiation Oncologist

Research Technician

Clinical Coordinator

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Research Fellow

Assistant Attending Pathologist

Senior Research Technician
Lab Affiliations
Achievements
- Team Science Award, American Association for Cancer Research (2012)
- Ramzi Cotran Young Investigator Award, United States and Canadian Academy of Pathology (2009)
- AACR-Barletta Foundation Career Development Award in Translational Pancreatic Cancer Research (2005)
- Member, Alpha Omega Alpha (2002)
- American Society of Clinical Investigators (2015)
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- Elected to American Association of University Pathologists (Pluto Society)
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Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Christine A. Iacobuzio-Donahue discloses the following relationships and financial interests:
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Bristol-Myers Squibb
Provision of Services (uncompensated)
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].