Human Oncology & Pathogenesis Program

The Christine Iacobuzio-Donahue Lab

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Research

Christine Iacobuzio-Donahue
Christine A. Iacobuzio-Donahue, MD, PhD
David M. Rubenstein Center Chair for Pancreatic Cancer Research; Director, Center for Pancreatic Cancer Research

Professor

Our lab investigates the fundamental evolutionary mechanisms underlying metastasis using pancreatic cancer as our model tumor type. Metastasis is the result of a series of biological hurdles subject to Darwinian selection including the birth of metastasis-enabled cells within a heterogeneous primary tumor microenvironment, intravasation of these cells into a functional vascular bed, survival in the circulation, extravasation from the vasculature, and establishment of an autonomous cell population within the newly encountered foreign microenvironment.

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The Christine Iacobuzio-Donahue Lab

Publications

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People

Christine Iacobuzio-Donahue

Christine A. Iacobuzio-Donahue, MD, PhD

David M. Rubenstein Center Chair for Pancreatic Cancer Research; Director, Center for Pancreatic Cancer Research

Professor

  • Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.
  • MD, PhD, Boston University
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Physician profile

Members

Priscilla Baez
Priscilla Baez

Research Project Associate

Jungeui Hong
Jungeui Hong
Jinlong  Huang
Jinlong Huang

Research Fellow

Rajya Kappagantula
Rajya Kappagantula

Research Technician

Michael Kinnaman
Michael Kinnaman

Special Fellow

Alicia Maisonet
Alicia Maisonet

Program Assistant

Alvin Makohon-Moore
Alvin Makohon-Moore

Research Associate

Helen Martirosova
Helen Martirosova

Graduate Research Assistant

Jerry Melchor
Jerry Melchor

Lab Manager

Alexandra  Miller
Alexandra Miller
Katelyn Mullen
Katelyn Mullen

Graduate Student

Derwin Pena
Derwin Pena

Morgue Attendant

Shigeaki Umeda

Research Associate

Yi Zhong
Yi Zhong

Research Associate

Amanda Zucker
Amanda Zucker

Research Technician

Lab Alumni
Marc  Attiyeh
Marc Attiyeh

Research Fellow

Jun  Fan
Jun Fan

Research Associate

Akimasa Hayashi
Akimasa Hayashi

Visiting Investigator

Jaclyn Hechtman
Zachary Kohutek
Zachary Kohutek

Assistant Attending Radiation Oncologist

Breanna McMahon
Breanna McMahon

Research Technician

Chelsea Michael
Chelsea Michael

Clinical Coordinator

Salvador Suarez Naranjo
Salvador Suarez Naranjo

Research Associate

Hitomi Sakamoto
Hitomi Sakamoto

Research Fellow

Efsevia Vakiani, MD, PhD
Efsevia Vakiani

Assistant Attending Pathologist

Liguo Zhang
Liguo Zhang

Senior Research Technician

Lab Affilations

Achievements

  • Team Science Award, American Association for Cancer Research (2012)
  • Ramzi Cotran Young Investigator Award, United States and Canadian Academy of Pathology (2009)
  • AACR-Barletta Foundation Career Development Award in Translational Pancreatic Cancer Research (2005)
  • Member, Alpha Omega Alpha (2002)
  • American Society of Clinical Investigators (2015)
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  • Elected to American Association of University Pathologists (Pluto Society)

Open Positions

Career Opportunities

Postdoctoral positions are currently available in our laboratory and are open to highly motivated candidates with a background in cancer genetics, metastasis, and/or evolutionary biology.

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