Epidemiology & Biostatistics

The Nikolaus Schultz Lab

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Research

Nikolaus schultz
Nikolaus Schultz, PhD
Director, Cancer Data Science Initiative; Head of Knowledge Systems, Marie-Josée & Henry R. Kravis Center for Molecular Oncology; Attending Computational Oncologist, Department of Epidemiology & Biostatistics

Professor

The Schultz lab focuses on identifying the genomic alterations that underlie different types of cancer. By applying existing and novel computational methods to large scale cancer genomics data sets, the lab aims to better understand the complex mechanisms at the gene and at the pathway level that drive tumor initiation, progression and response to therapy, with the ultimate goal of identifying targeted therapeutic options for cancer patients. A new focus of the lab is the systematic extraction and standardization of clinical data elements from electronic health records. The lab is also involved in collaborative large-scale projects such as The Cancer Genome Atlas (TCGA),  AACR Project GENIE, and the Human Tumor Atlas (HTAN). The group also has a strong interest in enabling discoveries by developing novel computational methods and databases that help bridge the divide between computer scientists on one side and clinicians and researchers on the other. Examples of these include the cBioPortal for Cancer Genomics, a popular resource for the visualization and analysis of cancer genomics data, and OncoKB®, a precision oncology knowledgebase.

Schultz lab

Featured News

colorful picture of cancer cells
The Mystery of Metastasis: Can a Tumor’s Genetic Mutations Predict Whether and Where Cancer Will Spread?
Data from 25,000 patients is helping scientists answer this and many other important questions.
Feature
Jianjiong Gao, Hongxin Zhang, Nikolaus Schultz, Debyani Chakravarty, and Sarah Suehnholz stand together on a terrace
A Milestone for Precision Oncology: FDA Gives Green Light to MSK’s Genetic Database
OncoKB, a database developed and maintained by investigators at MSK, helps match patients with targeted therapies based on the mutations found in their tumors.
In the Lab
Illustration of DNA base pairs
What Was MSK’s Role in TCGA, the Groundbreaking Cancer Genomic Study?
The multicenter project, which yielded dozens of scientific papers on more than 30 different kinds of cancer, has officially drawn to a close.

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Publications Highlights

 Kahn RM, Selenica P, Boerner T, Roche KL, Xiao Y, Sia TY, Maio A, Kemel Y, Sheehan M, Salo-Mullen E, Breen KE, Zhou Q, Iasonos A, Grisham RN, O’Cearbhaill RE, Chi DS, Berger MF, Kundra R, Schultz N, Ellenson LH, Stadler ZK, Offit K, Mandelker D, Aghajanian C, Zamarin D, Sabbatini P, Weigelt B, Liu YL. Pathogenic germline variants in non-BRCA1/2 homologous recombination genes in ovarian cancer: Analysis of tumor phenotype and survival. Gynecol Oncol. 2023 Dec 1;180:35-43. 

Jiagge E, Jin DX, Newberg JY, Perea-Chamblee T, Pekala KR, Fong C, Waters M, Ma D, Dei-Adomakoh Y, Erb G, Arora KS, Maund SL, Njiraini N, Ntekim A, Kim S, Bai X, Thomas M, van Eeden R, Hegde P, Jee J, Chakravarty D, Schultz N, Berger MF, Frampton GM, Sokol ES, Carrot-Zhang J. Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers. Cancer Cell. 2023 Oct 23:S1535-6108(23)00359-8. 

 Suehnholz SP, Nissan MH, Zhang H, Kundra R, Nandakumar S, Lu C, Carrero S, Dhaneshwar A, Fernandez N, Xu BW, Arcila ME, Zehir A, Syed A, Brannon AR, Rudolph JE, Paraiso E, Sabbatini PJ, Levine RL, Dogan A, Gao J, Ladanyi M, Drilon A, Berger MF, Solit DB, Schultz N, Chakravarty D. Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer. Cancer Discov. 2023 Oct 18. 

Lumish MA, Walch H, Maron SB, Chatila W, Kemel Y, Maio A, Ku GY, Ilson DH, Won E, Li J, Joshi SS, Gu P, Schattner MA, Laszkowska M, Gerdes H, Jones DR, Sihag S, Coit DG, Tang LH, Strong VE, Molena D, Stadler ZK, Schultz N, Janjigian YY, Cercek A. Clinical and Molecular Characteristics of Early-Onset versus Average-Onset Esophagogastric Cancer. J Natl Cancer Inst. 2023 Sep 12:djad186. 

Skakodub A, Walch H, Tringale KR, Eichholz J, Imber BS, Vasudevan HN, Li BT, Moss NS, Hei Yu KK, Mueller BA, Powell S, Razavi P, Yu HA, Reis-Filho JS, Gomez D, Schultz N, Pike LRG. Genomic analysis and clinical correlations of non-small cell lung cancer brain metastasis. Nat Commun. 2023 Aug 17;14(1):4980. 

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People

Nikolaus schultz

Nikolaus Schultz, PhD

Director, Cancer Data Science Initiative; Head of Knowledge Systems, Marie-Josée & Henry R. Kravis Center for Molecular Oncology; Attending Computational Oncologist, Department of Epidemiology & Biostatistics

Professor

  • Cancer biologist Nikolaus Schultz uses computational tools to study the diversity of genomic alterations underlying different cancer types.
  • PhD, Freie Universitat Berlin
[email protected]
Email Address
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Members

Sharafudeen Abukabar

Research Fellow

Tejiri Agbamu

GSK Graduate Student

Areej Alsaafin

Research Fellow

Pranita Atri

Research Fellow

Anika Begum

Senior Project Coordinator

Kevin Boehm
Kevin M. Boehm

Resident Physician, Memorial Sloan Kettering Cancer Center, New York, NY

Walid Chatila
Walid Chatila

Senior Computational Biologist Il

Ino de Bruijn, Bioinformatics Engineer
Ino de Bruijn

Bioinformatics Software Engineer III

Nikolaos Dimitriou

Research Fellow

Jordan Eiccholz
Jordan Eichholz

‪Computational Biologist I

Christopher Fong, Research Scholar
Christopher Fong

Bioinformatics Software Engineer III

Chenlian Fu
Chenlian (Tom) Fu

WGS Student

Xiang (Molly) Han

WGS Student

Justin Jee

Instructor

Ritika Kundra, MS
Ritika Kundra

Bioinformatics Software Engineer

Desiree Lara

Program Assistant

Brooke Mastrogiacomo
Brooke Mastrogiacomo

Computational Biologist Il

Enrico Moiso

Senior Computational Biologist I

Fatema Nagib

NE Agency Contingent

Subhiksha Nandakumar
Subhiksha Nandakumar

Senior Computational Biologist I

John Nguyen
John Nguyen

WGS Student

Karl Pichotta

Senior Computational Biologist Il

Julia Rudolph
Julia Rudolph

Associate Director, CRC Initiatives

Evan Seffar

Computational Biologist I

Farheen Shah

Computational Biologist I

Thinh Tran
Thinh Tran

GSK Graduate Student

Henry Walch
Henry Walch

Computational Biologist Il

Michele Waters

Senior Computational Biologist

Lab Alumni
Adam Abeshouse
Adam Abeshouse

Bioinformatics Software Engineer

Mirella Lorrainy Altoe

Research Fellow

Joshua Armenia
Joshua Armenia

Research Fellow

Craig Bielski, MS
Craig Bielski

WGS Student

Hsiao-Wei (Annice) Chen
Hsiao-Wei (Annice) Chen

Data Curator

Frederick Criscuolo

Computational Engineer

Jianjiong Gao, PhD
Jianjiong Gao

Assistant Attending

Benjamin Gross, MS
Benjamin Gross

Head of CMO Data Engineering

Zachary Heins
Zachary Heins

Bioinformatics Engineer

Christoph Kreitzer
Christoph Kreitzer

Graduate Research Assistant

Ayush Kris
Ayush Kris

WGS Student

Konnor La
Konnor La

Graduate Student

Dong Li

Computational Engineer

Xiang Li
Xiang Li

Bioinformatics Software Engineer

Calvin Lu

Bioinformatics Software Engineer

Divya Madala

Bioinformatics Software Engineer

Ramyasree Madupuri
Ramyasree Madupuri

Computational Biologist

Bastien Nguyen
Bastien Nguyen

Research Scholar

Angelica Ochoa
Angelica Ochoa

Lead Engineer, SMILE

Arjun Raj Rajanna
Arjun Raj Rajanna

Bioinformatics Engineer

Eduard Reznik

Manager, Biocomputing

Francisco Sanchez-Vega
Francisco Sanchez-Vega

Assistant Attending

Hongyu Shi
Hongyu Shi

Graduate Research Assistant

Shaleigh Smith
Shaleigh Smith

Bioinformatics Software Engineer

Jing Su
Jing Su

Bioinformatics Software Engineer

Selcuk Onur Sumer
Selcuk Onur Sumer

Software Engineer

Yichao Sun, MS
Yichao Sun

Bioinformatics Software Engineer

Cerise Tang

WGS Graduate Student

Jiaojiao Wang
Jiaojiao Wang

Bioinformatics Software Engineer

Qingguo Wang
Qingguo Wang

Bioinformatics Software Engineer

Yifu Yao

Bioinformatics Software Engineer

Lab Affiliations

Achievements

  • Memorial Hospital Award for Excellence in Mentoring (2022)
  • Geoffrey Beene Junior Faculty Chair (2019)
  • Josie Robertson Investigator (2013-2018)
  • Stupski Prize in Prostate Cancer Computational Oncology (2015)
  • Young Investigator Award, Prostate Cancer Foundation (2014)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Postdoctoral Researcher, Cancer Genomics – Schultz Laboratory Memorial Sloan Kettering Cancer Center

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Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Nikolaus Schultz discloses the following relationships and financial interests:

  • Cambridge Innovation Institute
    Professional Services and Activities (Uncompensated)
  • Innovation in Cancer Informatics
    Professional Services and Activities (Uncompensated)
  • Novartis
    Professional Services and Activities
  • OneOncology
    Professional Services and Activities

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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