Structural Biology Program

The Stephen Long Lab

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Research

Stephen B. Long, PhD
Stephen B. Long, PhD
Member

Professor

Our laboratory uses a combination of cryo-electron microscopy, x-ray crystallography, and functional approaches to study the mechanisms of eukaryotic ion channels involved in calcium signaling and membrane-embedded enzymes.

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Publications

Miller, A. N.*, Vaisey, G.*, & Long, S. B. (2019). Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin. eLife (Abstract | open state Cryo-EM map | Atomic Coordinates).  *A. N. Miller and G. Vaisey are co-first authors.

Vaisey, G., & Long, S. B. (2018). An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1. The Journal of General Physiology, jgp.201812190. (Abstract)

Hou, X., Burstein, S. R., & Long, S. B. (2018). Structures reveal opening of the store-operated calcium channel Orai. eLife, 7.  (Manuscript | Atomic Coordinates)

Baradaran, R., Wang, C., Siliciano, A. F., & Long, S. B. (2018). Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters. Nature, 559(7715), 580–584. (Abstract | Atomic Coordinates | Cryo-EM map)

Melinda Diver, Leanne Pedi, Akiko Koide, Shohei Koide, Stephen B. Long (2018). Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT. Nature. Jan 25; 553(7689):526-529. (Abstract | Manuscript | Atomic Coordinates)

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People

Stephen B. Long, PhD

Stephen B. Long, PhD

Member

Professor

  • The Long laboratory studies ion channels and enzymatic membrane proteins.
  • BA, Physics, Amherst College, 1994
  • PhD, Biochemistry, Duke University, 2001
  • Postdoc, Rockefeller University, 2007
longs@mskcc.org
Email Address
212-639-2903
Office Phone

Members

Rozbeh Baradaran
Rozbeh Baradaran

Postdoc

Xiaowei Hou, PhD
Xiaowei Hou

Postdoctoral Fellow

Agata Jacewicz
Agata Jacewicz

Senior Research Scientist

Yiyang Jiang
Yiyang Jiang

Research Scholar

Ian Outhwaite
Ian Outhwaite

Research Technician

George Vaisey, MBiochem
George Vaisey

Graduate Student

Chongyuan Wang
Chongyuan Wang

Postdoctoral Fellow

Lab Alumni
Veronica Kane-Dickson

Postdoctoral Fellow

Pictured: David Kerr
David Kerr

Undergraduate Researcher

Shana Burstein

Research Technician

Melinda Diver

Graduate Student

Pictured: Alexandria Miller
Alexandria N. Miller

Postdoctoral Fellow

Leanne Pedi
Leanne Pedi

Senior Research Assistant

Lab Affilations

Achievements

  • Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
  • Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2016)
  • Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)
  • Burroughs Wellcome Career Award in the Biomedical Sciences (2006-2014)

Open Positions

Postdoctoral Fellow Positions

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Stephen B. Long discloses the following relationships and financial interests:

  • Van Andel Institute
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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