The research of my laboratory focuses on two directions highly relevant to cancer biology, (1) the molecular basis of programmed cell death processes (including apoptosis and ferroptosis), and their roles in human disease; and (2) the molecular basis of autophagy and its role in cancer. We also study various cancer signaling and cellular metabolic events, especially those involved in cell death/survival determination. We aim to translate our basic research finding into potential therapeutic approaches. To achieve these goals, the laboratory utilizes a combination of approaches including biochemistry, chemical biology, proteomics, molecular cell biology, high-throughput screening, 3-dimensional microfluidic cell array, and mouse modeling.
Xuejun Jiang, PhD
Research FocusCell biologist Xuejun Jiang studies programmed cell death, molecular mechanisms, and their roles in tumorigenesis.
EducationPhD, University of Texas Southwestern Medical Center at Dallas
- Gammoh N, Florey O, Overholtzer M, & Jiang X. Interaction Between FIP200 and ATG16L1 Distinguishes ULK1 Complex-Dependent and -Independent Autophagy. Nature Structural & Molecular Biology 2013 (20) 144-149. PMCID: PMC3565010
- Shi Y, Wang J, Chandarlapaty S, Cross J, Thompson C, Rosen N, Jiang X. PTEN Is a Protein Tyrosine Phosphatase for IRS1. Nat Struct. Mol. Biol. 2014 (21) 522-527. PMCID: PMC4167033
- Louis and Allston Boyer Young Investigator Award for Basic Research, Memorial Sloan Kettering Cancer Center (2007)
- Scholar, American Cancer Society (2007-2010)
- Catherine and Frederick Adler Chair for junior faculty, Memorial Sloan Kettering Cancer Center (2006)
- V Scholar, The V Foundation for Cancer Research (2004-2006 )
- Alfred Bressler Scholar, Alref W. Bresller Scholars Fund (2004-2007)