Molecular Pharmacology Program
The Michael Kharas Lab
Savino AM, Fernandes SI, Olivares O, Zemlyansky A, Cousins A, Markert EK, Barel S, Geron I, Frishman L, Birger Y, Eckert C, Tumanov S, MacKay G, Kamphorst JJ, Herzyk P, Fernández-García J, Abramovich I, Mor I, Bardini M, Barin E, Janaki-Raman S, Cross JR, Kharas MG, Gottlieb E, Izraeli S, Halsey C Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase..Nat Cancer. 2020 Oct;1(10):998-1009. doi: 10.1038/s43018-020-00115-2. Epub 2020 Sep 28. [PMID: 33479702]
Cheng Y*, Xie W*, Pickering BF, Chu KL, Savino AM, Yang X, Luo H, Nguyen DTT, Mo S, Barin E, Velleca A, Rohwetter T, Patel DJ, Jaffrey SR, Kharas MG*. N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation Cancer Cell. July 2021.
Jeong S, Savino AM, Chirayil R, Cheng Y, Barin E, Park SM, Schurer A, Mullarky E, Cantley LC, Kharas MG*, Keshari KR*. Serine synthesis pathway flux is essential for acute myeloid leukemia cells to proliferate in fructose-rich conditions. Cell Metab. 5 January 2021, Pages 145-159.
Cheng Y, Luo H, Izzo F, Pickering BF, Nguyen D, Byers R, Schurer A, Gourkanti S, Bruning J, Vu L, Jaffrey S, Landau D, Kharas MG*. RNA methylation maintains hematopoietic stem cell identity and symmetric commitment. Cell Reports. 2019 August 13. 7:1703-11716
Michael G. Kharas, PhD
- Cancer biologist Michael Kharas studies RNA regulators of self-renewal in both normal and leukemic hematopoiesis.
- PhD, University of California Irvine
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- Leukemia and Lymphoma Society Career Development Award (2017)
- Alex Lemonade Stand Foundation ‘A’ Award (2016)
- American Society of Hematology Junior Faculty Scholar Award (2011)
- Kimmel Scholar Award (2013)
- V-Scholar Award (2013)
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As a Research Technician you will perform research activities in collaboration with internal/external personnel to complete science-based projects. You will normally receive detailed instructions while making observations, analyzing data and interpreting results according to laboratory procedures. The Research Technician will provide support to all technical/research staff and postdocs.
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Michael G. Kharas discloses the following relationships and financial interests:
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