Human Oncology & Pathogenesis Program

The Omar Abdel-Wahab Lab

Research

Omar Abdel-Wahab, MD

Associate Member, Human Oncology and Pathogenesis Program; Associate Attending, Leukemia Service; Director, MSK Center for Hematologic Malignancies

Omar Abdel-Wahab is an Associate Member in Human Oncology and Pathogenesis Program (HOPP) and an Associate Attending Physician on the Leukemia Service in the Department of Medicine at Memorial Sloan Kettering Cancer Center. Dr. Abdel-Wahab’s research focuses on the role of genomic alterations in the pathogenesis of hematopoietic malignancies.

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Featured News

In the Lab

In a Twist, Scientists Find Cancer Drivers Hiding in RNA, Not DNA

Monday, August 27, 2018

In the Lab

Splicing May Be an Effective Target in the Fight against Cancer

Wednesday, July 18, 2018

Feature

What Is Epigenetics, and Why Is Everyone Talking about It?

Tuesday, June 19, 2018

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Publications

Yoshimi A, Lin KT, Wiseman DH, Rahman MA, Pastore A, Wang B, Lee SC, Micol JB, Zhang XJ, de Botton S, Penard-Lacronique V, Stein EM, Cho H, Miles RE, Inoue D, Albrecht TR, Somervaille TCP, Batta K, Amaral F, Simeoni F, Wilks DP, Cargo C, Intlekofer AM, Levine RL, Dvinge H, Bradley RK, Wagner EJ, Krainer AR, Abdel-Wahab O. Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis. Nature. 2019 Oct;574(7777):273-277. doi: 10.1038/s41586-019-1618-0. Epub 2019 Oct 2. PMCID: PMC6858560.

Inoue D, Chew GL, Liu B, Michel BC, Pangallo J, D’Avino AR, Hitchman T, North K, Lee SC, Bitner L, Block A, Moore AR, Yoshimi A, Escobar-Hoyos L, Cho H, Penson A, Lu SX, Taylor J, Chen Y, Kadoch C, Abdel-Wahab O (co-corresponding), Bradley RK (co-corresponding). Spliceosomal disruption of the non-canonical BAF complex in cancer. Nature. 2019 Oct;574(7778):432-436. doi: 10.1038/s41586-019-1646-9. Epub 2019 Oct 9. PMCID: PMC6858563.

Durham BH, Lopez Rodrigo E, Picarsic J, Abramson D, Rotemberg V, De Munck S, Pannecoucke E, Lu SX, Pastore A, Yoshimi A, Mandelker D, Ceyhan-Birsoy O, Ulaner GA, Walsh M, Yabe M, Petrova-Drus K, Arcila ME, Ladanyi M, Solit DB, Berger MF, Hyman DM, Lacouture ME, Erickson C, Saganty R, Ki M, Dunkel IJ, Santa-María López V, Mora J, Haroche J, Emile JF, Decaux O, Geissmann F, Savvides SN, Drilon A, Diamond EL, Abdel-Wahab O. Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms. Nat Med. 2019 Dec;25(12):1839-1842. doi: 10.1038/s41591-019-0653-6. Epub 2019 Nov 25. PMCID: PMC6898787.

Fong JY, Pignata L, Goy PA, Kawabata KC, Lee SC, Koh CM, Musiani D, Massignani E, Kotini AG, Penson A, Wun CM, Shen Y, Schwarz M, Low DH, Rialdi A, Ki M, Wollmann H, Mzoughi S, Gay F, Thompson C, Hart T, Barbash O, Luciani GM, Szewczyk MM, Wouters BJ, Delwel R, Papapetrou EP, Barsyte-Lovejoy D, Arrowsmith CH, Minden MD, Jin J, Melnick A, Bonaldi T, Abdel-Wahab O (co-corresponding), Guccione E(co-corresponding). Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Cancer Cell. 2019 Aug 12;36(2):194-209.e9. doi: 10.1016/j.ccell.2019.07.003.

Taylor J, Sendino M, Gorelick AN, Pastore A, Chang MT, Penson AV, Gavrila EI, Stewart C, Melnik EM, Herrejon Chavez F, Bitner L, Yoshimi A, Lee SC, Inoue D, Liu B, Zhang XJ, Mato AR, Dogan A, Kharas MG, Chen Y, Wang D, Soni RK, Hendrickson RC, Prieto G, Rodriguez JA, Taylor BS, Abdel-Wahab O. Altered nuclear export signal recognition as a driver of oncogenesis. Cancer Discov. 2019 Jul 8. pii: CD-19-0298. doi: 10.1158/2159-8290.CD-19-0298. [Epub ahead of print]

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People

Omar Abdel-Wahab, MD

Associate Member, Human Oncology and Pathogenesis Program; Associate Attending, Leukemia Service; Director, MSK Center for Hematologic Malignancies

Physician-scientist Omar Abdel-Wahab studies the functional genomics of hematopoietic malignancies.
MD, Duke University School of Medicine

abdelwao@mskcc.org: Email Address
View physician profile: Physician profile

Members

Ha Na Cho, Research Assistant — Hana Cho
Research Assistant

Benjamin Durham, Instructor (Pathology) — Benjamin Durham
Instructor (Pathology)

Bo Liu, Research Associate — Bo Liu
Research Associate

Bin Lu, Research Associate — Bin Lu
Research Associate

Sydney Lu, Research Fellow — Sydney Lu
Assistant Member, Myeloma Service

Alexander Penson, PhD — Alexander Penson
Senior Computational Biologist

Lab Alumni

Lillian Bitner, Research Technician — Lillian Bitner
Research Technician

Luisa Escobar Hoyos

Research Fellow

Monisha Hosier
Administrative Assistant II

Daichi Inoue, Visiting Investigator — Daichi Inoue
Visiting Investigator

Pictured: Stanley Lee — Stanley Lee
Research Associate

Alessandro Pastore, Senior Research Scientist — Alessandro Pastore
Senior Research Scientist

Justin Taylor

Instructor (Dept. of Medicine)

Akihide Yoshimi, Senior Research Scientist — Akihide Yoshimi
Senior Research Scientist

Xiao Zhang

Lab Affilations

Achievements

Seldin-Smith Award for Pioneering Research, American Society of Clinical Investigation
Pershing Square Sohn Prize for Young Investigators in Cancer Research
Leukemia & Lymphoma Society Clinical Scholar Award
Joanne Levy Memorial Award for Outstanding Achievement, American Society of Hematology
V Scholar Award, V Foundation

Junior Faculty Scholar Award, American Society of Hematology (ASH)
Damon Runyon Clinical Investigator Award

Get in Touch

abdelwao@mskcc.org

Lab Head Email

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Omar Abdel-Wahab discloses the following relationships and financial interests:

AIchemy, Inc.
Ownership / Equity Interests; Provision of Services (uncompensated)
Envisagenics
Ownership / Equity Interests; Provision of Services (uncompensated)

Epizyme
Intellectual Property Rights
Janssen Global Services, LLC
Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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