The Alexander Rudensky Lab

The Alexander Rudensky Lab

Our research is focused on understanding the molecular mechanisms governing the differentiation and function of CD4 T lymphocytes and their role in immunity and tolerance. Major areas of interest include: the molecular and cellular mechanisms governing the differentiation and function of regulatory T cells; the roles these cells play in control of autoimmunity, tumor immunity, and immunity to infections, and in the maintenance of immune homeostasis at environmental interfaces. We are particularly interested in understanding the role of the forkhead family transcription factor Foxp3 in establishing and maintaining immune homeostasis; and in the plasticity of regulatory T cell transcriptional and functional programs and the molecular mechanisms of regulatory T cell lineage stability.

Learn more Arrow rightAn icon showing an arrow pointing to the right.
Alexander Rudensky, PhD

Alexander Rudensky, PhD

Chair, Immunology Program, SKI; Director, Ludwig Center at MSK

Professor

Research Focus

Immunology Program Chair Alexander Rudensky focuses on immunological tolerance and the differentiation and function of T cells.

Education

PhD, Gabrichevsky Institute for Microbiology and Epidemiology

Publications

  • Levine AG, Mendoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM,Rudensky AY. (2017) Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 546:421-425.
  • van der Veeken J, Gonzalez AJ, Cho H, Arvey A, Hemmers S, Leslie CS, Rudensky AY. (2016) Memory of Inflammation in Regulatory T Cells. Cell.166:977-990
Learn more Arrow rightAn icon showing an arrow pointing to the right.

Selected Achievements

  • Investigator, Howard Hughes Medical Institute
  • Vilcek Prize in Biomedical Science, New York, NY (2018)
  • Crafoord Prize, the Royal Swedish Academy of Sciences, Stockholm Sweden (2017)
  • Member, National Academy of Medicine (2015)
  • Member, American Academy of Arts and Sciences (2015)

  • Coley Award in Basic Immunology, Cancer Research Institute (2015)
  • Thomson Reuters Citation Laureate (2015)
  • Member, National Academy of Sciences (2012)
  • Merit Award, National Institutes of Health (2009)
  • Investigator Award, American Association of Immunologists/PharMingen (1999)
  • Searle Scholar Award (1993)
  • Investigator, Howard Hughes Medical Institute (1993)
  • Elucidation of the function of transcription factor Foxp3 in regulatory T cells and their critical role in immune homeostasis (2003-2010)
  • Identification of the primary structure of MHC class II bound peptides (1991)