
Developmental Biology Program
The Maria Jasin Lab
Research

Professor
Human chromosomes are constantly assaulted by challenges to their integrity as a result of either environmental agents that damage DNA or from normal DNA metabolism. The failure to repair damaged DNA faithfully is ultimately responsible for many human diseases, especially cancer. This laboratory focuses on the repair of 1 particular lesion in DNA, the double-strand break (DSB). DSBs arise from agents, such as ionizing radiation, and can also occur spontaneously during DNA replication. Our emphasis is on repair of DSBs by homologous recombination, with a particular interest in the role of homologous recombination in maintaining genetic stability. Understanding the repair of DSBs is not only important for basic science and health concerns, but also impacts on molecular genetic manipulations of mammalian genomes.
Research Projects

Featured News



Publications Highlights
Georgieva D, Wang N, Taglialatela A, Jerabek S, Reczek CR, Lim PX, Sung J, Du Q, Horiguchi M, Jasin M, Ciccia A, Baer R, Egli D. (2024) BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks. Cell Rep. doi: 10.1016/j.celrep.2024.114006.
People

Maria Jasin, PhD
William E. Snee Chair
Professor
- The Jasin laboratory focuses on double-strand break repair and genomic integrity in mammalian cells and the relationship to tumor suppression.
- PhD, Massachusetts Institute of Technology
- [email protected]
- Email Address
Members


Lab Head
Sr. Administrative Assistant

Senior Research Scientist

Graduate Student WCGS

Graduate Student WCGS

Senior Research Scientist

Research Associate

Research Associate

Graduate Student (BCMB)

Senior Research Scientist

Research Fellow

Senior Research Scientist

Graduate Student (BME)
Research Assistant

- University of Rome "Tor Vergata"

- Technical University of Graz
- 212-639-8384
- Office Phone

- Department of Cell Biology and Histology, AMC Uva, Amsterdam

- Cornell University
- 212-639-8384
- Office Phone

- Academic Medical Center, Department of Cell Biology and Histology- Amsterdam, The Netherlands
Lab Alumni

Postdoctoral Fellow

Postdoctoral Fellow

Postdoctoral Fellow

Research Fellow

Postdoctoral Fellow

Postdoctoral Fellow

Research Technician

Senior Research Scientist

Postdoctoral Fellow

Associate Member

Postdoctoral Fellow

Postdoctoral Fellow

Senior Research Scientist

Graduate Student

Senior Research Technician

Research Associate

Postdoctoral Fellow

Postdoctoral Fellow

Postdoctoral Fellow

Postdoctoral Fellow

Postdoctoral Fellow

Graduate Student

Postdoctoral Fellow

Research Fellow
Postdoctoral Fellow
Postdoctoral Fellow

Research Fellow
Graduate Student
Graduate Research Assistant

Visiting Investigator

Research Technician

Senior Research Scientist

Senior Research Scientist

Research Scholar

Postdoctoral Fellow

Senior Research Scientist

Postdoctoral Fellow

Graduate Student

Postdoctoral Fellow

Postdoctoral Fellow

Graduate Research Assistant

Postdoctoral Fellow

Graduate Research Assistant
Lab Affiliations
Achievements
- National Academy of Sciences (2015)
- National Academy of Medicine (2016)
- American Academy of Arts and Sciences (2017)
- Basser Global Prize for BRCA Research (2018)
- Shaw Prize in Life Science and Medicine (2019)
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- Fellow of the AACR Academy (2020)
- NCI Outstanding Investigator (2020)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Get in Touch
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Lab Head Email
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Lab Phone
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Maria Jasin discloses the following relationships and financial interests:
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Rutgers New Jersey Medical School
Professional Services and Activities
The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].