Marilyn Resh, PhD
Research FocusCell biologist Marilyn Resh investigates the regulation of protein function by fatty acylation, and the development of Hedgehog palmitoylation inhibitors to block pancreatic and lung cancer.
- PhD, Harvard University
- AB, Princeton University
- Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat Chem Biol. 2013 Apr;9(4):247-9. doi: 10.1038/nchembio.1184. Epub 2013 Feb 17.
- Resh MD. Targeting protein lipidation in disease. Trends Mol Med. 2012 Apr;18(4):206-14. doi: 10.1016/j.molmed.2012.01.007. Epub 2012 Feb 17.
- Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School (2009)
- Established Scientist, American Heart Association (1994-1999)
- Pew Scholar in the Biomedical Sciences, Pew Charitable Trusts (1987-1991)
- Discovery of the ""two-signal hypothesis"" for binding of myristoylated proteins to membranes
- Discovery of a myristoyl switch mechanism for membrane binding of HIV-1 Gag
- First to establish Hedgehog acyltransferase as a bona fide palmitoyl acyltransferase for Hedgehog proteins
- Discovery of the first-in-class hedgehog palmitoylation inhibitor