Cell Biology Program
The Marilyn Resh Lab
The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins.
Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat Chem Biol. 2013 Apr;9(4):247-9. doi: 10.1038/nchembio.1184. Epub 2013 Feb 17.
Buglino JA, Resh MD. Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J Biol Chem. 2008 Aug 8;283(32):22076-88. doi: 10.1074/jbc.M803901200. Epub 2008 Jun 4.
Marilyn Resh, PhD
- Cell biologist Marilyn Resh investigates the regulation of protein function by fatty acylation, and the development of Hedgehog palmitoylation inhibitors to block pancreatic and lung cancer.
- PhD, Harvard University
- AB, Princeton University
- Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School (2009)
- Established Scientist, American Heart Association (1994-1999)
- Pew Scholar in the Biomedical Sciences, Pew Charitable Trusts (1987-1991)
- Discovery of the ""two-signal hypothesis"" for binding of myristoylated proteins to membranes
- Discovery of a myristoyl switch mechanism for membrane binding of HIV-1 Gag
- First to establish Hedgehog acyltransferase as a bona fide palmitoyl acyltransferase for Hedgehog proteins
- Discovery of the first-in-class hedgehog palmitoylation inhibitor