Cancer Biology & Genetics Program
The Scott Lowe Lab
Research

Professor
About the Scott Lowe Lab
Our laboratory studies tumor-suppressor networks controlling apoptosis and senescence and how their disruption influences malignant behavior.
Research Projects
Inside My Lab: Scott Lowe

Featured News



Publications
A gene–environment-induced epigenetic program initiates tumorigenesis. Alonso-Curbelo, D, Ho, YJ, Burdziak, C, Maag, JLV, Morris IV, JP, Chandwani, R, Chen, HA, Tsanov, KM, Barriga, FM, Luan, W, Tasdemir, N, Livshits, G, Azizi, E, Chun, J, Wilkinson, JE, Mazutis, L, Leach, SD, Koche, R, Pe’er, D, Lowe, SW. Nature. 2021 Feb;590(7847):642-648. PMID: 33536616.
Senolytic CAR T Cells Reverse Senescence-Associated Pathologies. Amor, C, Feucht, J, Leibold, J, Ho, YJ, Zhu, C, Alonso-Curbelo, D, Mansilla-Soto, J, Boyer, JA, Li, X, Giavridis, T, Kulick, A, Houlihan, S, Peerschke, E, Friedman, SL, Ponomarev, V, Piersigilli, A, Sadelain, M, Lowe, SW. Nature. 2020 Jul;583(7814):127-132. PMID: 32555459.
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Ruscetti, M, Morris IV, JP, Mezzadra, R, Russell, J, Leibold, J, Romesser, PB, Simon, J, Kulick, A, Ho, YJ, Fennell, M, Li, J, Norgard, RJ, Wilkinson, JE, Alonso-Curbelo, D, Sridharan, R, Heller, DA, de Stanchina, E, Stanger, BZ, Sherr, CJ, Lowe, SW. Cell. 2020 Apr 16;181(2):424-441.e21. PMID: 32234521.
α-Ketoglutarate links p53 to cell fate during tumor suppression. Morris IV, JP, Yashinskie, JJ, Koche, R, Chandwani, R, Tian, S, Chen, C-C, Baslan, T, Marinkovic, ZS, Sanchez-Rivera, FJ, Leach, SD, Carmona-Fontaine, C, Thompson, CB, Finley, LWS, Lowe, SW. Nature. 2019 Sep;573(7775):595-599. PMID: 31534224.
NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Ruscetti, M, Leibold, J, Bott, MJ, Fennell, M, Kulick, A, Chen, C-C, Baslan, T, Salgado, NR, Sanchez-Rivera, FJ, Tian, S, Romesser PB, Poirier, JT, Rudin, CM, de Stanchina, E, Manchado, E, Sherr, CJ, and Lowe, SW. Science. 2018 Dec 21;362(6421):1416-1422. PMID: 30573629.
People

Scott W. Lowe, PhD
Chair, Cancer Biology & Genetics Program, SKI; Chair, Geoffrey Beene Cancer Research Center; Investigator, Howard Hughes Medical Institute
Professor
- Cancer biologist Scott Lowe uses genetically engineered mouse models to study how the genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response, and create molecular vulnerabilities that may be targeted therapeutically.
- PhD, Massachusetts Institute of Technology
- [email protected]
- Email Address
- 646-888-3342
- Office Phone
- Download CV
- PDF File
Members

- PhD, Universitat Pompeu Fabra and Institute for Research in Biomedicine [IRB] Barcelona (Spain)
- 646-888-3340
- Lab Phone

- PhD, University of Glasgow, Scotland, United Kingdom
- 646-888-3340
- Lab Phone

- BS, University of California, Santa Barbara, CA
- 646-888-3340
- Lab Phone

- PhD, Stanford University, Stanford, CA
- 646-888-3340
- Lab Phone

- PhD, Autonomous University of Madrid, Spain
- 646-888-3340
- Lab Phone

- MD, Johannes-Gutenberg-University, School of Medicine, Mainz, Germany
- 646-888-3340
- Lab Phone

- PhD, Cold Spring Harbor Laboratory, New York
- 646-888-3340
- Lab Phone

- BS, The College of New Jersey, Ewing, NJ
- 646-888-3340
- Lab Phone

- PhD, Imperial College London, United Kingdom
- 646-888-3340
- Lab Phone

- PhD, Netherlands Cancer Institute (Netherlands)
- 646-888-3340
- Lab Phone

- PhD, Harvard University, Cambridge, MA
- 646-888-3340
- Lab Phone

- PhD, Harvard University, Cambridge, MA
- 646-888-3340
- Lab Phone

- PhD, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY
- 646-888-3340
- Lab Phone

- PhD, Columbia University, New York, NY
- 646-888-3340
- Lab Phone

- MD, Capital University of Medical Sciences (China)
- 646-888-3340
- Lab Phone

- MS, University of Turku (Finland)
- 646-888-3340
- Lab Phone


- MS, Stony Brook University

Postdoctoral Researcher

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Graduate Student

Postdoctoral Researcher

Computational Biologist

Graduate Student

Postdoctoral Researcher

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Postdoctoral Researcher

Postdoctoral Researcher

Mouse Colony Manager

Lab Manager

Senior Research Technician

Senior Research Technician

Research Technician

Research Technician

Administrative Coordinator

Assistant to Chair

- PhD, Centro Nacional de Investigaciones Oncológicas [CNIO] (Spain)

- MD, Westphalian Wilhelms University (Germany)

- MD, Universidad Complutense de Madrid (Spain)
- PhD, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY

- PhD, Medical Research Council, Clinical Sciences Centre, Imperial College London (UK)

- PhD, University of Konstanz (Germany)

- PhD, Weill Cornell Medical College, New York, NY
- MD, National Taiwan University (Taiwan)

- BS, National Taiwan University (Taiwan)
- PhD, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY

- PhD, University of Michigan, Ann Arbor, MI

- PhD, University of Melbourne (Australia)

- PhD, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, NY

- PhD, Weill Cornell Medical College, New York, NY

- PhD, Northwestern University Feinberg School of Medicine, Chicago, IL

- MS, The Ohio State University, Columbus, OH
- PhD, Weill Cornell Medical College, New York, NY

- PhD, Weill Cornell Medical College, New York, NY

- PhD, Gerstner Sloan Kettering Graduate School, New York, NY

- PhD, University of Heidelberg (Germany)

- MD, University of Tübingen (Germany)

- PhD, Albert Einstein College of Medicine, New York, NY

- PhD, The Rockefeller University, New York, NY

- PhD, Weill Cornell Medical College, New York, NY

- PhD, Gerstner Sloan Kettering Graduate School, New York, NY

- PhD, Massachusetts Institute of Technology, Cambridge, MA

- PhD, Weill Cornell Medical College, New York, NY

- PhD, Centro Nacional de Investigaciones Oncológicas [CNIO] (Spain)

- PhD, Centro Nacional de Investigaciones Oncológicas [CNIO] (Spain)

- PhD, Baylor College of Medicine, Houston, TX

- PhD, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, NY

- PhD, University of Frankfurt (Germany)

- PhD, University of California, San Francisco, CA

- MD-PhD, Weill Cornell Medical College, New York, NY

- PhD, The Scripps Research Institute, La Jolla, CA

- PhD, University of California, Los Angeles, CA

- MD, Hannover Medical School (Germany)

- MD, University of Leipzig (Germany)


- PhD, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, NY

- MD, RWTH Aachen (Germany)

- PhD, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, NY

- MD, Medical University of China (China)
- PhD, Stony Brook University, New York

- BS, Carnegie Mellon University, Pittsburgh, PA

- MS, New York University

- BS, University of Connecticut

- AALAS Technician Certification

- BS, Yale University

- BS, Molloy College

- BA, City College of New York

- MS, New York University
- BSE, University of Pennsylvania

- BS, Binghamton University

- BS, Stony Brook University

- BS, Fairleigh Dickinson University

- BA, Hunter College

- MSc Oxon, University of Oxford (England)

- BS, University of Cincinnati
Lab Alumni

Junior Group Leader, Cancer Science, IRB Barcelona, Spain

Physician, University Hospital RWTH Aachen, Germany

CSHL Independent Fellow at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

Group Leader, German Cancer Research Center (DKFZ), Heidelberg, Germany

Principal Scientist, CTI, Pfizer Research, New York

Data Scientist, Agios Pharmaceuticals, Inc., Cambridge, MA

Postdoctoral Associate at Rockefeller University, New York, NY

Professor, Sichuan University, Sichuan, China

Assistant Professor, Weill Cornell Medical College, New York, NY

Director, Medical & Scientific Strategy, BluPrint Oncology, London

Senior Scientist, Oncology Biomarker Development, Genentech, San Francisco, CA

Associate Director, Liver Research, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY

Postdoctoral Fellow, Harvard University, Cambridge, MA

Co-Founder & CEO, Algen Biotechnologies, San Francisco, CA

Postdoctoral Associate, Weill Cornell Medicine, New York, NY

Senior Research Scientist, Philipps University of Marburg, Institute of Pharmacology, Germany

Group Leader, University of Tübingen, Germany

Professor, Sichuan University, Sichuan, China

Senior Research Analyst, Biotechnology and Pharmaceuticals, Chardan Capital Markets LLC, New York, NY

Group Leader, Altos Labs, San Francisco, CA

Venture Capital Associate, Nextech Invest, Boston, MA

Assistant Professor of Biology, Massachusetts Institute of Technology, Cambridge, MA

Senior Research Associate, Intelligencia, New York, NY

Associate Professor, Mount Sinai School of Medicine, New York, NY

Senior Principal Scientist, Novartis, Basel, Switzerland

Assistant Director, DNALC, Cold Spring Harbor Laboratory, New York

Senior Scientist, Pfizer, San Francisco, CA

Group Leader and Medical Fellow, University Medical Center Freiburg, Germany

Assistant Professor, Department of Pharmacology, University of North Carolina, Chapel Hill, NC

Investments, Roivant Sciences, New York, NY

Clinical Fellow, Pediatrics, Boston Children's Hospital, Boston, MA

Assistant Professor, Molecular, Cell & Cancer Biology, University of Massachusetts Medical School, Worcester, MA

Physician, Hannover Medical School, Germany

Physician, Hannover Medical School, Germany

Chair, Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN

Senior Scientist, Functional Genomics, Target Sciences, Pfizer, New York, NY

Group Leader, German Cancer Research Center (DKFZ), Heidelberg, Germany

Strategic Partnering Associate, Roche, Basel, Switzerland

Pathology Resident, The Mount Sinai Hospital, New York, NY

Research Specialist, Weill Cornell Medicine, New York, NY

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Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
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Scott Lowe Lab Plasmid and Animal Requests
Request plasmids through Addgene More »
For plasmids not listed on Addgene, please contact our Lab Manager, Anne Trumble-Koncelik, [email protected].
For animal requests, please contact our Mouse Colony Manager, Janelle Simon, [email protected].
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Scott W. Lowe discloses the following relationships and financial interests:
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Algen
Intellectual Property Rights -
Blueprint Medicines
Ownership / Equity Interests; Provision of Services -
Constellation Pharmaceuticals
Ownership / Equity Interests; Provision of Services -
Eli Lilly and Company
Provision of Services -
Faeth Therapeutics, Inc
Ownership / Equity Interests; Provision of Services (uncompensated)
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Geras Bio Inc
Ownership / Equity Interests; Provision of Services (uncompensated) -
Mirimus
Ownership / Equity Interests; Provision of Services -
Oric Pharmaceuticals
Ownership / Equity Interests; Provision of Services -
PMV Pharma
Ownership / Equity Interests; Provision of Services -
Petra Pharma Corporation
Ownership / Equity Interests; Provision of Services
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].