Cancer Biology & Genetics Program

The Luis Parada Lab

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Research

Luis Parada
Luis F. Parada, PhD
Director, Brain Tumor Center; Albert C. Foster Chair; American Cancer Society Research Professor

Professor

The Parada lab uses genetically engineered mouse models to recapitulate and study human disease. These mouse strains are used to understand the natural history of tumors of the nervous system, including glioblastoma multiforme (GBM), malignant peripheral nerve sheath tumors (MPNST), neurofibromas, and other diseases associated with neurofibromatosis (NF1). We seek to develop mouse cancer models based on concrete hypotheses and to rapidly transfer findings for validation in human cancer samples.

Research Projects

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Inside My Lab: Luis Parada

Go inside the lab of Luis Parada from MSK's Brain Tumor Center.
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The Luis Parada Lab

Featured News

In the Lab
Enhanced MRI of a glioblastoma
Starving Cancer Stem Cells Could Be the Trick to Treating Glioblastoma, Study Finds

MSK researchers have identified a compound that kills glioblastoma cells using a mechanism that’s completely different from earlier treatments.

Publications

Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy. 2022. Xie XP, Laks DR, Sun D, Ganbold M, Wang Z, Pedraza AM, Bale T, Tabar V, Brennan C, Zhou X, Parada LF. 2022, Dev Cell, PMCID: PMC8820651.

Stem-like cells drive NF1-associated MPNST functional heterogeneity and relapse after chemotherapy. 2021. Sun D, Xie X, Wang Z, Sait S, Iyer S, Chen Y, Brown R, Laks D, Chipman M, and Parada L. 2021, Cell Stem Cell, PMCID: PMC8349880

High resolution mouse subventricular zone stem cell niche transcriptome reveals features of lineage, anatomy, and aging.  Xie XP, Laks DR,  Sun D, Poran A,  Laughney AM,  Wang Z, Sam J, Belenguer G, Fariñas I, Elemento O, Zhou X, Parada LF., 2020. Proceedings of the National Academy of Sciences. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31448-31458. doi: 10.1073/pnas.2014389117. Epub 2020 Nov 23.

Cell Lineage-Based Stratification for Glioblastoma. Wang Z, Sun D, Chen YJ, Xie X, Shi Y, Tabar V, Brennan CW, Bale TA, Jayewickreme CD, Laks DR, Alcantara Llaguno S, Parada LF. Cancer Cell. 2020 Sep 14;38(3):366-379.e8. doi: 10.1016/j.ccell.2020.06.003. Epub 2020 Jul 9. PMID: 32649888; PMCID: PMC7494533.

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z, Xie X, Sun D, Chen YJ, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF. Nature. 2019 Mar;567(7748):341-346. doi: 10.1038/s41586-019-0993-x. Epub 2019 Mar 6.

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People

Luis Parada

Luis F. Parada, PhD

Director, Brain Tumor Center; Albert C. Foster Chair; American Cancer Society Research Professor

Professor

  • Developmental biologist Luis F. Parada uses genetically engineered mouse models to study neurofibromatosis, brain tumors, cancer stem cells, and tumor progression.
  • PhD, Massachusetts Institute of Technology
[email protected]
Email Address
646-888-2055 (Assistant to Dr. Parada)
Office Phone

Members

Sheila Alcantara
Sheila Alcantara

Senior Research Scientist

Yu-Jung Chen, Graduate Student
Yu-Jung Chen

Graduate Student

Mollie Chipman
Mollie Chipman

Graduate Student

Aimee Cowan- Project Manager
Aimee Cowan

Project Manager

Tünde Frankl

SKI Admin Assistant II

Mungunsarnai Ganbold

Computational Biologist I

Charlene Iltis
Charlene Iltis

Research Scholar

Swathi Iyer, Research Scholar
Swathi Iyer

Research Scholar

Jing Li, PhD
Jing Li

Research Assistant

Michelle Lien
Michelle Lien

Senior Research Technician

Senior Research Technician
Esther Njeri Njoroge

Senior Research Technician

Zainab Oketokoun

Research Assistant

Alicia Maria Pedraza, MA
Alicia Maria Pedraza

Senior Research Assistant

Sameer Farouk Sait, Hematology-oncology Fellows at MSKCC/Cornell
Sameer Farouk Sait

Hematology-oncology Fellows at MSKCC/Cornell

Mary Clare Slavinsky
Mary Clare Slavinsky

Research Assistant

Stefan Sweha

Research Scholar

Kacper Walentynowicz

Research Scholar

Tao Wang- Graduate Student
Tao Wang

Graduate Student

Xuanhua Xie, PhD
Xuanhua Xie

Senior Reasearch Scientist

Lab Alumni
Ashley Chandradat
Ashley Chandradat

SKI Admin Assistant II

Dan Laks, PhD
Dan Laks

Research Scholar

Lu Le
Kyun Lim
Zhenzhong Ma
Yufeng Shi, PhD
Yufeng Shi

Research Associate

Daochun Sun, PhD
Daochun Sun

Research Associate

Zilai Wang, PhD
Zilai Wang

Research Associate

Lab Affiliations

Achievements

  • Member, National Academy of Science (2011)
  • Fellow of American Association for the Advancement of Science (2009)
  • Member, National Academy of Medicine- Former Institute of Medicine (2007)
  • The Academy of Medicine, Engineering and Sciences of Texas (TAMEST) (2007)
  • Member, American Academy of Arts and Sciences (2007)
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  • Member, Dana Alliance for Brain Initiatives (2003)
  • Professor, American Cancer Society Research (2002)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Career Opportunities

The Luis F. Parada laboratory currently has a position open for a postdoctoral research fellow.

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Luis F. Parada discloses the following relationships and financial interests:

  • Thermo Fisher Scientific, Inc
    Ownership / Equity Interests

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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