Cancer Biology & Genetics Program

The Luis Parada Lab

Research

Luis F. Parada, PhD

Director, Brain Tumor Center; Albert C. Foster Chair; American Cancer Society Research Professor

Professor

The Parada lab uses genetically engineered mouse models to recapitulate and study human disease. These mouse strains are used to understand the natural history of tumors of the nervous system, including glioblastoma multiforme (GBM), malignant peripheral nerve sheath tumors (MPNST), neurofibromas, and other diseases associated with neurofibromatosis (NF1). We seek to develop mouse cancer models based on concrete hypotheses and to rapidly transfer findings for validation in human cancer samples.

Research Projects

Featured News

In the Lab

Starving Cancer Stem Cells Could Be the Trick to Treating Glioblastoma, Study Finds

Wednesday, March 6, 2019

Publications

A quiescent human glioblastoma stem cell gene expression signature. 2020. Xuanhua P. Xie, Dan R. Laks, Daochun Sun, Zilai Wang, Tejus Bale, Viviane Tabar, Cameron Brennan, Xiuping Zhou, Luis F. Parada; Submitted.

Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression. 2020. Daochun Sun1, X. Peter Xie, Xiyuan Zhang, Zilai Wang, Sameer Farouk Sait, Swathi V. Iyer, Yu-Jung Chen, Rebecca Brown, Dan R. Laks, Mollie E. Chipman, Jack F. Shern, and Luis F. Parada. Submitted.

Cell Lineage-Based Stratification for Glioblastoma. Wang Z, Sun D, Chen YJ, Xie X, Shi Y, Tabar V, Brennan CW, Bale TA, Jayewickreme CD, Laks DR, Alcantara Llaguno S, Parada LF. Cancer Cell. 2020 Sep 14;38(3):366-379.e8. doi: 10.1016/j.ccell.2020.06.003. Epub 2020 Jul 9. PMID: 32649888; PMCID: PMC7494533.

High resolution subventricular zone stem cell niche transcriptome reveals features of lineage, anatomy, and aging. Xie XP, Laks DR, Sun D, Poran A, Laughney AM, Wang Z, Sam J, Belenguer G, Fariñas I, Elemento O, Zhou X, Parada LF., 2020. Proceedings of the National Academy of Sciences. In Press.

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z, Xie X, Sun D, Chen YJ, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF. Nature. 2019 Mar;567(7748):341-346. doi: 10.1038/s41586-019-0993-x. Epub 2019 Mar 6.

Cell of Origin Susceptibility to Glioblastoma Formation Declines with Neural Lineage Restriction. Alcantara Llaguno S, Sun D, Pedraza AM, Vera E, Wang Z, Burns DK, Parada LF. Nat Neurosci. 2019 Apr;22(4):545-555. doi: 10.1038/s41593-018-0333-8. Epub 2019 Feb 18.

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People

Luis F. Parada, PhD

Director, Brain Tumor Center; Albert C. Foster Chair; American Cancer Society Research Professor

Professor

Developmental biologist Luis F. Parada uses genetically engineered mouse models to study neurofibromatosis, brain tumors, cancer stem cells, and tumor progression.
PhD, Massachusetts Institute of Technology

Paradal@mskcc.org: Email Address
646-888-2055 (Assistant to Dr. Parada): Office Phone

Members

Sheila Alcantara, MD, PhD — Sheila Alcantara
Senior Research Scientist

Ashley Chandradat, SKI Admin Assistant II — Ashley Chandradat
SKI Admin Assistant II

Yu-Jung Chen, Graduate Student — Yu-Jung Chen
Graduate Student

Swathi Iyer, Research Scholar — Swathi Iyer
Research Scholar

Chenura D. Jayewickreme
Weill Cornell Graduate Student

Jing Li, PhD — Jing Li
Research Technician Sr.

Alicia Maria Pedraza, MA — Alicia Maria Pedraza
Research Assistant, Sr.

Sameer Farouk Sait, Hematology-oncology Fellows at MSKCC/Cornell — Sameer Farouk Sait
Hematology-oncology Fellows at MSKCC/Cornell

Daochun Sun, PhD — Daochun Sun
Research Associate

Xuanhua Xie, PhD — Xuanhua Xie
Research Associate

Lab Alumni

Dan Laks, PhD — Dan Laks
Research Scholar

Lu Le

Kyun Lim

Zhenzhong Ma

Yufeng Shi, PhD — Yufeng Shi
Research Associate

Zilai Wang, PhD — Zilai Wang
Research Associate

Lab Affilations

Achievements

Member, National Academy of Science (2011)
Fellow of American Association for the Advancement of Science (2009)
Member, National Academy of Medicine- Former Institute of Medicine (2007)
The Academy of Medicine, Engineering and Sciences of Texas (TAMEST) (2007)
Member, American Academy of Arts and Sciences (2007)

Member, Dana Alliance for Brain Initiatives (2003)
Professor, American Cancer Society Research (2002)

Open Positions

Career Opportunities

The Luis F. Parada laboratory currently has a position open for a postdoctoral research fellow.

Apply now

Get in Touch

Paradal@mskcc.org

Lab Head Email
646-888-2055 (Assistant to Dr. Parada)

Office Phone
646-888-3780

Lab Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Luis F. Parada discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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