Cancer Biology & Genetics Program
The Luis Parada Lab
The Parada lab uses genetically engineered mouse models to recapitulate and study human disease. These mouse strains are used to understand the natural history of tumors of the nervous system, including glioblastoma multiforme (GBM), malignant peripheral nerve sheath tumors (MPNST), neurofibromas, and other diseases associated with neurofibromatosis (NF1). We seek to develop mouse cancer models based on concrete hypotheses and to rapidly transfer findings for validation in human cancer samples.
A quiescent human glioblastoma stem cell gene expression signature. 2020. Xuanhua P. Xie, Dan R. Laks, Daochun Sun, Zilai Wang, Tejus Bale, Viviane Tabar, Cameron Brennan, Xiuping Zhou, Luis F. Parada; Submitted.
Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression. 2020. Daochun Sun1, X. Peter Xie, Xiyuan Zhang, Zilai Wang, Sameer Farouk Sait, Swathi V. Iyer, Yu-Jung Chen, Rebecca Brown, Dan R. Laks, Mollie E. Chipman, Jack F. Shern, and Luis F. Parada. Submitted.
Cell Lineage-Based Stratification for Glioblastoma. Wang Z, Sun D, Chen YJ, Xie X, Shi Y, Tabar V, Brennan CW, Bale TA, Jayewickreme CD, Laks DR, Alcantara Llaguno S, Parada LF. Cancer Cell. 2020 Sep 14;38(3):366-379.e8. doi: 10.1016/j.ccell.2020.06.003. Epub 2020 Jul 9. PMID: 32649888; PMCID: PMC7494533.
High resolution subventricular zone stem cell niche transcriptome reveals features of lineage, anatomy, and aging. Xie XP, Laks DR, Sun D, Poran A, Laughney AM, Wang Z, Sam J, Belenguer G, Fariñas I, Elemento O, Zhou X, Parada LF., 2020. Proceedings of the National Academy of Sciences. In Press.
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z, Xie X, Sun D, Chen YJ, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF. Nature. 2019 Mar;567(7748):341-346. doi: 10.1038/s41586-019-0993-x. Epub 2019 Mar 6.
Luis F. Parada, PhD
Director, Brain Tumor Center; Albert C. Foster Chair; American Cancer Society Research Professor
- Developmental biologist Luis F. Parada uses genetically engineered mouse models to study neurofibromatosis, brain tumors, cancer stem cells, and tumor progression.
- PhD, Massachusetts Institute of Technology
- Member, National Academy of Science (2011)
- Fellow of American Association for the Advancement of Science (2009)
- Member, National Academy of Medicine- Former Institute of Medicine (2007)
- The Academy of Medicine, Engineering and Sciences of Texas (TAMEST) (2007)
- Member, American Academy of Arts and Sciences (2007)
- Member, Dana Alliance for Brain Initiatives (2003)
- Professor, American Cancer Society Research (2002)
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Luis F. Parada discloses the following relationships and financial interests:
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