We are interested in the mechanisms that support tissue homeostasis and cancer metastasis. Focusing on TGFβ as one of the most prevalent signaling pathways in metazoan biology, we are establishing how TGFβ signals control pluripotency and differentiation in stem cells, and homeostasis in mature cells. In addition, we are interested in the genes and pathways that drive metastasis. Ultimately, our goal is to use this basic knowledge to develop innovative cancer treatments.
Joan Massagué, PhD
Executive Director, GMTEC; Director, Sloan Kettering Institute; Member, Cancer Biology & Genetics Program
Professor
Research Focus
Sloan Kettering Institute Director Joan Massagué studies the control of stem cell growth and phenotype in tumor progression, metastasis, and response to therapy.Education
PhD, University of Barcelona- Office Phone: 646-888-2044
- Office Fax: 646-422-0197
- Lab Phone: 646-888-2521
Lab Members
Harihar Basnet
Research Associate
Ekrem Emrah Er
Research Associate
Karuna Ganesh
Assistant Member, L1, Department of Medicine
Jessica Hampton
Research Technician
Lan He
Senior Research Assistant
Jing Hu
Research Fellow
Yasemin Kaygusuz
Graduate Student
Weiping Shu
Senior Research Assistant
Jie Su
Research Fellow
Lin Tian
Research Scholar
Zhenghan Wang
Research Scholar
Fei Chen
Research Scholar
George Lampe
Research Technician
Ashley M. Laughney
Research Associate
Leah Myers
Administrative Assistant
Constantina (Dina) Rodriguez
Executive Assistant
Publications
- Malladi, S., Macalinao, D., Jin, X., He, L., de Stanchina, E.,, and Massagué, J. Metastatic latency and immune evasion through autocrine inhibition of WNT. Cell 165, 45-60 (2016) PMC4808520
- David, C.J., Huang, Y.-H., Chen, M., Su, J., Bardeesy, N., Iacobuzio-Donahue, C., and Massagué, J. TGF-β tumor suppression through a lethal EMT. Cell 164, 1015-30 (2016) PMC4801341
Selected Achievements
- Fellow, American Association for Cancer Research (AACR) Academy (2016)
- Pezcoller Foundation-AACR International Award for Cancer Research (2016)
- Charles Rodolphe Brupbacher Prize for Cancer Research (2015)
- National Prize for Research in Biology, Spain (2014)
- American Italian Cancer Foundation Price (2013)
