We are interested in the mechanisms that support tissue homeostasis and cancer metastasis. Focusing on TGFβ as one of the most prevalent signaling pathways in metazoan biology, we are establishing how TGFβ signals control pluripotency and differentiation in stem cells, and homeostasis in mature cells. In addition, we are interested in the genes and pathways that drive metastasis. Ultimately, our goal is to use this basic knowledge to develop innovative cancer treatments.
Joan Massagué, PhD
Executive Director, GMTEC; Director, Sloan Kettering Institute; Member, Cancer Biology & Genetics Program
Research FocusSloan Kettering Institute Director Joan Massagué studies the control of stem cell growth and phenotype in tumor progression, metastasis, and response to therapy.
EducationPhD, University of Barcelona
- Basnet H, Tian L, Ganesh K, Huang YH, Macalinao DG, Brogi E, Finley LW, and Massagué J. Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization. Elife (2019); 8: e43627. PMC6440742
- Er, E.E., Valiente, M., Ganesh, K., Agrawal, S., Hu, J., Griscom, B., Rosenblum, M., Boire, A., BRogi, E., Giancotti, F.G., Schachner, M., Malladi, S., and Massagué, J. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastaticcolonization. Nat Cell Biol. 2018 Aug;20(8):966-978. PMC6467203
- Fellow, American Association for Cancer Research (AACR) Academy (2016)
- Pezcoller Foundation-AACR International Award for Cancer Research (2016)
- Charles Rodolphe Brupbacher Prize for Cancer Research (2015)
- National Prize for Research in Biology, Spain (2014)
- American Italian Cancer Foundation Price (2013)