Molecular Biology Program
The Xiaolan Zhao Lab
Our lab studies two fundamental aspects of biology that have broad implications for human health. The first research direction examines how cells faithfully duplicate their genomes and repair DNA lesions arising from endogenous and exogenous sources. The second direction focuses on how a protein modifier called SUMO mediates signal transduction, directs the DNA stress response, and dynamically regulates the functions of many proteins. We have implemented a versatile combination of molecular, genetic, biochemical, cell biological, and genomic/proteomic approaches toward answering these questions. Our current work aims to elucidate new underlying principles of the above processes, and reveal how they are integrated with other cellular functions to achieve cell proliferation under various conditions.
Yu Y, Li S, Ser Z, Sanyal T, Choi K, Wan B, Kuang H, Sali A, Kentsis A, Patel DJ, Zhao X. (2021) Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A. 118(19):e2026844118.
Dhingra N, Kuppa S, Wei L, Pokhrel N, Baburyan S, Meng X, Antony E, Zhao X (2021). The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin. Proc Natl Acad Sci U S A. Feb 23;118(8):e2020185118.
Li S, Bonner JN, Wan B, So S, Summers A, Gonzalez L, Xue X, Zhao X (2021). Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes Dev. 35(3-4):261-272.
Shen M, Dhingra N, Wang Q, Cheng C, Zhu S, Tian , Yu J, Gong X, Li X, Zhang H, Xu X, Zhai L, Xie M, Gao Y, Deng H, He Y, Niu H, Zhao X, Xiang S (2021). Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nature Commun. 12: 321.
Xiaolan Zhao, PhD
- Molecular biologist Xiaolan Zhao studies chromosomal organization, genome integrity, DNA replication and repair, dynamic protein modification.
- PhD, Columbia University
- Bressler Scholar, Alfred W. Bressler Scholar Endowment Fund (2007-2010)
- Research Scholar, American Cancer Society (2012-2016)
- Scholar, Leukemia & Lymphoma Society (2013-2018)
- Discovery of the extensive SUMO-based DNA damage response
- Discovery of the connection between the nuclear pore complex and desumoylation
- Discovery of the Smc5/6 complex in budding yeast
- Discovery of the essential function of the DNA replication and damage checkpoint
Lab News & Events
Shibai and Jake’s paper on the functions of a sumoylation cofactor is out in Genes Dev (2021).
Bingbing started his own lab at Shanghai Jiao Tong University.
Michael’s new lab is not far from Bingbing’s lab in the same University!
Congrats to Michael and Wei for their work on POLe that synthesizes half of our body’s DNA (Nat Commun 2020).
We welcome new Research Scholars, Jiayi and Thane.
Congrats to Nalini for winning 2020 Kravis Women in Science Endeavor grant!
A shout out to Danying who won best Oral Presentation at 2020 ABRC conference.
Bingbing’s structural paper on a genome maintenance hub is out in Mol Cell, 2019.
Read up our reviews on SUMO-based controls in Genes Dev, 2019 and Mol Cell. 2018.
Congrats to Silva for winning the 2021 Jonas E Salk Scholarship!
Get in Touch
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Xiaolan Zhao discloses the following relationships and financial interests:
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