Mary Baylies, PhD
Research FocusThe Baylies laboratory studies the mechanisms that form and maintain muscle both during normal development and in disease.
EducationPhD, The Rockefeller University
- Windner SE, Manhart A, Brown A, Mogilner A, Baylies MK. 2019. Nuclear Scaling Is Coordinated among Individual Nuclei in Multinucleated Muscle Fibers. Dev Cell. Apr 8;49(1):48-62.e3. Featured as a cover image and in a Preview.
- Rosen JN, Azevedo M, Soffar DB, Boyko VP, Brendel MB, Schulman VK, Baylies MK. 2019. The Drosophila Ninein homologue Bsg25D cooperates with Ensconsin in myonuclear positioning. J Cell Biol. Feb 4; 218(2): 524-540. The Baylies Lab provided the cover image for this edition of JCB.
- Developed a Drosophila model for metastasis in alveolar rhabdomyosarcoma, a type of soft tissue cancer most often seen in children
- Demonstrated that properly placed nuclei are critical for healthy muscle function
- Described how nuclear polarization occurs during myonuclear movement in vivo
- Completed the first spatial and temporal characterization of an F-actin structure that forms at the myoblast fusion site
- Identified transcription factors and chromatin regulators that are critical for muscle identity
- Identified 3-D arrangement of myoblasts that occur during muscle specification and morphogenesis
- Discovered signal transduction pathways (Notch, Wnt, BMP, and RTK) and transcription factors that are critical for muscle identity
- President of the Society for Muscle Development (2009-2013)
- Frederick Adler Chair for Junior Faculty (1997-2003)