Mary Baylies, PhD
Research FocusDevelopmental biologist Mary Baylies studies the mechanisms that form and maintain muscle both during normal development and in disease.
EducationPhD, The Rockefeller University
- Dobi, KC, Halfon MS, Baylies MK., 2014 Whole-genome analysis of muscle founder cells implicates the chromatin regulator Sin3a in muscle identity. Cell Reports. 2014 Jul 30. pii: S2211-1247(14)00572-5. PMID:25088419. PMCID: PMC – in process.
- Bothe, I., Deng, S., Baylies MK 2014 PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site. Development. 141(11):2289-301. PMID: 24821989. PMCID: PMC4034421
- Developed a Drosophila model for metastasis in alveolar rhabdomyosarcoma, a type of soft tissue cancer most often seen in children
- Demonstrated that properly placed nuclei are critical for healthy muscle function
- Described how nuclear polarization occurs during myonuclear movement in vivo
- Completed the first spatial and temporal characterization of an F-actin structure that forms at the myoblast fusion site
- Identified transcription factors and chromatin regulators that are critical for muscle identity
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- Identified 3-D arrangement of myoblasts that occur during muscle specification and morphogenesis
- Discovered signal transduction pathways (Notch, Wnt, BMP, and RTK) and transcription factors that are critical for muscle identity
- President of the Society for Muscle Development (2009-2013)
- Frederick Adler Chair for Junior Faculty (1997-2003)