Developmental Biology Program
The Mary Baylies Lab
Developmental biologist Mary Baylies studies the mechanisms that form and maintain muscle both during normal development and in disease.
Balakrishnan M,Yu SF, Chin S, Soffar DB, Windner S, Goode B, Baylies MK (2020). Cofilin loss in Drosophila contributes to muscle weakness through defective sarcomerogenesis during muscle growth. Cell Reports. 32(3): 107893. PMCID: PMC7479987.
Windner SE, Manhart A, Brown A, Mogilner A, Baylies MK. (2019.) Nuclear Scaling Is Coordinated among Individual Nuclei in Multinucleated Muscle Fibers. Dev Cell. Apr 8;49(1):48-62.e3. Featured as a cover image and in a Preview.
Mary Baylies, PhD
- The Baylies laboratory studies the mechanisms that form and maintain muscle both during normal development and in disease.
- PhD, The Rockefeller University
- [email protected]
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- Identified that global, regional, and local inputs contribute to nuclear size regulation in multinucleated skeletal muscle fibers.
- Demonstrated that properly placed nuclei are critical for healthy muscle function.
- Discovered that microtubules are critical for the movement and positioning of nuclei in the multinucleated skeletal muscle cell.
- Developed Drosophila models of muscle wasting in cancer cachexia and aging.
- Identified how actin filament dysregulation contributes to skeletal muscle dysfunction in models of nemaline myopathy.
- Developed a Drosophila model for metastasis in alveolar rhabdomyosarcoma, a type of soft tissue cancer most often seen in children.
- Described how nuclear polarization occurs during myonuclear movement in vivo.
- Completed the first spatial and temporal characterization of an F-actin structure that forms at the myoblast fusion site.
- Identified transcription factors and chromatin regulators that are critical for muscle identity.
- Identified 3-D arrangement of myoblasts that occur during muscle specification and morphogenesis.
- Discovered signal transduction pathways (Notch, Wnt, BMP, and RTK) and transcription factors that are critical for muscle identity.
- President of the Society for Muscle Development (2009-2013).
- Frederick Adler Chair for Junior Faculty (1997-2003).
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Mary Baylies discloses the following relationships and financial interests:
French National Research Agency
Provision of Services (uncompensated)
Howard Hughes Medical Institute
Provision of Services
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