The focus of the Cheng laboratory is to elucidate the molecular mechanisms underlying cell death with the hope that the knowledge derived from our research can be translated into targeted therapeutics that trigger cell death in cancer.
Emily H. Cheng, MD, PhD
Attending Pathologist, Department of Pathology; Member, Human Oncology and Pathogenesis Program
Professor
Research Focus
Physician-scientist Emily Cheng focuses on the molecular mechanisms of cell death and their implications in tumorigenesis and cancer therapy, with primary emphasis on lung and kidney cancers.Education
- MD, Taipei Medical University
- PhD, Johns Hopkins University School of Medicine
- Office Phone: 646-888-3258
- Office Fax: 646-888-3266
Lab Members
Po Chan
Research Technician
Song Han
Research Technician
Paul Jeng
Graduate Student
Yogesh Tengarai Ganesan
Research Technician
Akane Yamauchi
Research Fellow
Yuchen Xie
Graduate Student
Publications
- Ren D, Tu H, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJD, Cheng EHY. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science. 2010 Dec 3;330(6009):1390-3. doi: 10.1126/science.1190217.
- Kim H, Rafiuddin-Shah M, Tu HC, Jeffers J, Zambetti GP, Hsieh JJD, Cheng EHY. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol. 2006 Dec;8(12):1348-58. Epub 2006 Nov 19.
Selected Achievements
- Distinguished Investigator Award, Washington University School of Medicine (2010)
- Searle Scholar Award (2005)
- Howard Temin Award, National Cancer Institute (2003)