Human Oncology & Pathogenesis Program
The Emily Cheng Lab
The focus of the Cheng laboratory is to elucidate the molecular mechanisms underlying cell death with the hope that the knowledge derived from our research can be translated into targeted therapeutics that trigger cell death in cancer.
Ren D, Tu H, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJD, Cheng EHY. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science. 2010 Dec 3;330(6009):1390-3. doi: 10.1126/science.1190217.
Kim H, Rafiuddin-Shah M, Tu HC, Jeffers J, Zambetti GP, Hsieh JJD, Cheng EHY. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol. 2006 Dec;8(12):1348-58. Epub 2006 Nov 19.
Kim H, Tu H, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJD, Cheng EHY. Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Mol Cell. 2009 Nov 13;36(3):487-99. doi: 10.1016/j.molcel.2009.09.030.
Bean GR, Ganesan YT, Dong Y, Takeda S, Liu H, Chan PM, Huang Y, Chodosh LA, Zambetti GP, Hsieh JJD, Cheng EHY. PUMA and BIM are required for oncogene inactivation-induced apoptosis. Sci Signal. 2013 Mar 26;6(268):ra20. doi: 10.1126/scisignal.2003483.
Emily H. Cheng, MD, PhD
Attending Pathologist, Department of Pathology; Member, Human Oncology and Pathogenesis Program
- Physician-scientist Emily Cheng focuses on the molecular mechanisms of cell death and their implications in tumorigenesis and cancer therapy, with primary emphasis on lung and kidney cancers.
- MD, Taipei Medical University
- PhD, Johns Hopkins University School of Medicine
- Distinguished Investigator Award, Washington University School of Medicine (2010)
- Searle Scholar Award (2005)
- Howard Temin Award, National Cancer Institute (2003)
Postdoctoral positions available for highly motivated candidates with a strong background in biochemistry, molecular biology, cell biology, and/or mouse genetics to join a research group studying the fundamental mechanisms of cell death and their impact on tumorigenesis and cancer therapy.
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Emily H. Cheng discloses the following relationships and financial interests:
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