Cell Biology Program

The Meng-Fu Bryan Tsou Lab

Share
Print

Research

Pictured: Meng-Fu Bryan Tsou
Meng-Fu Bryan Tsou, PhD


Professor

The goal of my research is to understand the biogenesis of centrioles/centrosomes and primary cilia, and how defects in these processes affect mammalian cell physiology and evoke stress responses. Using quantitative proteomics, super-resolution microscopy, comparative genomics, proximity labeling, and whole genome CRISPR screen, we have identified lists of new components associated with vertebrate centrosomes and ciliogenesis. Functions of these molecules are being examined in the most appropriate experimental system, including human culture cells for cell-based assays, and most recently, mice, as the genetic system to explore the regulation specific to vertebrate ciliogenesis. This multi-system approach has revealed complex regulatory networks underlying centriole homeostasis and ciliogenesis that have been either preserved throughout the evolution or modified specifically for vertebrates and mammals.

View Lab Overview

The Meng-Fu Bryan Tsou Lab

Publications

Fong CS, Ozaki K, Tsou MB*. (2018). PPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion.  Mol Biol Cell. 29(23):2801-2808.

Yang TT, Chong WM, Wang WJ, Mazo G, Tanos B, Chen Z, Tran TMN, Chen YD, Weng RR, Huang CE, Jane WN, Tsou MB*, Liao JC*. (2018). Architecture of mammalian centriole distal appendages accommodates distinct blade and matrix functional elements. Nature Communication. 9(1):2023.  (*Co-corresponding authors).

Shulman AS, Tsou MF*. (2017). Probing Cilia-Associated Signaling Proteomes in Animal Evolution. Dev Cell. 43(6):653-655.

Mazo G, Soplop N, Wang WJ, Uryu K, and Tsou MF*. (2016). Spatial control of primary ciliogenesis by subdistal appendages alters sensation-associated properties of cilia. Dev Cell. 39(4):424-437.

Kim M, O’Rourke BP, Soni RK, Jallepalli PV, Hendrickson RC, Tsou MF*. (2016). Promotion and suppression of centriole duplication are catalytically coupled through PLK4 to ensure centriole homeostasis. Cell Rep. 16(5):1195-203.

View All Publications

People

Pictured: Meng-Fu Bryan Tsou

Meng-Fu Bryan Tsou, PhD



Professor

  • Cell biologist Meng-Fu Bryan Tsou studies cell cycle control of centrosome duplication and degeneration, as well as cilia assembly and disassembly.
  • PhD, University of California, Davis
tsoum@mskcc.org
Email Address

Members

Bryan Tsou
Bryan Tsou

Lab Head

Kanako Ozaki
Kanako Ozaki

Research Scholar

Avital Shulman
Avital Shulman
Sonia Das

Sr. Administrative Assistant

Tatiana Omelchenko
Lab Alumni
Tuhin Das
Tuhin Das

Visiting Investigator

Sarvan K Radhakrishnan
Sarvan K Radhakrishnan

Research Fellow

Yun-Yu Tseng
Yun-Yu Tseng

Research Scholar

Mildred Perez
Mildred Perez

Admin Assistant

Chii Shyang Fong, PhD
Chii Shyang Fong

Research Fellow

Minhee Kim
Minhee Kim

Graduate Student

Gregory Mazo
Gregory Mazo

Graduate Student

Rajesh Soni
Barbara Tanos, PhD
Barbara Tanos

Postdoctoral Fellow

Cherisse Vickers-Salcedo
Cherisse Vickers-Salcedo

Administrative Assistant

Won-Jing Wang
Won-Jing Wang
Hui-Ju Yang, PhD
Hui-Ju Yang

Research Fellow

Jennifer Ka-Man Chu

Research Scholar

Denisse Izquierdo

Graduate Student

Brian P. O'Rourke
Lab Affilations

Open Positions

Career Opportunities

Research Technician Positions are available for applicants who have a degree in Biology or related fields, and at least one year of lab experience in cell & molecular biology.

Apply now

Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Meng-Fu Bryan Tsou discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


View all disclosures