Cell Biology Program

The Lydia Finley Lab

Research

Lydia Finley, PhD
Lydia Finley, PhD


Associate Professor

The Finley Lab investigates how cellular metabolic pathways regulate cell fate decisions in stem cells and cancer cells. We combine genetic and metabolomic approaches to investigate cell-type specific growth requirements and elucidate how flux through central metabolic pathways regulates key cellular activities, including self-renewal and differentiation. In particular, we are interested in understanding how changes in metabolite availability shape the chromatin landscape to influence gene expression programs that control cell survival, growth and differentiation. Our work aims to answer fundamental questions about how cells regulate the commitment to differentiation and how failure to execute terminal differentiation can underlie diseases such as cancer.

Publications

α-Ketoglutarate links p53 to cell fate during tumour suppression. Morris JP 4th*, Yashinskie JJ*, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS, Sánchez-Rivera FJ, Leach SD, Carmona-Fontaine C, Thompson CB, Finley LWS#, Lowe SW#. Nature. 2019 Sep;573(7775):595-599. doi: 10.1038/s41586-019-1577-5. Epub 2019 Sep 18. PMID: 31534224. (*co-first, #co-corresponding)

Glutamine independence is a selectable feature of pluripotent stem cells. Vardhana SA, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Fontaine CC, Thompson CB, Finley LWS. Nat Metab. 2019 Jul;1(7):676-687. doi: 10.1038/s42255-019-0082-3. Epub 2019 Jul 8. PMID: 31511848

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People

Lydia Finley, PhD

Lydia Finley, PhD



Associate Professor

  • Lydia Finley studies the mechanisms that link metabolic pathways to cell fate decisions.
  • PhD, Harvard University
[email protected]
Email Address
212-639-6722
Office Phone

Members

Pavlina Todorova, PhD
Pavlina Todorova

Research Associate

Julia Brunner
Julia Brunner

Research Fellow

Jossie  J Yashinskie
Jossie J Yashinskie

Graduate Student

Katrina Paras
Katrina Paras

Graduate Student

Benjamin Jackson
Benjamin Jackson

Graduate Student

Abigail Xie

Graduate Student

Anna Bridgeman

MSK Bridge Program Scholar

Natasha Freidman

Research Fellow

Sonia Das
Sonia Das

Sr. Administrative Assistant

Lab Alumni
Paige Arnold
Paige Arnold

Postdoctoral Associate at Rockefeller University, New York, NY

Yanyang Chen
Yanyang Chen

Research Technician

Yuma Tada
Yuma Tada

Graduate Student

Sanjeethan Baksh
Sanjeethan Baksh

Graduate Student

Lin Hedehus

Graduate Research Assistant

Lab Affiliations

Achievements

  • Searle Scholars Program
  • Damon Runyon-Dale F. Frey Award for Breakthrough Scientists
  • Jack Sorrell Fellow of the Damon Runyon Cancer Research Foundation

Lab News & Events

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