Structural Biology Program
The Nikola Pavletich Lab
Research
![Pictured: Dr. Nikola Pavletich](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/1647/person/pavletich_180501_10_1200x800.jpg?h=10d202d3)
Professor
Our research group is interested in understanding, at the structural and mechanistic levels, the maintenance of genomic integrity and the control of cell growth, both of which figure prominently in cancer. In the area of growth control, our recent work is focused on the mTOR pathway that controls multiple aspects of cell growth and homeostasis. Our work on genomic integrity ranges from the Fanconi Anemia pathway, which responds to DNA interstrand crosslinks, to the ATR and ATM checkpoint kinases that coordinate the cell’s response to replication stress and DNA double-strand breaks, respectively. Common to these genomic integrity pathways is eventual repair by homologous recombination, a process that has been a longstanding focus of our research.
Research Projects
![Nikola Pavletich Lab Group](https://www.sloankettering.edu/sites/default/files/node/1647/3x2/pavletich_lab_1190207_08_1200x800-1.jpg)
Featured News
![Structure of an intermediate during the homologous recombination reaction.](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/213856/main_image/figure_recolored-1200x800.jpg)
![Pictured: Three-dimensional structure of the protein mTOR](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/19573/image/paveltich-mskcc-figure-12x8.jpg)
![Pictured: Nikola Pavletich and Alexander Rudensky](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/17215/image/pavletich-rudensky-combo.jpg)
Publications Highlights
People
![Pictured: Dr. Nikola Pavletich](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/1647/person/pavletich_180501_10_1200x800.jpg?h=10d202d3)
Nikola P. Pavletich, PhD
Stephen and Barbara Friedman Chair
Professor
- The Pavletich laboratory studies the structural biology of pathways that control cell growth and maintain the integrity of the genome.
- PhD, Johns Hopkins University
- [email protected]
- Email Address
- 212-639-8544
- Office Phone
Members
![Yehuda Goldgur](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/3717/3x2/goldgur-_yehuda_190207_07_1200x800-1.jpg?h=10d202d3)
- 212-639-8547
- Lab Phone
![Buren Li](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/25539/image/li-buren-131104-12.jpg)
![Marie Benton](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/171535/3x2/benton-_marie_190207_05_1200x800-1.jpg)
![Ankita Dhar](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/158149/3x2/dhar-_ankita_190207_03_1200x800-1.jpg)
![Christopher Peralta](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/171538/3x2/peralta-_christopher_190207_06_1200x800-1.jpg?h=10d202d3)
![Christopher Warren](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/171541/3x2/warren-_christopher_190207_09_1200x800-1.jpg)
![Yehuda Goldgur](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/3717/3x2/goldgur-_yehuda_190207_07_1200x800-1.jpg?h=10d202d3)
Associate Laboratory Member & Head, X-Ray Crystallography Core Facility
![Buren Li](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/25539/image/li-buren-131104-12.jpg)
Research Technician
![Nikola Pavletich, PhD](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/13148/image/pavletich-nikola.jpg)
Member
![Madellyn Sosa](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/13154/3x2/sosa-madellyn_180511_06_1200x800.jpg)
Administrative Assistant
![Renjing Wang](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/13151/3x2/wang_180501_07_1200x800.jpg)
Research Fellow
![Haijuan Yang](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/13152/3x2/yang-haijuan_180511_04_1200x800.jpg)
Senior Research Scientist
![Marie Benton](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/171535/3x2/benton-_marie_190207_05_1200x800-1.jpg)
![Ankita Dhar](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/158149/3x2/dhar-_ankita_190207_03_1200x800-1.jpg)
Research Assistant
![Christopher Peralta](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/171538/3x2/peralta-_christopher_190207_06_1200x800-1.jpg?h=10d202d3)
![Christopher Warren](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/171541/3x2/warren-_christopher_190207_09_1200x800-1.jpg)
![Buren Li](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/142921/3x2/li-buren_170726_08_3x2.jpg?h=10d202d3)
- BS, MS, University of Toronto
Lab Alumni
![Buren Li](https://www.sloankettering.edu/sites/default/files/styles/width_200_1x1/public/node/142921/3x2/li-buren_170726_08_3x2.jpg?h=10d202d3)
Postdoctoral Fellow, Memorial Sloan Kettering Cancer Center, New York, NY
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Get in Touch
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Lab Head Email
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Office Phone
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Lab Phone
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Lab Fax
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Nikola P. Pavletich discloses the following relationships and financial interests:
No disclosures meeting criteria for time period
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].