The long-range objectives of our research are to understand the mechanism of meiotic recombination and to determine how this process is coordinated with other events of meiotic prophase. Several projects in the lab focus on Spo11 (the protein that makes the DNA double-strand breaks (DSBs) that initiate recombination), the proteins that interact with Spo11, the interactions of these proteins with meiotic chromosomes, and the mechanisms that regulate the timing, number, and location of DSB formation. We also study how DSBs are processed and repaired and we are seeking to expand knowledge of meiotic processes more generally through discovery of new genes important for germ cell function. Most of the meiosis research in the lab uses the yeast Saccharomyces cerevisiae and the mouse. Finally, our studies of Spo11 have also provided an entry point to research on the DSBs made by the enzyme Topoisomerase II when it is inhibited by chemotherapeutic agents such as etoposide or doxorubicin.
Scott Keeney, PhD
Research FocusMolecular biologist Scott Keeney investigates mechanisms of the initiation of meiotic recombination.
EducationPhD, University of California, Berkeley
- Jain D, Puno MR, Meydan C, Lailler N, Mason CE, Lima CD, Anderson KV, and Keeney S (2018) ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2. eLife doi: 10.7554/eLife.30919.
- Claeys Bouuaert C and Keeney S (2017) Distinct DNA-binding surfaces in the ATPase and linker domains of MutLgamma determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair. PLoS Genetics 13, e1006722.
- Investigator, Howard Hughes Medical Institute (2008)
- Blavatnik Award Finalist, New York Academy of Sciences (2007)
- Scholar, Leukemia and Lymphoma Society (2005-2010)
- Elected Fellow of the American Academy of Microbiology (2014)
- Member of the American Academy of Arts and Sciences (2017)
- Frederick R. Adler Chair, MSKCC (2017)