The Danwei Huangfu Lab

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The Danwei Huangfu Lab
We apply both precision gene editing and large-scale CRISPR screening in human pluripotent stem cells (hPSCs) to explore mechanisms underlying human development. Specifically, we are interrogating the protein-coding regulators of pancreatic development and β cell function. The pathways that regulate these processes can be exploited for therapeutics to prevent and reverse diseases such as type 1 and type 2 diabetes. In a second, closely related area, we are developing approaches to discover developmental enhancers, and to understand the epigenetic regulation of noncoding regulatory elements with a focus on DNA methylation.
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Pictured: Danwei Huangfu

Danwei Huangfu, PhD

Associate Professor

Research Focus

The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.

Education

PhD, Cornell University, Weill Graduate School of Medical Sciences

Lab Members

Publications
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Selected Achievements
  • Basil O’Connor Scholar, March of Dimes Birth Defects Foundation (2012-2014)
  • Louis V. Gerstner, Jr. Young Investigators Award, Memorial Sloan Kettering Cancer Center (2011-2014)
  • Award from Harvard Catalyst & InnoCentive for the Ideation Challenge on “What Do We Not Know to Cure Type 1 Diabetes” (2010)
  • Helen Hay Whitney Postdoctoral Fellowship (2006-2009)