The Danwei Huangfu Lab

The Danwei Huangfu Lab
We apply both precision gene editing and large-scale CRISPR screening in human pluripotent stem cells (hPSCs) to explore mechanisms underlying human development. Specifically, we are interrogating the protein-coding regulators of pancreatic development and β cell function. The pathways that regulate these processes can be exploited for therapeutics to prevent and reverse diseases such as type 1 and type 2 diabetes. In a second, closely related area, we are developing approaches to discover developmental enhancers, and to understand the epigenetic regulation of noncoding regulatory elements with a focus on DNA methylation.
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Pictured: Danwei Huangfu

Danwei Huangfu, PhD

Associate Professor

Research Focus

The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.


PhD, Cornell University, Weill Graduate School of Medical Sciences

Lab Members

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Selected Achievements
  • Basil O’Connor Scholar, March of Dimes Birth Defects Foundation (2012-2014)
  • Louis V. Gerstner, Jr. Young Investigators Award, Memorial Sloan Kettering Cancer Center (2011-2014)
  • Award from Harvard Catalyst & InnoCentive for the Ideation Challenge on “What Do We Not Know to Cure Type 1 Diabetes” (2010)
  • Helen Hay Whitney Postdoctoral Fellowship (2006-2009)