Developmental Biology Program
The Danwei Huangfu Lab
Research
Professor
Featured News
Publications Highlights
Glucose transporters are key components of the human glucostat. Caspi I, Tremmel DM, Pulecio J, Yang D, Liu D, Yan J, Odorico JS, Huangfu D. Diabetes. 2024 May 22:db230508. doi: 10.2337/db23-0508. Online ahead of print. [PMID: 38775784] (underlined are first author(s) from the Huangfu lab)
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions. Luo R, Yan J, Oh JW, Xi W, Shigaki D, Wong W, Cho HS, Murphy D, Cutler R, Rosen BP, Pulecio J, Yang D, Glenn RA, Chen T, Li QV, Vierbuchen T, Sidoli S, Apostolou E, Huangfu D#, Beer MA#. Nat Genet. 2023 Aug;55(8):1336-1346. doi: 10.1038/s41588-023-01450-7. Epub 2023 Jul 24. [PMID: 37488417] (#co-corresponding author)
CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction. Yang D, Cho H, Tayyebi Z, Shukla A, Luo R, Dixon G, Ursu V, Stransky S, Tremmel DM, Sackett SD, Koche R, Kaplan SJ, Li QV, Park J, Zhu Z, Rosen BP, Pulecio J, Shi ZD, Bram Y, Schwartz RE, Odorico JS, Sidoli S, Wright CV, Leslie CS#, Huangfu D#. Nat Cell Biol. 2022 Jul;24(7):1064-1076. doi: 10.1038/s41556-022-00946-4. Epub 2022 Jul 4. [PMID: 35787684]
QSER1 protects DNA methylation valleys from de novo methylation. Dixon G, Pan H, Yang D, Rosen BP, Jashari T, Verma N, Pulecio J, Caspi I, Lee K, Stransky S, Glezer A, Liu C, Rivas M, Kumar R, Lan Y, Torregroza I, He C, Sidoli S, Evans T, Elemento O#, Huangfu D#. Science. 2021 Apr 9;372(6538):eabd0875. doi: 10.1126/science.abd0875. [PMID: 33833093]
Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Li QV, Dixon G, Verma N, Rosen BP, Gordillo M, Luo R, Xu C, Wang Q, Soh CL, Yang D, Crespo M, Shukla A, Xiang Q, Dündar F, Zumbo P, Witkin M, Koche R, Betel D, Chen S, Massagué J, Garippa R, Evans T, Beer MA#, Huangfu D#. Nat Genet. 2019 Jun;51(6):999-1010. doi: 10.1038/s41588-019-0408-9. Epub 2019 May 20. [PMID: 31110351]
People
Danwei Huangfu, PhD
Professor
- The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.
- PhD, Cornell University, Weill Graduate School of Medical Sciences
- BS, Fudan University
- [email protected]
- Email Address
- Download CV
- PDF File
Members
- PhD, International Centre for Genetic Engineering and Biotechnology [ICGEB]
- PhD, Columbia University
- BS, CUNY Hunter College
- PhD, CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences
- PhD, Weill Cornell Graduate School of Medical Sciences
- PhD, Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India
- BS, Shanghai Jiaotong University
- PhD, Institute of Life Sciences, Odisha (India)
- PhD, Icahn School of Medicine at Mount Sinai
- PhD, Helmholtz Zentrum München German Research Center for Environmental Health
- BS, University of Chicago
- PhD, New York University School of Medicine
- BA, University of California, Berkeley
- MS, Imperial College London
- University of Arizona
- BS, Shanghai Jiaotong University
- Bachelor of Technology, National Institute of Technology Calicut
- MS, University of Minnesota Twin Cities
- PhD, University of Illinois at Chicago
Lab Alumni
Lab Affiliations
Achievements
- Basil O’Connor Scholar, March of Dimes Birth Defects Foundation (2012-2014)
- Louis V. Gerstner, Jr. Young Investigators Award, Memorial Sloan Kettering Cancer Center (2011-2014)
- Award from Harvard Catalyst & InnoCentive for the Ideation Challenge on “What Do We Not Know to Cure Type 1 Diabetes” (2010)
- Helen Hay Whitney Postdoctoral Fellowship (2006-2009)
Lab News & Events
Accolades
Team Recognitions
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Renhe Luo's paper on endoderm enhancer discovery is out in Nature Genetics (2023)
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Jeyaram (Jey) Ravichandran Damodaran is joining the Weill Cornell BCMB program (2023)
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Julian Pulecio is selected as a member of the 2023 cohort of MERIT Emerging Leaders
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Dingyu Liu receives the Bruce Charles Forbes Fellowship (2023)
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Tamara Casteels receives the NYSTEM Training Award at the CSCB (2022)
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Tamara Casteels receives the Award of Excellence for her PhD thesis with Stefan Kubicek in CeMM (2022)
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Nan Zhang receives CDMRP PRMRP Discovery Award (2022)
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Dapeng Yang's paper on HHEX and pancreas specification is out in Nature Cell Biology (2022)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
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Graduate Student, Postdoctoral Fellow, Research Technician and Project Manager
Get in Touch
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Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Danwei Huangfu discloses the following relationships and financial interests:
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Gene and Genome Editing
Professional Services and Activities (Uncompensated) -
Juvenile Diabetes Research Foundation (JDRF)
Professional Services and Activities
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Stem Cell Reports
Professional Services and Activities (Uncompensated) -
The Jackson Laboratory
Professional Services and Activities
The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].