
Developmental Biology Program
The Danwei Huangfu Lab
Research

Professor

Featured News



Publications
CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction. Yang D, Cho H, Tayyebi Z, Shukla A, Luo R, Dixon G, Ursu V, Stransky S, Tremmel DM, Sackett SD, Koche R, Kaplan SJ, Li QV, Park J, Zhu Z, Rosen BP, Pulecio J, Shi ZD, Bram Y, Schwartz RE, Odorico JS, Sidoli S, Wright CV, Leslie CS, Huangfu D. Nat Cell Biol. 2022 Jul;24(7):1064-1076. doi: 10.1038/s41556-022-00946-4. [PMID: 35787684]
QSER1 protects DNA methylation valleys from de novo methylation. Dixon G, Pan H, Yang D, Rosen BP, Jashari T, Verma N, Pulecio J, Caspi I, Lee K, Stransky S, Glezer A, Liu C, Rivas M, Kumar R, Lan Y, Torregroza I, He C, Sidoli S, Evans T, Elemento O, Huangfu D. Science. 2021 Apr 9;372(6538):eabd0875. doi: 10.1126/science.abd0875. [PMID: 33833093]
FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation. Lee K, Cho H, Rickert RW, Li QV, Pulecio J, Leslie CS, Huangfu D. Cell Rep. 2019;28(2):382-393.e7.
Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Li QV, Dixon G, Verma N, Rosen BP, Gordillo M, Luo R, Xu C, Wang Q, Soh CL, Yang D, Crespo M, Shukla A, Xiang Q, Dündar F, Zumbo P, Witkin M, Koche R, Betel D, Chen S, Massagué J, Garippa R, Evans T, Beer MA, Huangfu D. Nat Genet. 2019;51(6):999-1010.
TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells. Verma N, Pan H, Doré LC, Shukla A, Li QV, Pelham-Webb B, Teijeiro V, González F, Krivtsov A, Chang CJ, Papapetrou EP, He C, Elemento O, Huangfu D. Nat Genet. 2018;50(1):83-95.
People

Danwei Huangfu, PhD
Professor
- The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.
- PhD, Cornell University, Weill Graduate School of Medical Sciences
- BS, Fudan University
- [email protected]
- Email Address
- Download CV
- PDF File
Members

- BS, Shanghai Jiaotong University

- PhD, International Centre for Genetic Engineering and Biotechnology [ICGEB]

- PhD, Columbia University


- PhD, CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences

- PhD, Weill Cornell Graduate School of Medical Sciences

- Bachelor of Technology, National Institute of Technology Calicut
- MS, University of Minnesota Twin Cities

- BS, Shanghai Jiaotong University

- PhD, Helmholtz Zentrum München German Research Center for Environmental Health

- BS, University of Chicago

Graduate Research Assistant

Graduate Research Assistant

Sr. Research Scientist

Graduate Research Assistant

Sr. Research Scientist

Sr. Research Scientist

Administrative Assistant

Research Fellow - NYSTEM Training Award at the CSCB

Sr. Computational Biologist

Research Technician
Research Fellow
Bioinformatics Software Engineer
Research Scholar

Graduate Research Assistant

Graduate Research Assistant

Research Technician

Research Fellow

Research Technician

Graduate Research Assistant

Research Fellow

- BA, University of California, Berkeley
- MS, Imperial College London

- University of Arizona

- PhD, University of Illinois at Chicago
Lab Alumni

Graduate Research Assistant

Graduate Research Assistant
Research Technician

Graduate Research Assistant

Research Technician
Research Fellow

Research Fellow

Graduate Research Assistant

Graduate Research Assistant

Research Technician

Research Fellow

Research Fellow

Research Fellow

Research Associate

Senior Research Scientist
Scientific Research Lead
Lab Affiliations
Achievements
- Basil O’Connor Scholar, March of Dimes Birth Defects Foundation (2012-2014)
- Louis V. Gerstner, Jr. Young Investigators Award, Memorial Sloan Kettering Cancer Center (2011-2014)
- Award from Harvard Catalyst & InnoCentive for the Ideation Challenge on “What Do We Not Know to Cure Type 1 Diabetes” (2010)
- Helen Hay Whitney Postdoctoral Fellowship (2006-2009)
Lab News & Events
Open Positions
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Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Danwei Huangfu discloses the following relationships and financial interests:
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Gene and Genome Editing
Provision of Services (uncompensated) -
Stem Cell Reports
Provision of Services (uncompensated)
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The Jackson Laboratory
Provision of Services
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].