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The Scott Lowe Lab: Publications

View a full listing of Scott W. Lowe’s journal articles.


Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer. O’Rourke KP, Loizou E, Livshits G, Schatoff EM, Baslan T, Manchado E, Simon J, Romesser PB, Leach B, Han T, Pauli C, Beltran H, Rubin MA, Dow LE, Lowe SW. Nat Biotechnol. 2017 Jun;35(6):577-582. doi: 10.1038/nbt.3837. Epub 2017 May 1. PMID: 28459450

A pipeline for drug target identification and validation. Manchado E, Huang CH, Tasdemir N, Tschaharganeh DF, Wilkinson JE, Lowe SW. Cold Spring Harb Symp Quant Biol. 2016;81:257-267. doi: 10.1101/sqb.2016.81.031096. Epub 2017 Jan 5. PMID: 28057848

A combinatorial strategy for treating KRAS-mutant lung cancer. Manchado E, Weissmueller S, Morris JP 4th, Chen CC, Wullenkord R, Lujambio A, de Stanchina E, Poirier JT, Gainor JF, Corcoran RB, Engelman JA, Rudin CM, Rosen N, Lowe SW. Nature. 2016 Jun 30;534(7609):647-51. Epub 2016 Jun 22. PMID: 27338794

BRD4 connects enhancer remodeling to senescence immune surveillance. Tasdemir N, Banito A, Roe JS, Alonso-Curbelo D, Camiolo M, Tschaharganeh DF, Huang CH, Aksoy O, Bolden JE, Chen CC, Fennell M, Thapar V, Chicas A, Vakoc CR, Lowe SW. Cancer Discov. 2016 Jun;6(6):612-29. doi: 10.1158/2159-8290.CD-16-0217. Epub 2016 Apr 20. PMID: 27099234

Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Liu Y, Chen C, Xu Z, Scuoppo C, Rillahan CD, Gao J, Spitzer B, Bosbach B, Kastenhuber ER, Baslan T, Ackermann S, Cheng L, Wang Q, Niu T, Schultz N, Levine RL, Mills AA, Lowe SW. Nature. 2016 Mar 24;531(7595):471-475. doi: 10.1038/nature17157. Epub 2016 Mar 16. PMID: 26982726

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas. Ebbesen SH, Scaltriti M, Bialucha CU, Morse N, Kastenhuber ER, Wen HY, Dow LE, Baselga J, Lowe SW. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3030-5. doi: 10.1073/pnas.1523693113. Epub 2016 Feb 29. PMID: 26929372

Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer. Dow LE, O’Rourke KP, Simon J, Tschaharganeh DF, van Es JH, Clevers H, Lowe SW. Cell. 2015 Jun 18;161(7):1539-1552. doi: 10.1016/j.cell.2015.05.033. PMID: 26091037

Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW. Nat Genet. 2015 May;47(5):539-43. doi: 10.1038/ng.3251. Epub 2015 Mar 30. PMID: 25822087

Inducible in vivo genome editing with CRISPR-Cas9. Dow LE, Fisher J, O’Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW. Nat Biotechnol. 2015 Apr;33(4):390-394. doi: 10.1038/nbt.3155. Epub 2015 Feb 18. PMID: 25690852

p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G, Lowe SW. Cell. 2014 Jul 31;158(3):579-92. doi: 10.1016/j.cell.2014.05.051. PMID:25083869

PTEN action in leukaemia dictated by the tissue microenvironment. Miething C, Scuoppo C, Bosbach B, Appelmann I, Nakitandwe J, Ma J, Wu G, Lintault L, Auer M, Premsrirut PK, Teruya-Feldstein J, Hicks J, Benveniste H, Speicher MR, Downing JR, Lowe SW. Nature. 2014 Jun 19;510(7505):402-6. doi: 10.1038/nature13239. Epub 2014 May 4. PMID: 24805236

Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling. Weissmueller S, Manchado E, Saborowski M, Morris JP 4th, Wagenblast E, Davis CA, Moon SH, Pfister NT, Tschaharganeh DF, Kitzing T, Aust D, Markert EK, Wu J, Grimmond SM, Pilarsky C, Prives C, Biankin AV, Lowe SW. Cell. 2014 Apr 10;157(2):382-394. doi: 10.1016/j.cell.2014.01.066. PMID: 24725405