Scott W. Lowe: Publications

Scott W. Lowe: Publications

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Recent Highlights

A gene–environment-induced epigenetic program initiates tumorigenesis. Alonso-Curbelo, D, Ho, YJ, Burdziak, C, Maag, JLV, Morris IV, JP, Chandwani, R, Chen, HA, Tsanov, KM, Barriga, FM, Luan, W, Tasdemir, N, Livshits, G, Azizi, E, Chun, J, Wilkinson, JE, Mazutis, L, Leach, SD, Koche, R, Pe’er, D, Lowe, SW. Nature. 2021 Feb;590(7847):642-648. PMID: 33536616.

Senolytic CAR T Cells Reverse Senescence-Associated Pathologies. Amor, C, Feucht, J, Leibold, J, Ho, YJ, Zhu, C, Alonso-Curbelo, D, Mansilla-Soto, J, Boyer, JA, Li, X, Giavridis, T, Kulick, A, Houlihan, S, Peerschke, E, Friedman, SL, Ponomarev, V, Piersigilli, A, Sadelain, M, Lowe, SW. Nature. 2020 Jul;583(7814):127-132. PMID: 32555459.

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Ruscetti, M, Morris IV, JP, Mezzadra, R, Russell, J, Leibold, J, Romesser, PB, Simon, J, Kulick, A, Ho, YJ, Fennell, M, Li, J, Norgard, RJ, Wilkinson, JE, Alonso-Curbelo, D, Sridharan, R, Heller, DA, de Stanchina, E, Stanger, BZ, Sherr, CJ, Lowe, SW. Cell. 2020 Apr 16;181(2):424-441.e21. PMID: 32234521.

α-Ketoglutarate links p53 to cell fate during tumor suppression. Morris IV, JP, Yashinskie, JJ, Koche, R, Chandwani, R, Tian, S, Chen, C-C, Baslan, T, Marinkovic, ZS, Sanchez-Rivera, FJ, Leach, SD, Carmona-Fontaine, C, Thompson, CB, Finley, LWS, Lowe, SW. Nature. 2019 Sep;573(7775):595-599. PMID: 31534224.

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Ruscetti, M, Leibold, J, Bott, MJ, Fennell, M, Kulick, A, Chen, C-C, Baslan, T, Salgado, NR, Sanchez-Rivera, FJ, Tian, S, Romesser PB, Poirier, JT, Rudin, CM, de Stanchina, E, Manchado, E, Sherr, CJ, and Lowe, SW. Science. 2018 Dec 21;362(6421):1416-1422. PMID: 30573629.

Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis. Leibold, J, Ruscetti, M, Cao, Z, Ho, YJ, Baslan, T, Zou, M, Abida, W, Feucht, J, Han, T, Barriga, FM, Tsanov, KM, Zamechek, L, Kulick, A, Amor, C, Tian, S, Rybczyk, K, Salgado, NR, Sanchez-Rivera, FJ, Watson, PA, de Stanchina, E, Wilkinson, JE, Dow, LE, Abate-Shen, C, Sawyers, CL, Lowe, SW. Cancer Discov. 2020 Jul;10(7):1038-1057. PMID: 32376773.