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Hsuan-An (Sean) Chen, PhD

Postdoctoral Associate at Rockefeller University, New York, NY

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Hsuan-An Chen

Email

[email protected]

Dissertation

Senescence Rewires the Microenvironment Sensing Program to Facilitate Immune Surveillance (2022)

Mentor

Scott W. Lowe, PhD

Start Year

2015

End Year

2022

Education

BS, National Taiwan University (Taiwan); PhD, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY

Graduate Student in Lowe Lab from 2016-2022

Publications

Mao N, Zhang Z, Lee YS, Choi D, Rivera AA, Li D, Lee C, Haywood S, Chen X, Chang Q, Xu G, Chen HA, de Stanchina E, Sawyers C, Rosen N, Hsieh AC, Chen Y, Carver BS. (2021) Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers. Nat Commun.

Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP 4th, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan W, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe’er D, Lowe SW. (2021) A gene-enviroment-induced epigenetic program initiates tumorigenesis. Nature 590, 642-648

Zhang Z, Karthaus WR, Lee YS, Gao VR, Wu C, Russo JW, Liu M, Mota JM, Abida W, Linton E, Lee E, Barnes SD, Chen HA, Mao N, Wongvipat J, Choi D, Chen X, Zhao H, Manova-Todorova K, de Stanchina E, Taplin ME, Balk SP, Rathkopf DE, Gopalan A, Carver BS, Mu P, Jiang X, Watson PA, Sawyers CL.(2020) Tumor Microenviroment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer. Cancer Cell [Online ahead of print]

Ruscetti M, Leibold J, Bott MJ, Fennell M, Kulick A, Salgado NR, Chen CC, Ho YJ, Sanchez-Rivera FJ, Feucht J, Baslan T, Tian S, Chen HA, Romesser PB, Poirier JT, Rudin CM, de Stanchina E, Manchado E, Sherr CJ, Lowe SW. (2018) NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science. 362, 1416-1422.