Hsuan-An (Sean) Chen, BS

Graduate Student

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Hsuan-An Chen

Lab Phone

646-888-3340

Email

chenh2@sloankettering.edu

Mentor

Scott W. Lowe, PhD

Start Year

2015

Education

BS, National Taiwan University (Taiwan)

Fellowships

Geoffrey Beene Graduate Student Fellowship (2016-2017)
GSK Grayer Fellowship (2017-2018)
The NCI Predoctoral to Postdoctoral Fellow Transition Award (NCI F99/K00) (2019-2021)
The NCI Predoctoral to Postdoctoral Fellow Transition Award (NCI F99/K00) (2020-2022)

Sean got his undergraduate in Pharmacy in Taipei, Taiwan. Unlike his peers becoming pharmacists mostly, he found his passion more in doing research and decided to go on a different journey overseas to pursue his PhD in cancer biology in GSK graduate school, New York. He joined Dr. Lowe’s lab focusing on understanding the interplay between immune cells and tumor cells in the context of senescence and tumor development.

Outside of lab, Sean is a foodie and New York abundant with all kinds of exotic cuisine is definite a paradise for him. He also likes to cook good dishes. To him, cooking is also another way of experimenting, adding some tasteful flavors to life.

Publications

Mao N, Zhang Z, Lee YS, Choi D, Rivera AA, Li D, Lee C, Haywood S, Chen X, Chang Q, Xu G, Chen HA, de Stanchina E, Sawyers C, Rosen N, Hsieh AC, Chen Y, Carver BS. (2021) Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers. Nat Commun.

Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP 4th, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan W, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe’er D, Lowe SW. (2021) A gene-enviroment-induced epigenetic program initiates tumorigenesis. Nature 590, 642-648

Zhang Z, Karthaus WR, Lee YS, Gao VR, Wu C, Russo JW, Liu M, Mota JM, Abida W, Linton E, Lee E, Barnes SD, Chen HA, Mao N, Wongvipat J, Choi D, Chen X, Zhao H, Manova-Todorova K, de Stanchina E, Taplin ME, Balk SP, Rathkopf DE, Gopalan A, Carver BS, Mu P, Jiang X, Watson PA, Sawyers CL.(2020) Tumor Microenviroment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer. Cancer Cell [Online ahead of print]

Ruscetti M, Leibold J, Bott MJ, Fennell M, Kulick A, Salgado NR, Chen CC, Ho YJ, Sanchez-Rivera FJ, Feucht J, Baslan T, Tian S, Chen HA, Romesser PB, Poirier JT, Rudin CM, de Stanchina E, Manchado E, Sherr CJ, Lowe SW. (2018) NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science. 362, 1416-1422.