![Detail shot of a scientist handling samples](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/278091/main_image/path_210309_125-1200x800-1.jpg)
MSK Research Highlights, June 29, 2023
New MSK research discovered ferroptosis regulators that suggest therapeutic opportunities against hormone receptor-positive cancers; examined how tumor-associated macrophages might be turned against cancer; acquired new insights into joint inflammation in rheumatoid arthritis; developed a systems-level platform called epichaperomics to map changes in interactors among thousands of proteins involved in cancer-related processes; and investigated how artificial intelligence could help diagnose an invasive form of breast cancer.
In the Lab
![Scientist Gabriela Chiosis in her lab](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/229765/main_image/chiosis_170331_12-1200x800.jpg)
Experimental Drug Targets Misbehaving Proteins in Brain Cancer and Alzheimer’s Disease
Memorial Sloan Kettering researchers are studying how drugs that reverse malfunctioning proteins may treat disease.
In the Lab
![An illustration of sugar being sprinkled on a cancer cell.](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/199390/main_image/chiosis-image-1200x800.jpg)
Just Add Sugar: How a Protein’s Small Change Leads to Big Trouble for Cells
A study from investigators in the Sloan Kettering Institute uncovers the details of how a key protein called GRP94 becomes disrupted, leading to cancer and other diseases.
In the Lab
![Illustration of how PU-PET localizes to tumors](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/183784/main_image/cellcover_1200x800.jpg)
Bull’s-Eye: Imaging Technology Could Confirm When a Drug Is Going to the Right Place
Collaborative team advances a new approach for imaging a drug that’s been developed to stop cancer growth.
Finding
![An illustration of a magnifying glass over a brain.](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/188227/main_image/istock-693840850-1200x800.jpg)
Study Reveals a New Way That Stress and Aging Lead to Alzheimer’s
A targeted approach being developed to treat certain cancers may also be effective for Alzheimer’s disease.
In the Clinic
![Chemical biologist Gabriela Chiosis in a laboratory](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/153298/3x2/1c2c62e2-f0bf-4611-b529-b66b18b766f7.jpeg)
Experimental Cancer Drug Developed at MSK Leads to New Approach for Treating Alzheimer's Disease
A family of drugs developed at MSK targets disrupted processes in cells in diseases related to aging.
In the Lab
![Light micrograph of white blood cells from a patient with acute myeloid leukemia.](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/115339/3x2/chiosis_3x2.jpeg)
New Drug Developed at MSK Starves Acute Myeloid Leukemia of a Signaling Fix
An innovative collaboration between basic scientists and clinical researchers has led to a promising new drug for AML.
In the Lab
![Bees in a hive](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/130447/3x2/beehive.jpg)
Communal Behavior within Cells Makes Cancers Easier to Target
Findings about proteins called molecular chaperones are shedding new light on possible approaches to cancer treatment.
Finding
![Pictured: Gabriela Chiosis](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/34203/image/chiosis.jpg)
Hsp90: A Very Promising Target for Cancer Therapy
A small molecule discovered at MSK called PU-H71 blocks the growth of cancer cells and enables doctors to image tumors.
![Pictured: Gabriela Chiosis](https://www.sloankettering.edu/sites/default/files/styles/width_200/public/node/12214/image/chiosis-gabriela2007v2.jpg)
Out of the Lab and into the World: Hsp90 Inhibitor, a New Cancer Drug
A dynamic mix of experts in biology, chemistry, and medicine come together in the Sloan Kettering Institute lab of chemical biologist Gabriella Chiosis to investigate chaperone proteins involved in cancer.