The goal of my program is to investigate the nature of chronic stress as it occurs in numerous diseases and aging. Our approach takes advantage of the way nature has evolved to control such stresses, and that is by a unique usage of the chaperome, referred to here as the chronic stress chaperome (CSC). The CSC is structurally, dynamically and functionally distinct from the housekeeping chaperome, and my lab has pioneered an approach to take advantage of such feature. By using innovative methods, we develop small molecule chemical tool sets specifically targeted to the CSC; these act as “sensors” of the CSC and, in turn, of the chronic stress-associated proteome. By the use of these unique tool sets we aim to understand, diagnose, and treat cellular processes associated with chronic stress.
Gabriela Chiosis, PhD
Professor
Research Focus
The Chiosis lab uses a unique chemical biology approach to understand, diagnose, and treat cellular processes associated with chronic molecular stress, with the ultimate goal of developing novel therapeutic options for use in the clinic.Education
PhD, Columbia University- Office Phone: 646-888-2235
- Office Fax: 646-422-0416
- Lab Phone: 646-888-2216/2238
Lab Members
Anna Rodina
Senior Research Scientist
Tony Taldone
Senior Research Scientist
Tai Wang
Research Associate
Pengrong Yan
Research Scholar
Suhasini Joshi
Research Fellow
Alexander Bolaender
Research Scholar
Sahil Sharma
Research Fellow
Palak Panchal
Research Technician
Jenny Matalon
Administrative Assistant
Justina Almadovar
Research Technician
Chander Digwal
Research Fellow - Medicinal Chemist
Piyusha Pagare
Research Scholar - Medicinal Chemist
Publications
- The epichaperome is an integrated chaperome network that facilitates tumour survival. Rodina A, Wang T, Yan P, Gomes ED, Dunphy MP, Pillarsetty N, Koren J, Gerecitano JF, Taldone T, Zong H, Caldas-Lopes E, Alpaugh M, Corben A, Riolo M, Beattie B, Pressl C, Peter RI, Xu C, Trondl R, Patel HJ, Shimizu F, Bolaender A, Yang C, Panchal P, Farooq MF, Kishinevsky S, Modi S, Lin O, Chu F, Patil S, Erdjument-Bromage H, Zanzonico P, Hudis C, Studer L, Roboz GJ, Cesarman E, Cerchietti L, Levine R, Melnick A, Larson SM, Lewis JS, Guzman ML, Chiosis G. Nature. 2016 Oct 5. doi: 10.1038/nature19807.
- Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G. Nat Chem Biol. 2013 Sep 1. doi: 10.1038/nchembio.1335. [Epub ahead of print]
Selected Achievements
- AACR – Cancer Research and Prevention Career Development Award in Translational Lung Cancer Research, in Memory of Duffy Wall
- Susan G. Komen Breast Cancer Translational Research Award
- Frederick R. Adler Chair for Junior Faculty
- Award for Drug Discovery Research for Frontotemporal Dementia
- Top 5 percent cited author in Biology and Biochemistry 2010 (analysis by Thomson Reuters)
