Chemical Biology Program

The Gabriela Chiosis Lab

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Research

Pictured: Gabriela Chiosis
Gabriela Chiosis, PhD


Professor

The goal of my program is to investigate the nature of chronic stress as it occurs in numerous diseases and aging. Our approach takes advantage of the way nature has evolved to control such stresses, and that is by a unique usage of the chaperome, referred to here as the chronic stress chaperome (CSC). The CSC is structurally, dynamically and functionally distinct from the housekeeping chaperome, and my lab has pioneered an approach to take advantage of such feature. By using innovative methods, we develop small molecule chemical tool sets specifically targeted to the CSC; these act as “sensors” of the CSC and, in turn, of the chronic stress-associated proteome. By the use of these unique tool sets we aim to understand, diagnose, and treat cellular processes associated with chronic stress. 

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Research Projects

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Pictured: Chiosis Lab

Chiosis Lab - October 2013

Featured News

In the Lab
An illustration of sugar being sprinkled on a cancer cell.
Just Add Sugar: How a Protein’s Small Change Leads to Big Trouble for Cells

In the Lab
Illustration of how PU-PET localizes to tumors
Bull’s-Eye: Imaging Technology Could Confirm When a Drug Is Going to the Right Place

Finding
An illustration of a magnifying glass over a brain.
Study Reveals a New Way That Stress and Aging Lead to Alzheimer’s

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Publications

The epichaperome is an integrated chaperome network that facilitates tumour survival. Rodina A, Wang T, Yan P, Gomes ED, Dunphy MP, Pillarsetty N, Koren J, Gerecitano JF, Taldone T, Zong H, Caldas-Lopes E, Alpaugh M, Corben A, Riolo M, Beattie B, Pressl C, Peter RI, Xu C, Trondl R, Patel HJ, Shimizu F, Bolaender A, Yang C, Panchal P, Farooq MF, Kishinevsky S, Modi S, Lin O, Chu F, Patil S, Erdjument-Bromage H, Zanzonico P, Hudis C, Studer L, Roboz GJ, Cesarman E, Cerchietti L, Levine R, Melnick A, Larson SM, Lewis JS, Guzman ML, Chiosis G. Nature. 2016 Oct 5. doi: 10.1038/nature19807.

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G. Nat Chem Biol. 2013 Sep 1. doi: 10.1038/nchembio.1335. [Epub ahead of print]

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, Talele TT, Young JC, Chiosis G. Chem Biol. 2013 Dec 19;20(12):1469-80. doi: 10.1016/j.chembiol.2013.10.008. Epub 2013 Nov 14.

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Moulick K, Ahn JH, Zong H, Rodina A, Cerchietti L, Gomes DaGama EM, Caldas-Lopes E, Beebe K, Perna F, Hatzi K, Vu LP, Zhao X, Zatorska D, Taldone T, Smith-Jones P, Alpaugh M, Gross SS, Pillarsetty N, Ku T, Lewis JS, Larson SM, Levine R, Erdjument-Bromage H, Guzman ML, Nimer SD, Melnick A, Neckers L, Chiosis G. Nat Chem Biol. 2011 Sep 25;7(11):818-26. doi: 10.1038/nchembio.670.

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73. doi: 10.1073/pnas.0903392106. Epub 2009 May 5.

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People

Pictured: Gabriela Chiosis

Gabriela Chiosis, PhD



Professor

  • The Chiosis lab uses a unique chemical biology approach to understand, diagnose, and treat cellular processes associated with chronic molecular stress, with the ultimate goal of developing novel therapeutic options for use in the clinic.
  • PhD, Columbia University
chiosisg@mskcc.org
Email Address
646-888-2235
Office Phone

Members

Anna Rodina

Senior Research Scientist

Tony Taldone

Senior Research Scientist

Tai Wang
Tai Wang

Research Associate

Pengrong Yan

Research Scholar

Suhasini Joshi

Research Fellow

Alexander Bolaender

Research Scholar

Sahil Sharma

Research Fellow

Palak Panchal

Research Technician

Jenny Matalon

Administrative Assistant

Chander Digwal

Research Fellow - Medicinal Chemist

Piyusha Pagare

Research Scholar - Medicinal Chemist

Lab Alumni
Erica DaGama Gomes

Research Fellow

Sarah Kishinevsky

Graduate Student

John Koren

Research Scholar

Stefan Ochiana

Research Scholar

Hardik Patel

Research Scholar

Smit Shah
Smit Shah

Research Technician

Mohammad Uddin

Research Technician

Maria del Carmen Inda Garcia, PhD
Maria del Carmen Inda Garcia

Research Scholar

Chao Xu, PhD
Chao Xu

Research Fellow

Chenghua Yang

Research Scholar

Srinivasa Gandu
Srinivasa Gandu

Research Technician

Lampros Milanos, PhD
Lampros Milanos

Research Fellow

Fumiko Shimizu, PhD
Fumiko Shimizu
Mary Alpaugh

Research Associate

Liza Shrestha, PhD
Liza Shrestha

Research Fellow

Raul Alonso

Research Technician

Lab Affilations

Achievements

  • AACR – Cancer Research and Prevention Career Development Award in Translational Lung Cancer Research, in Memory of Duffy Wall
  • Susan G. Komen Breast Cancer Translational Research Award
  • Frederick R. Adler Chair for Junior Faculty
  • Award for Drug Discovery Research for Frontotemporal Dementia
  • Top 5 percent cited author in Biology and Biochemistry 2010 (analysis by Thomson Reuters)
Read more
  • Translated from bench-to-bedside the Hsp90 inhibitor PU-H71 and the non-invasive companion diagnostic 124I-PU-H71 PET assay

Lab News & Events

Upcoming event

Targeted Therapeutics for Triple Negative Breast Cancer

This seminar will be conducted by Zoom Webinar.

Open Positions

Chemist

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Research Technician

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Gabriela Chiosis discloses the following relationships and financial interests:

  • Samus Therapeutics LLC
    Fiduciary Role/Position; Intellectual Property Rights; Ownership / Equity Interests

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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