A postdoctoral position in Medicinal Chemistry, Organic Chemistry or Chemical Biology position is available immediately in a multidisciplinary team working in the discovery of chemical probes, drugs and diagnostics. The ultimate goal of the team is to translate these findings into novel treatments for cancers and neurodegenerative diseases.
Responsibilities include development of synthetic methodologies for the creation of new agents, synthesis and characterization of new compounds, and development of new insights into structure-function relationships. Chemistry efforts will be guided by structure-based design and in-house developed functional assays. Candidates with experience in heterocyclic chemistry and development of structure-activity relationships, with a strong desire to use these chemical tools to investigate biology, and with proven ability to work in a team environment are encouraged to apply.
Examples of publications relevant to the research to be conducted:
Nature Communications. 2021 Aug 3;12(1):4669. Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. doi: 10.1038/s41467-021-24821-2. DOI: 10.1038/s41467-021-24821-2
Methods Enzymol. 2020;639:289-311. Chemical probes and methods for single-cell detection and quantification of epichaperomes in hematologic malignancies. DOI: 10.1016/bs.mie.2020.04.057
Cell Chem Biol. 2016 Jan 21;23(1):158-172.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease. DOI: 10.1016/j.chembiol.2015.12.006
J Med Chem. 2015 May 14;58(9):3922-43. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. DOI: 10.1021/acs.jmedchem.5b00197
ACS Chem Biol. 2014 Aug 15;9(8):1698-705. Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer. DOI: 10.1021/cb500256u
Cell Chem Biol. 2013 Dec 19;20(12):1469-80.Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. DOI: 10.1016/j.chembiol.2013.10.008
Nature Chem Biol. 2013 Nov;9(11):677-84.Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. DOI: 10.1038/nchembio.1335