Palak Panchal

Lab Phone

+1 (646) 888-2216

Email

I am working as Research technician in Dr. Chiosis’ lab at Memorial Sloan Kettering cancer center. As a technician, I am assisting the post-doctoral scholars in numerous activities and experiments which include performing biochemical tests, tissue culture-based analyses, ex vivo analyses on and immunohistochemical staining of specimens. I am overseeing the maintenance of a transgenic mouse colony and performing drug administration to mice. Also, I am responsible for proper operation of the laboratory, such as contacting vendors and instrument maintenance engineers, maintaining a sterile tissue culture, preparing buffers and reagents and keeping an up-to-date inventory of chemicals and reagents.

Publications

Rodina A, Wang T, Yan P, Gomes ED, Dunphy MP, Pillarsetty N, Koren J,Gerecitano JF, Taldone T, Zong H, Caldas-Lopes E, Alpaugh M, Corben A, Riolo M, Beattie B, Pressl C, Peter RI, Xu C, Trondl R, Patel HJ, Shimizu F, Bolaender A, Yang C, Panchal P, Farooq MF, Kishinevsky S, Modi S, Lin O, Chu F, Patil S, Erdjument-Bromage H, Zanzonico P, Hudis C, Studer L, Roboz GJ, Cesarman E, Cerchietti L, Levine R, Melnick A, Larson SM, Lewis JS, Guzman ML, Chiosis G. The epichaperome is an integrated chaperome network that facilitates tumour survival. Nature. 2016 Oct 5; 538(7625):397-401. doi: 10.1038/nature19807. PubMed PMID: 27706135.
Kaittanis C, Andreou C, Hieronymus H, Mao N, Foss CA, Eiber M, Weirich G, Panchal P, Gopalan A, Zurita J, Achilefu S, Chiosis G, Ponomarev V, Schwaiger M, Carver BS, Pomper MG, Grimm J. Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors. J Exp Med. 2018 Jan 2;215(1):159-175. doi: 10.1084/jem.20171052. Epub 2017 Nov 15. PMID: 29141866
Inda MC, Joshi S, Wang T, Bolaender A, Gandu S, Koren Iii J, Che AY, Taldone T, Yan P, Sun W, Uddin M, Panchal P, Riolo M, Shah S, Barlas A, Xu K, Chan LYL, Gruzinova A, Kishinevsky S, Studer L, Fossati V, Noggle SA, White JR, de Stanchina E, Sequeira S, Anthoney KH, Steele JW, Manova-Todorova K, Patil S, Dunphy MP, Pillarsetty N, Pereira AC, Erdjument-Bromage H, Neubert TA, Rodina A, Ginsberg SD, De Marco Garcia N, Luo W, Chiosis G. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nat Commun. 2020 Jan 16;11(1):319. doi: 10.1038/s41467-019-14082-5.PMID: 31949159
Yan P, Patel HJ, Sharma S, Corben A, Wang T, Panchal P, Yang C, Sun W, Araujo TL, Rodina A, Joshi S, Robzyk K, Gandu S, White JR, de Stanchina E, Modi S, Janjigian YY, Hill EG, Liu B, Erdjument-Bromage H, Neubert TA, Que NLS, Li Z, Gewirth DT, Taldone T, Chiosis G. Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone. Cell Rep. 2020 Jun 30;31(13):107840. doi: 10.1016/j.celrep.2020.107840.PMID: 32610141
Alexander Bolaender, Danuta Zatorska, Huazhong He, Suhasini Joshi, Sahil Sharma, Chander S Digwal, Hardik J Patel, Weilin Sun, Brandon S Imber, Stefan O Ochiana, Maulik R Patel, Liza Shrestha, Smit K Shah, Shuo Wang, Rashad Karimov, Hui Tao, Pallav D Patel, Ananda Rodilla Martin, Pengrong Yan, Palak Panchal, Justina Almodovar, Adriana Corben, Andreas Rimner, Stephen D Ginsberg, Serge Lyashchenko, Eva Burnazi, Anson Ku, Teja Kalidindi, Sang Gyu Lee, Milan Grkovski, Bradley J Beattie, Pat Zanzonico, Jason S Lewis, Steve Larson, Anna Rodina, Nagavarakishore Pillarsetty, Viviane Tabar, Mark P Dunphy, Tony Taldone, Fumiko Shimizu, Gabriela Chiosis. Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. Nat Commun 2021 Aug 3;12(1):4669. doi: 10.1038/s41467-021-24821-2. PMID: 34344873
Mayumi Sugita, David C. Wilkes, Rohan Bareja, Kenneth W. Eng, Sarah Nataraj, Reyna A. Jimenez-Flores, LunBiao Yan, Jeanne Pauline De Leon, Jaclyn A. Croyle, Justin Kaner, Swathi Merugu, Sahil Sharma, Theresa Y. MacDonald, Zohal Noorzad, Palak Panchal, Danielle Pancirer, Shuhua Cheng, Jenny Z. Xiang, Luke Olson, Koen Van Besien, David S. Rickman, Susan Mathew, Wayne Tam, Mark A. Rubin, Himisha Beltran, Andrea Sboner, Duane C. Hassane, Gabriela Chiosis, Olivier Elemento, Gail J. Roboz, Juan Miguel Mosquera & Monica L. Guzman. Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia. NPJ Precis Oncol. 2021 May 26;5(1):44. doi: 10.1038/s41698-021-00183-2. PMID: 34040147
Suhasini Joshi, Erica DaGama Gomes, Tai Wang, Adriana Corben, Tony Taldone, Srinivasa Gandu, Chao Xu, Sahil Sharma, Salma Buddaseth, Pengrong Yan, Lon Yin L Chan, Askan Gokce, Vinagolu K Rajasekhar, Lisa Shrestha, Palak Panchal, Justina Almodovar, Chander S Digwal, Anna Rodina, Swathi Merugu, NagaVaraKishore Pillarsetty, Vlad Miclea, Radu I Peter, Wanyan Wang, Stephen D Ginsberg, Laura Tang, Marissa Mattar, Elisa de Stanchina, Kenneth H Yu, Maeve Lowery, Olivera Grbovic-Huezo, Eileen M O’Reilly, Yelena Janjigian, John H Healey, William R Jarnagin, Peter J Allen, Chris Sander, Hediye Erdjument-Bromage, Thomas A Neubert, Steven D Leach, Gabriela Chiosis. Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer. Commun Biol. 2021 Nov 25;4(1):1333. doi: 10.1038/s42003-021-02842-3. PMID: 34824367

My Projects

Protein-protein interaction networks in disease