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We develop and clinically deploy novel computational algorithms for analyzing multiscale, multimodal biomedical imaging data.

The Jasin laboratory focuses on double-strand break repair and genomic integrity in mammalian cells and the relationship to tumor suppression.

The Mara Sherman lab aims to understand the heterocellular interactions among pancreatic cancer cells and their surrounding microenvironment, and to target these networks for therapeutic benefit.

Physician-scientist Andrew Intlekofer investigates why cancer cells depend on specific pathways of nutrient metabolism.

Heeseon An’s lab studies protein degradation in health and disease using chemical, biological, and proteomics tools.

Mechanisms of genetic and epigenetic cooperativity which drive myeloid transformation; Elucidating and modeling evolution from hematopoietic stem/progenitor cells to clonal hematopoiesis and then to myeloid malignancies; Identification and credentialing novel therapeutic dependencies in myeloid malignancies

Physician-scientist Tobias Hohl studies the molecular pathogenesis of human fungal pathogens and how the immune system responds to them.

Cell biologist Michael Overholtzer studies the mechanisms of tumor initiation and progression, cell adhesion, and cell death.