Human Oncology & Pathogenesis Program

The Adrienne Boire Lab

Research

Adrienne A. Boire, MD, PhD

Scientific Director, Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center

Associate Professor

The Boire lab studies leptomeningeal metastasis as a means to understand the principles of metastasis as well as the nervous system’s relationship to the larger organism.

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Featured News

Finding

Scientists Jan Remsik, Adrienne Boire, and Jessica Wilcox in the lab

MSK Researchers Learn What’s Driving ‘Brain Fog’ in People with COVID-19

The presence of inflammatory molecules in the cerebrospinal fluid appears to be causing many of the neurologic effects seen in people with COVID-19.

In the Lab

Iron Fiends: Cancer Cells in Brain and Spinal Fluid Survive by Monopolizing a Nutrient

Researchers gain insight into leptomeningeal metastasis, a devastating complication of advanced cancer.

In the Lab

Inspired by a Patient, a Doctor Finds Answers for a Devastating Cancer Complication

Research is providing new clues about how cancer spreads to spinal fluid, a condition called leptomeningeal metastasis.

Publications Highlights

Remsik J, and A Boire. 2024 The path to leptomeningeal metastasis. Nat Rev Cancer. 24(7):448-460.

Tong X, Remsik J, Brook J, Petrova B, Xu L, Li MJ, Snyder J, Chabot K, Estrera R, Osei-Gyening I, Nobre AR, Wang H, Osman AM, Wong AYL, Sidharta M, Piedrafita-Ortiz S, Manoranjan B, Zhou T, Murali R, Hamard PJ, Koche R, He Y, Kanarek N, and A Boire 2024 Retinoid X Receptor Signaling Mediates Cancer Cell Lipid Metabolism in the Leptomeninges. bioRxiv doi: 10.1101/2024.10.13.618083

Wilcox JA, Chukwueke UN, Ahn MJ, Aizer AA, Bale TA, Brandsma D, Brastianos PK, Chang S, Daras M, Forsyth P, Garzia L, Glantz M, Oliva ICG, Kumthekar P, Le Rhun E, Nagpal S, O’Brien B, Pentsova E, Lee EQ, Remsik J, Rudà R, Smalley I, Taylor MD, Weller M, Wefel J, Yang JT, Young RJ, Wen PY, Boire AA 2024 Leptomeningeal metastases from solid tumors: A SNO and ASCO consensus review on clinical management and future directions. Neuro Oncol. 26(10):1781-1804.

Remsik J, Tong X, Kunes RZ, Li MJ, Osman A, Chabot K, Sener UT, Wilcox JA, Isakov D, Snyder J, Bale TA, Chaligné R, Pe’er D, and A Boire. 2023 Leptomeningeal anti-tumor immunity follows unique signaling principles. bioRxiv. doi: 10.1101/2023.03.17.533041. Preprint.

Umemura Y, Khan B, Weill BJ, Buthorn JJ, Skakodub A, Ridder AJ, Nevel KS, Sun Y, and A Boire 2022 Discordance between perceptions and experience of lumbar puncture: A prospective study. Neurol Clin Pract 12(5):344-351.

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People

Adrienne A. Boire, MD, PhD

Scientific Director, Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center

Associate Professor

Physician-scientist Adrienne Boire studies metastasis to the central nervous system.
PhD, Tufts University, Boston, MA
MD, University of Chicago, Chicago, IL

646-888-3861: Office Phone
View physician profile: Physician profile

Members

Ana Rita Lobato Cortesao Nobre
Postdoctoral Scholar

Francis He
Weill Cornell Graduate Student

Xinran Tong
Weil Cornell Graduate Student

Chelsea Toussaint

Administrative Assistant

Lab Alumni

Majdi Alghader
Senior Research Technician

Giscard Barbier
Administrative Assistant

Samantha De La Moneda

Administrative Assistant

Shama Farooq

Fellow

Sara Haddock
Graduate Student, Cornell BCMB

Anestashia Melford
Administrative Assistant

Sierra Norfleet
Administrative Assistant

Sofia Piedrafita-Ortiz
MSK Bridge Program Scholar

Jan Remsik, PharmD, PhD — Jan Remsik
Senior Research Scientist

Michelle Thompson

Administrative Assistant

Jessica Wilcox
Assistant Attending Neurologist

Lab Affiliations

Achievements

2021 Geoffrey Beene Junior Faculty Chair
American Academy of Neurology Neuro Oncology Investigator Award (2020)
Pershing Square Sohn Prize (2019)
Pew Biomedical Scholar (2018)
Damon Runyon Clinical Investigator Award (2017)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

General Opportunities

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Get in Touch

646-888-3861

Office Phone
646-888-2733

Office Fax

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Adrienne A. Boire discloses the following relationships and financial interests:

Apellis Pharmaceuticals
Professional Services and Activities
Department of Defense/Congressionally Directed Medical Research Programs (CDMRP)
Professional Services and Activities (Uncompensated)

Society for Neuro-Oncology (SNO)
Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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