Human Oncology & Pathogenesis Program
The Adrienne Boire Lab
My laboratory focuses on metastasis to the central nervous system (CNS), both leptomeningeal and parenchymal metastases. We employ multiple complementary approaches to identify and target cancer cell adaptations to the challenging microenvironmental constraints posed by the CNS.
Remsik J, Wilcox JA, Babady NE, McMillen TA, Vachha BA, Halpern NA, Dhawan V, Rosenblum M, Iacobuzio-Donahue CA, Avila EK, Santomasso B and A Boire 2021 Inflammatory leptomeningeal cytokines mediate COVID-19 neurologic symptoms in cancer patients Cancer Cell 39:1-8
Noura J Choudhury NJ, Yang SR, Arcila M, Mohanty AS, Boire A and A Drilon 2020 Genomic Characterization of a RET Inhibitor-Resistant RET Fusion-Positive Lung Cancer by CSF Cell-Free DNA Hybrid Capture-Based Sequencing CO Precis Oncol 4:PO.20.00188
Chi Y, Remsik J, Kiseliovas V, Derderian C, Sener U, Alghader M, Saadeh F, Nikishina K, Bale T, Iacobuzio-Donahue C, Thomas T, Pe’er D, Mazutis L and A Boire 2020 Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science 369(6501):276-282.
Yang TJ, Wijetunga NA, Yamada J, Wolden S, Mehallow M, Goldman DA, Zhang Z, Young RJ, Kris MG, Yu HA, Seidman AD, Gavrilovic IT, Lin A, Santomasso B, Grommes C, Piotrowski AF, Schaff L, Stone JB, DeAngelis LM, Boire A, Pentsova E. 2020 Clinical Trial of Proton Craniospinal Irradiation for Leptomeningeal Metastases Neuro Oncol Jun 27
Malani R, Fleisher M, Kumthekar P, Lin X, Omuro A, Groves MD, Lin NU, Melisko M, Lassman AB, Jeyapalan S, Seidman A, Skakodub A, Boire A, DeAngelis LM, Rosenblum M, Raizer J and E Pentsova 2020 Cerebrospinal Fluid Circulating Tumor Cells as a Quantifiable Measurement of Leptomeningeal Metastases in Patients with HER2 Positive Cancer. Neuro-Oncology Jun 6.
Adrienne A. Boire, MD, PhD
- Physician-scientist Adrienne Boire studies metastasis to the central nervous system.
- PhD, Tufts University, Boston, MA
- MD, University of Chicago, Chicago, IL
- 2021 Geoffrey Beene Junior Faculty Chair
- American Academy of Neurology Neuro Oncology Investigator Award (2020)
- Pershing Square Sohn Prize (2019)
- Pew Biomedical Scholar (2018)
- Damon Runyon Clinical Investigator Award (2017)
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Adrienne A. Boire discloses the following relationships and financial interests:
Department of Defense/Congressionally Directed Medical Research Programs (CDMRP)
Provision of Services (uncompensated)
Society for Neuro-Oncology (SNO)
Provision of Services
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This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.