Human Oncology & Pathogenesis Program

The Adrienne Boire Lab

Research

Adrienne A. Boire, MD, PhD

Assistant Professor

My laboratory focuses on metastasis to the central nervous system (CNS), both leptomeningeal and parenchymal metastases. We employ multiple complementary approaches to identify and target cancer cell adaptations to the challenging microenvironmental constraints posed by the CNS.

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Inside My Lab: Adrienne Boire

Go inside the lab of Adrienne Boire from MSK's Human Oncology & Pathogenesis Program.

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Featured News

Finding

MSK Researchers Learn What’s Driving ‘Brain Fog’ in People with COVID-19

Monday, February 8, 2021

In the Lab

Iron Fiends: Cancer Cells in Brain and Spinal Fluid Survive by Monopolizing a Nutrient

Friday, July 17, 2020

In the Lab

Inspired by a Patient, a Doctor Finds Answers for a Devastating Cancer Complication

Thursday, March 9, 2017

Publications

Remsik J, Wilcox JA, Babady NE, McMillen TA, Vachha BA, Halpern NA, Dhawan V, Rosenblum M, Iacobuzio-Donahue CA, Avila EK, Santomasso B and A Boire 2021 Inflammatory leptomeningeal cytokines mediate COVID-19 neurologic symptoms in cancer patients Cancer Cell 39:1-8

Noura J Choudhury NJ, Yang SR, Arcila M, Mohanty AS, Boire A and A Drilon 2020 Genomic Characterization of a RET Inhibitor-Resistant RET Fusion-Positive Lung Cancer by CSF Cell-Free DNA Hybrid Capture-Based Sequencing CO Precis Oncol 4:PO.20.00188

Chi Y, Remsik J, Kiseliovas V, Derderian C, Sener U, Alghader M, Saadeh F, Nikishina K, Bale T, Iacobuzio-Donahue C, Thomas T, Pe’er D, Mazutis L and A Boire 2020 Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science 369(6501):276-282.

Yang TJ, Wijetunga NA, Yamada J, Wolden S, Mehallow M, Goldman DA, Zhang Z, Young RJ, Kris MG, Yu HA, Seidman AD, Gavrilovic IT, Lin A, Santomasso B, Grommes C, Piotrowski AF, Schaff L, Stone JB, DeAngelis LM, Boire A, Pentsova E. 2020 Clinical Trial of Proton Craniospinal Irradiation for Leptomeningeal Metastases Neuro Oncol Jun 27

Malani R, Fleisher M, Kumthekar P, Lin X, Omuro A, Groves MD, Lin NU, Melisko M, Lassman AB, Jeyapalan S, Seidman A, Skakodub A, Boire A, DeAngelis LM, Rosenblum M, Raizer J and E Pentsova 2020 Cerebrospinal Fluid Circulating Tumor Cells as a Quantifiable Measurement of Leptomeningeal Metastases in Patients with HER2 Positive Cancer. Neuro-Oncology Jun 6.

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People

Adrienne A. Boire, MD, PhD

Assistant Professor

Physician-scientist Adrienne Boire studies metastasis to the central nervous system.
PhD, Tufts University, Boston, MA
MD, University of Chicago, Chicago, IL