Human Oncology & Pathogenesis Program

The Adrienne Boire Lab

Research

Adrienne A. Boire, MD, PhD

Assistant Professor

My laboratory focuses on metastasis to the central nervous system (CNS), both leptomeningeal and parenchymal metastases. We employ multiple complementary approaches to identify and target cancer cell adaptations to the challenging microenvironmental constraints posed by the CNS.

View Lab Overview

VIDEO | 02:04

Inside My Lab: Adrienne Boire

Go inside the lab of Adrienne Boire from MSK's Human Oncology & Pathogenesis Program.

Video Details

Featured News

In the Lab

Iron Fiends: Cancer Cells in Brain and Spinal Fluid Survive by Monopolizing a Nutrient

Friday, July 17, 2020

In the Lab

Inspired by a Patient, a Doctor Finds Answers for a Devastating Cancer Complication

Thursday, March 9, 2017

Publications

Chi Y, Remsik J, Kiseliovas V, Derderian C, Sener U, Alghader M, Saadeh F, Nikishina K, Bale T, Iacobuzio-Donahue C, Thomas T, Pe’er D, Mazutis L and A Boire 2020 Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science 369(6501):276-282.

Yang TJ, Wijetunga NA, Yamada J, Wolden S, Mehallow M, Goldman DA, Zhang Z, Young RJ, Kris MG, Yu HA, Seidman AD, Gavrilovic IT, Lin A, Santomasso B, Grommes C, Piotrowski AF, Schaff L, Stone JB, DeAngelis LM, Boire A, Pentsova E. 2020 Clinical Trial of Proton Craniospinal Irradiation for Leptomeningeal Metastases Neuro Oncol Jun 27

Malani R, Fleisher M, Kumthekar P, Lin X, Omuro A, Groves MD, Lin NU, Melisko M, Lassman AB, Jeyapalan S, Seidman A, Skakodub A, Boire A, DeAngelis LM, Rosenblum M, Raizer J and E Pentsova 2020 Cerebrospinal Fluid Circulating Tumor Cells as a Quantifiable Measurement of Leptomeningeal Metastases in Patients with HER2 Positive Cancer. Neuro-Oncology Jun 6.

Nevel K, DiStefano N, Lin X, Skakodub A, Ogilvie SQ, Reiner AS, Pentsova E and A Boire 2019 A quantitative assessment of disease burden in patients with leptomeningeal metastases from non-small-cell lung cancer. Neuro-Oncol. 22(5):675-683

Offin M, Feldman D, Ni A, Myers ML, Lai WV, Pentsova E, Boire A, Daras M, Jordan EJ, Solit DB, Arcila ME, Jones DR, Isbell JM, Beal K, Young RJ, Rudin CM, Riely GJ, Drilon A, Tabar V, DeAngelis LM, Yu HA, Kris MG, Li BT 2019 Frequency and Outcomes of Brain Metastases in Patients with HER2-mutant Lung Cancers. Cancer 125(24):4380-4387.

View All Publications

People

Adrienne A. Boire, MD, PhD

Assistant Professor

Physician-scientist Adrienne Boire studies metastasis to the central nervous system.
PhD, Tufts University, Boston, MA
MD, University of Chicago, Chicago, IL