Human Oncology & Pathogenesis Program

The Adrienne Boire Lab

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Research

Adrienne A. Boire, MD, PhD
Adrienne A. Boire, MD, PhD


Assistant Professor

My laboratory focuses on metastasis to the central nervous system (CNS), both leptomeningeal and parenchymal metastases. We employ multiple complementary approaches to identify and target cancer cell adaptations to the challenging microenvironmental constraints posed by the CNS.

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Publications

Chi Y, Remsik J, Kiseliovas V, Derderian C, Sener U, Alghader M, Saadeh F, Nikishina K, Bale T, Iacobuzio-Donahue C, Thomas T, Pe’er D, Mazutis L and A Boire 2020 Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science 369(6501):276-282.

Yang TJ, Wijetunga NA, Yamada J, Wolden S, Mehallow M, Goldman DA, Zhang Z, Young RJ, Kris MG, Yu HA, Seidman AD, Gavrilovic IT, Lin A, Santomasso B, Grommes C, Piotrowski AF, Schaff L, Stone JB, DeAngelis LM, Boire A, Pentsova E. 2020 Clinical Trial of Proton Craniospinal Irradiation for Leptomeningeal Metastases Neuro Oncol Jun 27

Malani R, Fleisher M, Kumthekar P, Lin X, Omuro A, Groves MD, Lin NU, Melisko M, Lassman AB, Jeyapalan S, Seidman A, Skakodub A, Boire A, DeAngelis LM, Rosenblum M, Raizer J and E Pentsova 2020 Cerebrospinal Fluid Circulating Tumor Cells as a Quantifiable Measurement of Leptomeningeal Metastases in Patients with HER2 Positive Cancer. Neuro-Oncology Jun 6.

Nevel K, DiStefano N, Lin X, Skakodub A, Ogilvie SQ, Reiner AS, Pentsova E and A Boire 2019 A quantitative assessment of disease burden in patients with leptomeningeal metastases from non-small-cell lung cancer. Neuro-Oncol. 22(5):675-683

Offin M, Feldman D, Ni A, Myers ML, Lai WV, Pentsova E, Boire A, Daras M, Jordan EJ, Solit DB, Arcila ME, Jones DR, Isbell JM, Beal K, Young RJ, Rudin CM, Riely GJ, Drilon A, Tabar V, DeAngelis LM, Yu HA, Kris MG, Li BT 2019 Frequency and Outcomes of Brain Metastases in Patients with HER2-mutant Lung Cancers. Cancer 125(24):4380-4387.

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People

Adrienne A. Boire, MD, PhD

Adrienne A. Boire, MD, PhD



Assistant Professor

  • Physician-scientist Adrienne Boire studies metastasis to the central nervous system.
  • PhD, Tufts University, Boston, MA
  • MD, University of Chicago, Chicago, IL
646-888-3861
Office Phone
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Physician profile

Members

Kiana Chabot

Research Technician

Yudan Chi

Research Scholar

Camille Derderian

Laboratory Technician

Min Jun Li

Research Technician

Anestashia Melford
Anestashia Melford

Administrative Assistant

Jan Remsik, PharmD, PhD
Jan Remsik

Research Fellow

Xinran Tong
Xinran Tong

Weill Cornell PhD student

Jessica Wilcox
Jessica Wilcox

Fellow

Lab Alumni
Majdi Alghader

Senior Research Technician

Giscard Barbier
Giscard Barbier

Administrative Assistant

Danielle Isakov
Danielle Isakov

Research Technician

Fadi Saadeh
Fadi Saadeh

Research Fellow

Ugur Sener
Ugur Sener

Clinical Fellow

Lab Affilations

Achievements

  • Vienna Medical Academy Award (2017)
  • Damon Runyon Clinical Investigator Award (2017)
  • Arnold P. Gold Foundation Humanism and Excellence in Teaching Award (2012)
  • Pew Biomedical Scholar (2018)
  • Pershing Square Sohn Prize (2019)

Open Positions

General Opportunities

Inquiries about graduate student rotations, postdoctoral fellowships or technician positions should be directed to melforda@mskcc.

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