The Adrienne Boire Lab


Inside My Lab: Adrienne Boire

My laboratory focuses on metastasis to the central nervous system (CNS), both leptomeningeal and parenchymal metastases. We employ multiple complementary approaches to identify and target cancer cell adaptations to the challenging microenvironmental constraints posed by the CNS.

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Adrienne A. Boire, MD, PhD

Adrienne A. Boire, MD, PhD

Assistant Professor

Research Focus

Physician-scientist Adrienne Boire studies metastasis to the central nervous system.


  • PhD, Tufts University, Boston, MA
  • MD, University of Chicago, Chicago, IL

Lab Members

  • Chi Y, Remsik J, Kiseliovas V, Derderian C, Sener U, Alghader M, Saadeh F, Nikishina K, Bale T, Iacobuzio-Donahue C, Thomas T, Pe’er D, Mazutis L and A Boire 2020 Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science 369(6501):276-282.
  • Yang TJ, Wijetunga NA, Yamada J, Wolden S, Mehallow M, Goldman DA, Zhang Z, Young RJ, Kris MG, Yu HA, Seidman AD, Gavrilovic IT, Lin A, Santomasso B, Grommes C, Piotrowski AF, Schaff L, Stone JB, DeAngelis LM, Boire A, Pentsova E. 2020 Clinical Trial of Proton Craniospinal Irradiation for Leptomeningeal Metastases Neuro Oncol Jun 27
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Selected Achievements
  • Vienna Medical Academy Award (2017)
  • Damon Runyon Clinical Investigator Award (2017)
  • Arnold P. Gold Foundation Humanism and Excellence in Teaching Award (2012)
  • Pew Biomedical Scholar (2018)
  • Pershing Square Sohn Prize (2019)