Human Oncology & Pathogenesis Program
The Adrienne Boire Lab
My laboratory focuses on metastasis to the central nervous system (CNS), both leptomeningeal and parenchymal metastases. We employ multiple complementary approaches to identify and target cancer cell adaptations to the challenging microenvironmental constraints posed by the CNS.
Wijetunga NA, Goglia AG, Weinhold N, Berger MF, Cislo M, Higginson DS, Chabot K, Osman AM, Schaff L, Pentsova E, Miller AM, Powell SN, Boire A, and JT Yang 2022 Dynamic Mutational Landscape of CSF Circulating Tumor DNA and Predictors of Survival after Proton Craniospinal Irradiation for Leptomeningeal Metastases. Clin Cancer Res Nov 30;CCR-22-2434.
Umemura Y, Khan B, Weill BJ, Buthorn JJ, Skakodub A, Ridder AJ, Nevel KS, Sun Y, and A Boire 2022 Discordance between perceptions and experience of lumbar puncture: A prospective study. Neurol Clin Pract 12(5):344-351.
Yang JT, Wijetunga NA, Pentsova E, Wolden S, Young RJ, Correa D, Zhang Z, Zheng J, Steckler A, Bucwinska W, Bernstein A, Betof Warner A, Yu H, Kris MG, Seidman AD, Wilcox JA, Malani R, Lin A, DeAngelis LM, Lee NY, Powell SN and A Boire 2022 Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis. J Clin Oncol 40(33):3858-3867.
Remsik J, Chi Y, Tong X, Sener U, Derderian C, ParkA, Saadeh F, Bale T and A Boire2022 Leptomeningeal metastatic cells adopt two phenotypic states. Cancer Rep (Hoboken) 5(4):e1236.
Haddock S, Alban TJ, Turcan Ş, Husic H, Rosiek E, Ma X, Wang Y, Bale T, Desrichard A, Makarov V, Monette S, Wu W, Gardner R, Manova K, Boire A, Chan TA. 2022 Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells. Neoplasia 28:100790.
Adrienne A. Boire, MD, PhD
- Physician-scientist Adrienne Boire studies metastasis to the central nervous system.
- PhD, Tufts University, Boston, MA
- MD, University of Chicago, Chicago, IL
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- BS, Pennsylvania State University
- 2021 Geoffrey Beene Junior Faculty Chair
- American Academy of Neurology Neuro Oncology Investigator Award (2020)
- Pershing Square Sohn Prize (2019)
- Pew Biomedical Scholar (2018)
- Damon Runyon Clinical Investigator Award (2017)
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Adrienne A. Boire discloses the following relationships and financial interests:
Department of Defense/Congressionally Directed Medical Research Programs (CDMRP)
Provision of Services (uncompensated)
Society for Neuro-Oncology (SNO)
Provision of Services
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