My laboratory focuses on metastasis to the central nervous system (CNS), both leptomeningeal and parenchymal metastases. We employ multiple complementary approaches to identify and target cancer cell adaptations to the challenging microenvironmental constraints posed by the CNS.
Adrienne A. Boire, MD, PhD
Assistant Professor
Research Focus
Physician-scientist Adrienne Boire studies metastasis to the central nervous system.Education
PhD, Tufts University, Boston, MA an MD, University of Chicago, Chicago, IL- Office Phone: 212-639-5371
- Office Fax: 212-717-3296
Lab Members
Majdi Alghader
Senior Research Technician
Giscard Barbier
Administrative Assistant
Yudan Chi
Research Scholar
Camille Derderian
Student Intern
Dejhy Pyram
Research Technician
Publications
- Boire A, Zou Y, Shieh J, Macalino D, Pentsova E and J Massagué. 2017 Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis. Cell 168(6):1101-1113.
- Chen Q, Boire A**, Jin X, Valiente M, Er EE, Lopez-Soto A, Patwa R, Shah H, Xu K, Cross JR and J Massagué. 2016 Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature 533(7604):493-8. **Co-first author
Selected Achievements
- Vienna Medical Academy Award (2017)
- Damon Runyon Clinical Investigator Award (2017)
- Arnold P. Gold Foundation Humanism and Excellence in Teaching Award (2012)
