Chemical Biology Program

The Heeseon An Lab

Research

Heeseon An
Heeseon An, PhD


Assistant Professor

The research in An lab centers around protein degradation processes in health and disease. We investigate protein degradation processes using chemical biology tools and unbiased proteomic approaches to discover previously unknown degradational pathways and molecular mechanisms. Specific research areas include 1) developing innovative chemical, biological, and proteomic tools to help advance protein degradation research, 2) identifying protein degradation pathways altered explicitly in disease and employing this information to develop small molecule probes with therapeutic potential, and 3) elucidating the fundamental role of ribosomal proteins and ribosome homeostasis using protein-degradation and chemical proteomics tools. Multidisciplinary and quantitative approaches are central to our research in addressing the questions mentioned above.

Heeseon An's Lab Picture

Publications Highlights

People

Heeseon An

Heeseon An, PhD



Assistant Professor

  • Heeseon An’s lab studies protein degradation in health and disease using chemical, biological, and proteomics tools.
  • BS and MS, Chemistry, Seoul National University
  • PhD, Chemistry, Northwestern University
  • Postdoc, Cell Biology, Harvard Medical School
[email protected]
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Members

Liang Sun
Liang Sun

Post-doctoral Fellow

Sang Ah Yi
Sang Ah Yi

Post-doctoral Fellow (NRF Korea Postdoctoral Fellow)

Ersilia Barin
Ersilia Barin

WCM Pharm graduate student

Victoria Jordan
Victoria Jordan

TPCB graduate student (NSF Graduate Research Fellow)

Brittany Pham
Brittany Pham

WCM Pharm graduate student

Karl Lin

TPCB graduate student (NSF Graduate Research Fellow)

Deepika Nambiar

TPCB graduate student (NSF Graduate Research Fellow)

Pascale Presendor

Administrative Assistant

Michelle (Ruiyang) Guo

TPCB graduate student (joint with Huse lab)

Lab Alumni
Mel-Quann Hodge

Administrative Assistant

Lab Affiliations

Achievements

Lab News & Events

Upcoming event

Targeting Chromatin Regulatory Proteins With Therapeutic Degraders

Memorial Sloan Kettering Cancer Center
Rockefeller Research Laboratories
430 East 67th Street
RRL-120 (Auditorium)
New York, NY 10065

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Heeseon An discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


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This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

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