Andrew Intlekofer is an Assistant Member in the Human Oncology and Pathogenesis Program and an Attending Physician on the Lymphoma Service in the Department of Medicine. Dr. Intlekofer’s research investigates how deregulated metabolic pathways contribute to cancer development and how metabolic enzymes can be targeted for cancer treatment.
Andrew M. Intlekofer, MD, PhD
Assistant Professor
Research Focus
Physician-scientist Andrew Intlekofer investigates why cancer cells depend on specific pathways of nutrient metabolism.Education
MD, PhD, University of Pennsylvania School of Medicine, PA.Lab Members
Giscard Barbier
Laboratory Administrator
Fabian Correa
Senior Research Technician
Naofumi Takemoto
Senior Research Assistant
Bo Wang
Senior Research Technician
Publications
- Intlekofer AM, Shih AH, Wang B, Nazir A, Rustenburg AS, Albanese SK, Patel M, Famulare C, Correa FM, Takemoto N, Durani V, Liu H, Taylor J, Farnoud NR, Papaemmanuil E, Cross JR, Tallman MS, Arcila ME, Roshal M, Petsko GA, Wu B, Choe S, Konteatis ZD, Biller SA, Chodera JD, Thompson CB, Levine RL, Stein EM. Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations. Nature. 2018 Jul;559(7712):125-129.
- Intlekofer AM, Wang B, Liu H, Shah H, Carmona-Fontaine C, Rustenburg AS, Salah S, Gunner MR, Chodera JD, Cross JR, Thompson CB. L-2-hydroxyglutarate production arises from non-canonical enzyme function at acidic pH. Nature Chemical Biology. 2017 May;13(5):494-500. doi: 10.1038/nchembio.2307.
Selected Achievements
- Damon Runyon Clinical Investigator Award (2018)
ASCI Young Physician-Scientist Award (2018)
- Damon Runyon Clinical Investigator Award (2018)
- ASCI Young Physician-Scientist Award (2018)
- Burroughs Wellcome Fund Career Award for Medical Scientists (2016)
- NCI K08 Mentored Clinical Scientist Research Career Development Award (2016)