Research Articles

Lee JH, Sánchez-Rivera FJ, He L, Basnet H, Chen F, Spina E, Li L, Torner C, Chan JE, Yarlagadda DVK, Park JS, Sussman C, Rudin CM, Lowe SW, Tammela T, Macias MJ, Koche RP, Massagué J. TGF-β and RAS jointly unmask primed enhancers to drive metastasis. Cell (2024) Aug 29:S0092-8674(24)00905-X.  https://doi.org/10.1016/j.cell.2024.08.014

Gan, S, Macalinao, DG, Shahoei, SH, Tian, L, Jin, X, Basnet, H, Muller, J, Seffar, E, Chatila, W, Hadjantonakis, AK, Schultz, N., Brogi, E, Bale, TA, Pe’er, D, and Massagué, J. Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain. Cancer Cell in press (2024) DOI: 10.1016/j.ccell.2024.08.015 

Hu, J., Sánchez-Rivera, F.J., Johnson, G., Wang, Z., Ho, YJ., Ganesh, K., Gan, S., Hampton, J., Zhao, H., Kottapalli, S., De Stanchina, E., Iacobuzio-Donahue, C.A., Pe’er, D., Lowe, S.W., Sun, J., and Massagué, J. STING suppresses the reactivation of dormant metastasis in lung adenocarcinoma. Nature 616(7958):806-813 (2023) PMC10569211

Laughney, A.M., Hu, J., Campbell, N.R., Bakhoum, S.F.,Setty, M.,  Lavallée, V.-P., Xie, Y., Masilonis, I., Carr, A.J., Allaj, V., Mattar, M., Rekhtman, N., Xavier, J., Mazutis, L., Poirier, J.T., Rudin, C.M., Pe’er, D. and Massagué, J. Regenerative lineages and immune-mediated pruning in lung cancer metastasis. Nature Medicine 26, 259-269 (2020). [PMC7021003]

Ganesh, G., Basnet, H., Laughney, A.M., Kaygusuz, Y., He, L., O’Rourke, K.P., Reuter, V., Huang, Y.-H., Er, E.E., Masilionis, I., Weiser, M.R., Saltz, L.B., Garcia-Aguilar, J., Koche, R., Lowe, S.W., Pe’er, D., Shia, J., and Massagué, J. L1CAM defines the regenerative origin of metastasis initiating cells in colorectal cancer. Nature Cancer 1, 28-44 (2020).[PMC7351134]

Su, J., M. Morgani, S.M., David, C.J., Wang, Q., Emrah Er, E.E., Huang, Y.-H., Basnet, H., Zou, Y., Shu, W., Hendrickson, R.C., Soni, R.K., Hadjantonakis, A.-K. and Massagué, J.  TGF-β orchestrates fibrogenic and developmental EMTs via RAS effector RREB1. Nature 577, 566–571 (2020)[PMC7450666]

Huang, Y.-H., Hu, J., Chen, F., Lecomte, N., Basnet, H., David, C.J., Witkin, M.D., Allen, P., Leach, S.D., Hollmann, T.J., Iacobuzio-Donahue, C.A., Massagué, J. ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer. Cancer Disc. 10, 142-157 (2020)[PMC6954299]

Reviews

Massagué, J. and Sheppard, D. TGF-β signaling in health and disease. Cell (186):4007-4037 (2023). [PMC10772989]

Lee, J.H. and Massagué, J. TGF-β in developmental and fibrogenic EMTs. Sem. Cancer Biol. (86):136-145 (2022). [PMC10155902]

Ganesh K, Massagué J. Targeting metastatic cancer. Nat Medine (1):34-44 (2021). [PMC7895475]

Massagué J, Ganesh K. Metastasis-Initiating Cells and Ecosystems. Cancer Disc. (4):971-994 (2021). [PMC8030695]