Research Articles

Gan, S, Macalinao, DG, Shahoei, SH, Tian, L, Jin, X, Basnet, H, Muller, J, Seffar, E, Chatila, W, Hadjantonakis, AK, Schultz, N., Brogi, E, Bale, TA, Pe’er, D, and Massagué, J. Distinct tumor architectures for metastatic colonization of the brain. bioRxiv (2023) PMC10081170

Hu, J., Sánchez-Rivera, F.J., Johnson, G., Wang, Z., Ho, YJ., Ganesh, K., Gan, S., Hampton, J., Zhao, H., Kottapalli, S., De Stanchina, E., Iacobuzio-Donahue, C.A., Pe’er, D., Lowe, S.W., Sun, J., and Massagué, J. STING suppresses the reactivation of dormant metastasis in lung adenocarcinoma. Nature 616(7958):806-813 (2023) PMC10569211

Paik, P., Luo, J., Ai, N., Kim, R., Ahn, L., Biswas, A., Coker, C., Ma, W., Wong, P., Buonocore, D., Lai, W.V., Chaft, J., Acharyya, S., Massagué, J. and Kris, M. Phase I trail of the TNF-a inhibitor certolizumab plus chemotherpy in stage IV lung adenocarcinomas. Nat Commun 13 (1): 6095 (2022) PMC9568581

Biswas, A.K., Han, S., Tai, Y., Ma, W., Coker, C., Quinn, A., Shakri, A.R., Zhong, T.J., Scholze, H., Lagos, G.G., Mela, A., Manova-Todorova, K., de Stanchina, E., Ferrando, A., Mendelsohn, C., Canoll, P.,  Yu, H.A., Paik, P., Saqi, A., Shu, C.A., Kris, M.G., Massagué, J. and Acharyya, S. Targeting S100A9-ALDH1A1-retinoic acid signaling to suppress brain relapse in EGFR-mutant lung cancer. Cancer Disc., 12, (4): 1002-1021 (2022). [PMC8983473]

Morgani SM, Su J, Nichols J, Massagué J, Hadjantonakis AK. The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos. Elife 30;10 (2021). [PMC8131102]

Tello-Lafoz M, Srpan K, Sanchez EE, Hu J, Remsik J, Romin Y, Calò A, Hoen D, Bhanot U, Morris L, Boire A, Hsu KC, Massagué J, Huse M, Er EE. Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer. Immunity 7. 54(5):1037-1054 (2021). [PMC8119359]

Laughney, A.M., Hu, J., Campbell, N.R., Bakhoum, S.F.,Setty, M.,  Lavallée, V.-P., Xie, Y., Masilonis, I., Carr, A.J., Allaj, V., Mattar, M., Rekhtman, N., Xavier, J., Mazutis, L., Poirier, J.T., Rudin, C.M., Pe’er, D. and Massagué, J. Regenerative lineages and immune-mediated pruning in lung cancer metastasis. Nature Medicine 26, 259-269 (2020). [PMC7021003]

Ganesh, G., Basnet, H., Laughney, A.M., Kaygusuz, Y., He, L., O’Rourke, K.P., Reuter, V., Huang, Y.-H., Er, E.E., Masilionis, I., Weiser, M.R., Saltz, L.B., Garcia-Aguilar, J., Koche, R., Lowe, S.W., Pe’er, D., Shia, J., and Massagué, J. L1CAM defines the regenerative origin of metastasis initiating cells in colorectal cancer. Nature Cancer 1, 28-44 (2020).[PMC7351134]

Su, J., M. Morgani, S.M., David, C.J., Wang, Q., Emrah Er, E.E., Huang, Y.-H., Basnet, H., Zou, Y., Shu, W., Hendrickson, R.C., Soni, R.K., Hadjantonakis, A.-K. and Massagué, J.  TGF-β orchestrates fibrogenic and developmental EMTs via RAS effector RREB1. Nature 577, 566–571 (2020)[PMC7450666]

Huang, Y.-H., Hu, J., Chen, F., Lecomte, N., Basnet, H., David, C.J., Witkin, M.D., Allen, P., Leach, S.D., Hollmann, T.J., Iacobuzio-Donahue, C.A., Massagué, J. ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer. Cancer Disc. 10, 142-157 (2020)[PMC6954299]

Reviews

Massagué, J. and Sheppard, D. TGF-β signaling in health and disease. Cell (186):4007-4037 (2023). [PMC10772989]

Lee, J.H. and Massagué, J. TGF-β in developmental and fibrogenic EMTs. Sem. Cancer Biol. (86):136-145 (2022). [PMC10155902]

Ganesh K, Massagué J. Targeting metastatic cancer. Nat Medine (1):34-44 (2021). [PMC7895475]

Massagué J, Ganesh K. Metastasis-Initiating Cells and Ecosystems. Cancer Disc. (4):971-994 (2021). [PMC8030695]