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The Joan Massagué Lab: Publications

Visit PubMed for a full listing of Joan Massagué’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Research Articles

Boire, A., Zou, Y., Shieh, J., Macalinao, D., Pentsova, E. and Massagué, J. Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis. Cell 168, 1101-1113 (2017).

Wang, Q., Zou, Y., Nowotschin, S., Kim, S.Y., Soh, C.L., Su, J., Zhang, C., Shu, W., Xi, Q., Huangfu, D., Hadjantonakis, A.K., and Massagué, J. The p53 family coordinates Wnt and nodal inputs in mesendoderm differentiation of embryonic stem cells. Cell Stem Cell 20, 70-86 (2017) PMC5218926

Chen, Q., Boire, A., Jin, X., Valiente, M., Er, E.E., Lopez-Soto, A., Pawta, R., Shah, H., Xu, K., Cross, J.R., and Massagué, J. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature 533, 493–498 (2016) PMC5021195

Malladi, S., Macalinao, D., Jin, X., He, L., de Stanchina, E.,, and Massagué, J. Metastatic latency and immune evasion through autocrine inhibition of WNT. Cell 165, 45-60 (2016) PMID27015306 PMC4808520

David, C.J., Huang, Y.-H., Chen, M., Su, J., Bardeesy, N., Iacobuzio-Donahue, C., and Massagué, J. TGF-β tumor suppression through a lethal EMT. Cell 164, 1015-30 (2016) PMID26898331 PMC4801341

Jacob, L.S., Vanharanta, S., Obenauf, A.C., Pirun, M., Viale, A., Socci, N.D., and Massagué, J. Metastatic competence can emerge with selection of pre-existing oncogenic alleles without a need of new mutations. Cancer Res. 75, 3713-3719 (2015) PMC4573898

Obenauf, A.C., Zou, Y., Ji, A.L., Vanharanta, S., Shu, W., Shi, H., Kong, X., Bosenberg, M.C., Wiesner, T., Rosen, N., Lo, R.S., and Massagué, J. Therapy induced tumour secretomes promote resistance and tumour progression. Nature 520, 368-372 (2015) PMC4507807

Sevenich, L. Bowman, R.L., Mason, S.D., Quail, D.F., Rapaport, F., Elie, B.T., Brogi, E., Brastianos, P.K., Hahn, W.C., Holsinger, L.J., Massagué, J., Leslie, C.S. and Joyce, J.A.   Analysis of tumor- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. Nature Cell Biol. 6, 876-888 (2014) PMC4249762

Vanharanta, S., Marney, C.B. Shu, W., Valiente, M., Zou, Y., Mele, A., Darnell R.B., and Massagué, J. Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. eLife Jun 4:e02734 (2014) doi: 10.7554/ eLife.02734; PMC4073284 

Morales, M., Arenas1, E.J., Urosevic, J., Guiu, M., Fernández, E., Planet, E., Fenwick, R.B., Fernández, S., Salvatella, X., Reverter, D., Carracedo, A., Massagué, J., Gomis, R.R. RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation. EMBO Mol. Med. DOI: 10.15252/emmm.201303675 PMC4119352

Valiente, M., Obenauf, A.C., Jin, X., Chen, Q., Zhang, X.H.F., Lee, D.J., Chaft, J.E., Kris, M.G., Huse, J.T., Brogi, E. and Massagué, J. Serpins promote cancer cell survival and vascular cooption in brain metastasis. Cell. 2014 Feb 27;156(5):1002–1016.PMC3988473

Zhang, X. H.-F., Jin, X., Malladi, S., Kim, J.Y., Wen, Y.H., Brogi, E., Smid, M., Foekens, J. and Massagué, J. Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 2013 Aug 29;154(5):1060-73. PMC3974915

Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, Viale A, Reuter VE, Hsieh JJ, Scandura JM, Massagué J. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nature Med. 19, 50-56 (2013). PMC3540187]

Acharyya S, Oskarsson T, Vanharanta S, Malladi S, Kim J, Morris PG, Manova-Todorova K, Leversha M, Hogg N, Seshan VE, Norton L, Brogi E, Massagué J. A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell 150, 165-178 (2012). PMC3528019

Xi Q, Wang Z, Zaromytidou AI, Zhang XH, Chow-Tsang LF, Liu JX, Kim H, Barlas A, Manova-Todorova K, Kaartinen V, Studer L, Mark W, Patel DJ, Massagué J. A poised chromatin platform for TGF-β access to master regulators. Cell 147, 1511-1524 (2011). PMC3582033

Chen Q, Zhang XH, Massagué J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20, 538-549 (2011). PMC3473104

Aragón, E., Goerner, N., Zaromytidou, A.-I., Xi, Q., Escobedo, A., Massagué, J.*, Macias, M.J. A Smad action-turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev. 25, 1275-1288 (2011). PMC3127429

Oskarsson, T., Acharyya, S., Zhang, X.H.F, Tavazoie, S., Morris, P.G., Downey, R., Manova-Todorova, K., Brogi, E. and Massagué, J. Breast cancer cells produce tenascin-C as a metastatic niche component to colonize the lungs. Nature Med. 17, 867-874 (2011). PMC4020577

Alarcon, C., Zaromytidou, A.I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A.N., Manova-Todorova, K., Macias, M.J., Sapkota, G., Pan, D. and Massague, J., Nuclear CDKs drive Smad transcriptional action and turnover in BMP and TGF-beta pathways. Cell 139, 757-769 (2009).PMC 2818353

Kim, M-Y., Oskarsson, T., Acharyya, S., Nguyen, D.X., Zhang, X. H-F., Norton, L. and Massague, J., Tumor self-seeding by circulating cancer cells. Cell 139, 1315-1326 (2009). PMC2810531

Bos, P.D., Zhang, X.H-F, Nadal, C., Shu, W., Gomis, R.R., Nguyen, D.X., Minn, A.J., van de Vijver, M.J., Gerald, W.L., Foekens, J.A. and Massague, J., Genes that mediate breast cancer metastasis to the brain. Nature 459: 1005-1009 (2009) PMC2698953

Zhang, X.H-F, Wang, Q., Gerald, W.L., Hudis, C.A., Norton, L., Smid, M., Foekens, J.A. and Massague, J., Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell 16: 67-78 (2009) PMC2749247.

Nguyen, D.X., Chiang, A.C., Zhang, X.H-F, Kim, J.Y., Kris, M.G., Ladanyi, M., Gerald, W.L. and Massague, J., WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell 138: 51-62 (2009) PMC2742946

Tavazoie, S.F., Alarcon, C., Oskarsson, T., Padua, D., Wang, Q., Bos, P.D., Gerald W.L. and Massague, J., Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451: 147-152 (2008) PMC2782491

Padua, D., Zhang, X.H., Wang, Q., Nadal, C., Gerald W.L., Gomis, R.R. and Massague, J., TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133: 66-77 (2008) PMC2390892

Gupta, G.P., Nguyen, D.X., Chiang, A., Kim, J.Y., Nadal, C., Gomis, R.R., Manova-Todorova, K. and Massagu-, J., Mediators of vascular remodeling co-opted for sequential steps in lung metastasis. Nature 446, 765-770 (2007)

Minn, A.J., Gupta, G.P., Siegel, P.M., Bos, P.D., Shu, W., Giri, D.D., Viale, A., Olshen, A.B., Gerald W.L. and Massagué, J., Genes that mediate breast cancer metastasis to lung. Nature 436, 518-524 (2005)

Review Articles

Oskarsson, T., Batlle, E. and Massagué, J. Metastatic stem cells. Cell Stem Cell 14, 306-321 (2014).

Vanharanta, S. and Massagué, J. Origins of metastatic traits. Cancer Cell 24, 410-421 (2013).

Massagué J. TGFβ signalling in context. Nat Rev Mol Cell Biol. 18, 5521-5525 (2012).

Nguyen, D.X, Bos, P.D. and Massagué, J. Metastasis: from dissemination to organ-specific colonization. Nature Rev. Cancer 9, 274-284 (2009).

Massague, J., TGF-beta in Cancer. Cell 134: 215-230 (2008).

Chiang, A.C. and Massague, J., Molecular basis of metastasis. N. Engl. J. Med. 359: 2814-2823 (2008).

Gupta, G.P. and Massagué, J., Cancer metastasis: building a framework Cell 127, 679-695 (2006).

Shi, Y. and Massagué, J., Mechanisms of TGFb signaling from cell membrane to the nucleus. Cell 113, 685-700 (2003).