Research Articles

Laughney, A.M., Hu, J., Campbell, N.R., Bakhoum, S.F.,Setty, M.,  Lavallée, V.-P., Xie, Y., Masilonis, I., Carr, A.J., Allaj, V., Mattar, M., Rekhtman, N., Xavier, J., Mazutis, L., Poirier, J.T., Rudin, C.M., Pe’er, D. and Massagué, J. Regenerative lineages and immune-mediated pruning in lung cancer metastasis. Nature Medicine 26, 259-269 (2020).

Ganesh, G., Basnet, H., Laughney, A.M., Kaygusuz, Y., He, L., O’Rourke, K.P., Reuter, V., Huang, Y.-H., Er, E.E., Masilionis, I., Weiser, M.R., Saltz, L.B., Garcia-Aguilar, J., Koche, R., Lowe, S.W., Pe’er, D., Shia, J., and Massagué, J. L1CAM defines the regenerative origin of metastasis initiating cells in colorectal cancer. Nature Cancer 1, 28-44 (2020).

Su, J., M. Morgani, S.M., David, C.J., Wang, Q., Emrah Er, E.E., Huang, Y.-H., Basnet, H., Zou, Y., Shu, W., Hendrickson, R.C., Soni, R.K., Hadjantonakis, A.-K. and Massagué, J.  TGF-β orchestrates fibrogenic and developmental EMTs via RAS effector RREB1. Nature 577, 566–571 (2020) 

Huang, Y.-H., Hu, J., Chen, F., Lecomte, N., Basnet, H., David, C.J., Witkin, M.D., Allen, P., Leach, S.D., Hollmann, T.J., Iacobuzio-Donahue, C.A., Massagué, J. ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer. Cancer Disc. 10, 142-157 (2020)

Aragón, E., Wang, Q., Zou, Y., Morgani, S.M., Ruiz, L., Kaczmarska, Z., Su, J., Torner, C., Tian, L., Hu, J., Shu, W., Agrawal, S., Márquez, J.A., Hadjantonakis, A.-K., Macias, M.J. and Massagué, J. Structural basis for distinct roles of SMAD2 and SMAD3 in  FOXH1 pioneer-directed TGF-β signaling. Genes Dev. 33, 1506-1524 (2019) 

Er, E.E., Valiente, M., Ganesh, K, Zou, Y., Agrawal, S., Griscom, B., Giancotti, F., Schachner, M., Malladi, S., Massagué, J. Pericyte-like spreading of disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nature Cell Biol. 20, 966-978 (2018).

Boire, A., Zou, Y., Shieh, J., Macalinao, D., Pentsova, E. and Massagué, J. Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis. Cell 168, 1101-1113 (2017)

Chen, Q., Boire, A., Jin, X., Valiente, M., Er, E.E., Lopez-Soto, A., Pawta, R., Shah, H., Xu, K., Cross, J.R., and Massagué, J. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature 533, 493–498 (2016)

Malladi, S., Macalinao, D., Jin, X., He, L., de Stanchina, E., and Massagué, J. Metastatic latency and immune evasion through autocrine inhibition of WNT. Cell 165, 45-60 (2016)

David, C.J., Huan, Y.-H., Chen, M., Su, J., Bardeesy, N., Iacobuzio-Donahue, C., and Massagué, J. TGF-β tumor suppression through a lethal EMT. Cell 164, 1015-1030 (2016)

Basnet H, Tian L, Ganesh K, Huang YH, Macalinao DG, Brogi E, Finley LW, and Massagué J. Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization. Elife (2019); 8: e43627. PMC6440742

David, C.J. and Massagué, J. Contextual determinants of TGFβ action in development, immunity and cancer. Nature Reviews Molecular Cell Biology.  2018 July;19(7):419-435.

Er, E.E., Valiente, M., Ganesh, K., Agrawal, S., Hu, J., Griscom, B.,  Rosenblum, M., Boire, A., BRogi, E., Giancotti, F.G., Schachner, M., Malladi, S., and Massagué, J. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastaticcolonization. Nat Cell Biol. 2018 Aug;20(8):966-978.

Boire, A., Zou, Y., Shieh, J., Macalinao, D., Pentsova, E. and Massagué, J. Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis. Cell 168, 1101-1113 (2017).

Wang, Q., Zou, Y., Nowotschin, S., Kim, S.Y., Soh, C.L., Su, J., Zhang, C., Shu, W., Xi, Q., Huangfu, D., Hadjantonakis, A.K., and Massagué, J. The p53 family coordinates Wnt and nodal inputs in mesendoderm differentiation of embryonic stem cells. Cell Stem Cell 20, 70-86 (2017) PMC5218926

Chen, Q., Boire, A., Jin, X., Valiente, M., Er, E.E., Lopez-Soto, A., Pawta, R., Shah, H., Xu, K., Cross, J.R., and Massagué, J. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature 533, 493–498 (2016) PMC5021195

Malladi, S., Macalinao, D., Jin, X., He, L., de Stanchina, E.,, and Massagué, J. Metastatic latency and immune evasion through autocrine inhibition of WNT. Cell 165, 45-60 (2016) PMC4808520

David, C.J., Huang, Y.-H., Chen, M., Su, J., Bardeesy, N., Iacobuzio-Donahue, C., and Massagué, J. TGF-β tumor suppression through a lethal EMT. Cell 164, 1015-30 (2016) PMC4801341

Obenauf, A.C., Zou, Y., Ji, A.L., Vanharanta, S., Shu, W., Shi, H., Kong, X., Bosenberg, M.C., Wiesner, T., Rosen, N., Lo, R.S., and Massagué, J. Therapy induced tumour secretomes promote resistance and tumour progression. Nature 520, 368-372 (2015) PMC4507807

Valiente, M., Obenauf, A.C., Jin, X., Chen, Q., Zhang, X.H.F., Lee, D.J., Chaft, J.E., Kris, M.G., Huse, J.T., Brogi, E. and Massagué, J. Serpins promote cancer cell survival and vascular cooption in brain metastasis. Cell. 2014 Feb 27;156(5):1002–1016.PMC3988473

Reviews:

Batlle, E. and Massagué, J. TGFβ signaling in immunity and cancer. Immunity 16;50(4):924-940 (2019)

David, C.J. and Massagué, J. Contextual determinants of TGFβ action in development, immunity and cancer. Nature Rev. Mol. Cell. Biol. 19, 419-435 (2018)

Massagué, J. and Obenauf, A. Metastatic colonization by circulating tumor cells. Nature 529, 298-306 (2016)