Research Articles
Wang Z, Elbanna Y, Godet I, Peters L, Lampe G, Chen Y, Xavier J, Huse M, Massagué J. TGF-β induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis. Nature Cancer. (2026) Jan 5; [PMID: ] [PMCID: ] DOI: 10.1038/s43018-025-01094-y
Kawasaki K, Salehi S, Zhan YA, Chen K, Lee JH, Salataj E, Zhong H, Manoj P, Kinyua D, Mello BP, Sridhar H, Tischfield SE, Linkov I, Ceglia N, Zatzman M, Havasov E, Shah NJ, Meng F, Loomis B, Bhanot UK, Redin E, de Stanchina E, Hamard PJ, Koche RP, McPherson A, Quintanal-Villalonga A, Shah SP, Massagué J* and Rudin CM* (*corresponding). FOXA2 promotes metastatic competence in small cell lung cancer. Nature Commun. 16:4865, (2025) [PMID: 40419484] [PMC1210783] https://doi.org/10.1038/s41467-025-60141-5
Lee JH, Sánchez-Rivera FJ, He L, Basnet H, Chen F, Spina E, Li L, Torner C, Chan JE, Yarlagadda DVK, Park JS, Sussman C, Rudin CM, Lowe SW, Tammela T, Macias MJ, Koche RP, Massagué J. TGF-β and RAS jointly unmask primed enhancers to drive metastasis. Cell (2024) Oct 31;187(22):6182-6199.e29. [PMID: 39243762] [PMCID: PMC12035776] DOI: 10.1016/j.cell.2024.08.014
Gan, S, Macalinao, DG, Shahoei, SH, Tian, L, Jin, X, Basnet, H, Muller, J, Seffar, E, Chatila, W, Hadjantonakis, AK, Schultz, N., Brogi, E, Bale, TA, Pe’er, D, and Massagué, J. Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain. Cancer Cell (2024) Oct 14;42(10):1693-1712.e24 [PMID: 39270646] [PMCID: PMC12093277] DOI: 10.1016/j.ccell.2024.08.015
Hu, J., Sánchez-Rivera, F.J., Johnson, G., Wang, Z., Ho, YJ., Ganesh, K., Gan, S., Hampton, J., Zhao, H., Kottapalli, S., De Stanchina, E., Iacobuzio-Donahue, C.A., Pe’er, D., Lowe, S.W., Sun, J., and Massagué, J. STING suppresses the reactivation of dormant metastasis in lung adenocarcinoma. Nature (2023) Apr; 616(7958):806-813 [PMID: 36991128] [PMCID: PMC10569211] DOI: 10.1038/s41586-023-05880-5
Laughney, A.M., Hu, J., Campbell, N.R., Bakhoum, S.F.,Setty, M., Lavallée, V.-P., Xie, Y., Masilonis, I., Carr, A.J., Allaj, V., Mattar, M., Rekhtman, N., Xavier, J., Mazutis, L., Poirier, J.T., Rudin, C.M., Pe’er, D. and Massagué, J. Regenerative lineages and immune-mediated pruning in lung cancer metastasis. Nature Medicine 26, 259-269 (2020). [PMC7021003] [PMID: 32042191] DOI: 10.1038/s41591-019-0750-6
Ganesh, G., Basnet, H., Laughney, A.M., Kaygusuz, Y., He, L., O’Rourke, K.P., Reuter, V., Huang, Y.-H., Er, E.E., Masilionis, I., Weiser, M.R., Saltz, L.B., Garcia-Aguilar, J., Koche, R., Lowe, S.W., Pe’er, D., Shia, J., and Massagué, J. L1CAM defines the regenerative origin of metastasis initiating cells in colorectal cancer. Nature Cancer 1, 28-44 (2020).[PMC7351134] [PMID: 32656539] DOI: 10.1038/s43018-019-0006-x
Su, J., M. Morgani, S.M., David, C.J., Wang, Q., Emrah Er, E.E., Huang, Y.-H., Basnet, H., Zou, Y., Shu, W., Hendrickson, R.C., Soni, R.K., Hadjantonakis, A.-K. and Massagué, J. TGF-β orchestrates fibrogenic and developmental EMTs via RAS effector RREB1. Nature 577, 566–571 (2020) [PMC7450666] [PMID:31915377] DOI: 10.1038/s41586-019-1897-5
Reviews
Massagué, J. and Sheppard, D. TGF-β signaling in health and disease. Cell (186):4007-4037 (2023). [PMC10772989] [PMID: 37714133] DOI: 10.1016/j.cell.2023.07.036
Lee, J.H. and Massagué, J. TGF-β in developmental and fibrogenic EMTs. Sem. Cancer Biol. (86):136-145 (2022). [PMC10155902] DOI: 10.1016/j.semcancer.2022.09.004
Ganesh K, Massagué J. Targeting metastatic cancer. Nat Medine (1):34-44 (2021). [PMC7895475] [PMID: 36183999] DOI: 10.1038/s41591-020-01195-4
Massagué J, Ganesh K. Metastasis-Initiating Cells and Ecosystems. Cancer Disc. (4):971-994 (2021). [PMC8030695] [PMID: 33811127] DOI: 10.1158/2159-8290.CD-21-0010