The Derek Tan Lab: Publications

The Derek Tan Lab

The Derek Tan Lab: Publications

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View a full listing of Derek Tan’s journal articles.


Read up on the latest publications in diversity-oriented synthesis, rational drug design, chemical biology, and drug discovery research from the Tan Lab!

Selected Publications: Text Only | Graphical Abstracts
Complete Publications: Text Only | Graphical Abstracts

Full-text versions of articles are available from the publisher with online journal subscription. PubMed Central (PMC) versions of articles are available free of charge.


  1. Structural basis for adenylation and thioester bond formation in the ubiquitin E1.
    Hann, Z. S.; Ji, C.; Olsen, S. K.; Lu, X.; Lux, M. C.; Tan, D. S. *; Lima, C. D.* Proc. Natl. Acad. Sci. U.S.A. 2019, 15475–15484.
    Abstract | PubMed | PMC ]

  2. Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors.
    Lux, M. C.; Standke, L. C.; Tan, D. S.* J. Antibiot. 2019, 72, 325–349.
    Abstract | PubMed | PMC ]

  3. Structure-based design, synthesis, and biological evaluation of non-acyl sulfamate inhibitors of the adenylate-forming enzyme MenE.
    Evans, C. E.; Si, Y.; Matarlo, J. S.; Yin, Y.; French, J. B.; Tonge, P. J.*; Tan, D. S.* Biochemistry 2019, 58, 1918–1930.
    Abstract | PubMed | PMC ]

  4. Family-level stereoselective synthesis and biological evaluation of pyrrolomorpholine spiroketal natural product antioxidants
    Verano, A. L.; Tan, D. S.* Chem. Sci. 2017, 8, 3687–3693.
    Abstract | PubMed | PMC ]

  5. Stereocontrolled Synthesis of Spiroketals: An Engine for Chemical and Biological Discovery
    Verano, A. L.; Tan, D. S.* Isr. J. Chem. 2017, 57, 279–291.
    Abstract ] PubMed | PMC ]

  6. Designed small-molecule inhibitors of the anthranilyl-CoA synthetase PqsA block quinolone biosynthesis in Pseudomonas aeruginosa.
    Ji, C.; Sharma, I.; Pratihar, I.; Hudson, L.; Maura, D.; Guney, T.; Rahme, L. G.; Pesci, E. C.; Coleman, J. P.; Tan, D. S.* ACS Chem. Biol. 2016, 11, 3061–3067.
    Abstract | PubMed | PMC ]

  7. General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.
    Davis, T. D.; Gerry, C. J.; Tan, D. S.* ACS Chem. Biol. 2014, 9, 2535–2544.
    Abstract | PubMed | PMC ]
    (Highlighted in ACS Chem. Biol.)

  8. Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion.
    Bauer, R. A.; Wenderski, T. A.; Tan, D. S.* Nat. Chem. Biol. 2013, 9, 21–29.
    Abstract | PubMed | PMC ]

  9. A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
    Kopp, F.; Stratton, C. F.; Akella, L. B.; Tan, D. S.* Nat. Chem. Biol. 2012, 8, 358–365.
    Abstract | PubMed | PMC ]
    (Highlighted in SciBX )

  10. Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals.
    Wurst, J. M.; Liu, G.; Tan, D. S.* J. Am. Chem. Soc. 2011, 133, 7916–7925.
    Abstract | PubMed | PMC ]

  11. Active site remodelling accompanies thioester bond formation in the SUMO E1.
    Olsen, S. K.; Capili. A. D.; Lu, X.; Tan, D. S.*; Lima, C. D.* Nature 2010, 463, 906–912.
    Abstract | PubMed | PMC ]
    (Highlighted in Nature, Chem. Eng. News, Nat. Rev. Mol. Cell Biol., Nat. Chem. Biol., Structure, ACS Chem. Biol., and Faculty of 1000 Biology )

  12. Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.
    Lu, X.; Olsen, S. K.; Capili, A. D.; Cisar, J. S.; Lima, C. D.*; Tan, D. S.* J. Am. Chem. Soc. 2010, 132, 1748–1749.
    Abstract | PubMed | PMC ]
    (Highlighted in Chem. Eng. News, Nat. Rev. Mol. Cell Biol., ACS Chem. Biol., and Faculty of 1000 Biology )