Read up on the latest publications in diversity-oriented synthesis, rational drug design, chemical biology, and drug discovery research from the Tan Lab!
Selected Publications: Text Only | Graphical Abstracts
Complete Publications: Text Only | Graphical Abstracts
Full-text versions of articles are available from the publisher with online journal subscription. PubMed Central (PMC) versions of articles are available free of charge.
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Defining new chemical space for drug penetration into Gram-negative bacteria.
Zhao, S.; Adamiak, J. W.; Bonifay, V.; Mehla, J.; Zgurskaya, H. I.; Tan, D. S.* Nat Chem Biol 2020, 16, 1293–1302.
[ Abstract | PubMed | PMC ] -
Structural basis for adenylation and thioester bond formation in the ubiquitin E1.
Hann, Z. S.; Ji, C.; Olsen, S. K.; Lu, X.; Lux, M. C.; Tan, D. S. *; Lima, C. D.* Proc. Natl. Acad. Sci. U.S.A. 2019, 15475–15484.
[ Abstract | PubMed | PMC ] -
Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors.
Lux, M. C.; Standke, L. C.; Tan, D. S.* J. Antibiot. 2019, 72, 325–349.
[ Abstract | PubMed | PMC ] -
Structure-based design, synthesis, and biological evaluation of non-acyl sulfamate inhibitors of the adenylate-forming enzyme MenE.
Evans, C. E.†; Si, Y.†; Matarlo, J. S.; Yin, Y.; French, J. B.; Tonge, P. J.*; Tan, D. S.* Biochemistry 2019, 58, 1918–1930.
[ Abstract | PubMed | PMC ] -
Family-level stereoselective synthesis and biological evaluation of pyrrolomorpholine spiroketal natural product antioxidants
Verano, A. L.; Tan, D. S.* Chem. Sci. 2017, 8, 3687–3693.
[ Abstract | PubMed | PMC ] -
Stereocontrolled Synthesis of Spiroketals: An Engine for Chemical and Biological Discovery
Verano, A. L.; Tan, D. S.* Isr. J. Chem. 2017, 57, 279–291.
[ Abstract ] PubMed | PMC ] -
General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.
Davis, T. D.; Gerry, C. J.; Tan, D. S.* ACS Chem. Biol. 2014, 9, 2535–2544.
[ Abstract | PubMed | PMC ]
(Highlighted in ACS Chem. Biol.) -
Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion.
Bauer, R. A.; Wenderski, T. A.; Tan, D. S.* Nat. Chem. Biol. 2013, 9, 21–29.
[ Abstract | PubMed | PMC ] -
A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
Kopp, F.; Stratton, C. F.; Akella, L. B.; Tan, D. S.* Nat. Chem. Biol. 2012, 8, 358–365.
[ Abstract | PubMed | PMC ]
(Highlighted in SciBX ) -
Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals.
Wurst, J. M.; Liu, G.; Tan, D. S.* J. Am. Chem. Soc. 2011, 133, 7916–7925.
[ Abstract | PubMed | PMC ] -
Active site remodelling accompanies thioester bond formation in the SUMO E1.
Olsen, S. K.; Capili. A. D.; Lu, X.; Tan, D. S.*; Lima, C. D.* Nature 2010, 463, 906–912.
[ Abstract | PubMed | PMC ]
(Highlighted in Nature, Chem. Eng. News, Nat. Rev. Mol. Cell Biol., Nat. Chem. Biol., Structure, ACS Chem. Biol., and Faculty of 1000 Biology ) -
Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.
Lu, X.; Olsen, S. K.; Capili, A. D.; Cisar, J. S.; Lima, C. D.*; Tan, D. S.* J. Am. Chem. Soc. 2010, 132, 1748–1749.
[ Abstract | PubMed | PMC ]
(Highlighted in Chem. Eng. News, Nat. Rev. Mol. Cell Biol., ACS Chem. Biol., and Faculty of 1000 Biology )