The Chairman’s Prize is a competitive award established by GSK’s Board of Trustees Chair Emeritus Louis V. Gerstner, Jr. The prestigious award is presented each year to recognize an outstanding first-author publication penned by a GSK student.

Click below to learn more about each year’s prize-winning research.

2023

Garg, A., Sanchez, A. M., Miele, M., Schwer, B., Shuman, S. (2023). Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis. Nucleic acids research, gkad063. Advance online publication.

Sanchez, A. M., Garg, A., Schwer, B., Shuman, S. (2023). Inorganic polyphosphate abets silencing of a sub-telomeric gene cluster in fission yeast. microPublication biology, 2023, 10.17912/micropub.biology.000744.

Zhang, H., Karnoub, E-R., Umeda, S., Chaligné, R., Masilionis, I., McIntyre, C.A., Hayashi, A., Sashittal, P., Zucker, A., Mullen, K., Makohon-Moore, A., Iacobuzio- Donahue, C.A. Application of high-throughput single-nucleus DNA sequencing in pancreatic cancer. Nature Communications (2023).

Sashittal, P., Zhang, H., Iacobuzio-Donahue, C.A., Raphael, B.J. ConDoR: Tumor phylogeny inference with a copy-number constrained mutation loss
model. bioRxiv (2023).

2022

Nguyen EM, Taniguchi H, Chan JM, Zhan YA, Chen XP, Qiu J, de Stanchina E, Allaj V, Shah N, Uddin F, Manoj P, Liu M, Cai SF, Levine R, Quintanal-Villalonga A, Sen T, Chow A and Rudin CM. Targeting Lysine-Specific Demethylase 1 rescues MHC-I antigen presentation and overcomes PD-L1 blockade resistance in small cell lung cancer. J Thorac. Oncol. 2022, 17(8): 1014-1031

Taniguchi H, Caesar R, Chavan SS, Zhan YA, Chow A, Manoj P, Uddin F, Kitai H, Qu R, Hayatt O, Shah N, Quintanal-Villalonga A, Nguyen EM, Chan JM, Michel A, Mukae H, de-Stanchina E, Rudin CM and Sen T. WEE1 inhibition enhances antitumor immune response to PD-L1 blockade by concomitant activation of STING and STAT1 pathways in small cell lung cancer. Cell Rep. 2022, 39(7): 110814.

Regan-Mochrie G, Hoggard T, Bhagwat N, Lynch G, Hunter N, Remus D, Fox CA, Zhao X. Yeast ORC sumoylation status fine-tunes origin licensing. Genes Dev. 2022 Aug 4;36(13-14):807–21. doi: 10.1101/gad.349610.122. Epub ahead of print. PMCID: PMC9480853.

Yan J, Chen Y, Patel AJ, Warda S, Lee CJ, Nixon BG, Wong EW, Miranda-Román MA, Yang N, Wang Y, Pachai MR, Sher J, Giff E, Tang F, Khurana E, Singer S, Liu Y, Galbo PM Jr, Maag JL, Koche RP, Zheng D, Antonescu CR, Deng L, Li MO, Chen Y, Chi P. Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses. J Clin Invest. 2022 Sep 1;132(17):e153437. doi: 10.1172/JCI153437. PMCID: PMC9433107

Lellupitiyage SS., Mas-Rosario JA, Lin HH, Nguyen EM, Taylor S R, Farkas, M. E. “Macrophage Circadian Rhythms are Differentially Affected Based on Stimuli.” Integr Biol. 2022, 14(3):62-75.

Chandran SS, Ma J, Klatt MG, Dündar F, Bandlamudi C, Razavi P, Wen HY, Weigelt B, Zumbo P, Fu SN, Banks LB, Yi F, Vercher E, Etxeberria I, Bestman WD, Da Cruz PaulaA, Aricescu IS, Drilon A, Betel D, Scheinberg DA, Baker BM, Klebanoff CA. (2022) Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA. Nat Med. Epub

Arnold PK*, Jackson BT*, Paras KI, Brunner JS, Hart ML, Newsom OJ, Alibeckoff SP, Endress J, Drill E, Sullivan LB, Finley LWS. (2022) A non-canonical tricarboxylic acid underlies cellular identity. Nature. Epub

Schwer B, Garg A, Sanchez AM, Bernstein MA, Benjamin B, Shuman S. (2022) Cleavage-Polydenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast. mBio. doi: 10.1128/mbio.03476-21. Online ahead of print.

Benjamin B, Garg A, Jork N, Jessen HJ, Schwer B, Shuman S. (2022) Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression. mBio. EPub 2022 May 10.

Boehm KM, Aherne EA, Ellenson L, Nikolovski I, Alghamdi M, Vázquez-García I, Zamarin D, Roche KL, Liu Y, Patel D, Aukerman A, Pasha A, Rose D, Selenica P, Causa Andrieu PI, Fong C, Capanu M, Reis-Filho JS, Vanguri R, Veeraraghavan H, Gangai N, Sosa R, Leung S, McPherson A, Gao J; MSK MIND Consortium, Lakhman Y, Shah SP. (2022) Multimodal data integration using machine learning improves risk stratification of high-grade serous ovarian cancer. Nat Cancer. 6, 723-733.

Chen T, Alcorn H, Devbhandari S, Remus D, Lacy E, Huangfu D, Anderson KV. (2022) A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation. Biol Open. 8.

Belk JA, Yao W, Ly N, Freitas KA, Chen YT, Shi Q, Valencia AM, Shifrut E, Kale N, Yost KE, Duffy CV, Daniel B, Hwee MA, Miao Z, Ashworth A, Mackall CL, Marson A, Carnevale J, Vardhana SA, Satpathy AT. (2022) Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence. Cancer Cell. 7; 768-786.

Petljak M, Dananberg A, Chu K, Bergstrom EN, Striepen J, von Morgen P, Chen Y, Shah H, Sale JE, Alexandrov LB, Stratton MR, Maciejowski J. (2022) Mechanisms of APOBEC3 mutagenesis in human cancer cells. Nature 607; 799-807.

Tello-Lafoz M, de Jesus MM, Huse M. (2022) Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert. Trends Immunol. 43 96-105

Wang MS, Hu Y, Sanchez EE, Xie X, Roy NH, de Jesus M, Winer BY, Zale EA, Jin W, Sachar C, Lee JH, Hong Y, Kim M, Kam LC, Salaita K, Huse M. (2022) Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity. Nat Commun.

Łuksza M, Sethna ZM, Rojas LA, Lihm J, Bravi B, Elhanati Y, Soares K, Amisaki M, Dobrin A, Hoyos D, Guasp P, Zebboudj A, Yu R, Chandra AK, Waters T, Odgerel Z, Leung J, Kappagantula R, Makohon-Moore A, Johns A, Gill A, Gigoux M, Wolchok J, Merghoub T, Sadelain M, Patterson E, Monasson R, Mora T, Walczak AM, Cocco S, Iacobuzio-Donahue C, Greenbaum BD, Balachandran VP. (2022) Neoantigen quality predicts immunoediting in survivors of pancreatic cancer. Nature. Online ahead of print.

Medina-Cano D, Corrigan EK, Glenn RA, Islam MT, Lin Y, Kim J, Cho H, Vierbuchen T. (2022) Rapid and robust directed differentiation of mouse epiblast stem cells into definitive endoderm and forebrain organoids. Development

Dey SK, Filonov GS, Olarerin-George AO, Jackson BT, Finley LWS, Jaffrey SR. (2022) Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag, Nat Chem Biol. 18

Feiner R, Johns E, Antman-Passig M, Irie T, Berisha N, Oved H, Khan D, Witek L, White RM, Heller DA. (2022) Drug-Eluting Rubber Bands for Tissue Ligation. ACS Appl Mater Interfaces. 24.

Chou C, Zhang X, Krishna C, Nixon BG, Dadi S, Capistrano KJ, Kansler ER, Steele M, Han J, Shyu A, Zhang J, Stamatiades EG, Liu M, Li S, Do MH, Edwards C, Kang DS, Chen CT, Wei IH, Pappou EP, Weiser MR, Garcia-Aguilar J, Smith JJ, Leslie CS, Li MO. (2022) Programme of self-reactive innate-like T cell-mediated. Nature 605. 139-145

Nixon BG, Chou C, Krishna C, Dadi S, Michel AO, Cornish AE, Kansler ER, Do MH, Wang X, Capistrano KJ, Rudensky AY, Leslie CS, Li MO. (2022) Cytotoxic granzyme C-expressing ILC1s ontribute to antitumor immunity and neonatal autoimmunity. Sci Immunol. Epub.

Kansler ER, Dadi S, Krishna C, Nixon BG, Stamatiades EG, Liu M, Kuo F, Zhang J, Zhang X, Capistrano K, Blum KA, Weiss K, Kedl RM, Cui G, Ikuta K, Chan TA, Leslie CS, Hakimi AA, Li MO. (2022) Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies. Nat Immunol. 6; 904-915

Heikamp EB, Henrich JA, Perner F, Wong EM, Hatton C, Wen Y, Barwe SP, Gopalakrishnapillai A, Xu H, Uckelmann HJ, Takao S, Kazansky Y, Pikman Y, McGeehan GM, Kolb EA, Kentsis A, Armstrong SA. (2022) The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML. Blood 894-906

Kennedy MC, Lowe SW. (2022) Mutant p53: it’s not all one and the same. (2022) Cell Death Differ Epub

Li X, Huang CH, Sánchez-Rivera FJ, Kennedy MC, Tschaharganeh DF, Morris JP 4th, Montinaro A, O’Rourke KP, Banito A, Wilkinson JE, Chen CC, Ho YJ, Dow LE, Tian S, Luan W, de Stanchina E, Zhang T, Gray NS, Walczak H, Lowe SW.(2022) A preclinical for assessing antitumor effects and systemic toxicities of cancer drug targets. Proc Natl Acd Sci USA.

Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, Durham BH, Pavletich TS, Fiala E, Walsh MF, Inoue D, Monette S, Taylor J, Rosen N, McCormick F, Lindsley RC, Castel P, Abdel-Wahab O. (2022) Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation. Cancer Discov.

Yang D, Cho H, Tayyebi Z, Shukla A, Luo R, Dixon G, Ursu V, Stransky S, Tremmel DM, Sackett SD, Koche R, Kaplan SJ, Li QV, Park J, Zhu Z, Rosen BP, Pulecio J, Shi ZD, Bram Y, Schwartz RE, Odorico JS, Sidoli S, Wright CV, Leslie CS, Huangfu D. (2022) CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction. Nat Cell Biol. 7 1064-1076

McGary LHF, Vardhana SA. (2022) Vive la Résistance: T-cell Immunity in the Protection against SARS-CoV-2 Infection. Cancer Discov. 12 892-894

Lopez A, Reyna DE, Gitego N, Kopp F, Zhou H, Miranda-Roman MA, Nordstrøm LU, Narayanagari SR, Chi P, Vilar E, Tsirigos A, Gavathiotis E. (2022) Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer. Nat Commun. 13

Yan J, Chen Y, Patel AJ, Warda S, Lee CJ, Nixon BG, Wong EW, Miranda-Román MA, Yang N, Wang Y, Pachai MR, Sher J, Giff E, Tang F, Khurana E, Singer S, Liu Y, Galbo PM Jr, Maag JL, Koche RP, Zheng D, Antonescu C, Deng L, Li M, Chen Y, Chi P. (2022) Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic therapeutic viruses. J Clin Invest.

Patel AJ, Warda S, Maag JLV, Misra R, Miranda-Roman MA, Pachai MR, Lee CJ, Li D, Wang N, Bayshtok G, Fishinevich E, Meng Y, Wong EWP, Yan J, Giff E, Pappalardi MB, McCabe MT, Fletcher JA, Rudin CM, Chandarlapaty S, Scandura JM, Koche RP, Glass JL, Antonescu CR, Zheng D, Chen Y, Chi P. (2022)PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry. Cancer Discov.

Docampo MD, da Silva MB, Lazrak A, Nichols KB, Lieberman SR, Slingerland AE, Armijo GK, Shono Y, Nguyen C, Monette S, Dwomoh E, Lee N, Geary CD, Perobelli SM, Smith M, Markey KA, Vardhana SA, Kousa AI, Zamir E, Greenfield I, Sun JC, Cross JR, Peled JU, Jenq RR, Stein-Thoeringer CK, van den Brink MRM. (2022) Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease Blood.

Paffenholz SV, Salvagno C, Ho YJ, Limjoco M, Baslan T, Tian S, Kulick A, de Stanchina E, Wilkinson JE, Barriga FM, Zamarin D, Cubillos-Ruiz JR, Leibold J, Lowe SW. (2022) Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer. Proc Natl Acad Sci USA.

Sánchez-Rivera FJ, Diaz BJ, Kastenhuber ER, Schmidt H, Katti A, Kennedy M, Tem V, Ho YJ, Leibold J, Paffenholz SV, Barriga FM, Chu K, Goswami S, Wuest AN, Simon JM, Tsanov KM, Chakravarty D, Zhang H, Leslie CS, Lowe SW, Dow LE. (2022) Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol. Online ahead of print.

Stahl M, Derkach A, Farnoud N, Bewersdorf JP, Robinson T, Famulare C, Cho C, Devlin S, Menghrajani K, Patel MA, Cai SF, Miles LA, Bowman RL, Geyer MB, Dunbar A, Epstein-Peterson ZD, McGovern E, Schulman J, Glass JL, Taylor J, Viny AD, Stein EM, Getta B, Arcila ME, Gao Q, Barker J, Shaffer BC, Papadopoulos EB, Gyurkocza B, Perales MA, Abdel-Wahab O, Levine RL, Giralt SA, Zhang Y, Xiao W, Pai N, Papaemmanuil E, Tallman MS, Roshal M, Goldberg AD. (2022) Molecular predictors of immunophenotypic measurable residual disease clearance in acute myeloid leukemia. Am J Hematol

Sanchez AM, Jacewicz A, Shuman S. (2022) Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate. J Biol Chem.

Schwer B, Garg A, Sanchez AM, Bernstein MA, Benjamin B, Shuman S. (2022) Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast. mBio 13.

Schonbrun AR, Resh MD. (2022) Hedgehog acyltransferase catalyzes a random sequential reaction and utilizes multiple fatty acyl-CoA substrates. J Biol Chem. 298 (10).

Shen Z, Belcheva KT, Jelcic M, Hui KL, Katikaneni A, Niethammer P. (2022) A synergy between mechanosensitive calcium- and membrane-binding mediates tension-sensing by C2-like domains. Pro Natl Acad Sci USA.

Shen Z, Lengyel M, Niethammer P. (2022) The yellow brick road to nuclear membrane mechanotransduction. APL Bioeng

Chowell D, Yoo SK, Valero C, Pastore A, Krishna C, Lee M, Hoen D, Shi H, Kelly DW, Patel N, Makarov V, Ma X, Vuong L, Sabio EY, Weiss K, Kuo F, Lenz TL, Samstein RM, Riaz N, Adusumilli PS, Balachandran VP, Plitas G, Ari Hakimi A, Abdel-Wahab O, Shoushtari AN, Postow MA, Motzer RJ, Ladanyi M, Zehir A, Berger MF, Gönen M, Morris LGT, Weinhold N, Chan TA. (2022) Improved prediction of immune checkpoint blockade efficacy across multiple cancer types. Nat Biotechnol.

Nacev BA, Sanchez-Vega F, Smith SA, Antonescu CR, Rosenbaum E, Shi H, Tang C, Socci ND, Rana S, Gularte-Mérida R, Zehir A, Gounder MM, Bowler TG, Luthra A, Jadeja B, Okada A, Strong JA, Stoller J, Chan JE, Chi P, D’Angelo SP, Dickson MA, Kelly CM, Keohan ML, Movva S, Thornton K, Meyers PA, Wexler LH, Slotkin EK, Glade Bender JL, Shukla NN, Hensley ML, Healey JH, La Quaglia MP, Alektiar KM, Crago AM, Yoon SS, Untch BR, Chiang S, Agaram NP, Hameed MR, Berger MF, Solit DB, Schultz N, Ladanyi M, Singer S, Tap WD. (2022) Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets. Nat Commun.

Fernandez KC, Feeney L, Smolkin RM, Yen WF, Matthews AJ, Alread W, Petrini JHJ, Chaudhuri J. (2022) The structure-selective endonucleases GEN 1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes. Elife

Remsik J, Saadeh F, Tong X, Li MJ, Snyder J, Bale T, Wu J, Derderian C, Guber D, Chi Y, Murali R, Boire A. (2021) Characterization, isolation, and in vitro culture of leptomeningeal fibroblasts. J Neuroimmunol.

Arora K, Tran TN, Kemel Y, Mehine M, Liu YL, Nandakumar S, Smith SA, Brannon AR, Ostrovnaya I, Stopsack KH, Razavi P, Safonov A, Rizvi HA, Hellmann MD, Vijai J, Reynolds TC, Fagin JA, Carrot-Zhang J, Offit K, Solit DB, Ladanyi M, Schultz N, Zehir A, Brown CL, Stadler ZK, Chakravarty D, Bandlamudi C, Berger MF. (2022) Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort Cancer Discov. doi: 10.1158/2159-8290.

Waarts MR, Stonestrom AJ, Park YC, Levine RL. (2022) Targeting mutations in cancer. J Clin Invest

van der Veeken J, Campbell C, Pritykin Y, Schizas M, Verter J, Hu W, Wang ZM, Matheis F, Mucida D, Charbonnier LM, Chatila TA, Rudensky AY. (2022) Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells. Immunity.

Szeglin BC, Wu C, Marco MR, Park HS, Zhang Z, Zhang B, Garcia-Aguilar J, Beauchamp RD, Chen XS, Smith JJ. (2022) A SMAD4-modulated gene profile predicts disease-free survival in stage II and III colorectal cancer. Cancer Rep. Epub 2021

2021

Humphreys IR, Pei J, Baek M, Krishnakumar A, Anishchenko I, Ovchinnikov S, Zhang J, Ness TJ, Banjade S, Bagde SR, Stancheva VG, Li XH, Liu K, Zheng Z, Barrero DJ, Roy U, Kuper J, Fernández IS, Szakal B, Branzei D, Rizo J, Kisker C, Greene EC, Biggins S, Keeney S, Miller EA, Fromme JC, Hendrickson TL, Cong Q, Baker D. Computed structures of core eukaryotic protein complexes. Science. 2021 Dec10;374(6573):eabm4805. doi: 10.1126/science.abm4805. Epub 2021 Dec 10. PMCID: PMC7612107.

Maguire OA, Ackerman SE, Szwed SK, Maganti AV, Marchildon F, Huang X, Kramer DJ, Rosas-Villegas A, Gelfer RG, Turner LE, Ceballos V, Hejazi A, Samborska B, Rahbani JF, Dykstra CB, Annis MG, Luo JD, Carroll TS, Jiang CS, Dannenberg AJ, Siegel PM, Tersey SA, Mirmira RG, Kazak L, Cohen P. Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. Cell Metab. 2021 Mar 2;33(3):499-512.e6. doi: 10.1016/j.cmet.2021.01.018. Epub 2021 Feb 16. PMCID: PMC7954401

Adams NM, Diaz-Salazar C, Dang C, Lanier LL, Sun JC. (2021) Cutting Edge: Heterogeneity in Cell Age Contributes to Functional Diversity of NK Cells. J Immunol. 206, 465-470

Lyczek A, Berger BT, Rangwala AM, Paung Y, Tom J, Philipose H, Guo J, Albanese SK, Robers MB, Knapp S, Chodera JD, Seeliger MA. (2021) Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance. Proc Natl Acad Scie USA.

Boehm KM, Khosravi P, Vanguri R, Gao J, Shah SP. (2021) Harnessing multimodal data integration to advance precision oncology. Nat Rev Cancer Online ahead of print doi: 10.1038/s41568-021-00408-3.

Mukherjee R, Vanaja KG, Boyer JA, Gadal S, Solomon H, Chandarlapaty S, Levchenko A, Rosen N. (2021) Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis. Mol Cell 84, 708-723.

Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N. (2021) Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth. Nat Chem Biol. Online ahead of print.

Benjamin B, Sanchez AM, Garg A, Schwer B, Shuman S. (2021) Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22. PloS Genet. e1009452.

Baggiolini A, Callahan SJ, Montal E, Weiss JM, Trieu T, Tagore MM, Tischfield SE, Walsh RM, Suresh S, Fan Y, Campbell NR, Perlee SC, Saurat N, Hunter MV, Simon-Vermot T, Huang TH, Ma Y, Hollmann T, Tickoo SK, Taylor BS, Khurana E, Koche RP, Studer L, White RM. (2021) Developmental chromatin programs determine oncogenic competence in melanoma. Science.

Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP 4th, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan W, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe’er D, Lowe SW. (2021) A gene-enviroment-induced epigenetic program initiates tumorigenesis. Nature 590, 642-648

Sun D, Xie XP, Zhang X, Wang Z, Sait SF, Iyer SV, Chen YJ, Brown R, Laks DR, Chipman ME, Shern JF, Parada LF. (2021) Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression. Cell Stem Cell. Online ahead of print.

Sun D, Xie XP, Zhang X, Wang Z, Sait SF, Iyer SV, Chen YJ, Brown R, Laks DR, Chipman ME, Shern JF, Parada LF. (2021) Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression. Cell Stem Cell. Online ahead of print.

Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma S, Lubin M, Ko M, Mane MM, Zhong H, Liu C, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher JA, Ho PC, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. (2021) CTLA-4 blockade drives loss of T_reg stability in glycolysis-low tumours. Nature [Online ahead of print]

Wiedemann GM, Santosa EK, Grassmann S, Sheppard S, Le Luduec JB, Adams NM, Dang C, Hsu KC, Sun JC, Lau CM. (2021) Deconvoluting global cytokine signaling networks in natural killer cells. Nat Immunol. 22 627-638

Hitchman TD, Bayshtok G, Ceraudo E, Moore AR, Lee C, Jia R, Wang N, Pachai MR, Shoushtari AN, Francis JH, Guan Y, Chen J, Chang MT, Taylor BS, Sakmar TP, Huber T, Chi P, Chen Y. (2021) Combined Inhibition of Gα _q and MEK Enhances Therapeutic Efficacy in Uveal Melanoma. Clin Cancer Res. 27 1476-1490

Lumaquin D, Johns E, Montal E, Weiss JM, Ola D, Abuhashem A, White RM. (2021) An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish. Elife. 10.

Joseph B, Lai EC. (2021) The Exon Junction Complex and intron removal prevent re-splicing of mRNA. PLos Genet. 17.

Kan L, Ott S, Joseph B, Park ES, Dai W, Kleiner RE, Claridge-Chang A, Lai EC. (2021) A neural m⁶A/Ythdf pathway is required for learning and memory in Drosophila. Nat Commun. 12.

Krishna C, DiNatale RG, Kuo F, Srivastava RM, Vuong L, Chowell D, Gupta S, Vanderbilt C, Purohit TA, Liu M, Kansler E, Nixon BG, Chen YB, Makarov V, Blum KA, Attalla K, Weng S, Salmans ML, Golkaram M, Liu L, Zhang S, Vijayaraghavan R, Pawlowski T, Reuter V, Carlo MI, Voss MH, Coleman J, Russo P, Motzer RJ, Li MO, Leslie CS, Chan TA, Hakimi AA. (2021) Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy. Cancer Cell. 39, 662-677

Sheppard S, Santosa EK, Lau CM, Violante S, Giovanelli P, Kim H, Cross JR, Li MO, Sun JC. (2021) Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural keller cell anti-viral and anti-tumor function. Cell Rep.

La Rocca G, King B, Shui B, Li X, Zhang M, Akat K, Ogrodowski P, Mastroleo C, Chen K, Cavalieri V, Ma Y, Anelli V, Betel D, Vidigal J, Tuschl T, Meister G, Thompson CB, Lindsten T, Haigis K, Ventura A. (2021) Inducible and reversible inhinition of miRNA-mediated gene repressin in vivo. Elife. Online ahead of print.

Campbell NR, Rao A, Hunter MV, Sznurkowska MK, Briker L, Zhang M, Baron M, Heilmann S, Deforet M, Kenny C, Ferretti LP, Huang TH, Perlee S, Garg M, Nsengimana J, Saini M, Montal E, Tagore M, Newton-Bishop J, Middleton MR, Corrie P, Adams DJ, Rabbie R, Aceto N, Levesque MP, Cornell RA, Yanai I, Xavier JB, White RM. (2021) Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation. Dev Cell. Online ahead of print.

Chow A, Schad S, Green MD, Hellmann MD, Allaj V, Ceglia N, Zago G, Shah NS, Sharma SK, Mattar M, Chan J, Rizvi H, Zhong H, Liu C, Bykov Y, Zamarin D, Shi H, Budhu S, Wohlhieter C, Uddin F, Gupta A, Khodos I, Waninger JJ, Qin A, Markowitz GJ, Mittal V, Balachandran V, Durham JN, Le DT, Zou W, Shah SP, McPherson A, Panageas K, Lewis JS, Perry JSA, de Stanchina E, Sen T, Poirier JT, Wolchok JD, Rudin CM, Merghoub T. (2021) Tim-4 ⁺ cavity-resident macrophages impair anti-tumor CD8 ⁺ T cell immunity. Cancer Cell. 39, 973-988.

Xu K, Yin N, Peng M, Stamatiades EG, Chhangawala S, Shyu A, Li P, Zhang X, Do MH, Capistrano KJ, Chou C, Leslie CS, Li MO. (2021) Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses. Immunity 54. 976-987

Funato K, Smith RC, Saito Y, Tabar V. (2021) Dissecting the impact of regional identity and the oncogenic role of human-specific NOTCH2NL in an hESC model of H3.3G34R-mutant glioma. Cell Stem Cell.

Yewdell WT, Smolkin RM, Belcheva KT, Mendoza A, Michaels AJ, Cols M, Angeletti D, Yewdell JW, Chaudhuri J. (2021) Temporal dynamics of persistent centers and memory B cell differentiation following respiratory virus infection. Cell Rep.

Dikiy S, Li J, Bai L, Jiang M, Janke L, Zong X, Hao X, Hoyos B, Wang ZM, Xu B, Fan Y, Rudensky AY, Feng Y. (2021) A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity. 54, 931-946.

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