Student Publications

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2018

Ruff EF, Muretta JM, Thompson AR, Lake EW, Cyphers S, Albanese SK, Hanson SM, Behr JM, Thomas DD, Chodera JD, Levinson NM. (2018) A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation. Elife 7, e32766.

Intlekofer AM, Shih AH, Wang B, Nazir A, Rustenburg AS, Albanese SK, Patel M, Famulare C, Correa FM, Takemoto N, Durani V, Liu H, Taylor J, Farnoud N, Papaemmanuil E, Cross JR, Tallman MS, Arcila ME, Roshal M, Petsko GA, Wu B, Choe S, Konteatis ZD, Biller SA, Chodera JD, Thompson CB, Levine RL, Stein EM. (2018) Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations. Nature 559, 125-129.

Hauser K, Negron C, Albanese SK, Ray S, Steinbrecher T, Abel R, Chodera JD, Wang L. (2018) Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations. Commun Biol 1, pii: 70. PMCID: PMC6110136

Callahan SJ, Tepan S, Zhang YM, Lindsay H, Burger A, Campbell NR, Kim IS, Hollmann TJ, Studer L, Mosimann C, White RM. (2018) Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). Dis Model Mech. pii: dmm.034561 [Epub ahead of print] 

Zhang YM, Zimmer MA, Guardia T, Callahan SJ, Mondal C, Di Martino J, Takagi T, Fennell M, Garippa R, Campbell NR, Bravo-Cordero JJ, White RM. (2018) Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Dev Cell. pii: S1534-5807(18)30357-5 [Epub ahead of print]

Casey E, Bournazos S, Mo G, Mondello P, Tan KS, Ravetch JV, Scheinberg DA. (2018). A new mouse expressing human Fcγ receptors to better predict therapeutic efficacy of human anti-cancer antibodies. Leukemia. 32, 547-549. PMCID: PMC5803448

Serganova I, Cohen IJ, Vemuri K, Shindo M, Maeda M, Mane M, Moroz E, Khanin R, Satagopan J, Koutcher JA, Blasberg R. (2018) LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response. PLoS One 13, e0203965.

Feng W, Jasin M. (2018) Homologous Recombination and Replication Fork Protection: BRCA2 and More! Cold Spring Harb Symp Quant Biol. pii: 035006.

Chen CC, Feng W, Lim PX, Kass EM, Jasin M. (2018) Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer. Annu Rev Cancer Biol. 2, 313-336. PMCID: PMC619349.

Gala K, Li Q, Sinha A, Razavi P, Dorso M, Sanchez-Vega F, Chung YR, Hendrickson R, Hsieh J, Berger M, Schultz N, Pastore A, Abdel-Wahab O, Chandarlapaty S. (2018) KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function. Oncogene. [Epub ahead of print]

Hawk MA, Gorsuch CL, Fagan P, Lee C, Kim SE, Hamann JC, Mason JA, Weigel KJ, Tsegaye MA, Shen L, Shuff S, Zuo J, Hu S, Jiang L, Chapman S, Leevy WM, DeBerardinis RJ, Overholtzer M, Schafer ZT. (2018) RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells. Nat Cell Biol. 20, 272-284.

Moore AR, Ran L, Guan Y, Sher JJ, Hitchman TD, Zhang JQ, Hwang C, Walzak EG, Shoushtari AN, Monette S, Murali R, Wiesner T, Griewank KG, Chi P, Chen Y. (2018) GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma. Cell Rep. 22, 2455-2468.

Kavaler J, Duan H, Aradhya R, de Navas LF, Joseph B, Shklyar B, Lai EC. (2018) miRNA suppression of a Notch repressor directs non-neuronal fate in Drosophila mechanosensory organs. J Cell Biol 217, 571-583. PMCID:PMC5800810

Joseph B, Kondo S, Lai EC. (2018) Short cryptic exons mediate recursive splicing in Drosophila. Nat Struct Ml Biol. 25, 365-371.

Zafra MP, Schatoff EM, Katti A, Foronda M, Breinig M, Schweitzer AY, Simon A, Han T, Goswami S, Montgomery E, Thibado J, Kastenhuber ER, Sánchez-Rivera FJ, Shi J, Vakoc CR, Lowe SW, Tschaharganeh DF, Dow LE. (2018) Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. PMID: 29969439 doi: 10.1038/nbt.4194. [Epub ahead of print]

Keith JW, Pamer EG. (2018) Enlisting commensal microbes to resist antibiotic-resistant pathogens. J Exp Med, pii: jem.20180399. [Epub ahead of print].

Klein ME, Kovatcheva M, Davis LE, Tap WD, Koff A. (2018) CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought. Cancer Cell. [Epub ahead of print]

Klein ME, Dickson MA, Antonescu C, Qin LX, Dooley SJ, Barlas A, Manova K, Schwartz GK, Crago AM, Singer S, Koff A, Tap WD. (2018) PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence. Oncogene. [Epub ahead of print]

Azizi E, Carr AJ, Plitas G, Cornish AE, Konopacki C, Prabhakaran S, Nainys J, Wu K, Kiseliovas V, Setty M, Choi K, Fromme RM, Dao P, McKenney PT, Wasti RC, Kadaveru K, Mazutis L, Rudensky AY, Pe’er D. (2018) Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment. Cell, pii: S0092-8674(18)30723-2. PMID: 29961579 [Epub ahead of print]

Verma N, Pan H, Doré LC, Shukla A, Li QV, Pelham-Webb B, Teijeiro V, González F, Krivtsov A, Chang CJ, Papapetrou EP, He C, Elemento O, Huangfu D. (2018) TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells. Nat Genet, 50, 83-95. PMCID: PMC5742051 [Available on 2018-06-04]

Yang TT, Chong WM, Wang WJ, Mazo G, Tanos B, Chen Z, Tran TMN, Chen YD, Weng RR, Huang CE, Jane WN, Tsou MB, Liao JC (2018) Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components. Nat Commun. 9, 2023. PMCID: PMC5964178

Hobbs GS, Hanasoge Somasundara AV, Kleppe M, Litvin R, Arcila M, Ahn J, McKenney AS, Knapp K, Ptashkin R, Weinstein H, Heinemann MH, Francis J, Chanel S, Berman E, Mauro M, Tallman MS, Heaney ML, Levine RL, Rampal RK. (2018) Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms. Haematologica. 103, e5-e9. PMCID: PMC5777196

McKenney AS, Lau AN, Somasundara AVH, Spitzer B, Intlekofer AM, Ahn J, Shank K, Rapaport FT, Patel MA, Papalexi E, Shih AH, Chiu A, Freinkman E, Akbay EA, Steadman M, Nagaraja R, Yen K, Teruya-Feldstein J, Wong KK, Rampal R, Heiden MGV, Thompson CB, Levine RL. (2018) JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition. J Clin Invest. 128, 789-804. PMCID: PMC5785272

Wu Z, Santich BH, Liu H, Liu C, Cheung NV. (2018) Targeting Intracellular Antigens with pMHC-Binding Antibodies: A Phage Display Approach. Methods Mol Biol. 1701, 255-269.

Ahmed M, Lopez-Albaitero A, Pankov D, Santich BH, Liu H, Yan S, Xiang J, Wang P, Hasan AN, Selvakumar A, O’Reilly RJ, Liu C, Cheung NV. (2018) TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies. JCI Insight. 3, pii: 97805. PMCID: PMC5916246 [Epub ahead of print]

Vaisey G, Long SB. (2018) An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1. J Gen Physiol. pii: jgp.201812190.

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2017

Rapp M, Lau CM, Adams NM, Weizman OE, O’Sullivan TE, Geary CD, Sun JC; Core-binding factor ß and Runx transcription factors promote adaptive natural killer cell responses.; Science immunology; 2017; 2(18);

Weizman OE, Adams NM, Schuster IS, Krishna C, Pritykin Y, Lau C, Degli-Esposti MA, Leslie CS, Sun JC, O’Sullivan TE; ILC1 Confer Early Host Protection at Initial Sites of Viral Infection.; Cell; 2017; 171(4):795-808.e12;

Rapp M, Lau CM, Adams NM, Weizman OE, O’Sullivan TE, Geary CD, Sun JC. (2017) Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses. Sci Immunol 2.

Gardner EE, Lok BH, Schneeberger VE, Desmeules P, Miles LA, Arnold PK, Ni A, Khodos I, de Stanchina E, Nguyen T, Sage J, Campbell JE, Ribich S, Rekhtman N, Dowlati A, Massion PP, Rudin CM, Poirier JT. (2017) Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis. Cancer Cell 31, 286-299. PMCID: PMC5313262 [Available on 2018-02-13]

Sansone P, Berishaj M, Rajasekhar VK, Ceccarelli C, Chang Q, Strillacci A, Savini C, Shapiro L, Bowman R, Mastroleo C, De Carolis S, Daly L, Benito-Martin A, Perna F, Fabbri N, Healey JH, Spisni E, Cricca M, Lyden D, Bonafé M, Bromberg J. (2017) Evolution of cancer stem-like cells in endocrine-resistant metastatic breast cancers is mediated by stromal microvesicles. Cancer Res. [Epub ahead of print]

Bowman RL, Wang Q, Carro A, Verhaak RG, Squatrito M. (2017) GlioVis data portal for visualization and analysis of brain tumor expression datasets. Neuro Oncol. 19, 139-141. PMCID: PMC5193031 [Available on 2018-01-01]

Kim IS, Heilmann S, Kansler ER, Zhang Y, Zimmer M, Ratnakumar K, Bowman RL, Simon-Vermot T, Fennell M, Garippa R, Lu L, Lee W, Hollmann T, Xavier JB, White RM. (2017) Microenvironment-derived factors driving metastatic plasticity in melanoma. Nat Commun. 8, 14343. PMCID: PMC5309794

Cohen I, Blasberg R. (2017) Impact of the Tumor Microenvironment on Tumor-Infiltrating Lymphocytes: Focus on Breast Cancer. Breast Cancer (Auckl) 11. PMCID: PMC5617083

Feng W, Jasin M. (2017) BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination. Nat Commun. 8, 525. PMCID: PMC5597640

Vanoli F, Tomishima M, Feng W, Lamribet K, Babin L, Brunet E, Jasin M. (2017) CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells. Proc Natl Acad Sci U S A. 114, 3696-3701. PMCID: PMC5389291 [Available on 2017-10-04]

Hamann JC, Overholtzer M. (2017) Entosis enables a population response to starvation. Oncotarget 8, 57934-57935. PMCID: PMC5601622

Hamann JC, Surcel A, Chen R, Teragawa C, Albeck JG, Robinson DN, Overholtzer M. (2017) Entosis Is Induced by Glucose Starvation. Cell Rep. 20, 201-210. PMCID: PMC5559205

Hamann J, Overholtzer M. (2017) Killing me softly: microparticles target deformable cells. Cell Res. 26, 637-8. PMCID: PMC4897184 [Available on 2017-06-01]

Durgan J, Tseng YY, Hamann JC, Domart MC, Collinson L, Hall A, Overholtzer M, Florey O. (2017) Mitosis can drive cell cannibalism through entosis. Elife 6, pii: e27134. PMCID: PMC5505699

Spraggon L, Martelotto LG, Hmeljak J, Hitchman TD, Wang J, Wang L, Slotkin EK, Fan PD, Reis-Filho JS, Ladanyi M. (2017) Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair. J Pathol. 242, 102-112. PMCID: PMC5397343 [Available on 2018-05-01]

Jelcic M, Enyedi B, Xavier JB, Niethammer P. (2017) Image-Based Measurement of H2O2 Reaction-Diffusion in Wounded Zebrafish Larvae. Biophys J. 112, 2011-2018. PMCID:PMC5425381 [Available on 2018-05-09]

Gao J, Chang MT, Johnsen HC, Gao SP, Sylvester BE, Sumer SO, Zhang H, Solit DB, Taylor BS, Schultz N, Sander C. (2017) 3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets. Genome Med. 9, 4. PMCID: PMC5260099

Jordan EJ, Kim HR, Arcila ME, Barron DA, Chakravarty D, Gao J, Chang MT, Ni A, Kundra R, Jonsson P, Jayakumaran G, Gao SP, Johnsen HC, Hanrahan AJ, Zehir A, Rekhtman N, Ginsberg MS, Li BT, Yu H, Paik PK, Drilon A, Hellmann MD, Reales DN, Benayed R, Rusch VW, Kris MG, Chaft JE, Baselga J, Taylor BS, Schultz N, Rudin CM, Hyman DM, Berger MF, Solit DB, Ladanyi M, Riely GJ. (2017) Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapie pii: CD-16-1337[Epub ahead of print].

Kan L, Grozhik AV, Vedanayagam J, Patil DP, Pang N, Lim KS, Huang YC, Joseph B, Lin CJ, Despic V, Guo J, Yan D, Kondo S, Deng WM, Dedon PC, Jaffrey SR, Lai EC. (2017) The m6A pathway facilitates sex determination in Drosophila. Nat Commun. 8, 15737. PMCID: PMC5500889

Kastenhuber ER, Lowe SW. (2017) Putting p53 in Context. Cell 170, 1062-1078.

Shirole NH, Pal D, Kastenhuber ER, Senturk S, Boroda J, Pisterzi P, Miller M, Munoz G, Anderluh M, Ladanyi M, Lowe SW, Sordella R. (2017) TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions. Elife. 6. PMCID: PMC5287711

Kastenhuber ER, Lalazar G, Houlihan SL, Tschaharganeh DF, Baslan T, Chen CC, Requena D, Tian S, Bosbach B, Wilkinson JE, Simon SM, Lowe SW. (2017) DNAJB1-PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma. Proc Natl Acad Sci U S A 114, 13076-13084. PMCID: PMC5740683

Bakst RL, Xiong H, Chen CH, Deborde S, Lyubchik A, Zhou Y, He S, McNamara W, Lee SY, Olson OC, Leiner IM, Marcadis AR, Keith JW, Al-Ahmadie HA, Katabi N, Gil Z, Vakiani E, Joyce JA, Pamer E, Wong RJ. (2017) Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression. Cancer Res. 77, 6400-6414. PMCID: PMC5831809 [Available on 2018-11-15]

Levine AG, Hemmers S, Baptista AP, Schizas M, Faire MB, Moltedo B, Konopacki C, Schmidt-Supprian M, Germain RN, Treuting PM, Rudensky AY. (2017) Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. J Exp Med. 214, 609-622. PMCID: PMC5339675 [Available on 2017-09-06]

Kovatcheva M, Liao W, Klein ME, Robine N, Geiger H, Crago AM, Dickson MA, Tap WD, Singer S, Koff A. (2017) ATRX is a regulator of therapy induced senescence in human cells. Nat Commun. 8, 386. PMCID: PMC5577318

Kovatcheva M, Klein ME, Tap WD, Koff A. (2017). Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors. Mol Cell Oncol. 5, e1384882. PMCID: PMC5791849

Zaritsky A, Tseng YY, Rabadán MA, Krishna S, Overholtzer M, Danuser G, Hall A. (2017) Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration. J Cell Biol. 216, 1543-1556. PMCID: PMC5461017 [Available on 2017-12-05]

Lam I, Mohibullah N, Keeney S. (2017) Sequencing Spo11 Oligonucleotides for Mapping Meiotic DNA Double-Strand Breaks in Yeast. Methods Mol Biol. 1471, 51-98.

Shi ZD, Lee K, Yang D, Amin S, Verma N, Li QV, Zhu Z, Soh CL, Kumar R, Evans T, Chen S, Huangfu D. (2017) Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell [Epub ahead of print]

Wang Q, Zou Y, Nowotschin S, Kim SY, Li QV, Soh CL, Su J, Zhang C, Shu W, Xi Q, Huangfu D, Hadjantonakis AK, Massagué J. (2017) The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. Cell Stem Cell 20 70-86. PMCID: PMC5218926 [Available on 2018-01-05]

Boire A, Zou Y, Shieh J, Macalinao DG, Pentsova E, Massagué J. (2017) Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis. Cell 168 1101-1113.

Maciejowski J, Drechsler H, Grundner-Culemann K, Ballister ER, Rodriguez-Rodriguez JA, Rodriguez-Bravo V, Jones MJK, Foley E, Lampson MA, Daub H, McAinsh AD, Jallepalli PV. (2017) Mps1 Regulates Kinetochore-Microtubule Attachment Stability via the Ska Complex to Ensure Error-Free Chromosome Segregation. Dev Cell. 41, 143-156. PMCID: PMC5477644.

Marks DH, Thomas R, Chin Y, Shah R, Khoo C, Benezra R. (2017) Mad2 overexpression uncovers a critical role for TRIP13 in mitotic exit. Cell Rep. 19, 1832-1845. PMCID: PMC5526606.

Kunimoto H, McKenney AS, Meydan C, Shank K, Nazir A, Rapaport F, Durham B, Garrett-Bakelman FE, Pronier E, Shih AH, Melnick A, Chaudhuri J, Levine RL. (2017) Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells. Blood 129 1779-1790.

Quail DF, Olson OC, Bhardwaj P, Walsh LA, Akkari L, Quick ML, Chen IC, Wendel N, Ben-Chetrit N, Walker J, Holt PR, Dannenberg AJ, Joyce JA. (2017) Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF. Nat Cell Biol.19, 974-987.

Pucella JN, Chaudhuri J. (2017) AID Invited to the G4 Summit. Mol Cell. 67, 355-357.

Yen WF, Chaudhry A, Vaidyanathan B, Yewdell WT, Pucella JN, Sharma R, Liang Y, Li K, Rudensky AY, Chaudhuri J. (2017) BRCT-domain protein BRIT1 influences class switch recombination. Proc Natl Acad Sci U S A pii: 201708211 [Epub ahead of print]. PMCID: PMC5547652 [Available on 2018-02-01]

Lin CJ, Wen J, Bejarano F, Hu F, Bortolamiol-Becet D, Kan L, Sanfilippo P, Kondo S, Lai EC. (2017) Characterization of a TUTase/RNase complex required for Drosophila gametogenesis. RNA. 23, 284-296. PMCID: PMC5311484 [Available on 2018-03-01]

Sanfilippo P, Miura P, Lai EC. (2017) Genome-wide profiling of the 3’ ends of polyadenylated RNAs. Methods 126, 86-94. PMCID: PMC5583017 [Available on 2018-08-15]

Sanfilippo P, Wen J, Lai EC. (2017) Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Genome Biol. 18, 229. PMCID: PMC5707805

Shah N, Wang P, Wongvipat J, Karthaus WR, Abida W, Armenia J, Rockowitz S, Drier Y, Bernstein BE, Long HW, Freedman ML, Arora VK, Zheng D, Sawyers CL. (2017) Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer. Elife 6, pii: e27861. PMCID: PMC5593504

Spencer AK, Schaumberg AJ, Zallen JA. (2017) Scaling of cytoskeletal organization with cell size in Drosophila. Mol Biol Cell. 28, 1519-1529. PMCID: PMC5449150 [Available on 2017-08-16]

Grommes C, Pastore A, Palaskas N, Tang SS, Campos C, Schartz D, Codega P, Nichol D, Clark O, Hsieh WY, Rohle D, Rosenblum M, Viale A, Tabar VS, Brennan CW, Gavrilovic IT, Kaley TJ, Nolan CP, Omuro A, Pentsova E, Thomas AA, Tsyvkin E, Noy A, Palomba ML, Hamlin P, Sauter CS, Moskowitz CH, Wolfe J, Dogan A, Won M, Glass J, Peak S, Lallana EC, Hatzoglou V, Reiner AS, Gutin PH, Huse JT, Panageas KS, Graeber TG, Schultz N, DeAngelis LM, Mellinghoff IK. (2017) Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. Cancer Discov. 7, 1018-1029. PMCID: PMC5581705 [Available on 2018-09-01]

Fernández-Tejada A, Walkowicz WE, Tan DS, Gin DY. (2017) Semisynthesis of Analogues of the Saponin Immunoadjuvant QS-21. Methods Mol Biol. 1494, 45-71. PMCID: PMC5120590

Bose R, Karthaus WR, Armenia J, Abida W, Iaquinta PJ, Zhang Z, Wongvipat J, Wasmuth EV, Shah N, Sullivan PS, Doran MG, Wang P, Patruno A, Zhao Y, International SU2C/PCF Prostate Cancer Dream Team, Zheng D, Schultz N, Sawyers CL. (2017) ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis. Nature 546, 671-675. PMCID: PMC5576182 [Available on 2018-06-29]

Wasmuth EV, Zinder JC, Zattas D, Das M, Lima CD. (2017) Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. Elife 6, pii: e29062. PMCID: PMC5553935

Wasmuth EV, Lima CD. (2017) The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome. Nucleic Acids Res. 45, 846-860. PMCID: PMC5314766

Nargund AM, Pham CG, Dong Y, Wang PI, Osmangeyoglu HU, Xie Y, Aras O, Han S, Oyama T, Takeda S, Ray CE, Dong Z, Berge M, Hakimi AA, Monette S, Lekaye CL, Koutcher JA, Leslie CS, Creighton CJ, Weinhold N, Lee W, Tickoo SK, Wang Z, Cheng EH, Hsieh JJ.(2017) The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma. Cell Rep.18, 2893-2906.

Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, Wongvipat J, Ku SY, Gao D, Cao Z, Shah N, Adams EJ, Abida W, Watson PA, Prandi D, Huang CH, de Stanchina E, Lowe SW, Ellis L, Beltran H, Rubin MA, Goodrich DW, Demichelis F, Sawyers CL. (2017) SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer. Science 355, 84-88. PMCID: PMC5247742 [Available on 2017-04-06]

Bose R, Karthaus WR, Armenia J, Abida W, Iaquinta PJ, Zhang Z, Wongvipat J, Wasmuth EV, Shah N, Sullivan PS, Doran MG, Wang P, Patruno A, Zhao Y; International SU2C/PCF Prostate Cancer Dream Team, Zheng D, Schultz N, Sawyers CL. (2017) ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis. Nature 546, 671-675. PMCID: PMC5576182 [Available on 2018-06-29]

Wang Q, Zou Y, Nowotschin S, Kim SY, Li QV, Soh CL, Su J, Zhang C, Shu W, Xi Q, Huangfu D, Hadjantonakis AK, Massagué J. (2017) The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. Cell Stem Cell. 20, 70-86. PMCID: PMC5218926

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2016

O’Sullivan TE, Rapp M, Fan X, Weizman OE, Bhardwaj P, Adams NM, Walzer T, Dannenberg AJ, Sun JC. (2016) Adipose-resident group 1 innate lymphoid cells promote obesity-associated insulin resistance. Immunity 45, 428-41. PMCID: PMC5004886 [Available on 2017-08-16]

Adams NM, O’Sullivan TE, Geary CD, Karo JM, Amezquita RA, Joshi NS, Kaech SM, Sun JC. (2016) NK Cell Responses Redefine Immunological Memory. J Immunol. 197, 2963-2970. PMCID: PMC5108457 [Available on 2017-10-15]

Xu J, Pham CG, Albanese SK, Dong Y, Oyama T, Lee CH, Rodrik-Outmezguine V, Yao Z, Han S, Chen D, Parton DL, Chodera JD, Rosen N, Cheng EH, Hsieh JJ. (2016) Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin. J Clin Invest. 126, 3526-40. PMCID: PMC5004947 [Available on 2016-12-01]

Alidori S, Bowman RL, Yarilin D, Romin Y, Barlas A, Mulvey JJ, Fujisawa S, Xu K, Ruggiero A, Riabov V, Thorek DL, Ulmert HD, Brea EJ, Behling K, Kzhyshkowska J, Manova-Todorova K, Scheinberg DA, McDevitt MR. (2016) Deconvoluting hepatic processing of carbon nanotubes. Nat Commun. 7: 12343. PMCID:PMC4974572

Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue CA, Brennan CW, Tabar V, Gutin PH, Joyce JA. (2016) Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies. Cell Rep. 17, 2445-2459.

Sansone P, Ceccarelli C, Berishaj M, Chang Q, Rajasekhar VK, Perna F, Bowman RL, Vidone M, Daly L, Nnoli J, Santini D, Taffurelli M, Shih NN, Feldman M, Mao JJ, Colameco C, Chen J, DeMichele A, Fabbri N, Healey JH, Cricca M, Gasparre G, Lyden D, Bonafé M, Bromberg J. (2016)  Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.  Nat Commun7: 10442. PMCID: PMC4748123.

Yan D, Wang HW, Bowman RL, Joyce JA. (2016) STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation. Cell Rep. 16, 2914-27

Quail DF, Bowman RL, Akkari L, Quick ML, Schuhmacher AJ, Huse JT, Holland EC, Sutton JC, Joyce JA. (2016)  The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science 352, aad3018.

Callahan SJ, Mica Y, Studer L. (2016) Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells. J Vis Exp. e53806.

Thorek DL, Watson PA, Lee SG, Ku AT, Bournazos S, Braun K, Kim K, Sjöström K, Doran MG, Lamminmäki U, Santos E, Veach D, Turkekul M, Casey E, Lewis JS, Abou DS, van Voss MR, Scardino PT, Strand SE, Alpaugh ML, Scher HI, Lilja H, Larson SM, Ulmert D. (2016) Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis. Sci Transl Med. 8, 367ra167.

Dubrovsky L, Brea EJ, Pankov D, Casey E, Dao T, Liu C, Scheinberg DA. (2016) Mechanisms of leukemia resistance to antibody dependent cellular cytotoxicity. Oncoimmunology 5, e1211221. PMCID: PMC5048777 [Available on 2017-08-03]

Chang AY, Gejman RS, Brea EJ, Oh CY, Mathias MD, Pankov D, Casey E, Dao T, Scheinberg DA. (2016). Opportunities and challenges for TCR mimic antibodies in cancer therapy. Expert Opin Biol Ther. 16, 979-87. PMCID: PMC4936943 [Available on 2017-08-01]

Serganova I, Moroz E, Cohen I, Moroz M, Mane M, Zurita J, Shenker L, Ponomarev V, Blasberg R. (2016) Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade. Mol Ther Oncolytics. 14 41-54. PMCID: PMC5363727

Gauthier NP, Reznik E, Gao J, Sumer SO, Schultz N, Sander C, Miller ML. (2016) MutationAligner: a resource of recurrent mutation hotspots in protein domains in cancer. Nucleic Acids Res., 44, D986-91. PMCID: PMC4702822

O’Sullivan TE, Geary CD, Weizman OE, Geiger TL, Rapp M, Dorn GW, Overholtzer M, Sun JC. (2016) Atg5 Is Essential for the Development and Survival of Innate Lymphocytes. Cell Rep. 15, 1910-9. PMCID: PMC4889506

Geiger TL, Sun JC. (2016) Development and Maturation of Natural Killer Cells.  Curr Opin Immunol.39: 82-9. PMCID: PMC4801705 [Available on 2017-04-01]

Cortez VS, Cervantes-Barragan L, Robinette ML, Bando JK, Wang Y, Geiger TL, Gilfillan S, Fuchs A, Vivier E, Sun JC, Cella M, Colonna M. (2016) Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands. Immunity 44, 1127-39.

David CJ, Huang YH, Chen M, Su J, Zou Y, Bardeesy N, Iacobuzio-Donahue CA, Massagué J.  (2016) TGF-β Tumor Suppression through a Lethal EMT.  Cell 164, 1015-30. PMCID: PMC4801341 [Available on 2017-02-25]

Enyedi B, Jelcic M, Niethammer P. (2016) The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation. Cell 165, 1160-70. PMCID: PMC4875569 [Available on 2017-05-19]

Ebbesen SH, Scaltriti M, Bialucha CU, Morse N, Kastenhuber ER, Wen HY, Dow LE, Baselga J, Lowe SW. (2016) Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas. Proc Natl Acad Sci U S A 113, 3030-5. PMCID: PMC4801318

Liu Y, Chen C, Xu Z, Scuoppo C, Rillahan CD, Gao J, Spitzer B, Bosbach B, Kastenhuber ER, Baslan T, Ackermann S, Cheng L, Wang Q, Niu T, Schultz N, Levine RL, Mills AA, Lowe SW. (2016)  Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Nature 531, 471-5. PMCID: PMC4836395

Xiong H, Keith JW, Samilo DW, Carter RA, Leiner IM, Pamer EG. (2016) Innate Lymphocyte/Ly6Chi Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance. Cell 165, 679-89. PMCID: PMC4842125 [Available on 2017-04-21]

Abt MC, Buffie CG, Sušac B, Becattini S, Carter RA, Leiner I, Keith JW, Artis D, Osborne LC, Pamer EG. (2016) TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus. Sci Transl Med. 8, 327ra25.  doi:10.1126/scitranslmed.aad6663. PMCID: PMC4991618

Plitas G, Konopacki C, Wu K, Bos PD, Morrow M, Putintseva EV, Chudakov DM, Rudensky. (2016)  AYRegulatory T Cells Exhibit Distinct Features in Human Breast Cancer. Immunity 45, 1122-1134. PMCID: PMC5134901 [Available on 2017-11-15]

Krishna S, Overholtzer M. (2016) Germ Cells Get by with a Little Cannibalistic Help from Their Friends. Dev Cell. 39, 631-633.

Krishna S, Overholtzer M. (2016) Mechanisms and consequences of entosis. Cell Mol Life Sci. 73, 2379-86. PMCID: PMC4889469 [Available on 2017-06-01]

Krishna S, Palm W, Lee Y, Yang W, Bandyopadhyay U, Xu H, Florey O, Thompson CB, Overholtzer M. (2016) PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.  Dev Cell 38, 536-47. PMCID: PMC5046836 [Available on 2017-09-12]

Malandro N, Budhu S, Kuhn NF, Liu C, Murphy JT, Cortez C, Zhong H, Yang X, Rizzuto G, Altan-Bonnet G, Merghoub T, Wolchok JD. (2016)  Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion.  Immunity 44, 179-93. PMCID: PMC4996670 [Available on 2017-01-19]

LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, Shi X, Doud EH, Krivtsov AV, Chung YR, Khodos I, de Stanchina E, Ouerfelli O, Adusumilli PS, Thomas PM, Kelleher NL, Luo M, Keilhack H, Abdel-Wahab O, Melnick A, Armstrong SA, Levine RL. (2016) Reply to “Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status”. Nat Med. 22, 578-9.

LaFave LM, Levine RL. (2016)  Targeting a regulator of protein homeostasis in myeloproliferative neoplasms. Nat Med. 22, 20-1.

Zhu Z, Li QV, Lee K, Rosen BP, González F, Soh CL, Huangfu D. (2016) Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes. Cell Stem Cell 18, 755-68. PMCID: PMC4892994 [Available on 2017-06-02]

Li X, Wu R, Ventura A. (2016) The present and future of genome editing in cancer research. Hum. Genet. 135, 1083-92.

Luo CT, Liao W, Dadi S, Toure A, Li MO. (2016) Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature 529, 532-6. PMCID: PMC4978705

Dadi S, Chhangawala S, Whitlock BM, Franklin RA, Luo CT, Oh SA, Toure A, Pritykin Y, Huse M, Leslie CS, Li MO. (2016) Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells. Cell 164, 365-77. PMCID: PMC4733424 [Available on 2017-01-28]

Malladi S, Macalinao DG, Jin X, He L, Basnet H, Zou Y, de Stanchina E, Massagué J. (2016) Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT. Cell 165, 45-60. PMCID: PMC4808520 [Available on 2017-03-24]

Mazo G, Soplop N, Wang WJ, Uryu K, Tsou MB.(2016) Spatial Control of Primary Ciliogenesis by Subdistal Appendages Alters Sensation-Associated Properties of Cilia. Dev Cell. 39 424-437. PMCID: PMC5125554 [Available on 2017-11-21]

Fong CS, Mazo G, Das T, Goodman J, Kim M, O’Rourke BP, Izquierdo D, Tsou MF.(2016) 53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis. Elife. 5 pii: e16270. PMCID: PMC4946878

Guryanova OA, Shank K, Spitzer B, Luciani L, Koche RP, Garrett-Bakelman FE, Ganzel C, Durham BH, Mohanty A, Hoermann G, Rivera SA, Chramiec AG, Pronier E, Bastian L, Keller MD, Tovbin D, Loizou E, Weinstein AR, Gonzalez AR, Lieu YK, Rowe JM, Pastore F, McKenney AS, Krivtsov AV, Sperr WR, Cross JR, Mason CE, Tallman MS, Arcila ME, Abdel-Wahab O, Armstrong SA, Kubicek S, Staber PB, Gönen M, Paietta EM, Melnick AM, Nimer SD, Mukherjee S, Levine RL. (2016) DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling. Nat Med. [Epub ahead of print]

Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W, Zhao H, de Stanchina E, Gershon MD, Grikscheit TC, Chen S, Studer L. (2016) Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature. 531, 105-9. PMCID: PMC4846424

Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X.(2016) Ferroptosis is an autophagic cell death process. Cell Res. 26, 1021-32. PMCID: PMC5034113 [Available on 2017-09-01]

Monian P, Jiang X. (2016) The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation. J Biol Chem. 291, 2379-88. PMCID: PMC4732220 [Available on 2017-01-29]

Sharma SK, Nemieboka B, Sala E, Lewis JS, Zeglis BM. (2016) Molecular Imaging of Ovarian Cancer. J Nucl Med. 57, 827-33. PMCID: PMC5047520

Prudova A, Gocheva V, Auf dem Keller U, Eckhard U, Olson OC, Akkari L, Butler GS, Fortelny N, Lange PF, Mark JC, Joyce JA, Overall CM. (2016) TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors. Cell Rep. 16, 1762-73.

Puente C, Hendrickson RC, Jiang X. (2016) Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy. J Biol Chem. 291, 6026-35. PMCID: PMC4786734

Gammoh N, Fraser J, Puente C, Syred HM, Kang H, Ozawa T, Lam D, Acosta JC, Finch AJ, Holland E, Jiang X. (2016) Suppression of autophagy impedes glioblastoma development and induces senescence. Autophagy 12, 1431-9. PMCID: PMC5082770 [Available on 2017-06-15]

Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, Papillon-Cavanagh S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis PW. (2016) Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science 352, 844-849. PMCID: PMC4928577

Kim SE, Zhang L, Ma K, Riegman M, Chen F, Ingold I, Conrad M, Turker MZ, Gao M, Jiang X, Monette S, Pauliah M, Gonen M, Zanzonico P, Quinn T, Wiesner U, Bradbury MS, Overholtzer M. (2016) Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth. Nat Nanotechnol. 11, 977-985.

Sanfilippo P, Smibert P, Duan H, Lai EC. (2016) Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues. Development. 143, 4474-4485. PMCID: PMC5201049

Cheng M, Santich BH, Xu H, Ahmed M, Huse M, Cheung NK. (2016) Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors. Oncoimmunology 5, e1168557. PMCID: PMC4938304.

Caley MP, King H, Shah N, Wang K, Rodriguez-Teja M, Gronau JH, Waxman J, Sturge J. (2016)  Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces. Clin Exp Metastasis 33, 151-65. PMCID: PMC4761374

Akkari L, Gocheva V, Quick ML, Kester JC, Spencer AK, Garfall AL, Bowman RL, Joyce JA. (2016) Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer. Genes Dev. 30, 220-32. PMCID: PMC4719311

Vaisey G, Miller A, Long, S. (2016) Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel. Proc Natl Acad Sci U S A 113, E7399-E7408. PMCID: PMC5127342 [Available on 2017-05-22]

Taggart J, Ho TC, Amin E, Xu H, Barlowe TS, Perez AR, Durham BH, Tivnan P, Okabe R, Chow A, Vu L, Park SM, Prieto C, Famulare C, Patel M, Lengner CJ, Verma A, Roboz G, Guzman M, Klimek VM, Abdel-Wahab O, Leslie C, Nimer SD, Kharas MG. (2016) MSI2 is required for maintaining activated myelodysplastic syndrome stem cells. Nat Commun. 7, 10739. PMCID: PMC4764878

Walkowicz WE, Fernández-Tejada A, George C, Corzana F, Jiménez-Barbero J, Ragupathi G, Tan DS, Gin DY. (2016) Quillaja Saponin Variants with Central Glycosidic Linkage Modifications Exhibit Distinct Conformations and Adjuvant Activities. Chem Sci, 7, 2371-2380. PMCID: PMC4800320. 

Zinder JC, Wasmuth EV, Lima CD. (2016) Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3. Mol Cell. 64, 734-745. PMCID: PMC5115963 

Wei L, Zhao X. (2016) A new MCM modification cycle regulates DNA replication initiation. Nat Struct Mol Biol. 23, 209-16. PMCID: PMC4823995

Bonner JN Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X. (2016) Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates. Cell Rep. 16, 368-78. PMCID: PMC5051638 [Available on 2017-07-12]

Gao D, Zhan Y, Di W, Moore AR, Sher JJ, Guan Y, Wang S, Zhang Z, Murphy DA, Sawyers CL, Chi P, Chen Y.(2016) A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon. PLoS One 11, e0161084. PMCID: PMC4990297

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2015

Kleppe M, Kwak M, Koppikar P, Riester M, Keller M, Bastian L, Hricik T, Bhagwat N, McKenney AS, Papalexi E, Abdel-Wahab O, Rampal R, Marubayashi S, Chen JJ, Romanet V, Fridman JS, Bromberg J, Teruya-Feldstein J, Murakami M, Radimerski T, Michor F, Fan R, Levine RL. (2015) JAK-STAT Pathway Activation in Malignant and Non-Malignant Cells Contributes to MPN Pathogenesis and Therapeutic Response.  Cancer Discov 5, 316-31. PMCID: PMC4355105

Kucine N, Marubayashi S, Bhagwat N, Papalexi E, Koppikar P, Sanchez Martin M, Dong L, Tallman MS, Paietta E, Wang K, He J, Lipson D, Stephens P, Miller V, Rowe JM, Teruya-Feldstein J, Mullighan CG, Ferrando AA, Krivtsov A, Armstrong S, Leung L, Ochiana SO, Chiosis G, Levine RL, Kleppe . (2015)  Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias. Blood, 126, 2479-83. PMCID: PMC4661170. 

Dubrovsky L, Dao T, Gejman RS, Brea EJ, Chang AY, Oh CY, Casey E, Pankov D, Scheinberg DA. (2015) T cell receptor mimic antibodies for cancer therapy. Oncoimmunology 5, e1049803. PMCID: PMC4760335

Prakash R, Zhang Y, Feng W, Jasin M. (2015) Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins. Cold Spring Harb Perspect Biol. 7   pii: a016600. PMCID: PMC4382744

Miller ML, Reznik E, Gauthier NP, Aksoy BA, Korkut A, Gao J, Ciriello G, Schultz N, Sander C. (2015) Pan-Cancer Analysis of Mutation Hotspots in Protein Domains. Cell Syst., 1, 197-209. PMCID: PMC4982675

Jelcic M, Niethammer P. (2015) Do not scratch that mole! Trends Immunol36, 503-504. PMCID: PMC4567386

Karo JM, Sun JC. (2015) A novel molecular mechanism for generating NK-cell fitness and memory. Eur J Immunol. 45, 1906-15. PMCID: PMC4561546

Dow LE, Fisher J, O’Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW. (2015) Inducible in vivo genome editing with CRISPR-Cas9. Nat Biotechnol. 33, 390-4. PMCID: PMC4390466

Konopacki C, Plitas G, Rudensky A. (2015) Reigning in regulatory T-cell function. Nat Biotechnol. 33, 718-9.

Kovatcheva M, Liu DD, Dickson MA, Klein ME, O’Connor R, Wilder FO, Socci ND, Tap WD, Schwartz GK, Singer S, Crago, Koff A. (2015) MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. Oncotarget. 6, 8226-43. PMCID: PMC4480747

LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, Shi X, Doud EH, Krivtsov AV, Chung YR, Khodos I, de Stanchina E, Ouerfelli O, Adusumilli PS, Thomas PM, Kelleher NL, Luo M, Keilhack H, Abdel-Wahab O, Melnick A, Armstrong SA, Levine RL. (2015)  Loss of BAP1 function leads to EZH2-dependent transformation. Nat Med. 21, 1344-9. PMCID: PMC4636469

Lam I, Keeney S. (2015) Non-paradoxical evolutionary stability of the meiotic recombination initiation landscape in yeasts. Science 350, 932–937. PMCID: PMC4656144

Vincenten N, Kuhl LM, Lam I, Oke A, Kerr AR, Hochwagen A, Fung J, Keeney S, Vader G, Marston AL. (2015) The kinetochore prevents centromere-proximal crossover recombination during meiosis. ELife. 4, 1-25. PMCID: PMC4749563

Yao Z, Torres NM, Tao A, Gao Y, Luo L, Li Q, de Stanchina E, Abdel-Wahab O, Solit DB, Poulikakos PI, Rosen N. (2015) BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition. Cancer Cell 28, 370-83. PMCID: PMC4894664

Matevossian A, Resh MD. (2015) Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells. Mol Cancer, 14: 72. PMCID: PMC4711017

Petrova E., Matevossian A., Resh M.D. (2015) Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene  34, 263-8. PMCID: PMC4513646

Matevossian A, Resh MD. (2015) Membrane topology of hedgehog acyltransferase. J Biol Chem 290, 2235-43. PMCID: PMC4303674

Meyer SC, Keller MD, Chiu S, Koppikar P, Guryanova OA, Rapaport F, Xu K, Manova K, Pankov D, O’Reilly RJ, Kleppe M, McKenney AS, Shih AH, Shank K, Ahn J, Papalexi E, Spitzer B, Socci N, Viale A, Mandon E, Ebel N, Andraos R, Rubert J, Dammassa E, Romanet V, Dölemeyer A, Zender M, Heinlein M, Rampal R, Weinberg RS, Hoffman R, Sellers WR, Hofmann F, Murakami M, Baffert F, Gaul C, Radimerski T, Levine RL. (2015) CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms. Cancer Cell, 28, 15-28. PMCID: PMC4503933

Gao M, Monian P, Quadri N, Ramasamy R, Jiang X. (2015) Glutaminolysis and Transferrin Regulate Ferroptosis. Mol Cell, 59, 298-308. PMCID: PMC4506736

Gao M, Monian P, Jiang X. (2015) Metabolism and iron signaling in ferroptotic cell death. Oncotarget 6, 35145-6. PMCID: PMC4742090

Olson OC, Joyce JA. (2015) Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response. Nat Rev Cancer 15, 712-29.

Hughes R, Qian BZ, Rowan C, Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Clemons M, Gonzalez-Angulo AM, Joyce JA, De Palma M, Pollard JW, Lewis CE. (2015)  Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy. Cancer Res. 75, 3479-91. PMCID: PMC5024531

Pucella JN, Yen WF, Kim MV, van der Veeken J, Luo CT, Socci ND, Naito Y, Li MO, Iwai N, Chaudhuri J. (2015) miR-182 is largely dispensable for adaptive immunity: lack of correlation between expression and function. J Immunol., 194, 2635-42. PMCID: PMC4355037

Rahman S, Jones MJ, Jallepalli PV.  (2015) Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells. Proc Natl Acad Sci U S A 112, 11270-5. PMCID: PMC4568707

Wiesner T, Lee W, Obenauf AC, Ran L, Murali R, Zhang QF, Wong EW, Hu W, Scott SN, Shah RH, Landa I, Button J, Lailler N, Sboner A, Gao D, Murphy DA, Cao Z, Shukla S, Hollmann TJ, Wang L, Borsu L, Merghoub T, Schwartz GK, Postow MA, Ariyan CE, Fagin JA, Zheng D, Ladanyi M, Busam KJ, Berger MF, Chen Y, Chi P. (2015) Alternative transcription initiation leads to expression of a novel ALK isoform in cancer. Nature 526, 453-7. PMCID: PMC4807020

Ran L, Sirota I, Cao Z, Murphy D, Chen Y, Shukla S, Xie Y, Kaufmann MC, Gao D, Zhu S, Rossi F, Wongvipat J, Taguchi T, Tap WD, Mellinghoff IK, Besmer P, Antonescu CR, Chen Y, Chi P. (2015)  Combined inhibition of MAP kinase and KIT signaling effectively destabilizes the ETV1 protein and synergistically suppresses GIST tumor growth. Cancer Discov. 5, 304-15. PMCID: PMC4355391

Shenker S, Miura P, Sanfilippo P, Lai EC. (2015) IsoSCM: improved and alternative 3’ UTR annotation using multiple change-point inference. RNA 21, 14-27. PMCID: PMC4274634

Santich BH, Liu H, Liu C, Cheung NK. (2015) Generation of TCR-Like Antibodies Using Phage Display. Methods Mol Biol. 1348, 191-204.

Spratt DE, Evans MJ, Davis BJ, Doran MG, Lee MX, Shah N, Wongvipat J, Carnazza KE, Klee GG, Polkinghorn W, Tindall DJ, Lewis JS, Sawyers CL. (2015) Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation. Cancer Res. 75, 4688-96. PMCID: PMC4651750

Zhao Q, Ahmed M, Tassev DV, Hasan A, Kuo TY, Guo HF, O’Reilly RJ, Cheung NK. (2015) Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential.  Leukemia 29, 2238-47. PMCID: PMC4788467

Perna F, Vu LP, Themeli M, Kriks S, Hoya-Arias R, Khanin R, Hricik T, Mansilla-Soto J, Papapetrou EP, Levine RL, Studer L, Sadelain M, Nimer SD. (2015) The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells. Stem Cell Reports 4, 658-69. PMCID: PMC4400644

Shih AH, Jiang Y, Meydan C, Shank K, Pandey S, Barreyro L, Antony-Debre I, Viale A, Socci N, Sun Y, Robertson A, Cavatore M, de Stanchina E, Hricik T, Rapaport F, Woods B, Wei C, Hatlen M, Baljevic M, Nimer SD, Tallman M, Paietta E, Cimmino L, Aifantis I, Steidl U, Mason C, Melnick A, Levine RL. (2015) Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia. Cancer Cell 27, 502-15. PMCID: PMC4518555

Woods BA, Levine RL. (2015) The role of mutations in epigenetic regulators in myeloid malignancies. Immunol Rev  263, 22-35

Obenauf AC, Zou Y, Ji AL, Vanharanta S, Shu W, Shi H, Kong X, Bosenberg MC, Wiesner T, Rosen N, Lo RS, Massagué J. (2015) Therapy-induced tumour secretomes promote resistance and tumour progression. Nature 520, 368-72. PMCID: PMC4507807

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2014

Balbas MD, Burgess MR, Murali R, Wongvipat J, Skaggs BJ, Mundel 5, Weins A, Sawyers CL. (2014) MAGI-2 scaffold protein is critical for kidney barrier function. Proc Natl Acad Sci U S A. 111, 14876-81. PMCID: PMC4205655

Grundschober E, Hoelbl-Kovacic A, Bhagwat N, Kovacic B, Scheicher R, Eckelhart E, Kollmann K, Keller M, Grebien F, Wagner KU, Levine RL, Sexl V. (2014) Acceleration of Bcr-Abl+ leukemia induced by deletion of JAK2. Leukemia 28, 1918-22. PMCID: PMC4158830

Bhagwat N, Koppikar P, Keller M, Marubayashi S, Shank K, Rampal R, Qi J, Kleppe M, Patel HJ, Shah SK, Taldone T, Bradner JE, Chiosis G, Levine RL. (2014). Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms. Blood.

Sevenich L, Bowman R, Mason S, Quail D, Rapaport F, Elie B, Brogi E, Brastianos P, Hahn W, Holsinger L, Massagué J, Leslie C, Joyce J. (2014) Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. Nat Cell Biol16, 876-88. PMCID: PMC4249762

Bowman R, Joyce J. (2014) Therapeutic targeting of tumor-associated macrophages and microglia in glioblastoma. Immunotherapy 6, 663-6.

Mulvey JJ, Villa CH, McDevitt MR, Escorcia FE, Casey E, Scheinberg DA. (2014) Self-assembly of carbon nanotubes and antibodies on tumours for targeted amplified delivery. Nat Nanotechnol 8, 763-71. PMCID: PMC3798027

Veomett N, Dao T, Liu H, Xiang J, Pankov D, Dubrovsky L, Whitten J, Park S, Korontsvit T, Zakhaleva V, Casey E, Curcio M, Kharas M, O’Reilly R, Liu C, Scheinberg D. (2014) Therapeutic Efficacy of an Fc-Enhanced TCR-like Antibody to the Intracellular WT1 Oncoprotein. Clin Cancer Res. 20, 4036-46. PMCID: PMC4119489

Gala K, Chandarlapaty S. (2014) Molecular pathways: HER3 targeted therapy. Clin Cancer Res. 20, 1410-6. PMCID: PMC3977203

Geiger T, Abt M, Gasteiger G, Firth M, O’Connor M, Geary C, O’Sullivan T, van den Brink M, Pamer E, Hanash A, Sun J. (2014) Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. J Exp Med.  211, 1723-31. PMCID: PMC4144732

Halliday J, Helmy K, Pattwell SS, Pitter KL, LaPlant Q, Ozawa T, Holland EC. (2014) In vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift. Proc Natl Acad Sci U S A. 111, 5248-53. PMCID: PMC3986190

Pietras A, Katz A, Ekström E, Wee B, Halliday J, Pitter K, Werbeck J, Amankulor N, Huse J, Holland E. (2014) Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth. Cell Stem Cell 14, 357-369. PMCID: PMC3999042

Gong Y, Zack TI, Morris LG, Lin K, Hukkelhoven E, Raheja R, Tan IL, Turcan S, Veeriah S, Meng S, Viale A, Schumacher SE, Palmedo P, Beroukhim R, Chan TA. (2014) Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. Nat Genet. 46, 588-94. PMCID: PMC4251771

Liu Y, Raheja R, Yeh N, Ciznadija D, Pedraza AM, Ozawa T, Hukkelhoven E, Erdjument-Bromage H, Tempst P, Gauthier NP, Brennan C, Holland EC, Koff A. (2014) TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.). Oncogene 33, 308-15. PMCID: PMC3928554

Raheja R, Liu Y, Hukkelhoven E, Yeh N, Koff A. (2014) The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity. Biochem J. 458, 537-45. PMCID: PMC4404499

Akkari L, Gocheva V, Kester JC, Hunter KE, Quick ML, Sevenich L, Wang HW, Peters C, Tang LH, Klimstra DS, Reinheckel T, Joyce JA. (2014) Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Genes Dev.  28, 2134-50. PMCID: PMC4180975

Hunter KE, Palermo C, Kester JC, Simpson K, Li JP, Tang LH, Klimstra DS, Vlodavsky I, Joyce JA. (2014) Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors. Oncogene.  33, 1799-808.

Westholm JO, Miura P, Olson S, Shenker S, Joseph B, Sanfilippo P, Celniker SE, Graveley BR, Lai EC. (2014) Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation. Cell Rep.  9, 1966-80. PMCID: PMC4279448

Karo J, Schatz D, Sun J. (2014) The RAG recombinase dictates functional heterogeneity and cellular fitness in natural killer cells. Cell 159, 94-107. PMCID: PMC4371485

Lito P, Saborowski A, Yue J, Solomon M, Joseph E, Gadal S, Saborowski M, Kastenhuber E, Fellmann C, Ohara K, Morikami K, Miura T, Lukacs C, Ishii N, Lowe S, Rosen N. (2014) Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors. Cancer Cell  25, 697-710. PMCID: PMC4049532

Tschaharganeh D, Xue W, Calvisi D, Evert M, Michurina T, Dow L, Banito A, Katz S, Kastenhuber E, Weissmueller S, Huang C, Lechel A.,Andersen J, Capper D, Zender L, Longerich T, Enikolopov G, Lowe S. (2014) p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer. Cell 158, 579-92. PMCID: PMC4221237

Krishna S, OverholtzerM. (2014) Milk makes lysosomes lethal. Nat Cell Biol  16, 1029-31.

Lam I, Keeney S. (2014) Mechanism and Regulation of Meiotic Recombination Initiation. Cold Spring Harb Perspect Biol. 7. pii: a016634. doi: 10.1101/cshperspect.a016634. PMCID: PMC4292169

González F, Zhu Z, Shi Z, Lelli K, Verma N, Li Q, Huangfu D. (2014) An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells. Cell Stem Cell 15, 215-26. PMCID: PMC4127112

Rodriguez-Bravo V, Maciejowski J, Corona J, Buch HK, Collin P, Kanemaki MT, Shah JV, Jallepalli PV. (2014) Nuclear pores protect genome integrity by assembling  a premitotic  and Mad1-dependent anaphase inhibitor. Cell 156, 1017-31. PMCID: PMC3947552

Petrova E, Matevossian A, Resh M. (2014) Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34, 263-8. PMCID: PMC4513646

Callier P, Calvel P, Matevossian A,  Makrythanasis P, Bernard P, Kurosaka H, Vannier A,  Thauvin-Robinet C, Borel C, Mazaud-Guittot S, Rolland A, Desdoits-Lethimonier C, Guipponi M,  Zimmermann C, Stévant I,  Kuhne F, Conne B, Santoni F, Lambert S, Huet F, Mugneret F, Jaruzelska J,  Faivre L, Wilhelm D, Jégou B, Trainor P, Resh M, Antonarakis S, Nef S. (2014) Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling. PLoS Genet. 10,  e1004340. PMCID: PMC4006744

Matevossian A, Resh MD. (2014) Membrane Topology of Hedgehog Acyltransferase. J Biol Chem. 290, 2235-43. PMCID: PMC4303674

Rampal R, Ahn J, Abdel-Wahab O, Nahas M, Wang K, Lipson D, Otto GA, Yelensky R, Hricik T, McKenney AS, Chiosis G, Chung YR, Pandey S, van den Brink MR, Armstrong SA, Dogan A, Intlekofer A, Manshouri T, Park CY, Verstovsek S, Rapaport F, Stephens PJ, Miller VA, Levine RL. (2014)  Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms. Proc Natl Acad Sci U S A  111, E5401-10. PMCID: PMC4273376

Miller J, Studer L. (2014) Aging in iPS cells. Aging (Albany NY). 6, 246-7. PMCID: PMC4032792

Will M, Qin A, Toy W, Yao Z, Rodrik-Outmezguine V, Schneider C, Huang X, Monian P, Jiang X, de Stanchina E, Baselga J, Liu N, Chandarlapaty S, Rosen N. (2014) Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling. Cancer Discov  4, 334-47. PMCID: PMC4049524

Nissan M, Solit B. (2014) Ch. 22: BRAF mutations in human cancer: biologic and therapeutic implications. Molecular Oncology: Causes of Cancer and Targets fot Treatment , Edited by Edward P. Gelmann, Charles L. Sawyers and Frank J. Rauscher. Cambridge University Press, 272-277.

Nissan MH, Pratilas CA, Jones AM, Ramirez R, Won H, Liu C, Tiwari S, Kong L, Hanrahan AJ, Yao Z, Merghoub T, Ribas A, Chapman PB, Yaeger R, Taylor BS, Schultz N, Berger MF, Rosen N, Solit DB. (2014) Loss of NF1 in cutaneous melanoma  is associated with RAS activation and MEK dependence. Cancer Res. 74, 2340-50. PMCID: PMC4005042

Gholami S, Chen CH, Gao S, Lou E, Fujisawa S, Carson J, Nnoli JE, Chou TC, Bromberg J, Fong Y. (2014) Role of MAPK in oncolytic herpes viral therapy in triple-negative breast cancer. Cancer Gene Ther21, 283-9.

Ortiz B, White J, Wu W, Chan T. (2014) Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis.  Oncotarget  5, 6976-82. PMCID: PMC4196177

Ortiz B, Fabius A, Wu W, Pedraza A, Brennan C, Schultz N, Pitter K, Bromberg J, Huse J, Holland E, Chan T. (2014) Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis. Proc Natl Acad Sci U S A.  111, 8149-54. PMCID: PMC4050622

Vaidyanathan B, Yen W, Pucella J, Chaudhuri J. (2014)   AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination. Front Immunol  5, 120. PMCID: PMC3975107

Sheth A, Escobar-Alvarez S, Gardner J, Ran L, Heaney ML, Scheinberg DA. (2014) Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressinghematopoietic cancers. Cell Death Dis. 5:e1152. doi: 10.1038/cddis.2014.112. PMCID: PMC3973238

Gao D, Vela I, Sboner A, Iaquinta P, Karthaus W, Gopalan A, Dowling C, Wanjala J, Undvall E, Arora V, Wongvipat J, Kossai M, Ramazanoglu S, Barboza L, Di W, Cao Z, Zhang Q, Sirota I, Ran L, MacDonald T,  Beltran H, Mosquera J, Touijer K, Scardino P, Laudone V, Curtis K, Rathkopf D, Morris M, Danila D, Slovin S, Solomon S, Eastham J, Chi P, Carver B, Rubin M, Scher H, Clevers H, Sawyers C, Chen Y. (2014) Organoid Cultures Derived from Patients with Advanced Prostate Cancer. Cell 159, 176-87. PMCID: PMC4237931

Lee W, Teckie S, Wiesner T, Ran L, Prieto Granada CN, Lin M, Zhu S, Cao Z, Liang Y, Sboner A, Tap WD, Fletcher JA, Huberman KH, Qin LX, Viale A, Singer S, Zheng D, Berger MF, Chen Y, Antonescu CR, Chi P. (2014)  PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.  Nat Genet  46, 1227-32. PMCID: PMC4249650

Rios-Esteves J, Haugen B, Resh MD. (2014) Identification of key residues and regions important for Porcupine-mediated Wnt acylation. J Biol Chem13, 17009-19. PMCID: PMC4059143

Miura P, Sanfilippo P, Shenker S, Lai E. (2014) Alternative polyadenylation in the nervous system: to what lengths will 3’ UTR extensions take us? Bioessays 36, 766-77. PMCID: PMC4503322

Garaulet D, Castellanos M, Bejarano F, Sanfilippo P, Tyler D, Allan D, Sánchez-Herrero E, Lai E. (2014) Homeotic function of Drosophila Bithorax-complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the CNS. Dev Cell.  29, 635-48. PMCID: PMC4111139

Wasmuth E, Januszyk K, Lima C.  (2014) Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA. Nature  511, 435-9. PMCID: PMC4310248

Hang LE, Lopez CR, Liu X, Williams JM, Chung I, Wei L, Bertuch AA, Zhao X. (20104)  Regulation of Ku-DNA association by Yku70 C-terminal tail and SUMO modification.  J Biol Chem289, 10308-17. PMCID: PMC4036155

Beauchamp EM, Woods BA, Dulak AM, Tan L, Xu C, Gray NS, Bass AJ, Wong KK, Meyerson M, Hammerman PS. (2014) Acquired resistance to dasatinib in lung cancer cell lines conferred by DDR2 gatekeeper mutation and NF1 loss. Mol Cancer Ther. 13, 475-82. PMCID: PMC3946067

Meyer S, Keller M, Woods B, LaFave L, Bastian L, Kleppe M, Bhagwat N, Marubayashi S, Levine R. (2014) Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis. Blood 124, 2280-4. PMCID: PMC4183987

Vanharanta S, Marney C, Shu W, Valiente M, Zou Y, Mele A, Darnell R, Massague J. (2014) Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. Elife  e02734. PMCID: PMC4073284

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2013

Arora VK, Schenkein E, Murali R, Subudhi SK, Wongvipat J, Balbas MD, Shah N, Cai L, Efstathiou E, Logothetis C, Zheng D, Sawyers CL. (2013) Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade. Cell 155, 1309-22. PMCID: PMC3932525

Balbas M, Evans M, Hosfield D, Wongvipat J, Arora V, Watson P, Chen Y, Greene G, Shen Y, Sawyers C. (2013) Overcoming mutation-based resistance to antiandrogens with rational drug design. Elife 2, e00499. PMCID: PMC3622181

Murphy AJ, Bijl N, Yvan-Charvet L, Welch CB, Bhagwat N, Reheman A, Wang Y, Shaw JA, Levine RL, Ni H, Tall AR, Wang N. (2013). Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med., 19, 586-94. PMCID: PMC3683965

Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel-Wahab O, Lütjohann D, Randolph G, Levine R, Tall A, Yvan-Charvet L. (2013) HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. J Exp Med 210, 339-53. PMCID: PMC3570097

Murphy AJ, Bijl N, Yvan-Charvet L, Welch CB, Bhagwat N, Reheman A, Wang Y, Shaw JA, Levine RL, Ni H, Tall AR, Wang N. (2013). Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med.19, 586-94. PMCID: PMC3683965

Bhagwat N, Levine RL, Koppikar P. (2013). Sensitivity and resistance of JAK2 inhibitors to myeloproliferative neoplasms. Int J Hematol.  97, 695-702.

Pyonteck S, Akkari L, Schuhmacher A, Bowman R, Sevenich L, Quail D, Olson O, Quick M, Huse J, Teijeiro V, Setty M, Leslie C, Oei Y, Pedraza A, Zhang J, Brennan C, Sutton J, Holland E, Daniel D, Joyce J. (2013) CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med 19, 1264-72. PMCID: PMC3840724

Mulvey JJ, Villa CH, McDevitt MR, Escorcia FE, Casey E, Scheinberg DA. (2013). Self-assembly of carbon nanotubes and antibodies on tumours for targeted amplified delivery. Nat Nanotechnol. 8, 763-71. PMCID: PMC3798027 

Dao T, Yan S, Veomett N, Pankov D, Zhou L, Korontsvit T, Scott A, Whitten J, Maslak P, Casey E, Tan T, Liu H, Zakhaleva V, Curcio M, Doubrovina E, O’Reilly R, Liu C, Scheinberg D. (2013) Targeting the intracellular WT1 oncogene product with a therapeutic human antibody. Sci Transl Med. 5, 176ra33. PMCID: PMC3963696

Dowdle J, Mehta M, Kass E, Vuong B, Inagaki A, Egli D, Jasin M, Keeney S. (2013) Mouse BAZ1A (ACF1) Is Dispensable for Double-Strand Break Repair but Is Essential for Averting Improper Gene Expression during Spermatogenesis. PLoS Genet. 9: e1003945. PMCID: PMC3820798

Toy W, Shen Y, Won H, Green B, Sakr R, Will M, Li Z, Gala K, Fanning S, King T, Hudis C, Chen D, Taran T, Hortobagyi G, Greene G, Berger M, Baselga J, Chandarlapaty S. (2013) ESR1 ligand-binding domain mutations in hormone-resistant breast cancer. Nat Genet  45, 1439-45. PMCID: PMC3903423

Gauthier NP, Soufi B, Walkowicz WE, Pedicord VA, Mavrakis KJ, Macek B, Gin DY, Sander C, Miller ML. (2013) Cell-selective labeling using amino acid precursors for proteomic studies of multicellular environments. Nat Methods 10, 768-73. PMCID: PMC4002004

Curran M, Geiger T, Montalvo W, Kim M, Reiner S, Al-Shamkhani A, Sun J, Allison J. (2013)  Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin. J Exp Med 210, 743-55. PMCID: PMC3620352

Huse JT, Edgar M, Halliday J, Mikolaenko I, Lavi E, Rosenblum MK. (2013) Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure-associated lesion. Brain Pathol. 23, 515-24.

Hunter KE, Quick ML, Sadanandam A, Hanahan D, Joyce JA. (2013) Identification and characterization of poorly differentiated invasive carcinomas in a mouse model of pancreatic neuroendocrine tumorigenesis. PLoS One.  8, 64472. PMCID: PMC3653861

Hayama R, Bahng S, Karasu M, Marians K. (2013) The MukB-ParC Interaction Affects Intramolecular, not Intermolecular, Activities of Topoisomerase IV. J Biol Chem  288, 7653-61. PMCID: PMC3597806

Zawislak C, Beaulieu A, Loeb G, Karo J, Canner D, Bezman N, Lanier L, Rudensky A, Sun J. (2013) Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proc Natl Acad Sci U S A. 110, 6967-72. PMCID: PMC3637707

Krajcovic M, Krishna S, Akkari L, Joyce J, Overholtzer M. (2013) mTOR regulates phagosome and entotic vacuole fission. Mol Biol Cell. 24, 3736-45. PMCID: PMC3842999

Abdel-Wahab O, Gao J, Adli M, Dey A, Trimarchi T, Chung Y, Kuscu C, Hricik T, Ndiaye-Lobry D, Lafave L, Koche R, Shih A, Guryanova O, Kim E, Li S, Pandey S, Shin J, Telis L, Liu J, Bhatt P, Monette S, Zhao X, Mason C, Park C, Bernstein B, Aifantis I, Levine R. (2013) Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med. 210, 2641-59. PMCID: PMC3832937

Lafave L, Levine R. (2013) Mining the epigenetic landscape in ALL. Nat Genet. 45, 1269-70.

Luo C, Li M. (2013) Transcriptional control of regulatory T cell development and function. Trends  Immunol. 34, 531-9.

Mahaffey J, Grego-Bessa J, Liem K Jr, Anderson K. (2013) Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development 140,1262-71. PMCID: PMC3585660

McKenney AS, Levine RL. (2013) Isocitrate dehydrogenase mutations in leukemia. J Clin Invest 123, 3672-7. PMCID: PMC3754251

Mica Y, Lee G, Chambers S, Tomishima M, Studer L. (2013) Modeling Neural Crest Induction, Melanocyte Specification, and Disease-Related Pigmentation Defects in hESCs and Patient-Specific iPSCs. Cell Rep 3, 1140-52. PMCID: PMC3681528

Miller J, Ganat Y, Kishinevsky S, Bowman R, Liu B, Tu E, Mandal P, Vera E, Shim J, Kriks S, Taldone T, Fusaki N, Tomishima M, Krainc D, Milner T, Rossi D, Studer L. (2013) Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging. Cell Stem Cell. 13, 691-705. PMCID: PMC4153390

Nissan M, Rosen N, Solit D. (2013) ERK pathway inhibitors: how low should we go? Cancer  Discov. 3, 719-21.

Olson O, Joyce J. (2013) A splicing twist on metastasis. Sci Transl Med  5, 169fs2.

Olson O, Joyce J. (2013) Microenvironment-mediated resistance to anticancer therapies. Cell Res  23, 179-81. PMCID: PMC3567818

Wong PM, Puente C, Ganley IG, Jiang X. (2013) The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy 9, 124-37. PMCID: PMC3552878

Vuong B, Herrick-Reynolds K, Vaidyanathan B, Pucella J, Ucher A, Donghia N, Gu X, Nicolas L, Nowak U, Rahman N, Strout M, Mills K, Stavnezer J, Chaudhuri J. (2013) A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. Nat Immunol. 14, 1183-9. PMCID: PMC4005274

Petrova E, Rios-Esteves J, Ouerfelli O, Glickman J, Resh M. (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat Chem Biol  9, 247-9. PMCID: PMC3604071

Rios-Esteves  J, Resh M. (2013) Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins. Cell Rep  4, 1072-81. PMCID: PMC3845236

Polkinghorn W, Parker J, Lee M, Kass E, Spratt D, Iaquinta P, Arora V, Yen W, Cai L, Zheng D, Carver B,  Chen Y, Watson P, Shah N, Fujisawa S, Goglia A, Gopalan A,  Hieronymus H, Wongvipat J,  Scardino P, Zelefsky M,  Jasin M,  Chaudhuri J, Powell S,  Sawyers C. (2013) Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer Discov  3, 1245-53. PMCID: PMC3888815

Vu L, Luciani L, Nimer S. (2013) Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential. Int J Hematol 97, 198-209.

Vu LP, Perna F, Wang L, Voza F, Figueroa ME, Tempst P, Erdjument-Bromage H, Gao R, Chen S, Paietta E, Deblasio T, Melnick A, Liu Y, Zhao X, Nimer SD. (2013) PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex. Cell Rep. 5, 1625-38. PMCID: PMC4073674

Yu SF, Baylies MK. (2013) Cell biology: Death brings new life to muscle. Nature  497, 196-7. PMCID: PMC4019331

Morris LG, Kaufman AM, Gong Y, Ramaswami D, Walsh LA, Turcan Ş, Eng S, Kannan K, Zou Y, Peng L., Banuchi V., Paty P., Zeng Z., Vakiani E., Solit D., Singh B., Ganly I., Liau L., Cloughesy T., Mischel P., Mellinghoff I., Chan T. (2013) Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat Genet 45, 253-61. PMCID: PMC3729040

Zhang X, Jin X, Malladi S, Zou Y, Wen Y, Brogi E, Smid M, Foekens J, Massagué J. (2013) Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell 154, 1060-73. PMCID: PMC3974915

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2012

Koppikar P, Bhagwat N, Kilpivaara O, Manshouri T, Adli M, Hricik T, Liu F, Saunders L, Mullally A, Abdel-Wahab O, Leung L, Weinstein A, Marubayashi S, Goel A, Gönen M, Estrov Z, Ebert B, Chiosis G, Nimer S, Bernstein B, Verstovsek S, Levine R. (2012) Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature 489, 155-9. PMCID: PMC3991463

Andraosr R, Qian Z, Bonenfant D, Rubert J, Vangrevelinghe E, Scheufler C, Marque F, Régnier C, De Pover A, Ryckelynck H, Bhagwat N, Koppikar P, Goel A, Wyder L, Tavares G, Baffert F, Pissot-Soldermann C, Manley P, Gaul C, Voshol H, Levine R, Sellers W, Hofmann F, Radimerski T. (2012) Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent. Cancer Discov 2, 512-23. PMCID: PMC5022112

Helmy K, Halliday J, Fomchenko E, Setty M, Pitter K, Hafemeister C, Holland E. (2012) Identification of global alteration of translational regulation in glioma in vivo. PLoS One 7, e46965. PMCID: PMC3463531

Hukkelhoven E, Liu Y, Yeh N, Ciznadija D, Blain SW, Koff A. (2012) Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma. J Biol Chem. 287, 38523-30. PMCID: PMC3493897

Pyonteck SM, Gadea BB, Wang HW, Gocheva V, Hunter KE, Tang LH, Joyce JA. (2012) Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development. Oncogene 31, 1459-67.

Abdel-Wahab O, Adli M, LaFave L, Gao J, Hricik T, Shih A, Pandey S, Patel J, Chung Y, Koche R, Perna F, Zhao X, Taylor J, Park C, Carroll M, Melnick A, Nimer S, Jaffe J, Aifantis I, Bernstein B, Levine R. (2012) ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell 22, 180-93. PMCID: PMC3422511

Dey A, Seshasayee D, Noubade R, French D, Liu J, Chaurushiya M, Kirkpatrick D, Pham V, Lill J, Bakalarski C, Wu J, Phu L, Katavolos P, LaFave L, Abdel-Wahab O, Modrusan Z, Seshagiri S, Dong K, Lin Z, Balazs M, Suriben R, Newton K, Hymowitz S, Garcia-Manero G, Martin F, Levine R, Dixit V. (2012) Loss of the tumor suppressor BAP1 causes myeloid transformation. Science 337, 1541-6.

Lafave L, Levine R. (2012) JAK2 the future: therapeutic strategies for JAK-dependent malignancies. Trends Pharmacol Sci 33, 574-82.

Ouyang W, Liao W, Luo C, Yin N, Huse M, Kim M, Peng M, Chan P, Ma Q, Mo Y, Meijer D, Zhao K, Rudensky A, Atwal G, Zhang M, Li M. (2012) Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature 491, 554-9. PMCID: PMC3771531

Paschal CR, Maciejowski J, Jallepalli PV.  (2012) A stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congression. Chromosoma 121, 565-72. PMCID: PMC3519967

Chambers SM, Qi Y, Mica Y, Lee G, Zhang XJ, Niu L, Bilsland J, Cao L, Stevens E, Whiting P, Shi SH, Studer L. (2012) Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat Biotechnol 30, 715-20. PMCID: PMC3516136

Miller A, Long S. (2012) Crystal structure of the human two-pore domain potassium channel K2P1. Science 335, 432-6.

Monian P., Jiang X. (2012) Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release. Exp Oncol.  34, 185-91.

Meehan M, Parthasarathi L, Moran N, Jefferies C, Foley N, Lazzari E, Murphy D, Ryan J, Ortiz B, Fabius A, Chan T, Stallings R. (2012) Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene. Mol Cancer  11:6. PMCID: PMC3395855

Gammoh N, Lam D, Puente C, Ganley I, Marks P, Jiang X. (2012) Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death. Proc Natl Acad Sci USA  109, 6561-5. PMCID: PMC3340088

Cremona CA, Sarangi P, Yang Y, Hang LE, Rahman S, Zhao X. (2012) Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint. Mol Cell. 45, 422-32. PMCID: PMC3340930

Cheung N, Guo H, Hu J, Tassev D, Cheung I. (2012) Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo. Oncoimmunology 1, 477-486. PMCID: PMC3382886

Wasmuth E, Lima C. (2012) Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel. Mol Cell 48, 133-44. PMCID: PMC3472098

Wasmuth E, Lima C. (2012) Structure and activities of the Eukaryotic RNA exosome. Enzymes 31, 53-75. PMCID: PMC5336833

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2011

Alonzo ES, Sant’angelo DB. (2011) Development of PLZF-expressing innate T cells.  Curr Opin Immunol. 23, 220-7. PMCID: PMC3073746

Gordon SM, Carty SA, Kim JS, Zou T, Smith-Garvin J, Alonzo ES, Haimm E, Sant’Angelo DB, Koretzky GA, Reiner SL, Jordan MS. (2011) Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. J Immunol. 186, 4573-8. PMCID: PMC3085897

Villa CH, Dao T, Ahearn I, Fehrenbacher N, Casey E, Rey DA, Korontsvit T, Zakhaleva V, Batt CA, Philips MR, Scheinberg DA. (2011). Single-walled carbon nanotubes deliver peptide antigen into dendritic cells and enhance IgG responses to tumor-associated antigens. ACS Nano., 5, 5300-11. PMCID: PMC3143710 

Halliday JJ, Holland EC. (2011) Connective tissue growth factor and the parallels between brain injury and brain tumors. J Natl Cancer Inst. 103, 1141-3.

Thacker D, Lam I, Knop M, Keeney S. (2011) Exploiting Spore-Autonomous Fluorescent Protein Expression to Quantify Meiotic Chromosome Behaviors in Saccharomyces cerevisiae. Genetics 189, 423-39. PMCID: PMC3189805

Siaud N, BarberaM, Egashira A, Lam I, Christ N, Schlacherk, Xia B, Jasin M. (2011) Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. PLoS Genet 7, e1002409. PMCID: PMC3240595

Qian L, Mahaffey J, Alcorn H, Anderson K. (2011) Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo. Proc Natl Acad Sci U S A. 108, 8692-7. PMCID: PMC3102376

Amrani Y, Gill J, Matevossian A, Alonzo E, Yang C, Shieh J, Moore M, Park C, Sant’Angelo D, Denzin L. (2011) The Paf oncogene is essential for hematopoietic stem cell function and development. J Exp Med. 208, 1757-65. PMCID: PMC3171089

Chambers S, Mica Y, Studer L, Tomishima M. (2011) Converting human pluripotent stem cells to neural tissue and neurons to model neurodegeneration. Methods Mol Biol. 793, 87-97.

Miller J, Schlaeger T. (2011) Generation of induced pluripotent stem cell lines from human  fibroblasts via retroviral gene transfer. Methods Mol Biol 767, 55-65.

Mukherjee S, Simon J, Bayuga S, Ludwig E, Yoo S, Orlow I, Viale A, Offit K, Kurtz R, Olson S, Klein R. (2011) Including additional controls from public databases improves the power of a genome wide association study. Hum Hered. 72, 21-34. PMCID: PMC3171281

Nissan M, Solit D. (2011) The “SWOT” of BRAF inhibition in melanoma: RAF inhibitors, MEK inhibitors or both? Curr Oncol Rep. 13, 479-87.

Azare J, Doane A, Leslie K, Chang Q, Berishaj M, Nnoli J, Mark K, Al-Ahmadie H, Gerald W, Hassimi M, Viale A, Stracke M, Lyden D, Bromberg J. (2011) Stat3 mediates expression of autotaxin in breast cancer. PLoS One 6, e27851. PMCID: PMC3225372

Shree T, Olson O, Elie B, Kester J, Garfall A, Simpson K, Bell-McGuinn K, Zabor E, Brogi E, Joyce J. (2011) Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev. 25, 2465-79. PMCID: PMC3243057

Dawson M, Bannister A, Saunders L, Wahab O, Liu F, Nimer S, Levine R, Göttgens B, Kouzarides T, Green A. (2011) Nuclear JAK2. Blood 118, 6987-8. PMCID: PMC4729533

Tassev D, Cheng M, Cheung N. (2011) Retargeting NK92 cells using an HLA-A2-restricted, EBNA3C-specific chimeric antigen receptor. Cancer Gene Ther.19, 84-100.

Moulick K, Ahn J, Zong H, Rodina A, Cerchietti L, Gomes Dagama E, Caldas-Lopes E, Beebe K, Perna F, Hatzi K, Vu L, Zhao X, Zatorska D, Taldone T, Smith-Jones P, Alpaugh M, Gross S, Pillarsetty N, Ku T, Lewis J, Larson S, Levine R, Erdjument-Bromage H, Guzman M, Nimer S, Melnick A, Neckers L, Chiosis G. (2011) Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nat Chem Biol. 7, 818-26. PMCID: PMC3265389

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2010

Alonzo ES, Gottschalk RA, Das J, Egawa T, Hobbs RM, Pandolfi PP, Pereira P, Nichols KE, Koretzky GA, Jordan MS, Sant’Angelo DB. (2010) Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. J Immunol. 184, 1268-79. PMCID: PMC3991695

Kim HJ, Alonzo ES, Dorothee G, Pollard JW, Sant’Angelo DB. (2010) Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus.  PLoS One 5 e11439. PMCID: PMC2897847

Kovalovsky D, Alonzo ES, Uche OU, Eidson M, Nichols KE, Sant’Angelo DB. (2010) PLZF Induces the Spontaneous Acquisition of Memory/Effector Functions in T Cells Independently of NKT Cell-Related Signals. J Immunol. 184, 6746-55.

Watson PA, Chen YF, Balbas MD, Wongvipat J, Socci ND, Viale A, Kim K, Sawyers CL. (2010) Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci U S A. 107, 16759-65. PMCID: PMC2947883

Bhagwat N, Levine RL. (2010) Metabolic syndromes and malignant transformation: where the twain shall meet. Sci Transl Med. 2, 54ps50.

Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Löwenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A. (2010) Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18, 553-67. PMCID: PMC4105845

Marubayashi S, Koppikar P, Taldone T, Abdel-Wahab O, West N, Bhagwat N, Caldas-Lopes E, Ross KN, Gönen M, Gozman A, Ahn JH, Rodina A, Ouerfelli O, Yang G, Hedvat C, Bradner JE, Chiosis G, Levine RL. (2010) HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans. J Clin Invest. 120, 3578-93. PMCID: PMC2947224

Roig I, Dowdle JA, Toth A, de Rooij DG, Jasin M, Keeney S. (2010) Mouse TRIP13/PCH2 Is Required for Recombination and Normal Higher-Order Chromosome Structure during Meiosis. PLoS Genet. 6. E1001062. PMCID: PMC2920839

Gauthier NP, Jensen LJ, Wernersson R, Brunak S, Jensen TS. (2010) Cyclebase.org: version 2.0, an updated comprehensive, multi-species repository of cell cycle experiments and derived analysis results. Nucleic Acids Res 38(Database issue)D699-702. PMCID: PMC2808877

Gocheva V, Wang HW, Gadea BB, Shree T, Hunter KE, Garfall AL, Berman T, Joyce JA. (2010) IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion.  Genes Dev. 24, 241-55. PMCID: PMC2811826

Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV. (2010) Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol. 190, 89-100. PMCID: PMC2911671

Klein RJ, Xu X, Mukherjee S, Willis J, Hayes J. (2010) Successes of genome wide association studies. Cell 142, 350-1.

Rochlin K, Yu S, Roy S, Baylies MK. (2010) Myoblast fusion: When it takes more to make one. Dev Biol. 341, 66-83. PMCID: PMC2854170

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2009

Attwooll CL, Akpinar M, Petrini JH. (2009) The Mre11 Complex and the Response to Dysfunctional Telomeres. Mol Cell Biol. 29, 5540-51. PMCID: PMC2756889

Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV. (2009) Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 7, e1000111. PMCID: PMC2680336

Papapetrou EP, Tomishima MJ, Chambers SM, Mica Y, Reed E, Menon J, Tabar V, Mo Q, Studer L, and Sadelain M. (2009) Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci U S A. 106, 12759-64. PMCID: PMC2722286

Alarcón C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota G, Pan D, Massagué J. (2009) Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 139, 757-69. PMCID: PMC2818353

Kilpivaara O, Mukherjee S, Schram AM, Wadleigh M, Mullally A, Ebert BL, Bass A, Marubayashi S, Heguy A, Garcia-Manero G, Kantarjian H, Offit K, Stone RM, Gilliland DG, Klein RJ, Levine RL. (2009) A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms. Nat Genet. 41, 455-9. PMCID: PMC3676425

Pomerantz JH, Mukherjee S, Palermo AT, Blau HM. (2009) Reprogramming to a muscle fate by fusion recapitulates differentiation. J Cell Sci. 122, 1045-53. PMCID: PMC2720934

Terret M, Sherwood R, Rahman S, Qin J, Jallepalli P. (2009) Cohesin acetylation speeds the replication fork. Nature 462, 231-234. PMCID: PMC2777716

Gao S, Alarcón C, Sapkota G, Rahman S, Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P, Massagué J. (2009) Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell 36, 457-68. PMCID: PMC2796330

Tassev DV, Cheung NK. (2009) Monoclonal Antibody Therapies for Solid Tumors. Expert Opin Biol Ther. 9, 341-53.

Wang L, Huang G, Zhao X, Hatlen MA, Vu L, Liu F, Nimer SD. (2009). Post-translational modifications of Runx1 regulate its activity in the cell. Blood Cells Mol Dis43, 30-4.  PMCID: PMC2743917 

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2008

Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, Kim HJ, Im JS, Pandolfi PP, Sant’Angelo DB (2008) The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nature Immunology 9, 1055-1064. PMCID: PMC2662733

Shah NP, Kasap C, Weier C, Balbas M, Nicoll JM, Bleickardt E, Nicaise C, Sawyers CL. (2008) Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis. Cancer Cell  14, 485-93.

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