The Chairman’s Prize is a competitive award established by GSK’s Board of Trustees Chair Emeritus Louis V. Gerstner, Jr. The prestigious award is presented each year to recognize an outstanding first-author publication penned by a GSK student.
Click below to learn more about each year’s prize-winning research.
2023
M Wang , CA Wisniewski, C Xiong, P Chhoy , HL Goel , A Kumar, LJ Zhu, R Li, PA St. Louis, LM Ferreira, H Pakula, Z Xu, M Loda, Z Jiang, MA Brehm, AM Mercurio Therapeutic Blocking of VEGF Binding to Neuropilin-2 Diminishes PD-L1 Expression to Activate Anti-Tumor Immunity in Prostate Cancer; Science Translational Medicine; 2023
Robinson TM, Levine RL. Oncogenic IDH1 Mutation Imparts Therapeutically Targetable Metabolic Dysfunction in Multiple Tumor Types. Cancer Discov. 2023 Feb 6;13(2):266-268. doi: 10.1158/2159-8290.CD-22-1325. PMID: 36744320.
Fortin J, Chiang MF, Meydan C, Foox J, Ramachandran P, Leca J, Lemonnier F, Li WY, Gams MS, Sakamoto T, Chu M, Tobin C, Laugesen E, Robinson TM, You-Ten A, Butler DJ, Berger T, Minden MD, Levine RL, Guidos CJ, Melnick AM, Mason CE, Mak TW. Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2208176120. doi: 10.1073/pnas.2208176120. Epub 2023 Jan 18. PMID: 36652477; PMCID: PMC9942850.
Garg, A., Sanchez, A. M., Miele, M., Schwer, B., Shuman, S. (2023). Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis. Nucleic acids research, gkad063. Advance online publication. [PMID: 36794724]
Sanchez, A. M., Garg, A., Schwer, B., Shuman, S. (2023). Inorganic polyphosphate abets silencing of a sub-telomeric gene cluster in fission yeast. microPublication biology, 2023, 10.17912/micropub.biology.000744.
Sanchez AM, Garg A, Schwer B, Shuman S. Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination. RNA. 2023 Mar 7:rna.079595.123. doi: 10.1261/rna.079595.123. Epub ahead of print. PMID: 36882296.
Zhang, H., Karnoub, E-R., Umeda, S., Chaligné, R., Masilionis, I., McIntyre, C.A., Hayashi, A., Sashittal, P., Zucker, A., Mullen, K., Makohon-Moore, A., Iacobuzio- Donahue, C.A. Application of high-throughput single-nucleus DNA sequencing in pancreatic cancer. Nature Communications (2023). [PMID: 36765116]
Sashittal, P., Zhang, H., Iacobuzio-Donahue, C.A., Raphael, B.J. ConDoR: Tumor phylogeny inference with a copy-number constrained mutation loss
model. bioRxiv (2023).
2022
Chandran SS, Ma J, Klatt MG, Dündar F, Bandlamudi C, Razavi P, Wen HY, Weigelt B, Zumbo P, Fu SN, Banks LB, Yi F, Vercher E, Etxeberria I, Bestman WD, Da Cruz PaulaA, Aricescu IS, Drilon A, Betel D, Scheinberg DA, Baker BM, Klebanoff CA. (2022) Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA. Nat Med. Epub [PMID: 35484264]
Arnold PK*, Jackson BT*, Paras KI, Brunner JS, Hart ML, Newsom OJ, Alibeckoff SP, Endress J, Drill E, Sullivan LB, Finley LWS. (2022) A non-canonical tricarboxylic acid underlies cellular identity. Nature. Epub
Benjamin B, Garg A, Jork N, Jessen HJ, Schwer B, Shuman S. (2022) Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression. mBio. EPub 2022 May 10. [PMID: 35536002]
Boehm KM, Aherne EA, Ellenson L, Nikolovski I, Alghamdi M, Vázquez-García I, Zamarin D, Roche KL, Liu Y, Patel D, Aukerman A, Pasha A, Rose D, Selenica P, Causa Andrieu PI, Fong C, Capanu M, Reis-Filho JS, Vanguri R, Veeraraghavan H, Gangai N, Sosa R, Leung S, McPherson A, Gao J; MSK MIND Consortium, Lakhman Y, Shah SP. (2022) Multimodal data integration using machine learning improves risk stratification of high-grade serous ovarian cancer. Nat Cancer. 6, 723-733. [PMID: 35764743]
Bowman, R.L., Dunbar, A., Mishra, T., Xiao, W., Waarts, M.R., Cai, L., Eisman, S.E., Fernández-Maestre I., et al. Functionalizing clonal evolution with multi-recombinase mouse models of sequential mutagenesis and oncogenedependency; In preparation (to be submitted in Feb this year); 2022;
Dunbar, A., Bowman, R.L., Park, Y., Karzai, A., Waarts, M.R., Nazir, A., Brodsky, M., Farina, M., Fernández- Maestre, I., et al. Modeling Improved Targeting of Jak2V617F in Myeloproliferative Neoplasms. Manuscript in preparation; In preparation (to be submitted in Feb this year); 2022;
Chen T, Alcorn H, Devbhandari S, Remus D, Lacy E, Huangfu D, Anderson KV. (2022) A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation. Biol Open. 8. [PMID: 35876795]
Belk JA, Yao W, Ly N, Freitas KA, Chen YT, Shi Q, Valencia AM, Shifrut E, Kale N, Yost KE, Duffy CV, Daniel B, Hwee MA, Miao Z, Ashworth A, Mackall CL, Marson A, Carnevale J, Vardhana SA, Satpathy AT. (2022) Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence. Cancer Cell. 7; 768-786. [PMID: 35750052]
Petljak M, Dananberg A, Chu K, Bergstrom EN, Striepen J, von Morgen P, Chen Y, Shah H, Sale JE, Alexandrov LB, Stratton MR, Maciejowski J. (2022) Mechanisms of APOBEC3 mutagenesis in human cancer cells. Nature 607; 799-807. [PMID: 35859169]
Wang YT, Trzeciak AJ, Rojas WS, Saavedra P, Chen YT, Chirayil R, Etchegaray JI, Lucas CD, Puleston DJ, Keshari KR, Perry JSA. Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments. Cell Metab. 2023 Feb 7;35(2):316-331.e6. doi: 10.1016/j.cmet.2022.12.005. Epub 2022 Dec 29. PMID: 36584675; PMCID: PMC9908853.
Walker MR, Goel HL, Mukhopadhyay D, Chhoy P, Karner ER, Clark JL, Liu H, Li R, Zhu JL, Chen S, Mahal LK, Bensing BA, Mercurio AM. O-linked α2,3 sialylation defines stem cell populations in breast cancer. Sci Adv. 2022 Jan 7;8(1):eabj9513. doi: 10.1126/sciadv.abj9513. Epub 2022 Jan 7. PMID: 34995107; PMCID: PMC8741191.
Tello-Lafoz M, de Jesus MM, Huse M. (2022) Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert. Trends Immunol. 43 96-105 [PMID: 34973924]
Wang MS, Hu Y, Sanchez EE, Xie X, Roy NH, de Jesus M, Winer BY, Zale EA, Jin W, Sachar C, Lee JH, Hong Y, Kim M, Kam LC, Salaita K, Huse M. (2022) Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity. Nat Commun. [PMID: 35680882]
Łuksza M, Sethna ZM, Rojas LA, Lihm J, Bravi B, Elhanati Y, Soares K, Amisaki M, Dobrin A, Hoyos D, Guasp P, Zebboudj A, Yu R, Chandra AK, Waters T, Odgerel Z, Leung J, Kappagantula R, Makohon-Moore A, Johns A, Gill A, Gigoux M, Wolchok J, Merghoub T, Sadelain M, Patterson E, Monasson R, Mora T, Walczak AM, Cocco S, Iacobuzio-Donahue C, Greenbaum BD, Balachandran VP. (2022) Neoantigen quality predicts immunoediting in survivors of pancreatic cancer. Nature. [PMID: 35589842]
Mansilla-Soto J, Eyquem J, Haubner S, Hamieh M, Feucht J, Paillon N, Zucchetti AE, Li Z, Sjöstrand M, Lindenbergh PL, Saetersmoen M, Dobrin A, Maurin M, Iyer A, Garcia Angus A, Miele MM, Zhao Z, Giavridis T, van der Stegen SJC, Tamzalit F, Rivière I, Huse M, Hendrickson RC, Hivroz C, Sadelain M. HLA-independent T cell receptors for targeting tumors with low antigen density. Nat Med. 2022 Feb;28(2):345-352. doi: 10.1038/s41591-021-01621-1. Epub 2022 Jan 13. PMID: 35027758; PMCID: PMC9469647
Fernández Maestre I, Chen Y, Naizir B, Neill US. A conversation with Elizabeth Blackburn and Viviane Tabar. J Clin Invest. 2022 Jun 1;132(11):e161661. doi: 10.1172/JCI161661. PMID: 35642637; PMCID: PMC9151708.
Medina-Cano D, Corrigan EK, Glenn RA, Islam MT, Lin Y, Kim J, Cho H, Vierbuchen T. (2022) Rapid and robust directed differentiation of mouse epiblast stem cells into definitive endoderm and forebrain organoids. Development [PMID: 35899604]
Dey SK, Filonov GS, Olarerin-George AO, Jackson BT, Finley LWS, Jaffrey SR. (2022) Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag, Nat Chem Biol. 18 [PMID: 35064247]
Feiner R, Johns E, Antman-Passig M, Irie T, Berisha N, Oved H, Khan D, Witek L, White RM, Heller DA. (2022) Drug-Eluting Rubber Bands for Tissue Ligation. ACS Appl Mater Interfaces. 24. [PMID: 35670525]
Chou C, Zhang X, Krishna C, Nixon BG, Dadi S, Capistrano KJ, Kansler ER, Steele M, Han J, Shyu A, Zhang J, Stamatiades EG, Liu M, Li S, Do MH, Edwards C, Kang DS, Chen CT, Wei IH, Pappou EP, Weiser MR, Garcia-Aguilar J, Smith JJ, Leslie CS, Li MO. (2022) Programme of self-reactive innate-like T cell-mediated. Nature 605. 139-145 [PMID: 35444279]
Nixon BG, Chou C, Krishna C, Dadi S, Michel AO, Cornish AE, Kansler ER, Do MH, Wang X, Capistrano KJ, Rudensky AY, Leslie CS, Li MO. (2022) Cytotoxic granzyme C-expressing ILC1s ontribute to antitumor immunity and neonatal autoimmunity. Sci Immunol. Epub. [PMID: 35394814]
Kansler ER, Dadi S, Krishna C, Nixon BG, Stamatiades EG, Liu M, Kuo F, Zhang J, Zhang X, Capistrano K, Blum KA, Weiss K, Kedl RM, Cui G, Ikuta K, Chan TA, Leslie CS, Hakimi AA, Li MO. (2022) Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies. Nat Immunol. 6; 904-915 [PMID: 35618834]
Sánchez-Rivera FJ, Diaz BJ, Kastenhuber ER, Schmidt H, Katti A, Kennedy M, Tem V, Ho YJ, Leibold J, Paffenholz SV, Barriga FM, Chu K, Goswami S, Wuest AN, Simon JM, Tsanov KM, Chakravarty D, Zhang H, Leslie CS, Lowe SW, Dow LE. Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol. 2022 Jun;40(6):862-873. doi: 10.1038/s41587-021-01172-3. Epub 2022 Feb 14. PMID: 35165384; PMCID: PMC9232935.
Heikamp EB, Henrich JA, Perner F, Wong EM, Hatton C, Wen Y, Barwe SP, Gopalakrishnapillai A, Xu H, Uckelmann HJ, Takao S, Kazansky Y, Pikman Y, McGeehan GM, Kolb EA, Kentsis A, Armstrong SA. (2022) The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML. Blood 894-906 [PMID: 34582559]
Kennedy MC, Lowe SW. (2022) Mutant p53: it’s not all one and the same. (2022) Cell Death Differ Epub [PMID: 35361963]
Li X, Huang CH, Sánchez-Rivera FJ, Kennedy MC, Tschaharganeh DF, Morris JP 4th, Montinaro A, O’Rourke KP, Banito A, Wilkinson JE, Chen CC, Ho YJ, Dow LE, Tian S, Luan W, de Stanchina E, Zhang T, Gray NS, Walczak H, Lowe SW.(2022) A preclinical for assessing antitumor effects and systemic toxicities of cancer drug targets. Proc Natl Acd Sci USA. [PMID: 35442775]
Li X, Huang CH, Sánchez-Rivera FJ, Kennedy MC, Tschaharganeh DF, Morris JP 4th, Montinaro A, O’Rourke KP, Banito A, Wilkinson JE, Chen CC, Ho YJ, Dow LE, Tian S, Luan W, de Stanchina E, Zhang T, Gray NS, Walczak H, Lowe SW. A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2110557119. doi: 10.1073/pnas.2110557119. Epub 2022 Apr 20. PMID: 35442775; PMCID: PMC9169916
Wang E, Pineda JMB, Kim WJ, Chen S, Bourcier J, Stahl M, Hogg SJ, Bewersdorf JP, Han C, Singer ME, Cui D, Erickson CE, Tittley SM, Penson AV, Knorr K, Stanley RF, Rahman J, Krishnamoorthy G, Fagin JA, Creger E, McMillan E, Mak CC, Jarvis M, Bossard C, Beaupre DM, Bradley RK, Abdel-Wahab O. Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia. Cancer Cell. 2023 Jan 9;41(1):164-180.e8. doi: 10.1016/j.ccell.2022.12.002. Epub 2022 Dec 22. PMID: 36563682; PMCID: PMC9839614.
Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, Durham BH, Pavletich TS, Fiala E, Walsh MF, Inoue D, Monette S, Taylor J, Rosen N, McCormick F, Lindsley RC, Castel P, Abdel-Wahab O. (2022) Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation. Cancer Discov. [PMID: 35904492]
Niec RE, Chu T, Schernthanner M, Gur-Cohen S, Hidalgo L, Pasolli HA, Luckett KA, Wang Z, Bhalla SR, Cambuli F, Kataru RP, Ganesh K, Mehrara BJ, Pe’er D, Fuchs E. Lymphatics act as a signaling hub to regulate intestinal stem cell activity. Cell Stem Cell. 2022 Jul 7;29(7):1067-1082.e18. doi: 10.1016/j.stem.2022.05.007. Epub 2022 Jun 20. PMID: 35728595; PMCID: PMC9271639.
Yang D, Cho H, Tayyebi Z, Shukla A, Luo R, Dixon G, Ursu V, Stransky S, Tremmel DM, Sackett SD, Koche R, Kaplan SJ, Li QV, Park J, Zhu Z, Rosen BP, Pulecio J, Shi ZD, Bram Y, Schwartz RE, Odorico JS, Sidoli S, Wright CV, Leslie CS, Huangfu D. (2022) CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction. Nat Cell Biol. 7 1064-1076
McGary LHF, Vardhana SA. (2022) Vive la Résistance: T-cell Immunity in the Protection against SARS-CoV-2 Infection. Cancer Discov. 12 892-894 [PMID: 35373282]
Lopez A, Reyna DE, Gitego N, Kopp F, Zhou H, Miranda-Roman MA, Nordstrøm LU, Narayanagari SR, Chi P, Vilar E, Tsirigos A, Gavathiotis E. (2022) Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer. Nat Commun. 13 [PMID: 35256598]
Yan J, Chen Y, Patel AJ, Warda S, Lee CJ, Nixon BG, Wong EW, Miranda-Román MA, Yang N, Wang Y, Pachai MR, Sher J, Giff E, Tang F, Khurana E, Singer S, Liu Y, Galbo PM Jr, Maag JL, Koche RP, Zheng D, Antonescu C, Deng L, Li M, Chen Y, Chi P. (2022) Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic therapeutic viruses. J Clin Invest. [PMID: 35852856]
Patel AJ, Warda S, Maag JLV, Misra R, Miranda-Roman MA, Pachai MR, Lee CJ, Li D, Wang N, Bayshtok G, Fishinevich E, Meng Y, Wong EWP, Yan J, Giff E, Pappalardi MB, McCabe MT, Fletcher JA, Rudin CM, Chandarlapaty S, Scandura JM, Koche RP, Glass JL, Antonescu CR, Zheng D, Chen Y, Chi P. (2022)PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry. Cancer Discov. [PMID: 35789380]
Yan J, Chen Y, Patel AJ, Warda S, Lee CJ, Nixon BG, Wong EW, Miranda-Román MA, Yang N, Wang Y, Pachai MR, Sher J, Giff E, Tang F, Khurana E, Singer S, Liu Y, Galbo PM Jr, Maag JL, Koche RP, Zheng D, Antonescu CR, Deng L, Li MO, Chen Y, Chi P. Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses. J Clin Invest. 2022 Sep 1;132(17):e153437. doi: 10.1172/JCI153437. PMCID: PMC9433107 [PMID: 35852856]
Nguyen EM, Taniguchi H, Chan JM, Zhan YA, Chen XP, Qiu J, de Stanchina E, Allaj V, Shah N, Uddin F, Manoj P, Liu M, Cai SF, Levine R, Quintanal-Villalonga A, Sen T, Chow A and Rudin CM. Targeting Lysine-Specific Demethylase 1 rescues MHC-I antigen presentation and overcomes PD-L1 blockade resistance in small cell lung cancer. J Thorac. Oncol. 2022, 17(8): 1014-1031 [PMID: 35691495]
Taniguchi H, Caesar R, Chavan SS, Zhan YA, Chow A, Manoj P, Uddin F, Kitai H, Qu R, Hayatt O, Shah N, Quintanal-Villalonga A, Nguyen EM, Chan JM, Michel A, Mukae H, de-Stanchina E, Rudin CM and Sen T. WEE1 inhibition enhances antitumor immune response to PD-L1 blockade by concomitant activation of STING and STAT1 pathways in small cell lung cancer. Cell Rep. 2022, 39(7): 110814.
Lellupitiyage SS., Mas-Rosario JA, Lin HH, Nguyen EM, Taylor S R, Farkas, M. E. “Macrophage Circadian Rhythms are Differentially Affected Based on Stimuli.” Integr Biol. 2022, 14(3):62-75
Docampo MD, da Silva MB, Lazrak A, Nichols KB, Lieberman SR, Slingerland AE, Armijo GK, Shono Y, Nguyen C, Monette S, Dwomoh E, Lee N, Geary CD, Perobelli SM, Smith M, Markey KA, Vardhana SA, Kousa AI, Zamir E, Greenfield I, Sun JC, Cross JR, Peled JU, Jenq RR, Stein-Thoeringer CK, van den Brink MRM. (2022) Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease Blood. [PMID: 34653248]
Paffenholz SV, Salvagno C, Ho YJ, Limjoco M, Baslan T, Tian S, Kulick A, de Stanchina E, Wilkinson JE, Barriga FM, Zamarin D, Cubillos-Ruiz JR, Leibold J, Lowe SW. (2022) Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer. Proc Natl Acad Sci USA. [PMID: 35082152]
Sánchez-Rivera FJ, Diaz BJ, Kastenhuber ER, Schmidt H, Katti A, Kennedy M, Tem V, Ho YJ, Leibold J, Paffenholz SV, Barriga FM, Chu K, Goswami S, Wuest AN, Simon JM, Tsanov KM, Chakravarty D, Zhang H, Leslie CS, Lowe SW, Dow LE. (2022) Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol. [PMID: 35165384]
Taylor J, Mi X, Penson AV, Paffenholz SV, Alvarez K, Sigler A, Chung SS, Rampal RK, Park JH, Stein EM, Tallman MS, Sen F, Gönen M, Abdel-Wahab O, Klimek VM. Safety and activity of selinexor in patients with myelodysplastic syndromes or oligoblastic acute myeloid leukaemia refractory to hypomethylating agents: a single-centre, single-arm, phase 2 trial. Lancet Haematol. 2020 Aug;7(8):e566-e574. doi: 10.1016/S2352-3026(20)30209-X. PMID: 32735836; PMCID: PMC9209897.
Paffenholz P, Peine A, Hellmich M, Paffenholz SV, Martin L, Luedde M, Haverkamp M, Roderburg C, Marx G, Heidenreich A, Trautwein C, Luedde T, Loosen SH. Perception of the 2020 SARS-CoV-2 pandemic among medical professionals in Germany: results from a nationwide online survey. Emerg Microbes Infect. 2020 Dec;9(1):1590-1599. doi: 10.1080/22221751.2020.1785951. PMID: 32573350; PMCID: PMC7473195.
Regan-Mochrie G, Hoggard T, Bhagwat N, Lynch G, Hunter N, Remus D, Fox CA, Zhao X. Yeast ORC sumoylation status fine-tunes origin licensing. Genes Dev. 2022 Aug 4;36(13-14):807–21. doi: 10.1101/gad.349610.122. PMCID: PMC9480853.
Stahl M, Derkach A, Farnoud N, Bewersdorf JP, Robinson T, Famulare C, Cho C, Devlin S, Menghrajani K, Patel MA, Cai SF, Miles LA, Bowman RL, Geyer MB, Dunbar A, Epstein-Peterson ZD, McGovern E, Schulman J, Glass JL, Taylor J, Viny AD, Stein EM, Getta B, Arcila ME, Gao Q, Barker J, Shaffer BC, Papadopoulos EB, Gyurkocza B, Perales MA, Abdel-Wahab O, Levine RL, Giralt SA, Zhang Y, Xiao W, Pai N, Papaemmanuil E, Tallman MS, Roshal M, Goldberg AD. (2022) Molecular predictors of immunophenotypic measurable residual disease clearance in acute myeloid leukemia. Am J Hematol [PMID: 36251406]
Schwer B, Garg A, Sanchez AM, Bernstein MA, Benjamin B, Shuman S. (2022) Cleavage-Polydenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast. mBio. doi: 10.1128/mbio.03476-21.
Sanchez AM, Jacewicz A, Shuman S. (2022) Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate. J Biol Chem.
Schwer B, Garg A, Sanchez AM, Bernstein MA, Benjamin B, Shuman S. (2022) Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast. mBio 13. [PMID: 35012333]
Schonbrun AR, Resh MD. (2022) Hedgehog acyltransferase catalyzes a random sequential reaction and utilizes multiple fatty acyl-CoA substrates. J Biol Chem. 298 (10). [PMID: 36030053]
Schonbrun AR, Resh MD. A Direct in vitro Fatty Acylation Assay for Hedgehog Acyltransferase. Bio Protoc. 2022 Dec 20;12(24):e4573. doi: 10.21769/BioProtoc.4573. PMID: 36618094; PMCID: PMC9797357.
Shen Z, Belcheva KT, Jelcic M, Hui KL, Katikaneni A, Niethammer P. (2022) A synergy between mechanosensitive calcium- and membrane-binding mediates tension-sensing by C2-like domains. Pro Natl Acad Sci USA. [PMID: 34969839]
Shen Z, Lengyel M, Niethammer P. (2022) The yellow brick road to nuclear membrane mechanotransduction. APL Bioeng [PMID: 35382443]
Chowell D, Yoo SK, Valero C, Pastore A, Krishna C, Lee M, Hoen D, Shi H, Kelly DW, Patel N, Makarov V, Ma X, Vuong L, Sabio EY, Weiss K, Kuo F, Lenz TL, Samstein RM, Riaz N, Adusumilli PS, Balachandran VP, Plitas G, Ari Hakimi A, Abdel-Wahab O, Shoushtari AN, Postow MA, Motzer RJ, Ladanyi M, Zehir A, Berger MF, Gönen M, Morris LGT, Weinhold N, Chan TA. (2022) Improved prediction of immune checkpoint blockade efficacy across multiple cancer types. Nat Biotechnol. [PMID: 34725502]
Nacev BA, Sanchez-Vega F, Smith SA, Antonescu CR, Rosenbaum E, Shi H, Tang C, Socci ND, Rana S, Gularte-Mérida R, Zehir A, Gounder MM, Bowler TG, Luthra A, Jadeja B, Okada A, Strong JA, Stoller J, Chan JE, Chi P, D’Angelo SP, Dickson MA, Kelly CM, Keohan ML, Movva S, Thornton K, Meyers PA, Wexler LH, Slotkin EK, Glade Bender JL, Shukla NN, Hensley ML, Healey JH, La Quaglia MP, Alektiar KM, Crago AM, Yoon SS, Untch BR, Chiang S, Agaram NP, Hameed MR, Berger MF, Solit DB, Schultz N, Ladanyi M, Singer S, Tap WD. (2022) Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets. Nat Commun. [PMID: 35705560]
Fernandez KC, Feeney L, Smolkin RM, Yen WF, Matthews AJ, Alread W, Petrini JHJ, Chaudhuri J. (2022) The structure-selective endonucleases GEN 1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes. Elife [PMID: 36190107]
Remsik J, Saadeh F, Tong X, Li MJ, Snyder J, Bale T, Wu J, Derderian C, Guber D, Chi Y, Murali R, Boire A. (2021) Characterization, isolation, and in vitro culture of leptomeningeal fibroblasts. J Neuroimmunol. [PMID: 34688068]
Arora K, Tran TN, Kemel Y, Mehine M, Liu YL, Nandakumar S, Smith SA, Brannon AR, Ostrovnaya I, Stopsack KH, Razavi P, Safonov A, Rizvi HA, Hellmann MD, Vijai J, Reynolds TC, Fagin JA, Carrot-Zhang J, Offit K, Solit DB, Ladanyi M, Schultz N, Zehir A, Brown CL, Stadler ZK, Chakravarty D, Bandlamudi C, Berger MF. (2022) Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort Cancer Discov. doi: 10.1158/2159-8290. [PMID: 36048199]
Waarts MR, Stonestrom AJ, Park YC, Levine RL. (2022) Targeting mutations in cancer. J Clin Invest [PMID: 35426374]
van der Veeken J, Campbell C, Pritykin Y, Schizas M, Verter J, Hu W, Wang ZM, Matheis F, Mucida D, Charbonnier LM, Chatila TA, Rudensky AY. (2022) Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells. Immunity. [PMID: 35700740]
Yan J, Huangfu D. Epigenome rewiring in human pluripotent stem cells. Trends Cell Biol. 2022 Mar;32(3):259-271. doi: 10.1016/j.tcb.2021.12.001. Epub 2021 Dec 23. PMID: 34955367; PMCID: PMC8840982.
Szeglin BC, Wu C, Marco MR, Park HS, Zhang Z, Zhang B, Garcia-Aguilar J, Beauchamp RD, Chen XS, Smith JJ. (2022) A SMAD4-modulated gene profile predicts disease-free survival in stage II and III colorectal cancer. Cancer Rep. Epub 2021 [PMID: 34114372]
2021
Adams NM, Diaz-Salazar C, Dang C, Lanier LL, Sun JC. (2021) Cutting Edge: Heterogeneity in Cell Age Contributes to Functional Diversity of NK Cells. J Immunol. 206, 465-470 [PMID: 33443057]
Lyczek A, Berger BT, Rangwala AM, Paung Y, Tom J, Philipose H, Guo J, Albanese SK, Robers MB, Knapp S, Chodera JD, Seeliger MA. (2021) Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance. Proc Natl Acad Scie USA. [PMID: 34750265]
Boehm KM, Khosravi P, Vanguri R, Gao J, Shah SP. (2021) Harnessing multimodal data integration to advance precision oncology. Nat Rev Cancer doi: 10.1038/s41568-021-00408-3. [PMID: 34663944]
Mukherjee R, Vanaja KG, Boyer JA, Gadal S, Solomon H, Chandarlapaty S, Levchenko A, Rosen N. (2021) Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis. Mol Cell 84, 708-723. [PMID: 33606974]
Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N. (2021) Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth. Nat Chem Biol. [PMID: 34168367]
Benjamin B, Sanchez AM, Garg A, Schwer B, Shuman S. (2021) Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22. PloS Genet. e1009452. [PMID: 33711009]
Baggiolini A, Callahan SJ, Montal E, Weiss JM, Trieu T, Tagore MM, Tischfield SE, Walsh RM, Suresh S, Fan Y, Campbell NR, Perlee SC, Saurat N, Hunter MV, Simon-Vermot T, Huang TH, Ma Y, Hollmann T, Tickoo SK, Taylor BS, Khurana E, Koche RP, Studer L, White RM. (2021) Developmental chromatin programs determine oncogenic competence in melanoma. Science. [PMID: 34516843]
Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP 4th, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan W, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe’er D, Lowe SW. (2021) A gene-enviroment-induced epigenetic program initiates tumorigenesis. Nature 590, 642-648 [PMID: 33536616]
Sun D, Xie XP, Zhang X, Wang Z, Sait SF, Iyer SV, Chen YJ, Brown R, Laks DR, Chipman ME, Shern JF, Parada LF. (2021) Stem-like cells drive NF1-associated MPNST functional heterogeneity and tumor progression. Cell Stem Cell.[PMID: 34010628]
Zappasodi R, Serganova I, Cohen IJ, Maeda M, Shindo M, Senbabaoglu Y, Watson MJ, Leftin A, Maniyar R, Verma S, Lubin M, Ko M, Mane MM, Zhong H, Liu C, Ghosh A, Abu-Akeel M, Ackerstaff E, Koutcher JA, Ho PC, Delgoffe GM, Blasberg R, Wolchok JD, Merghoub T. (2021) CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours. Nature[PMID: 33588426]
Wiedemann GM, Santosa EK, Grassmann S, Sheppard S, Le Luduec JB, Adams NM, Dang C, Hsu KC, Sun JC, Lau CM. (2021) Deconvoluting global cytokine signaling networks in natural killer cells. Nat Immunol. 22 627-638 [PMID: 33859404]
Hitchman TD, Bayshtok G, Ceraudo E, Moore AR, Lee C, Jia R, Wang N, Pachai MR, Shoushtari AN, Francis JH, Guan Y, Chen J, Chang MT, Taylor BS, Sakmar TP, Huber T, Chi P, Chen Y. (2021) Combined Inhibition of Gα q and MEK Enhances Therapeutic Efficacy in Uveal Melanoma. Clin Cancer Res. 27 1476-1490 [PMID: 33229459]
Lumaquin D, Johns E, Montal E, Weiss JM, Ola D, Abuhashem A, White RM. (2021) An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish. Elife. 10. [PMID:34114952]
Joseph B, Lai EC. (2021) The Exon Junction Complex and intron removal prevent re-splicing of mRNA. PLos Genet. 17. [PMID: 34033644]
Kan L, Ott S, Joseph B, Park ES, Dai W, Kleiner RE, Claridge-Chang A, Lai EC. (2021) A neural m6A/Ythdf pathway is required for learning and memory in Drosophila. Nat Commun. 12. [PMID: 33674589]
Krishna C, DiNatale RG, Kuo F, Srivastava RM, Vuong L, Chowell D, Gupta S, Vanderbilt C, Purohit TA, Liu M, Kansler E, Nixon BG, Chen YB, Makarov V, Blum KA, Attalla K, Weng S, Salmans ML, Golkaram M, Liu L, Zhang S, Vijayaraghavan R, Pawlowski T, Reuter V, Carlo MI, Voss MH, Coleman J, Russo P, Motzer RJ, Li MO, Leslie CS, Chan TA, Hakimi AA. (2021) Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy. Cancer Cell. 39, 662-677 [PMID: 33861994]
Sheppard S, Santosa EK, Lau CM, Violante S, Giovanelli P, Kim H, Cross JR, Li MO, Sun JC. (2021) Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural keller cell anti-viral and anti-tumor function. Cell Rep. [PMID: 34077737]
Tan KT, Kim H, Carrot-Zhang J, Zhang Y, Kim WJ, Kugener G, Wala JA, Howard TP, Chi YY, Beroukhim R, Li H, Ha G, Alper SL, Perlman EJ, Mullen EA, Hahn WC, Meyerson M, Hong AL. Haplotype-resolved germline and somatic alterations in renal medullary carcinomas. Genome Med. 2021 Jul 14;13(1):114. doi: 10.1186/s13073-021-00929-4. PMID: 34261517; PMCID: PMC8281718.
La Rocca G, King B, Shui B, Li X, Zhang M, Akat K, Ogrodowski P, Mastroleo C, Chen K, Cavalieri V, Ma Y, Anelli V, Betel D, Vidigal J, Tuschl T, Meister G, Thompson CB, Lindsten T, Haigis K, Ventura A. (2021) Inducible and reversible inhinition of miRNA-mediated gene repressin in vivo. Elife. [PMID: 34463618]
Maguire OA, Ackerman SE, Szwed SK, Maganti AV, Marchildon F, Huang X, Kramer DJ, Rosas-Villegas A, Gelfer RG, Turner LE, Ceballos V, Hejazi A, Samborska B, Rahbani JF, Dykstra CB, Annis MG, Luo JD, Carroll TS, Jiang CS, Dannenberg AJ, Siegel PM, Tersey SA, Mirmira RG, Kazak L, Cohen P. Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. Cell Metab. 2021 Mar 2;33(3):499-512.e6. doi: 10.1016/j.cmet.2021.01.018. Epub 2021 Feb 16. PMCID: PMC7954401
Campbell NR, Rao A, Hunter MV, Sznurkowska MK, Briker L, Zhang M, Baron M, Heilmann S, Deforet M, Kenny C, Ferretti LP, Huang TH, Perlee S, Garg M, Nsengimana J, Saini M, Montal E, Tagore M, Newton-Bishop J, Middleton MR, Corrie P, Adams DJ, Rabbie R, Aceto N, Levesque MP, Cornell RA, Yanai I, Xavier JB, White RM. (2021) Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation. Dev Cell. [PMID: 34529939]
Garg A, Sanchez AM, Schwer B, Shuman S. Transcriptional profiling of fission yeast RNA polymerase II CTD mutants. RNA. 2021 Feb 12;27(5):560–70. doi: 10.1261/rna.078682.121. Epub ahead of print. PMID: 33579781; PMCID: PMC8051263.
Yaari Z, Yang Y, Apfelbaum E, Cupo C, Settle AH, Cullen Q, Cai W, Long Roche K, Levine DA, Fleisher M, Ramanathan L, Zheng M, Jagota A, Heller DA. A perception-based nanosensor platform to detect cancer biomarkers. Sci Adv. 2021 Nov 19;7(47):eabj0852. doi: 10.1126/sciadv.abj0852. Epub 2021 Nov 19. PMID: 34797711; PMCID: PMC8604403.
Chow A, Schad S, Green MD, Hellmann MD, Allaj V, Ceglia N, Zago G, Shah NS, Sharma SK, Mattar M, Chan J, Rizvi H, Zhong H, Liu C, Bykov Y, Zamarin D, Shi H, Budhu S, Wohlhieter C, Uddin F, Gupta A, Khodos I, Waninger JJ, Qin A, Markowitz GJ, Mittal V, Balachandran V, Durham JN, Le DT, Zou W, Shah SP, McPherson A, Panageas K, Lewis JS, Perry JSA, de Stanchina E, Sen T, Poirier JT, Wolchok JD, Rudin CM, Merghoub T. (2021) Tim-4 + cavity-resident macrophages impair anti-tumor CD8 + T cell immunity. Cancer Cell. 39, 973-988. [PMID: 34115989]
Kemeny NE, Chou JF, Capanu M, Chatila WK, Shi H, Sanchez-Vega F, Kingham TP, Connell LC, Jarnagin WR, D’Angelica MI. A Randomized Phase II Trial of Adjuvant Hepatic Arterial Infusion and Systemic Therapy With or Without Panitumumab After Hepatic Resection of KRAS Wild-type Colorectal Cancer. Ann Surg. 2021 Aug 1;274(2):248-254. doi: 10.1097/SLA.0000000000004923. PMID: 33938493; PMCID: PMC9351589.
Xu K, Yin N, Peng M, Stamatiades EG, Chhangawala S, Shyu A, Li P, Zhang X, Do MH, Capistrano KJ, Chou C, Leslie CS, Li MO. (2021) Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses. Immunity 54. 976-987 [PMID: 33979589]
Funato K, Smith RC, Saito Y, Tabar V. (2021) Dissecting the impact of regional identity and the oncogenic role of human-specific NOTCH2NL in an hESC model of H3.3G34R-mutant glioma. Cell Stem Cell. [PMID: 33631117]
Yewdell WT, Smolkin RM, Belcheva KT, Mendoza A, Michaels AJ, Cols M, Angeletti D, Yewdell JW, Chaudhuri J. (2021) Temporal dynamics of persistent centers and memory B cell differentiation following respiratory virus infection. Cell Rep. [PMID: 34758310]
Dikiy S, Li J, Bai L, Jiang M, Janke L, Zong X, Hao X, Hoyos B, Wang ZM, Xu B, Fan Y, Rudensky AY, Feng Y. (2021) A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance. Immunity. 54, 931-946. [PMID: 33838102]
Hu W, Wang ZM, Feng Y, Schizas M, Hoyos BE, van der Veeken J, Verter JG, Bou-Puerto R, Rudensky AY. (2021) Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity. Nat Immunol. [PMID: 34426690]
Tanaka K, Yu HA, Yang S, Han S, Selcuklu SD, Kim K, Ramani S, Ganesan YT, Moyer A, Sinha S, Xie Y, Ishizawa K, Osmanbeyoglu HU, Lyu Y, Roper N, Guha U, Rudin CM, Kris MG, Hsieh JJ, Cheng EH. (2021) Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis. Cancer Cell. [PMID: 34388376]
Mao N, Zhang Z, Lee YS, Choi D, Rivera AA, Li D, Lee C, Haywood S, Chen X, Chang Q, Xu G, Chen HA, de Stanchina E, Sawyers C, Rosen N, Hsieh AC, Chen Y, Carver BS. (2021) Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers. Nat Commun. [PMID: 34417459]
Humphreys IR, Pei J, Baek M, Krishnakumar A, Anishchenko I, Ovchinnikov S, Zhang J, Ness TJ, Banjade S, Bagde SR, Stancheva VG, Li XH, Liu K, Zheng Z, Barrero DJ, Roy U, Kuper J, Fernández IS, Szakal B, Branzei D, Rizo J, Kisker C, Greene EC, Biggins S, Keeney S, Miller EA, Fromme JC, Hendrickson TL, Cong Q, Baker D. Computed structures of core eukaryotic protein complexes. Science. 2021 Dec10;374(6573):eabm4805. doi: 10.1126/science.abm4805. Epub 2021 Dec 10. PMCID: PMC7612107.
2020
Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman SL, Ponomarev V, Piersigilli A, Sadelain M, Lowe SW; (2020) Senolytic CAR T Cells Reverse Senescence-Associated Pathologies Nature 583. 127-132. [PMID: 32555459]
Leibold J, Ruscetti M, Cao Z, Ho YJ, Baslan T, Zou M, Abida W, Feucht J, Han T, Barriga FM, Tsanov KM, Zamechek L, Kulick A, Amor C, Tian S, Rybczyk K, Salgado NR, Sánchez-Rivera FJ, Watson PA, de Stanchina E, Wilkinson JE, Dow LE, Abate-Shen C, Sawyers CL, Lowe SW; (2020) Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis Cancer Discov. 10 1038-1057. [PMID: 32376773]
Albanese SK, Chodera JD, Volkamer A, Keng S, Abel R, Wang L. (2020) Is Stucture-Based Drug Design Ready for Selectivity Optimization? J Chem Info Model. 2020 10, 1021. [PMID: 33119284]
Guo Y, Kasahara S, Jhingran A, Tosini NL, Zhai B, Aufiero MA, Mills KAM, Gjonbalaj M, Espinosa V, Rivera A, Luster AD, Hohl TM; (2020) During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense Through CXCR3-Dependent Crosstalk Cell Host Microbe. 28, 104-116. [PMID: 32485165]
Boehm KM, Chen J, Trichter S, Abdallah H, Zhuo R, Nowak EJ, Ng J, Swistel AJ. (2020) Characterization of Recurrences Following Second Breast-Conserving Surgery With Intraoperative Radiotherapy Ann Surg Oncol. 5, 1638-1644. [PMID: 31646449]
Zhang Z, Karthaus WR, Lee YS, Gao VR, Wu C, Russo JW, Liu M, Mota JM, Abida W, Linton E, Lee E, Barnes SD, Chen HA, Mao N, Wongvipat J, Choi D, Chen X, Zhao H, Manova-Todorova K, de Stanchina E, Taplin ME, Balk SP, Rathkopf DE, Gopalan A, Carver BS, Mu P, Jiang X, Watson PA, Sawyers CL.(2020) Tumor Microenviroment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer. Cancer Cell [PMID: 32679108]
Wang Z, Sun D, Chen YJ, Xie X, Shi Y, Tabar V, Brennan CW, Bale TA, Jayewickreme CD, Laks DR, Alcantara Llaguno S, Parada LF. Cell Lineage-Based Stratification for Glioblastoma. Cancer Cell. 2020 Sep 14;38(3):366-379.e8. doi: 10.1016/j.ccell.2020.06.003. Epub 2020 Jul 9. PMID: 32649888; PMCID: PMC7494533.
Vorselen D, Wang Y, de Jesus MM, Shah PK, Footer MJ, Huse M, Cai W, Theriot JA. (2020) Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell-target interactions. Nat Commun 11, PMCID:PMC6946705 [PMID: 31911639]
Ceraudo E, Horioka M, Mattheisen JM, Hitchman TD, Moore AR, Kazmi MA, Chi P, Chen Y, Sakmar TP, Huber T.(2020) Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling. J Biol Chem. [PMID: 33288675]
Su J, Morgani SM, David CJ, Wang Q, Er EE, Huang YH, Basnet H, Zou Y, Shu W, Soni RK, Hendrickson RC, Hadjantonakis AK, Massague J. (2020) TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1. Nature. 578. [PMID: 31915377]
Hulton, C.H., Costa, E.A., Shah, N.S. et al. Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapid in vivo functional genomics. (2020) Nat Cancer 1, 359–369 (2020). doi.org/10.1038/s43018-020-0040-8
Brooks ER, Islam MT, Anderson KV, Zallen JA. Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure. (2020) Elife [PMID: 33103996]
Jelcic M, Wang K, Hui KL, Cai XC, Enyedi B, Luo M, Niethammer P.(2020) A Photoclickable ATP-Mimetic Reveals Nucleaotide Interactors in the Membrane Proteome. Cell Chem Biol. [PMID: 32521230]
Katikaneni A, Jelcic M, Gerlach GF, Ma Y, Overholtzer M, Niethammer P. (2020) Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish. Nat Cell Biol. [PMID: 32868902]
Ganesh K, Basnet H, Kaygusuz Y, Laughney AM, He L, Sharma R, O’Rourke KP, Reuter VP, Huang YH, Turkekul M, Emrah E, Masilionis I, Manova-Todorova K, Weiser MR, Saltz LB, Garcia-Aguilar J, Koche R, Lowe SW, Pe’er D, Shia J, Massagué J. (2020) L1CAM defines tge regenerative origin of metastatis0-initiating cells in colorectal cancer. Nat.Cancer 28-45 [PMID: 32656539]
Gjonbalaj M, Keith JW, Do MH, Hohl TM, Pamer EG, Becattini S. Antibiotic degradation by commensal microbes shields pathogens.(2020) Infect Immun., pii: IAI.00012-20[PMID: 31964746]
Keith J, Dong Q, Sorbara MT, Becattini S, Sia JK, Gjonbalaj M, Seok R, Leiner I, Littmann E, Pamer EG. (2020) Impact of antibiotic-resistant bacteria in the mouse intestine on immune activation and Clostridioides difficile infection. Infect Immun., pii: IAI.00362-19. [PMID: 31907198]
Kuhn NF, Lopez AV, Li X, Cai W, Daniyan AF, Brentjens RJ. (2020) CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.Nat Commun. 11. 6171. [PMID: 33268774]
Li X, Pritykin Y, Concepcion CP, Lu Y, La Rocca G, Zhang M, King B, Cook PJ, Au YW, Popow O, Paulo JA, Otis HG, Mastroleo C, Ogrodowski P, Schreiner R, Haigis KM, Betel D, Leslie CS, Ventura A. (2020) High-Resolution in Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down. Mol Cell. doi: 10.1016/j.molcel.2020.05.009. [PMID: 32497496]
Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan CH, Singh RK, Apken LH, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP 4th, Askan G, Grbovic-Huezo O, Ogrodowski P, Bermeo J, Saglimbeni J, Cruz CD, Ho YJ, Lawrence SA, Melchor JP, Goda GA, Bai K, Pastore A, Hogg SJ, Raghavan S, Bailey P, Chang DK, Biankin A, Shroyer KR, Wolpin BM, Aguirre AJ, Ventura A, Taylor B, Der CJ, Dominguez D, Kümmel D, Oeckinghaus A, Lowe SW, Bradley RK, Abdel-Wahab O, Leach SD. (2020) Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer. Cancer Cell. 20. doi: 10.1016/j.ccell.2020.05.010 [PMID: 32559497]
Nguyen CL, Docampo MD, van den Brink MR, Markey KA. The role of the intestinal microbiota in allogeneic HCT: clinical associations and preclinical mechanisms. (2020) Curr opin Genet Dev.[PMID: 33388483]
Riegman M, Sagie L, Galed C, Levin T, Steinberg N, Dixon SJ, Wiesner U, Bradbury MS, Niethammer P, Zaritsky A, Overholtzer M. (2020) Ferrotosis occurs through an osmotic mechanism and propagates independently of cell rupture. Nat Cell Biol. 9, 1042-1048. [PMID: 32868903]
Sanchez AM, Garg A, Shuman S, Schwer B (2020) Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3’ processing and transcription termination that functions via its effects on CTD phosphatase Ssu72. Nucleic Acids Res. 48 4811-4826 [PMID: 32282918]
Schwer B, Sanchez AM, Shuman S. (2020) Inactivation of fission yeast Erh1 de-represses pho1 expression: evidence that Erh1 is a negative regulator of prt lncRNA termination. RNA 10. 1334-1344 [PMID: 32546512]
Santich BH, Park JA, Tran H, Guo HF, Huse M, Cheung NV (2020) Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies.Sci Transi Med. 534, pii: eaax1315 [PMID: 32161106]
Shen Z, Niethammer P. (2020) A cellular sense of space and pressure. Science.370 295-296
Gao T, Ptashkin R, Bolton KL, Sirenko M, Fong C, Spitzer B, Menghrajani K, Ossa JEA, Zhou Y, Bernard E, Levine M, Martinez JSM, Zhang Y, Franch-Expósito S, Patel M, Braunstein LZ, Kelly D, Yabe M, Benayed R, Caltabellotta NM, Philip J, Paraiso E, Mantha S, Solit DB, Diaz LA Jr, Berger MF, Klimek V, Levine RL, Zehir A, Devlin SM, Papaemmanuil E. (2020) Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis. Nat Commun. 12. 338. [PMID: 33436578]
Temprine K, Campbell NR, Huang R, Langdon EM, Simon-Vermot T, Mehta K, Clapp A, Chipman M, White RM. (2020) Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance. Science Signal. [PMID: 32345725]
Tischler BY, Tosini NL, Cramer RA, Hohl TM. (2020) Platelets are critical for survival and tissue integrity during murine pulmonary Aspergillus fumigatus infection. Plos Pathog. 5 [PMID: 32407390]
Xiao W, Chan A, Waarts MR, Mishra T, Liu Y, Cai SF, Yao J, Gao Q, Bowman RL, Koche RP, Csete IS, DelGaudio NL, Derkach A, Baik J, Yanis S, Famulare CA, Patel M, Arcila ME, Stahl M, Rampal R, Tallman MS, Zhang Y, Dogan A, Goldberg AD, Roshal M, Levine RL. (2020) Plasmacytoid dendritic cell expansion defines a distinct subset of TUNX1 mutated acute myeloid leukemia. Blood. [PMID: 32871587]
van der Veeken J, Glasner A, Zhong Y, Hu W, Wang ZM, Bou-Puerto R, Charbonnier LM, Chatila TA, Leslie CS, Rudensky AY. The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries. Immunity. 2020 Nov 17;53(5):971-984.e5. doi: 10.1016/j.immuni.2020.10.010. Epub 2020 Nov 10. PMID: 33176163; PMCID: PMC8363055.
Whalen JM, Dhingra N, Wei L, Zhao X, Freudenreich CH. (2020) Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association.Cell Rep.doi: 10.1016/j.celrep.2020.107635. [PMID: 32402281]
Amodio V, Yaeger R, Arcella P, Cancelliere C, Lamba S, Lorenzato A, Arena S, Montone M, Mussolin B, Bian Y, Whaley A, Pinnelli M, Murciano-Goroff YR, Vakiani E, Valeri N, Liao WL, Bhalkikar A, Thyparambil S, Zhao HY, de Stanchina E, Marsoni S, Siena S, Bertotti A, Trusolino L, Li BT, Rosen N, Di Nicolantonio F, Bardelli A, Misale S. (2020) Cancer Discov. [PMID: 32430388]
Zhang Z, Zhou C, Li X, Barnes SD, Deng S, Hoover E, Chen CC, Lee YS, Zhang Y, Wang C, Metang LA, Wu C, Tirado CR, Johnson NA, Wongvipat J, Navrazhina K, Cao Z, Choi D, Huang D, Huang CH, Linton E, Chen X, Liang Y, Mason CE, de Stanchina E, Abida W, Lujambio A, Li S, Lowe SW, Mendell JT, Malladi VS, Sawyers CL, Mu P. (2020) Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation. Cancer Cell 34, 584-598 [PMID: 32220301]
Mao N, Gao D, Hu W, Gadal S, Hieronymus H, Wang S, Sullivan P, Zhang Z, Choi D, Rosen N, Sawyers CL, Gopalan A, Chen Y, Carver BS. (2020) Oncogenic ERG represses PI3K signaling through down-regulation of IRS2. Cancer Res. pii: canres.1394.2019 [PMID: 32015092]
2019
Adams NM, Geary CD, Santosa EK, Lumaquin D, Le Luduec JB, Sottile R, van der Ploeg K, Hsu J, Whitlock BM, Jackson BT, Weizman OE, Huse M, Hsu KC, Sun JC. (2019) Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells. Immunity. pii: S1074-7613(19)30189-X. [PMID: 31103381]
Dong H, Adams NM, Xu Y, Cao J, Allan DSJ, Carlyle JR, Chen X, Sun JC, Glimcher LH; (2019) The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc. Nat Immunol. PMCID: PMC6588410. [PMID: 31086333]
Weizman OE, Song E, Adams NM, Hildreth AD, Riggan L, Krishna C, Aguilar OA, Leslie CS, Carlyle JR, Sun JC, O’Sullivan TE. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nat Immunol. 2019 Aug;20(8):1004-1011. doi: 10.1038/s41590-019-0430-1. Epub 2019 Jul 1. PMID: 31263280; PMCID: PMC6697419.
Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A, Schurer A, Park SM, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, Passarelli MC, Fairchild L, Adura C, Glickman JF, Schulman J, Famulare C, Patel M, Eibl JK, Ross GM, Bhattacharya S, Tan DS, Leslie CS, Beuming T, Patel DJ, Goldgur Y, Chodera JD, Kharas MG; (2019) Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nat Commun. 10, 2691. PMCID:PMC6584500. [PMID: 31217428]
Vardhana SA, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Fontaine CC, Thompson CB, Finley LWS (2019) Glutamine independence is a selectable feature of pluripotent stem cells. Nat Metab. 1, 676-687. PMCID: PMC6737941 [PMID: 31511848]
Boehm KM, Bhinder B, Raja VJ, Dephoure N, Elemento O. Predicting peptide presentation by major histocompatibility complex class I: an improved machine learning approach to the immunopeptidome. BMC Bioinformatics. 2019 Jan 5;20(1):7. doi: 10.1186/s12859-018-2561-z. PMID: 30611210; PMCID: PMC6321722.
Osmanbeyoglu HU, Shimizu F, Rynne-Vidal A, Alonso-Curbelo D, Chen HA, Wen HY, Yeung TL, Jelinic P, Razavi P, Lowe SW, Mok SC, Chiosis G, Levine DA, Leslie CS. (2019) Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers. Nat Commun. 10, 4369. PMCID: PMC6761109 [PMID: 31554806]
Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z, Xie X, Sun D, Chen YJ, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF. (2019) Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. doi: 10.1038/s41586-019-0993-x.[PMID: 30842654]
Hamieh M, Dobrin A, Cabriolu A, van der Stegen SJC, Giavridis T, Mansilla-Soto J, Eyquem J, Zhao Z, Whitlock BM, Miele MM, Li Z, Cunanan KM, Huse M, Hendrickson RC, Wang X, Rivière I, Sadelain M. (2019) CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape. Nature. 568, 112-116. [PMID: 30918399]
Lee Y, Hamann JC, Pellegrino M, Durgan J, Domart MC, Collinson LM, Haynes CM, Florey O, Overholtzer M. (2019) Entosis Controls a Developmental Cell Clearance in C. elegans. Cell Rep. 26, 3212-3220. [PMID: 30893595]
Hamann JC, Kim SE, Overholtzer M. (2019) Methods for the Study of Entotic Cell Death. Methods Mol Biol. 1880, 447-454. [PMID: 30610714]
Taylor J, Sendino M, Gorelick AN, Pastore A, Chang MT, Penson AV, Gavrila EI, Stewart C, Melnik EM, Herrejon Chavez F, Bitner L, Yoshimi A, Lee SC, Inoue D, Liu B, Zhang XJ, Mato AR, Dogan A, Kharas MG, Chen Y, Wang D, Soni RK, Hendrickson RC, Prieto G, Rodriguez JA, Taylor BS, Abdel-Wahab O. (2019) Altered nuclear export signal recognition as a driver of oncogenesis. Cancer Discov. 9, 1452-1467. [PMID: 31285298]
Inoue D, Chew GL, Liu B, Michel BC, Pangallo J, DAvino AR, Hitchman T, North K, Bitner L, Block A, Moore AR, Yoshimi A, Escobar-Hoyos L, Cho H, Penson A, Lu SX, Taylor J, Chen Y, Kadoch C, Abdel-Wahab o, Bradley RK. (2019) Spliceosomal disruption of the non-canonical BAF complex in cancer. Nature.574, 432-436. [PMID: 31597964]
Basnet H, Tian L, Ganesh K, Huang YH, Macalinao DG, Brogi E, Finley LW, Massagué J. (2019) Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization. Elife. 8, pii: e43627. PMCID: PMC6440742.
Huang YH, Hu J, Chen F, Lecomte N, Basnet H, David CJ, Witkin MD, Allen PJ, Leach SD, Hollmann TJ, Iacobuzio-Donahue CA, Massague J. (2019) ID1 mediates escape from TGF-β tumor suppression in pancreatic cancer. Cancer Discov. [PMID: 31582374]
Jelcic M, Enyedi B, Niethammer P. (2019) Quantitative Imaging of Endogenous and Exogenous H2O2 Gradients in Live Zebrafish Larvae. Methods Mol Biol. 1982 , 283-299. [PMID: 31172479]
Kansler ER, Li MO. (2019) Innate lymphocytes-lineage, localization and timing of differentiation. Cell Mol Immunol. doi: 10.1038/s41423-019-0211-7 [PMID: 30804475]
Karasu ME, Bouftas N, Keeney S, Wassmann K. (2019) Cyclin B3 promotes anaphase I onset in oocyte meiosis. J Cell Biol. 218, 1265-1281. PMCID: PMC6446836. [PMID: 30723090]
Karasu ME, Keeney S. Cyclin B3 is dispensable for mouse spermatogenesis. Chromosoma. 2019 Sep;128(3):473-487. doi: 10.1007/s00412-019-00725-5. Epub 2019 Aug 24. PMID: 31446450; PMCID: PMC6824995.
Boekhout M, Karasu ME, Wang J, Acquaviva L, Pratto F, Brick K, Eng DY, Xu J, Camerini-Otero RD, Patel DJ, Keeney S. (2019) REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks. Mol Cell. pii: S1097-2765(19)30227-8.[PMID: 31003867]
Loizou E, Banito A, Livshits G, Ho YJ, Koche RP, Sanchez-Rivera FJ, Mayle A, Chen CC, Kinalis S, Bagger FO, Kastenhuber ER, Durham BH, Lowe SW. (2019) A gain-of-function p53 mutant oncogene promotes cell fate plasticity and myeloid leukemia through the pluripotency factor Foxh1. Cancer Discov. pii: CD-18-1391 [PMID: 31068365]
Dinh TA, Jewell ML, Kanke M, Francisco A, Sritharan R, Turnham RE, Lee S, Kastenhuber ER, Wauthier E, Guy CD, Yeung RS, Lowe SW, Reid LM, Scott JD, Diehl AM, Sethupathy P. (2019) MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma. Cell Mol Gastroenterol Hepatol. 7, 803-817. PMID: 30763770. [PMCID: PMC6468197]
Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D’Alessandro A, Lowe SW, Prives C. (2019) p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 176, 564-580. PMCID: PMC6483089. [PMID: 30580964]
Konopacki C, Pritykin Y, Rubtsov Y, Leslie CS, Rudensky AY. (2019) Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function. Nat Immunol. 20, 232-242. [PMID: 30643266]
Kuhn NF, Purdon TJ, van Leeuwen DG, Lopez AV, Curran KJ, Daniyan AF, Brentjens RJ; (2019) CD40 Ligand-Modified Chimeric Antigen Receptor T Cells Enhance Antitumor Function by Eliciting an Endogenous Antitumor Response.Cancer Cell. 35, 473-488. PMCID: PMC6428219. [PMID: 30889381]
Li QV, Dixon G, Verma N, Rosen BP, Gordillo M, Luo R, Xu C, Wang Q, Soh CL, Yang D, Crespo M, Shukla A, Xiang Q, Dündar F, Zumbo P, Witkin M, Koche R, Betel D, Chen S, Massagué J, Garippa R, Evans T, Beer MA, Huangfu D. (2019) Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Nat Genet. 51, 999-1010. [PMID: 31110351]
Li QV, Rosen BP, Huangfu D. Decoding pluripotency: Genetic screens to interrogate the acquisition, maintenance, and exit of pluripotency. Wiley Interdiscip Rev Syst Biol Med. 2020 Jan;12(1):e1464. doi: 10.1002/wsbm.1464. Epub 2019 Aug 13. PMID: 31407519; PMCID: PMC6898739.
Lee K, Cho H, Rickert RW, Li QV, Pulecio J, Leslie CS, Huangfu D. FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation. Cell Rep. 2019 Jul 9;28(2):382-393.e7. doi: 10.1016/j.celrep.2019.06.034. PMID: 31291575; PMCID: PMC6636862.
Li X, Ventura A. (2019) ALK7 Erects a Suppressive Barrier to Tumor Progression and Metastasis. Dev Cell. 49, 304-305. [PMID: 31063746]
Basnet H, Tian L, Ganesh K, Huang YH, Macalinao DG, Brogi E, Finley LW, Massagué J. (2019) Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization. Elife. 8, pii: e43627. PMCID: PMC6440742. [PMID: 30912515]
Yen WF, Sharma R, Cols M, Lau CM, Chaudhry A, Chowdhury P, Yewdell WT, Vaidyanathan B, Sun A, Coffre M, Pucella JN, Chen CC, Jasin M, Sun JC, Rudensky AY, Koralov SB, Chaudhuri J. (2019) Distinct Requirements of CHD4 during B Cell Development and Antibody Response. Cell Rep. 27, 1472-1486. [PMID: 31042474]
Pucella JN, Cols M, Yen WF, Xu S, Chaudhuri J. (2019) The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses. J Immunol. pii: ji1800071. [PMID: 30683701]
Riegman M, Bradbury MS, Overholtzer M. (2019) Population Dynamics in Cell Death: Mechanisms of Propagation. Trends Cancer. 5, 558-568. [PMID: 31474361]
Smith RC, Tabar V. (2019) Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids. Cell Stem Cell . 24, 12-24. PMCID: PMC6516073 [PMID: 30581078]
Phillips RE, Yang Y, Smith RC, Thompson BM, Yamasaki T, Soto-Feliciano YM, Funato K, Liang Y, Garcia-Bermudez J, Wang X, Garcia BA, Yamasaki K, McDonald JG, Birsoy K, Tabar V, Allis CD. (2019) Target identification reveals lanosterol synthase as a vulnerability in glioma. Proc Natl Acad Sci USA. pii: 201820989. [PMID: 30923116]
Nicolas L, Cols M, Smolkin R, Fernandez KC, Yewdell WT, Yen WF, Zha S, Vuong BQ, Chaudhuri J. (2019) Cutting Edge: ATM Influences Germinal Center Integrity. J Immunol. pii: ji1801033.[PMID: 31028119]
Grommes C, Tang SS, Wolfe J, Kaley TJ, Daras M, Pentsova EI, Piotrowski AF, Stone J, Lin A, Nolan CP, Manne M, Codega P, Campos C, Viale A, Thomas AA, Berger MF, Hatzoglou V, Reiner AS, Panageas KS, DeAngelis LM, Mellinghoff IK; (2019) Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma. Blood. 133, 436-445. PMCID: PMC6356986. [PMID: 30567753]
Tischler BY, Hohl TM. (2019) Menacing Mold: Recent Advances in Aspergillus Pathogenesis and Host Defense. J Mol Biol. pii: S0022-2836(19)30176-7. [PMID: 30954573]
Miller AN, Vaisey G, Long SB. (2019) Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin. eLife. 8. pii: e43231. PMCID: PMC6342527. [PMID: 30628889]
Kim SG, Becattini S, Moody TU, Shliaha PV, Littmann ER, Seok R, Gjonbalaj M, Eaton V, Fontana E, Amoretti L, Wright R, Caballero S, Wang ZX, Jung HJ, Morjaria SM, Leiner IM, Qin W, Ramos RJJF, Cross JR, Narushima S, Honda K, Peled JU, Hendrickson RC, Taur Y, van den Brink MRM, Pamer EG. Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus. Nature. 2019 Aug;572(7771):665-669. doi: 10.1038/s41586-019-1501-z. Epub 2019 Aug 21. PMID: 31435014; PMCID: PMC6717508.
Wise HC, Solit DB. Precision Oncology: Three Small Steps Forward. Cancer Cell. 2019 Jun 10;35(6):825-826. doi: 10.1016/j.ccell.2019.05.009. PMID: 31185208; PMCID: PMC7398581.
Woods B, Chen W, Chiu S, Marinaccio C, Fu C, Gu L, Bulic M, Yang Q, Zouak A, Jia S, Suraneni PK, Xu K, Levine RL, Crispino JD, Wen QJ. (2019) Activation of JAK/STAT signaling in megakaryocytes sustains myeloproliferation in vivo. Clin Cancer Res. pii: clincanres.4089.2018. [PMID: 31217200]
Adams EJ, Karthaus WR, Hoover E, Liu D, Gruet A, Zhang Z, Cho H, DiLoreto R, Chhangawala S, Liu Y, Watson PA, Davicioni E, Sboner A, Barbieri CE, Bose R, Leslie CS, Sawyers CL (2019) FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. Nature. doi: 10.1038/s41586-019-1318-9. [PMID: 31243370]
2018
Geary CD, Krishna C, Lau CM, Adams NM, Gearty SV, Pritykin Y, Thomsen AR, Leslie CS, Sun JC. Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection. Cell Rep. 2018 Aug 21;24(8):1949-1957.e6. doi: 10.1016/j.celrep.2018.07.060. PMID: 30134157; PMCID: PMC6153266.
Lau CM, Adams NM, Geary CD, Weizman OE, Rapp M, Pritykin Y, Leslie CS, Sun JC. Epigenetic control of innate and adaptive immune memory. Nat Immunol. 2018 Sep;19(9):963-972. doi: 10.1038/s41590-018-0176-1. Epub 2018 Aug 6. PMID: 30082830; PMCID: PMC6225771.
Seelige R, Saddawi-Konefka R, Adams NM, Picarda G, Sun JC, Benedict CA, Bui JD. Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection. Sci Rep. 2018 Sep 12;8(1):13670. doi: 10.1038/s41598-018-32011-2. PMID: 30209334; PMCID: PMC6135835.
Adams NM, Sun JC. Spatial and temporal coordination of antiviral responses by group 1 ILCs. Immunol Rev. 2018 Nov;286(1):23-36. doi: 10.1111/imr.12710. PMID: 30294970; PMCID: PMC6178831.
Ruff EF, Muretta JM, Thompson AR, Lake EW, Cyphers S, Albanese SK, Hanson SM, Behr JM, Thomas DD, Chodera JD, Levinson NM. (2018) A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation. Elife 7, e32766. [PMID: 29465396]
Intlekofer AM, Shih AH, Wang B, Nazir A, Rustenburg AS, Albanese SK, Patel M, Famulare C, Correa FM, Takemoto N, Durani V, Liu H, Taylor J, Farnoud N, Papaemmanuil E, Cross JR, Tallman MS, Arcila ME, Roshal M, Petsko GA, Wu B, Choe S, Konteatis ZD, Biller SA, Chodera JD, Thompson CB, Levine RL, Stein EM. (2018) Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations. Nature 559, 125-129. [PMID: 29950729]
Hauser K, Negron C, Albanese SK, Ray S, Steinbrecher T, Abel R, Chodera JD, Wang L. (2018) Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations. Commun Biol 1, pii: 70. PMCID: PMC6110136 [PMID: 30159405]
Rajshekar S, Yao J, Arnold PK, Payne SG, Zhang Y, Bowman TV, Schmitz RJ, Edwards JR, Goll M. (2018) Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. Elife. pii: e39658. PMCID: PMC6261255 [PMID: 30484769]
Callahan SJ, Tepan S, Zhang YM, Lindsay H, Burger A, Campbell NR, Kim IS, Hollmann TJ, Studer L, Mosimann C, White RM. (2018) Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). Dis Model Mech. pii: dmm.034561 [PMID: 30061297]
Zhang YM, Zimmer MA, Guardia T, Callahan SJ, Mondal C, Di Martino J, Takagi T, Fennell M, Garippa R, Campbell NR, Bravo-Cordero JJ, White RM. (2018) Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Dev Cell. pii: S1534-5807(18)30357-5[PMID:29804876]
Casey E, Bournazos S, Mo G, Mondello P, Tan KS, Ravetch JV, Scheinberg DA. (2018). A new mouse expressing human Fcγ receptors to better predict therapeutic efficacy of human anti-cancer antibodies. Leukemia. 32, 547-549. PMCID: PMC5803448 [PMID: 28924242]
Ruscetti M, Leibold J, Bott MJ, Fennell M, Kulick A, Salgado NR, Chen CC, Ho YJ, Sanchez-Rivera FJ, Feucht J, Baslan T, Tian S, Chen HA, Romesser PB, Poirier JT, Rudin CM, de Stanchina E, Manchado E, Sherr CJ, Lowe SW. (2018) NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science. 362, 1416-1422. [PMID: 30573629]
Serganova I, Cohen IJ, Vemuri K, Shindo M, Maeda M, Mane M, Moroz E, Khanin R, Satagopan J, Koutcher JA, Blasberg R. (2018) LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response. PLoS One 13, e0203965. [PMID: 30248111]
Feucht J, Sun J, Eyquem J, Ho YJ, Zhao Z, Leibold J, Dobrin A, Cabriolu A, Hamieh M, Sadelain M. (2018) Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency. Nat Med. [PMID: 30559421]
Feng W, Jasin M. (2018) Homologous Recombination and Replication Fork Protection: BRCA2 and More! Cold Spring Harb Symp Quant Biol. pii: 035006. [PMID: 29686033]
Chen CC, Feng W, Lim PX, Kass EM, Jasin M. (2018) Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer. Annu Rev Cancer Biol. 2, 313-336. PMCID: PMC619349. [PMID: 30345412]
Gala K, Li Q, Sinha A, Razavi P, Dorso M, Sanchez-Vega F, Chung YR, Hendrickson R, Hsieh J, Berger M, Schultz N, Pastore A, Abdel-Wahab O, Chandarlapaty S. (2018) KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function. Oncogene. [PMID: 29755131]
Hawk MA, Gorsuch CL, Fagan P, Lee C, Kim SE, Hamann JC, Mason JA, Weigel KJ, Tsegaye MA, Shen L, Shuff S, Zuo J, Hu S, Jiang L, Chapman S, Leevy WM, DeBerardinis RJ, Overholtzer M, Schafer ZT. (2018) RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells. Nat Cell Biol. 20, 272-284. [PMID: 29459781]
Moore AR, Ran L, Guan Y, Sher JJ, Hitchman TD, Zhang JQ, Hwang C, Walzak EG, Shoushtari AN, Monette S, Murali R, Wiesner T, Griewank KG, Chi P, Chen Y. (2018) GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma. Cell Rep. 22, 2455-2468. [PMID: 29490280]
Kavaler J, Duan H, Aradhya R, de Navas LF, Joseph B, Shklyar B, Lai EC. (2018) miRNA suppression of a Notch repressor directs non-neuronal fate in Drosophila mechanosensory organs. J Cell Biol 217, 571-583. PMCID:PMC5800810 [PMID:29196461]
Joseph B, Kondo S, Lai EC. (2018) Short cryptic exons mediate recursive splicing in Drosophila. Nat Struct Ml Biol. 25, 365-371. [PMID: 29632374]
Zafra MP, Schatoff EM, Katti A, Foronda M, Breinig M, Schweitzer AY, Simon A, Han T, Goswami S, Montgomery E, Thibado J, Kastenhuber ER, Sánchez-Rivera FJ, Shi J, Vakoc CR, Lowe SW, Tschaharganeh DF, Dow LE. (2018) Optimized base editors enable efficient editing in cells, organoids and mice. Nat Biotechnol. PMID: 29969439 doi: 10.1038/nbt.4194.
Keith JW, Pamer EG. (2018) Enlisting commensal microbes to resist antibiotic-resistant pathogens. J Exp Med, pii: jem.20180399. [PMID: 30309968]
Klein ME, Kovatcheva M, Davis LE, Tap WD, Koff A. (2018) CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought. Cancer Cell. [PMID: 29731395]
Klein ME, Dickson MA, Antonescu C, Qin LX, Dooley SJ, Barlas A, Manova K, Schwartz GK, Crago AM, Singer S, Koff A, Tap WD. (2018) PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence. Oncogene. [PMID: 29789718]
Azizi E, Carr AJ, Plitas G, Cornish AE, Konopacki C, Prabhakaran S, Nainys J, Wu K, Kiseliovas V, Setty M, Choi K, Fromme RM, Dao P, McKenney PT, Wasti RC, Kadaveru K, Mazutis L, Rudensky AY, Pe’er D. (2018) Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment. Cell, pii: S0092-8674(18)30723-2. PMID: 29961579
Verma N, Pan H, Doré LC, Shukla A, Li QV, Pelham-Webb B, Teijeiro V, González F, Krivtsov A, Chang CJ, Papapetrou EP, He C, Elemento O, Huangfu D. (2018) TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells. Nat Genet, 50, 83-95. PMCID: PMC5742051 [PMID: 29203910]
Yang TT, Chong WM, Wang WJ, Mazo G, Tanos B, Chen Z, Tran TMN, Chen YD, Weng RR, Huang CE, Jane WN, Tsou MB, Liao JC (2018) Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components. Nat Commun. 9, 2023. PMCID: PMC5964178 [PMID: 29789620]
Hobbs GS, Hanasoge Somasundara AV, Kleppe M, Litvin R, Arcila M, Ahn J, McKenney AS, Knapp K, Ptashkin R, Weinstein H, Heinemann MH, Francis J, Chanel S, Berman E, Mauro M, Tallman MS, Heaney ML, Levine RL, Rampal RK. (2018) Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms. Haematologica. 103, e5-e9. PMCID: PMC5777196 [PMID: 29051283]
McKenney AS, Lau AN, Somasundara AVH, Spitzer B, Intlekofer AM, Ahn J, Shank K, Rapaport FT, Patel MA, Papalexi E, Shih AH, Chiu A, Freinkman E, Akbay EA, Steadman M, Nagaraja R, Yen K, Teruya-Feldstein J, Wong KK, Rampal R, Heiden MGV, Thompson CB, Levine RL. (2018) JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition. J Clin Invest. 128, 789-804. PMCID: PMC5785272 [PMID: 29355841]
Wu Z, Santich BH, Liu H, Liu C, Cheung NV. (2018) Targeting Intracellular Antigens with pMHC-Binding Antibodies: A Phage Display Approach. Methods Mol Biol. 1701, 255-269. [PMID:29116509]
Ahmed M, Lopez-Albaitero A, Pankov D, Santich BH, Liu H, Yan S, Xiang J, Wang P, Hasan AN, Selvakumar A, O’Reilly RJ, Liu C, Cheung NV. (2018) TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies. JCI Insight. 3, pii: 97805. PMCID: PMC5916246 [PMID:29467338]
Vaisey G, Long SB. (2018) An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1. J Gen Physiol. pii: jgp.201812190. [PMID: 30237227]
Wang W, Liu W, Fidler T, Wang Y, Tang Y, Woods B, Welch C, Cai B, Silvestre-Roig C, Ai D, Yang YG, Hidalgo A, Soehnlein O, Tabas I, Levine RL, Tall AR, Wang N. (2018) Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice. Circ Res. 123, e35-e47. [PMID: 30571460]
Woods B, Chen W, Chiu S, Marinaccio C, Fu C, Gu L, Bulic M, Yang Q, Zouak A, Jia S, Suraneni PK, Xu K, Levine RL, Crispino JD, Wen QJ. (2019) Activation of JAK/STAT signaling in megakaryocytes sustains myeloproliferation in vivo. Clin Cancer Res. pii: clincanres.4089.2018.
2017
Rapp M*, Lau CM*, Adams NM*, Weizman OE, O’Sullivan TE, Geary CD, Sun JC; Core-binding factor ß and Runx transcription factors promote adaptive natural killer cell responses.; Science immunology; 2017; 2(18); [PMID: 29222089]
Weizman OE, Adams NM, Schuster IS, Krishna C, Pritykin Y, Lau C, Degli-Esposti MA, Leslie CS, Sun JC, O’Sullivan TE; ILC1 Confer Early Host Protection at Initial Sites of Viral Infection.; Cell; 2017; 171(4):795-808.e12; [PMID: 29056343]
Gardner EE, Lok BH, Schneeberger VE, Desmeules P, Miles LA, Arnold PK, Ni A, Khodos I, de Stanchina E, Nguyen T, Sage J, Campbell JE, Ribich S, Rekhtman N, Dowlati A, Massion PP, Rudin CM, Poirier JT. (2017) Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis. Cancer Cell 31, 286-299. PMCID: PMC5313262 [PMID: 28196596]
Sansone P, Berishaj M, Rajasekhar VK, Ceccarelli C, Chang Q, Strillacci A, Savini C, Shapiro L, Bowman R, Mastroleo C, De Carolis S, Daly L, Benito-Martin A, Perna F, Fabbri N, Healey JH, Spisni E, Cricca M, Lyden D, Bonafé M, Bromberg J. (2017) Evolution of cancer stem-like cells in endocrine-resistant metastatic breast cancers is mediated by stromal microvesicles. Cancer Res. [PMID: 28202520]
Bowman RL, Wang Q, Carro A, Verhaak RG, Squatrito M. (2017) GlioVis data portal for visualization and analysis of brain tumor expression datasets. Neuro Oncol. 19, 139-141. PMCID: PMC5193031 [PMID: 28031383]
Kim IS, Heilmann S, Kansler ER, Zhang Y, Zimmer M, Ratnakumar K, Bowman RL, Simon-Vermot T, Fennell M, Garippa R, Lu L, Lee W, Hollmann T, Xavier JB, White RM. (2017) Microenvironment-derived factors driving metastatic plasticity in melanoma. Nat Commun. 8, 14343. PMCID: PMC5309794 [PMID: 28181494]
Cohen I, Blasberg R. (2017) Impact of the Tumor Microenvironment on Tumor-Infiltrating Lymphocytes: Focus on Breast Cancer. Breast Cancer (Auckl) 11. PMCID: PMC5617083 [PMID: 28979132]
Green JA, Arpaia N, Schizas M, Dobrin A, Rudensky AY. A nonimmune function of T cells in promoting lung tumor progression. J Exp Med. 2017 Dec 4;214(12):3565-3575. doi: 10.1084/jem.20170356. Epub 2017 Oct 16. PMID: 29038367; PMCID: PMC5716034.
Feng W, Jasin M. (2017) BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination. Nat Commun. 8, 525. PMCID: PMC5597640 [PMID: 28904335]
Vanoli F, Tomishima M, Feng W, Lamribet K, Babin L, Brunet E, Jasin M. (2017) CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells. Proc Natl Acad Sci U S A. 114, 3696-3701. PMCID: PMC5389291 [PMID: 28325870]
Hamann JC, Overholtzer M. (2017) Entosis enables a population response to starvation. Oncotarget 8, 57934-57935. PMCID: PMC5601622 [PMID: 28938526]
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2010
Alonzo ES, Gottschalk RA, Das J, Egawa T, Hobbs RM, Pandolfi PP, Pereira P, Nichols KE, Koretzky GA, Jordan MS, Sant’Angelo DB. (2010) Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. J Immunol. 184, 1268-79. PMCID: PMC3991695 [PMID: 20038637]
Kim HJ, Alonzo ES, Dorothee G, Pollard JW, Sant’Angelo DB. (2010) Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus. PLoS One 5 e11439. PMCID: PMC2897847 [PMID: 20625428]
Kovalovsky D, Alonzo ES, Uche OU, Eidson M, Nichols KE, Sant’Angelo DB. (2010) PLZF Induces the Spontaneous Acquisition of Memory/Effector Functions in T Cells Independently of NKT Cell-Related Signals. J Immunol. 184, 6746-55. [PMID: 20495068]
Watson PA, Chen YF, Balbas MD, Wongvipat J, Socci ND, Viale A, Kim K, Sawyers CL. (2010) Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci U S A. 107, 16759-65. PMCID: PMC2947883 [PMID: 20823238]
Bhagwat N, Levine RL. (2010) Metabolic syndromes and malignant transformation: where the twain shall meet. Sci Transl Med. 2, 54ps50. [PMID: 20962328]
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Löwenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A. (2010) Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18, 553-67. PMCID: PMC4105845 [PMID: 21130701]
Marubayashi S, Koppikar P, Taldone T, Abdel-Wahab O, West N, Bhagwat N, Caldas-Lopes E, Ross KN, Gönen M, Gozman A, Ahn JH, Rodina A, Ouerfelli O, Yang G, Hedvat C, Bradner JE, Chiosis G, Levine RL. (2010) HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans. J Clin Invest. 120, 3578-93. PMCID: PMC2947224 [PMID: 20852385]
Roig I, Dowdle JA, Toth A, de Rooij DG, Jasin M, Keeney S. (2010) Mouse TRIP13/PCH2 Is Required for Recombination and Normal Higher-Order Chromosome Structure during Meiosis. PLoS Genet. 6. E1001062. PMCID: PMC2920839 [PMID: 20711356]
Gauthier NP, Jensen LJ, Wernersson R, Brunak S, Jensen TS. (2010) Cyclebase.org: version 2.0, an updated comprehensive, multi-species repository of cell cycle experiments and derived analysis results. Nucleic Acids Res 38(Database issue)D699-702. PMCID: PMC2808877 [PMID: 19934261]
Gocheva V, Wang HW, Gadea BB, Shree T, Hunter KE, Garfall AL, Berman T, Joyce JA. (2010) IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev. 24, 241-55. PMCID: PMC2811826 [PMID: 20080943]
Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV. (2010) Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol. 190, 89-100. PMCID: PMC2911671 [PMID: 20624902]
Klein RJ, Xu X, Mukherjee S, Willis J, Hayes J. (2010) Successes of genome wide association studies. Cell 142, 350-1. [PMID: 20691890]
Rochlin K, Yu S, Roy S, Baylies MK. (2010) Myoblast fusion: When it takes more to make one. Dev Biol. 341, 66-83. PMCID: PMC2854170 [PMID: 19932206]
2009
Attwooll CL, Akpinar M, Petrini JH. (2009) The Mre11 Complex and the Response to Dysfunctional Telomeres. Mol Cell Biol. 29, 5540-51. PMCID: PMC2756889 [PMID: 19667076]
Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV. (2009) Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 7, e1000111. PMCID: PMC2680336 [PMID: 19468302]
Papapetrou EP, Tomishima MJ, Chambers SM, Mica Y, Reed E, Menon J, Tabar V, Mo Q, Studer L, and Sadelain M. (2009) Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci U S A. 106, 12759-64. PMCID: PMC2722286 [PMID: 19549847]
Alarcón C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota G, Pan D, Massagué J. (2009) Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 139, 757-69. PMCID: PMC2818353 [PMID: 19914168]
Kilpivaara O, Mukherjee S, Schram AM, Wadleigh M, Mullally A, Ebert BL, Bass A, Marubayashi S, Heguy A, Garcia-Manero G, Kantarjian H, Offit K, Stone RM, Gilliland DG, Klein RJ, Levine RL. (2009) A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms. Nat Genet. 41, 455-9. PMCID: PMC3676425 [PMID: 19287384]
Pomerantz JH, Mukherjee S, Palermo AT, Blau HM. (2009) Reprogramming to a muscle fate by fusion recapitulates differentiation. J Cell Sci. 122, 1045-53. PMCID: PMC2720934 [PMID: 19295131]
Terret M, Sherwood R, Rahman S, Qin J, Jallepalli P. (2009) Cohesin acetylation speeds the replication fork. Nature 462, 231-234. PMCID: PMC2777716 [PMID: 19907496]
Gao S, Alarcón C, Sapkota G, Rahman S, Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P, Massagué J. (2009) Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell 36, 457-68. PMCID: PMC2796330 [PMID: 19917253]
Tassev DV, Cheung NK. (2009) Monoclonal Antibody Therapies for Solid Tumors. Expert Opin Biol Ther. 9, 341-53. [PMID: 19216623]
Wang L, Huang G, Zhao X, Hatlen MA, Vu L, Liu F, Nimer SD. (2009). Post-translational modifications of Runx1 regulate its activity in the cell. Blood Cells Mol Dis. 43, 30-4. PMCID: PMC2743917 [PMID: 19386523]
2008
Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, Kim HJ, Im JS, Pandolfi PP, Sant’Angelo DB (2008) The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nature Immunology 9, 1055-1064. PMCID: PMC2662733 [PMID: 18660811]
Shah NP, Kasap C, Weier C, Balbas M, Nicoll JM, Bleickardt E, Nicaise C, Sawyers CL. (2008) Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis. Cancer Cell 14, 485-93. [PMID:19061839]