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Selected Recent Papers
Meng X, Claussin C, Regan-Mochrie G, Whitehouse I, Zhao X. (2023). Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry. Genes Dev. 37:74-79.
Yu Y, Li S, Ser Z, Kuang H, Than T, Guan D, Zhao X*, Patel DJ* (*co-corresponding authors). (2022). Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes. Proc Natl Acad Sci U S A. 119:e2202799119.
Yu Y, Li S, Ser Z, Sanyal T, Choi K, Wan B, Kuang H, Sali A, Kentsis A, Patel DJ, Zhao X. (2021). Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A. 118:e2026844118.
Dhingra N, Kuppa S, Wei L, Pokhrel N, Baburyan S, Meng X, Antony E, Zhao X. (2021). The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin. Proc Natl Acad Sci U S A. 118:e2020185118.
Li S, Bonner JN, Wan B, So S, Summers A, Gonzalez L, Xue X, Zhao X. (2021). Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes Dev. 35:261-272.
Shen M, Dhingra N, Wang Q, Cheng C, Zhu S, Tian , Yu J, Gong X, Li X, Zhang H, Xu X, Zhai L, Xie M, Gao Y, Deng H, He Y, Niu H, Zhao X*, Xiang S* (*co-corresponding authors). (2021). Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun. 12: 321.
Meng X, Wei L, Devbhandari S, Zhang T, Xiang J, Remus D, Zhao X. (2020). DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis. Nat Commun. 11:2437.
Dhingra N, Zhao X. (2019). Intricate SUMO-based control of the homologous recombination machinery. Genes Dev. 33: 1346-1354.
Wan B, Wu J, Meng X, Lei M, Zhao X.(2019). Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Mol Cell. 75: 238-251.