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Xiaolan Zhao: Publications

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Selected Recent Papers

Peng XP, Zhao X. (2023). The multi-functional Smc5/6 complex in genome protection and disease. Nat Struct Mol Biol. 30:724-734.

Meng X, Claussin C, Regan-Mochrie G, Whitehouse I, Zhao X. (2023). Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry. Genes Dev. 37:74-79.

Chang JT, Li S, Beckwitt E, Than T, Haluska C, Chandanani J, O’Donnell ME, Zhao X*, Liu S* (*co-corresponding authors). (2022). Smc5/6’s multi-faceted DNA binding capacities stabilize branched DNA structures. Nat Commun. 13:7179.

Regan-Mochrie G, Hoggard T, Bhagwat N, Lynch G, Hunter N, Remus D, Fox C, Zhao X. (2022) Yeast ORC sumoylation status fine-tunes origin licensing. Genes Dev. 36:807-821

Yu Y, Li S, Ser Z, Kuang H, Than T, Guan D, Zhao X*, Patel DJ* (*co-corresponding authors). (2022). Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes. Proc Natl Acad Sci U S A. 119:e2202799119.

Yu Y, Li S, Ser Z, Sanyal T, Choi K, Wan B, Kuang H, Sali A, Kentsis A, Patel DJ, Zhao X. (2021). Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A. 118:e2026844118.

Dhingra N, Kuppa S, Wei L, Pokhrel N, Baburyan S, Meng X, Antony E, Zhao X. (2021). The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin . Proc Natl Acad Sci U S A. 118:e2020185118.

Li S, Bonner JN, Wan B, So S, Summers A, Gonzalez L, Xue X, Zhao X. (2021). Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes Dev. 35:261-272.

Shen M, Dhingra N, Wang Q, Cheng C, Zhu S, Tian , Yu J, Gong X, Li X, Zhang H, Xu X, Zhai L, Xie M, Gao Y, Deng H, He Y, Niu H, Zhao X*, Xiang S* (*co-corresponding authors). (2021). Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun. 12: 321.

Meng X, Wei L, Devbhandari S, Zhang T, Xiang J, Remus D, Zhao X. (2020). DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis. Nat Commun. 11:2437.

Dhingra N, Zhao X. (2019). Intricate SUMO-based control of the homologous recombination machinery. Genes Dev. 33: 1346-1354.

Wan B, Wu J, Meng X, Lei M, Zhao X.(2019). Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Mol Cell. 75: 238-251 .

Zhao X.(2018). SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes. Mol Cell. 71:409-418.

Peng XP, Lim S, Li S, Marjavaara L, Chabes A, Zhao X. (2018). Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites. PLoS Genet 14: e1007129

Bonner J.N., Choi K, Xue X, Torres N.T., Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown, P.W., Branzei D, Zhao X. (2016). Smc5/6 mediated sumoylation of the Sgs1-Top3-Rmi1 complex promotes removal of recombination intermediates. Cell Reports. 16:368-378.

Wei L, Zhao X. (2016). A new MCM modification cycle regulates DNA replication initiation. Nat Struct Mol Biol. 23: 209–216.

Hang L.E., Peng J, Tan W, Szakal B, Menolfi D, Sheng Z, Lobachev K, Branzei D, Feng W, Zhao X. (2015). Rtt107 Is a multi-functional scaffold supporting replication progression with partner SUMO and ubiquitin ligases. Mol Cell. 60: 268-279.

Xue X, Sung P, Zhao X. (2015). Functions and regulation of the multitasking FANCM family of DNA motor proteins. Genes Dev. 29: 1777-1788.

Chung I, Zhao X. (2015). DNA break-induced sumoylation is enabled by collaboration between a SUMO ligase and the ssDNA-binding complex RPA. Genes Dev. 29: 1593-1598.

Sarangi P, Zhao X. (2015). SUMO-mediated regulation of DNA damage repair and responses. Trends Biochem Sci. 40: 233-242.

Xue X, Choi K, Bonner J.N., Szakal B, Chen Y.H., Papusha A, Saro D, Niu H, Ira G, Branzei D, Sung P, Zhao X. (2015). Selective modulation of the functions of a conserved DNA motor by a histone fold complex. Genes Dev. 29: 1000-1005.

Xue X, Choi K, Bonner J, Chiba T, Kwon Y, Xu Y, Sanchez H, Wyman C, Niu H, Zhao X*, Sung P* (*co-corresponding authors). (2014). Restriction of replication fork regression activities by a conserved SMC complex. Mol Cell. 56: 436-445.