Cancer is a condition promoted by cells undergoing an identity crisis. An understanding of how cells control their identity (cell fate specification), and how they organize themselves into normal tissues (morphogenesis) provides the blueprint for the fundamental biological processes that become deregulated in cancer.
The Hadjantonakis laboratory uses high-resolution quantitative methods to investigate the mechanisms underlying stem cell specification, cellular differentiation, tissue organization and growth. They use the mammalian embryo as a platform, and the mouse as a primary model system. They also exploit in vitro cultured stem cells, including pluripotent stem cells, for their studies.
Anna-Katerina Hadjantonakis, PhD
Chair, Developmental Biology Program, SKI
Research FocusThe Hadjantonakis laboratory studies pluripotency, cell lineage commitment, tissue patterning, and morphogenesis in mammalian embryos and in vitro stem cell models.
EducationPhD, Imperial College (London)
- Nowotschin S, Setty M, Kuo YY, Liu V, Garg V, Sharma R, Simon CS, Saiz N, Gardner R, Boutet SC, Church DM, Hoodless PA, Hadjantonakis AK, Pe’er D. The emergent landscape of the mouse gut endoderm at single-cell resolution. Nature. 2019 May;569(7756):361-367. doi: 10.1038/s41586-019-1127-1.
- Morgani SM, Metzger JJ, Nichols J, Siggia ED, Hadjantonakis AK. Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning. Elife. 2018 Feb 7;7. pii: e32839. doi: 10.7554/eLife.32839.
- Demonstration of a lineage relationship between the extra-embryonic endoderm and the somatic endoderm tissues of the embryo
- First single-cell resolution live imaging study of pluripotent epiblast versus extra-embryonic endoderm cell lineage commitment within the inner cell mass (ICM) of the mouse embryo
- Development of reporters for quantitative live cell imaging in mice