Claire Simon, PhD

Research Fellow - NYSTEM Training Award at the CSCB

Claire Simon, PhD

Research Fellow - NYSTEM Training Award at the CSCB

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Claire  Simon, PhD

Lab Phone

212-639-8215

Lab Fax

646-422-2355

Start Year

2017

NYSTEM Training Award at the CSCB

Education & Training

2017 – present
Postdoctoral Fellow, Developmental Biology Program, Sloan Kettering Institute (lab of Kat Hadjantonakis)

2011 – 2016

PhD in Developmental Biology, University of Oxford, UK (lab of Elizabeth Robertson)

Thesis title: Transcriptional regulation of Eomesodermin and its roles in cell fate allocation during early mouse development

2008 – 2011

BA in Natural Sciences, University of Cambridge, UK

Research Interests

During mammalian pre-implantation development, two successive binary cell fate decisions separate the embryo from two extra-embryonic lineages that support the embryo during gestation. The first cell fate decision specifies outer cells as extra-embryonic trophectoderm, while inner cells form the inner cell mass (ICM). The ICM is then further bifurcated into the extra-embryonic primitive endoderm and the pluripotent embryonic epiblast. Pluripotent cells have the potential to differentiate into germ cells and any somatic tissue, and can be propagated in vitro as embryonic stem cells. However, it is not yet fully understood how the pluripotent state emerges and evolves in the native context of the developing embryo.

My research focuses on understanding the molecular mechanism driving cell fate specification within the ICM to either the pluripotent epiblast or the extra-embryonic primitive endoderm. I am particularly interested in the dynamics of FGF4 signaling in initiating this cell fate decision, and the downstream effectors mediating lineage-specific outputs of FGF/ERK signaling.

Publications

Nowotschin S*, Setty M*, Kuo YY, Liu V, Garg V, Sharma R, Simon CS, Saiz N, Gardner R, Boutet SC, Church DM, Hoodless PA, Hadjantonakis AK*, Pe’er D*. (2019) The emergent landscape of the mouse gut endoderm at single-cell resolution. Nature, 1. Apr 8. doi: 10.1038/s41586-019-1127-1. PMID: 30959515 PMCID: PMC6724221

Simon CS, Zhang L, Wu T, Saiz N, Nowotschin S, Cai C, Hadjantonakis AK. (2018) A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in mouse. Biology Open 2018 Dec 10;7(12). pii: bio036517. doi: 10.1242/bio.036517. PMID: 30530745 PMCID: PMC6310872

Simon CS, Hadjantonakis AK (2018) Top to Tail: Anterior-Posterior Patterning Precedes Regional Nervous System Identity. Cell Nov 1;175(4):905-907. doi: 10.1016/j.cell.2018.10.040. PMID: 30388450

Morgani SM. Saiz N, Garg V, Raina D, Simon CS, Kang M, Arias AM, Nichols J, Schroter C, Hadjantonakis AK. (2018) A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice. Devl Biol.  441(1): 104-126. doi: 10.1016/j.ydbio.2018.06.017. Epub 2018 Jun 30. PMID: 29964027 PMCID: PMC6455974

Simon CS, Hadjantonakis AK*, Schroter C. (2018) Making lineage decisions with biological noise: lessons from the early mouse embryo. WIRES-Dev. Biol. 2018 Jul;7(4):e319. doi: 10.1002/wdev.319. PMID: 29709110 PMCID: PMC6002940

Simon, C.S., Downes, D.J., Gosden, M.E., Telenius, J., Higgs, D.R., Hughes, J.R., Costello, I., Bikoff, E.K. and Robertson, E.J. (2017) Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo. Development, 144(7), pp.1249-1260. PMID: 28174238 PMCID: PMC5399628

View a full listing of Claire Simon’s journal articles.