2014-present: Senior Research Scientist, Developmental Biology Program, Sloan Kettering Institute (lab of Kat Hadjantonakis)
2011–2014: Research Associate, Developmental Biology Program, Sloan Kettering Institute (lab of Kat Hadjantonakis)
2006–2011: Postdoctoral Fellow, Developmental Biology Program, Sloan Kettering Institute (lab of Kat Hadjantonakis)
2005–2006: Postdoctoral Fellow, Albert Einstein College of Medicine (lab of Bernice Morrow)
2002–2005: Graduate studies, University of Karlsruhe, Germany and Albert Einstein College of Medicine, New York (lab of Bernice Morrow)
My research interests are centered on investigating mechanisms of tissue morphogenesis and cell lineage patterning at the time of gastrulation. I use the mouse embryo, embryo-derived and pluripotent stem cells as mammalian model systems. The goal of my work is to formulate a blueprint for understanding analogous events in human development.
My studies specifically focus on the mechanisms driving cell fate decisions towards mesoderm and/or endoderm, the transitions between epithelial and mesenchymal (EMT & MET) states, and how these events are coordinated during embryonic development at gastrulation.
Optical imaging, single-cell transcriptomics, mouse genetics and embryology, and stem cell methods are central approaches that I use.
Visit PubMed for a full listing of Sonja Nowotschin’s journal articles
Wu T, Hadjantonakis AK, Nowotschin S. Visualizing endoderm cell populations and their dynamics in the mouse embryo with a Hex-tdTomato reporter. Biology Open. 6(5):678-687. PMID: 28288969. PMCID: PMC5450328.
Wang Q., Zou Y., Nowotschin S., Kim SY., Li Q., Soh CL., Xi Q., Zhang C., Su J., Shu W., Huangfu D., Hadjantonakis AK., Massague J. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. Cell Stem Cell. 20(10:70-86). PMID: 27889317. PMCID: PMC5218926
Costello I., Nowotschin S., Sun X., Mould AW., Hadjantonakis AK., Bikoff, EK., Robertson EJ. Lhx1 functions together with Otx2, Foxa2 and the Ldb1 chromatin looping machinery to govern anterior mesendoderm, node and midline development. Genes and Development. 29(20);2108-22. PMID: 26494787. PMCID: PMC4617976
Viotti M., Nowotschin S. and Hadjantonakis AK. (2014) SOX17 links gut endoderm morphogenesis and germ layer segregation. Nature Cell Biology. 16(12):1146-56. PMID:25419850. PMCID: PMC4250291
Nowotschin S., Costello I., Piliszek A., Kwon GS., Mao CA., Klein WH., Robertson EJ., Hadjantonakis AK. (2013) The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. Genes & Development. 27(9):997-1002. PMID: 23651855. PMCID: PMC3656330