Alexander Rudensky: Publications

Alexander Rudensky: Publications


Campbell C, McKenney PT, Konstantinovsky D, Isaeva OI, Schizas M, Verter J, Mai C, Jin WB, Guo CJ, Violante S, Ramos RJ, Cross JR, Kadaveru K, Hambor J, Rudensky AY. (2020) Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature. 581(7809):475-479.

Brown CC, Gudjonson H, Pritykin Y, Deep D, Lavallée VP, Mendoza A, Fromme R, Mazutis L, Ariyan C, Leslie C, Pe’er D, Rudensky AY. (2019) Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity. Cell. 179(4):846-863.

Hemmers S, Schizas M, Azizi E, Dikiy S, Zhong Y, Feng Y, Altan-Bonnet G, Rudensky AY. (2019) IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus. J Exp Med. 216(11):2466-2478.

van der Veeken J, Zhong Y, Sharma R, Mazutis L, Dao P, Pe’er D, Leslie CS, Rudensky AY. (2019) Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells. Immunity. 50(5):1202-1217.

Konopacki C, Pritykin Y, Rubtsov Y, Leslie CS, Rudensky AY. (2019) Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function. Nature immunology. 20(2):232.

Fan X, Moltedo B, Mendoza A, Davydov AN, Faire MB, Mazutis L, Sharma R, Pe’er D, Chudakov DM, Rudensky AY. (2018) CD49b defines functionally mature Treg cells that survey skin and vascular tissues. J Exp Med. 215(11):2796-2814.

Azizi E, Carr AJ, Plitas G, Cornish AE, Konopacki C, Prabhakaran S, Nainys J, Wu K, Kiseliovas V, Setty M, Choi K, Fromme RM, Dao P, McKenney PT, Wasti RC, Kadaveru K, Mazutis L, Rudensky AY, Pe’er. (2018) Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment. Cell. 174(5):1293-1308

Campbell C, Dikiy S, Bhattarai SK, Chinen T, Matheis F, Calafiore M, Hoyos B, Hanash A, Mucida D, Bucci V, Rudensky AY. (2018) Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Immunity. 48(6):1245-1257.

Green JA, Arpaia N, Schizas M, Dobrin A, Rudensky AY. (2017) A nonimmune function of T cells in promoting lung tumor progression. JEM. 214(12):3565-3575.

Levine AG, Mendoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM,Rudensky AY. (2017) Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 546:421-425.

Levine AG, Hemmers S, Baptista AP, Schizas M, Faire MB, Moltedo B, Konopacki C, Schmidt-Supprian M, Germain RN, Treuting PM, Rudensky AY. (2017) Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. JEM. 214(3):609-622.

Plitas G, Konopacki C, Wu K, Bos PD, Morrow M, Putintseva EV, Chudakov DM,Rudensky AY. (2016) Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer. Immunity. 45:1122-1134.

Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Zheng Y, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY. (2016) An essential role for the IL-2 receptor in Treg cell function. Nat Immunol. 17(11):1322-1333. 

van der Veeken J, Gonzalez AJ, Cho H, Arvey A, Hemmers S, Leslie CS, Rudensky AY. (2016) Memory of Inflammation in Regulatory T Cells. Cell.166:977-990.

Arpaia N, Green J, Moltedo B, Arvey A, Hemmers S, Yuan S, Treuting P, Rudensky A. (2015) A Distinct Function of Regulatory T Cells in Tissue Protection. Cell. 162: 1078- 1089.

Feng Y, van der Veeken J, Shugay M, Putintseva EV, Osmanbeyoglu HU, Dikiy S,Hoyos BE, Moltedo B, Hemmers S, Treuting P, Leslie CS, Chudakov DM, Rudensky AY. (2015) A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. Nature.528:132-136.

Gasteiger G, Fan X, Dikiy S, Lee SY, Rudensky AY. (2015) Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs. Science. 350:981-5.

Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY. (2014) Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus. Cell. 158:749-63

Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY. (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 504:451-5.


Campbell C, Rudensky A. (2019) Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism. Cell Metab. S1550-4131(19)30513-3.

Elias S, Rudensky AY. (2019) Therapeutic use of regulatory T cells for graft-versus-host disease. Br J Haematol. 187(1):25-38.

Plitas G, Rudensky AY. (2016) Regulatory T Cells: Differentiation and Function. Cancer Immunol Res. 4(9):721-5.

Li MO, Rudensky AY. (2016) T cell receptor signalling in the control of regulatory T cell differentiation and function. Nat Rev Immunol. 16(4):220-33.

Fan X, Rudensky AY. (2016) Hallmarks of Tissue-Resident Lymphocytes. Cell.164:1198-1211.

Gasteiger G, Rudensky AY. (2014) Interactions between innate and adaptive lymphocytes. Nat Rev Immunol. 14(9):631-9.

van der Veeken J, Arvey A, Rudensky A. (2013) Transcriptional control of regulatory T-cell differentiation. Cold Spring Harb Symp Quant Biol.78:215-22.

Chaudhry A, Rudensky AY. (2013) Control of inflammation by integration of environmental cues by regulatory T cells. J Clin Invest. 123(3):939-44.

Josefowicz SZ, Lu LF, Rudensky AY. (2012) Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 30:531-64.

Chinen T, Rudensky AY. (2012) The effects of commensal microbiota on immune cell subsets and inflammatory responses. Immunol Rev. 245(1):45-55.

Rudensky AY. (2011) Regulatory T cells and Foxp3. Immunol Rev. 241(1):260-8.

Littman DR, Rudensky AY. (2010) Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 140(6):845-58.

Josefowicz SZ, Rudensky A. (2009) Control of regulatory T cell lineage commitment and maintenance. Immunity. 30(5):616-25.