Agnel Sfeir: Publications

Agnel Sfeir: Publications


PenevA, BazleyA, Shen M, BoekeJ, SavageSA, and Sfeir A*. (2021) Alternative splicing is a developmental switch for hTERT expression. bioRxiv doi:

Tigano M, Vargas DC, Fu Y, Tremblay-Belzile S, and Sfeir A*. (2021) Nuclear sensing of mitochondrial DNA breaks enhances immune surveillance. Nature. Feb 24; online.

Pinzaru AM, Lamm N, Al-Kareh M, Lazzerini-Denchi E, Cesare AJ, and Sfeir A*. (2020) Replication stress conferred by POT1 dysfunction promotes telomere relocalization to the nuclear pore. Genes and Development. 34:1-19 doi/10.1101/gad.337287

Smith MJ, Querido E, Chartrand C*, and Sfeir A*. (2020) Quantitative Imaging of MS2-Tagged hTR in Cajal Bodies: Photobleaching and Photoactivation. STAR protocols. Sept 25,2020. DOI: 10.1016/j.xpro.2020.100112.

Fu Y, Tigano M, Sfeir A*. (2020) Safeguarding mitochondrial genomes in higher eukaryotes. Nat Struct Mol Biol 2020 Aug;27(8):687-695. doi: 10.1038/s41594-020-0474-9.

Laprade H, Querido E, Smith MJ, Guerit D, Crimmins H, Conomos D, Pourret E, Chartrand C*, and Sfeir A*. (2020) Single-molecule imaging of telomerase RNA reveals a Recruitment-Retention model for telomere elongation. Mol Cell. Jul 2;79(1):115-126.e6. doi: 10.1016/j.molcel.2020.05.005.

Brambati A, Barry R, and Sfeir A*. (2020) DNA Polymerase theta (Polq) – an error-prone polymerase necessary for genome stability. Current Opinion in Genetics & Development. 2020 Feb;60:119-126. doi: 10.1016/j.gde.2020.02.017.

Mateos-Gomez P, Kent T, Deng SK, McDevitt S, Kashkina E, Hoang TM, Pomerantz, R, and Sfeir A*. (2017) The helicase domain of Polθ counteracts RPA to promote alt-NHEJ. NSMB. Dec;24(12):1116-1123. doi: 10.1038/nsmb.3494.

Phillips A, Miller A, Tigano M, Dubois S, Crimmins H, Babin L, Piganeau M, Brune E*, and Sfeir, A*. (2017) Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion.  Mol Cell. Jan 11. pii: S1097-2765(16)30852-8.

Pinzaru A, Hom R, Beal A, Phillips A, Ni E, Cardozo T, Nair N, Choi J, Wuttke D, Sfeir A*, and Lazzerini-Denchi E*. (2016) Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis. Cell Reports. June 7. DOI:10.1016/j.celrep.2016.43.

Lazzerini-Denchi E and Sfeir A*. (2016) Stop pulling my strings - what telomeres taught us about the DNA damage response. Nature Review Molecular Cell Biology. Jun;17(6):364-78. doi: 10.1038/nrm.2016.43

Tong A, Stern J, Sfeir A, Kartawinata M, de Lange T, Zhu X and Bryan T*. (2015) ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Reports. Nov 24;13(8):1633-46

Sfeir, A*, Symington, L*. (2015) Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway? Trends Biochem Sci. Sep 21. pii: S0968-0004(15)00158-9.

Mateos-GomezPA, GongF, NairN, MillerKM, Lazzerini-DenchiE, SfeirA*. (2015) Mammalian Polymerase Theta Promotes Alternative-NHEJ and Suppresses Recombination. Nature. Feb 12;518(7538):254-7.

Yeung F, Mateos-Gomez P, Pinzaru A, Ceccarini G, Kabir S, and Sfeir A*. (2013) Non-telomeric role for RAP1 in regulating metabolism and protecting against obesity. Cell Reports. S2211-1247(13)00249-0.