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Physician-scientist Samuel Singer studies the genomic alterations that define new targets for therapy in sarcoma. I am a surgical oncologist who specializes in the diagnosis and treatment of soft tissue sarcoma. I have extensive experience with this group of cancers, and am one of just a few surgeons in the world focused solely on treating sarcoma patients. My years of experience have enabled me to devise surgical techniques that improve the ability to completely remove these tumors. In addition to my clinical sarcoma practice, I conduct laboratory research to develop new methods to improve the diagnosis and treatment of sarcoma. I lead both a National Cancer Institute Specialized Program in Research Excellence (SPORE) and the Sarcoma Genome Project.
Systems biologist Joao Xavier combines experimental and computational approaches to study diverse problems relevant to cancer: how the microbiome influences cancer and cancer treatment, how cancer cells metastasize, and how metabolic fluxes command the behavior of living cells.
Physician-scientist David Solit studies human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.
The Greenbaum lab utilizes techniques from statistical physics, information theory, and evolutionary biology to better understand the role of self/non-self discrimination in tumor evolution, model response to immunotherapies, and quantify drivers of virus and cancer evolution.
Our group, the Laboratory of Experimental Cancer Immunogenomics, is a multi-disciplinary team of cancer scientists working at the intersection of genomics, molecular genetics, animal modeling, and biostatistical data sciences.
The Diver lab studies the physiological roles and molecular mechanisms of understudied membrane-embedded proteins with the goal of revealing novel therapeutic targets for diseases such as pain and cancer.
Chemical biologist Daniel Bachovchin designs selective inhibitors to study enzymes and pathways in cancer and immune system signaling.
Human Oncology and Pathogenesis Program Chair Charles Sawyers develops molecularly targeted cancer therapy.
The Wilkinson laboratory studies reverse transcriptases and retrotransposons using biochemistry, structural biology, and genome mining.
The Studer laboratory investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based strategies for regenerative medicine.