Chemical Biology Program

The Daniel Bachovchin Lab

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Research

Daniel Bachovchin
Daniel Bachovchin, PhD


Associate Professor

The Bachovchin lab uses chemical and cell biology approaches to study important questions in innate immunity. We are particularly interested in characterizing the molecular mechanisms controlling the formation of inflammasomes, key components of the innate immune system that sense intracellular danger signals and trigger pyroptotic cell death. 

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Inside My Lab: Daniel Bachovchin

Go inside the lab of Daniel Bachovchin from SKI’s Chemical Biology Program.
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Featured News

MSK chemical biologist Daniel Bachovchin in his laboratory
At Work: Chemical Biologist Daniel Bachovchin

Meet chemical biologist Daniel Bachovchin.
Science Byte
Ribbon diagram of an anthrax protein.
Scientists Discover Keys to Immune Response against Anthrax

Researchers clarify how the immune system activates an inflammatory defense against pathogens.
In the Lab
Image of fireball-type explosion on black background.
Researchers Gain Insight into How a Drug Fires Up an Immune Response to Cancer

Scientists have learned that a drug activates a form of highly inflammatory programmed cell death called pyroptosis — a discovery that sheds light on immune function.

Publications

Chui, A.J*; Okondo, M.C.*; Rao, S.D.*; Gai, K.; Griswold, A.R.; Johnson, D.C.; Ball, D.P.; Taabazuing, C.Y.; Orth, E.L.; Vittimberga, B.A.; Bachovchin, D.A. # “N-terminal degradation activates the Nlrp1b inflammasome.” Science. 2019, 365, 82-85.

Rao, S.D.*; Chen, Q.*; Wang, Q.*; Orth-He, E.L.*; Saoi, M.; Griswold, A.R.; Bhattacharjee, A.; Ball, D.P.; Huang, H.-C.; Chui, A.J.; Covelli, D.J.; You, S.; Cross, J.R.; Bachovchin, D.A. # “M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.” Nat Chem Biol. 2022, in press.

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People

Daniel Bachovchin

Daniel Bachovchin, PhD



Associate Professor

  • Chemical biologist Daniel Bachovchin designs selective inhibitors to study enzymes and pathways in cancer and immune system signaling.
  • PhD, The Scripps Research Institute
[email protected]
Email Address
Download CV
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Members

Samantha Phaggoo
Samantha Phaggoo

Administrative Assistant

Daniel Ball, Research Fellow
Daniel Ball

Research Fellow

Michael Geeson
Michael Geeson

Research Fellow

Jeff Chieh Hsiao
Jeff Chieh Hsiao

Graduate Student

Hsin-Che Huang

Graduate Student

Claire O'Mara

Research Technician

Lydia Tsamouri

Graduate Student

Ashley Tucewicz

Graduate Student

Alvin Wang
Alvin Wang

Research Technician

Qinghui Wang
Qinghui Wang

Research Fellow

Anqi Zhou

Graduate Student

Lab Alumni
Abir Bhattacharjee
Abir Bhattacharjee

Research Fellow

Qifeng Chen
Qifeng Chen

Research Fellow

Ashley Chui
Ashley Chui

Graduate Student

Kuo Gai, Research Technician
Kuo Gai

Research Technician

Andrew Griswold
Andrew Griswold

Graduate Student

Darren Johnson
Darren Johnson

Graduate Student

Marian Okondo
Marian Okondo

Research Technician

Elizabeth Orth

Graduate Student

Sahana Rao
Sahana Rao

Graduate Student

Cornelius Taabazuing
Cornelius Taabazuing

Research Fellow

Lab Affiliations

Achievements

  • Josie Robertson Investigator (2015-2020)
  • Louise and Allston Boyer Young Investigator Award for Distinguished Achievement in Basic Research
  • Sloan Research Fellow in Chemistry (2018)
  • Pew-Stewart Scholar for Cancer Research (2017-2021)
  • Pershing Square Sohn Prize for Young Innovators in Cancer Research (2018)
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  • Stand Up to Cancer 2017 Innovative Research Grant Recipient (2017-2020)
  • California Breast Cancer Research Program Fellowship (2011-2012)
  • National Science Foundation Predoctoral Fellowship (2006-2007)

Lab News & Events

Upcoming event

Investigating The Mechanism of Ferroptosis in Cancer Cells

Memorial Sloan Kettering Cancer Center
Zuckerman Research Center
417 East 68th Street
Room ZRC-105
New York, NY 10065

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

Graduate Students

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Postdoctoral Fellows

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Daniel Bachovchin discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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