Chemical Biology Program

The Daniel Bachovchin Lab

Daniel Bachovchin, PhD

Geoffrey Beene Junior Faculty Chair

Professor

The Bachovchin lab uses chemical and cell biology approaches to study important questions in innate immunity. We are particularly interested in characterizing the molecular mechanisms controlling the formation of inflammasomes, key components of the innate immune system that sense intracellular danger signals and trigger pyroptotic cell death.

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Go inside the lab of Daniel Bachovchin from SKI’s Chemical Biology Program.

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Featured News

MSK chemical biologist Daniel Bachovchin in his laboratory

At Work: Chemical Biologist Daniel Bachovchin

Meet chemical biologist Daniel Bachovchin.

Science Byte

Scientists Discover Keys to Immune Response against Anthrax

Researchers clarify how the immune system activates an inflammatory defense against pathogens.

In the Lab

Image of fireball-type explosion on black background.

Researchers Gain Insight into How a Drug Fires Up an Immune Response to Cancer

Scientists have learned that a drug activates a form of highly inflammatory programmed cell death called pyroptosis — a discovery that sheds light on immune function.

Publications Highlights

Chui, A.J*; Okondo, M.C.*; Rao, S.D.*; Gai, K.; Griswold, A.R.; Johnson, D.C.; Ball, D.P.; Taabazuing, C.Y.; Orth, E.L.; Vittimberga, B.A.; Bachovchin, D.A. # “N-terminal degradation activates the Nlrp1b inflammasome.” Science. 2019, 365, 82-85.

Rao, S.D.*; Chen, Q.*; Wang, Q.*; Orth-He, E.L.*; Saoi, M.; Griswold, A.R.; Bhattacharjee, A.; Ball, D.P.; Huang, H.-C.; Chui, A.J.; Covelli, D.J.; You, S.; Cross, J.R.; Bachovchin, D.A. # “M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.” Nat Chem Biol. 2022, 18, 565-574.

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People

Daniel Bachovchin, PhD

Geoffrey Beene Junior Faculty Chair

Professor

Chemical biologist Daniel Bachovchin designs selective inhibitors to study enzymes and pathways in cancer and immune system signaling.
PhD, The Scripps Research Institute
AB, Harvard College

[email protected]: Email Address
Download CV: PDF File

Members

Alexa Borkowski
Administrative Assistant

Daniel Ball, Research Fellow — Daniel Ball
Research Fellow

Lauren Hollmer

Graduate Student

Donyell Logan
MSK Bridge Program Scholar

Lydia Paraskevi Tsamouri — Lydia Tsamouri
Graduate Student

Lab Alumni

Kuo Gai, Research Technician — Kuo Gai
Research Technician

Elizabeth Orth

Graduate Student

Lab Affiliations

Achievements

David P. Hajjar Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School (2023)
Louise and Allston Boyer Young Investigator Award for Distinguished Achievement in Basic Research (2021)
Sloan Research Fellow in Chemistry (2018)
Pew-Stewart Scholar for Cancer Research (2017)
Pershing Square Sohn Prize for Young Innovators in Cancer Research (2018)

Josie Robertson Investigator (2015-2020)
Stand Up to Cancer 2017 Innovative Research Grant Recipient (2017)
California Breast Cancer Research Program Fellowship (2011)
National Science Foundation Predoctoral Fellowship (2006)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Graduate Students

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Postdoctoral Fellows

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Get in Touch

[email protected]

Lab Head Email

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Daniel Bachovchin discloses the following relationships and financial interests:

AbbVie
Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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