Research in the Bachovchin lab focuses on characterizing the functions of enzymes in normal and pathological processes. In particular, we are interested in the roles that serine proteases play in cancer and immune system signaling. We use a variety of tools and approaches to study these enzymes and pathways, including new chemical probes developed in our lab, mass spectrometry-based proteomics, activity-based protein profiling, and genome engineering (CRISPR).
- Okondo, M. C.*; Rao, S. D.*; Taabazuing, C. Y.*; Chui, A. J.; Poplawski, S. E.; Johnson, D. C.; Bachovchin, D. A. # “Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome.” Cell Chem Biol. 2018, 25, 262-267.
- Okondo, M.C.; Johnson, D. C., Sridharan, R., Go, E. B., Chui, A. J., Wang, M. S., Poplawski, S. E., Wu, W., Liu, Y.; Lai, J. H.; Sanford, D. G.; Arciprete, M. O.; Golub, T. R.; Bachovchin, W. W.; Bachovchin, D. A.# “Inhibition of DPP8/9 induces pro-caspase-1-dependent pyroptosis in monocytes and macrophages.” Nat Chem Biol. 2017, 13, 46-53.
- Josie Robertson Investigator (2015-2020)
- Sloan Research Fellow in Chemistry (2018)
- Stand Up to Cancer 2017 Innovative Research Grant Recipient (2017-2020)
- Pew-Stewart Scholar for Cancer Research (2017-2021)
- Pershing Square Sohn Prize for Young Innovators in Cancer Research (2018)