Computational & Systems Biology Program

The Joao Xavier Lab

Research

Joao Xavier
Joao Xavier, PhD
Member, Computational & Systems Biology Program

Professor

We combine computation and experiment to investigate how cells interact with each other to produce complex cell group behaviors.

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Xavier Lab

Publications Highlights

Liao C, Rolling T, Djukovic A, Fei T, Mishra V, Liu H, Lindberg C, Dai L, Zhai B, Peled JU, Brink MRMvd, Hohl TM, Xavier JB. A high fraction of oral bacteria in the feces indicates gut microbiota depletion with implications for human health. bioRxiv. 2023:2022.10.24.513595. doi: 10.1101/2022.10.24.513595. (Accepted for publication in Nature Microbiology)

Mathur D, Liao C, Lin W, La Ferlita A, Alaimo S, Taylor S, Zhong Y, Iacobuzio-Donahue C, Ferro A, Xavier JB. The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lung. Cancer Res. 2023 Oct 13;83(20):3478-3491. doi: 10.1158/0008-5472.CAN-23-0153. PMID: 37526524; PMCID: PMC10570685.

Schluter J, Djukovic A, Taylor BP, Yan J, Duan C, Hussey GA, Liao C, Sharma S, Fontana E, Amoretti LA, Wright RJ, Dai A, Peled JU, Taur Y, Perales MA, Siranosian BA, Bhatt AS, van den Brink MRM, Pamer EG, Xavier JB. The TaxUMAP atlas: Efficient display of large clinical microbiome data reveals ecological competition in protection against bacteremia. Cell Host Microbe. 2023 Jul 12;31(7):1126-1139.e6. doi: 10.1016/j.chom.2023.05.027. Epub 2023 Jun 16. PMID: 37329880; PMCID: PMC10527165.

Santamaria G, Liao C, Lindberg C, Chen Y, Wang Z, Rhee K, Pinto FR, Yan J, Xavier JB. Evolution and regulation of microbial secondary metabolism. Elife. 2022 Nov 21;11:e76119. doi: 10.7554/eLife.76119. PMID: 36409069; PMCID: PMC9708071.

Schluter J, Peled JU, Taylor BP, Markey KA, Smith M, Taur Y, Niehus R, Staffas A, Dai A, Fontana E, Amoretti LA, Wright RJ, Morjaria S, Fenelus M, Pessin MS, Chao NJ, Lew M, Bohannon L, Bush A, Sung AD, Hohl TM, Perales MA, van den Brink MRM, Xavier JB. The gut microbiota is associated with immune cell dynamics in humans. Nature. 2020 Dec;588(7837):303-307. doi: 10.1038/s41586-020-2971-8. Epub 2020 Nov 25. PMID: 33239790; PMCID: PMC7725892.

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People

Joao Xavier

Joao Xavier, PhD

Member, Computational & Systems Biology Program

Professor

  • Systems biologist Joao Xavier combines experimental and computational approaches to study diverse problems relevant to cancer: how the microbiome influences cancer and cancer treatment, how cancer cells metastasize, and how metabolic fluxes command the behavior of living cells.
  • PhD, Universidade Nova de Lisboa
[email protected]
Email Address
646-888-3195
Office Phone

Members

Andras
Andras Bimbo-Szuhai

Research Technician

Ana Djokovic
Ana Djukovic

Senior Research Scientist

Qixiu Han

Graduate Student

Heesoo
Heesoo Jeong

Research Scholar

Diego
Diego Kaune

Research Technician

Chen Liao
Chen Liao

Research Scholar

Deepti Mathur
Deepti Mathur

Postdoctoral Research Fellow

Vishwas Mishra
Vishwas Mishra

Graduate Student

Sneh
Sneh Sharma

Lab Manager

Benjamin Wucher

Research Scholar

Lab Alumni
Farah Abdul-Rahman

Research Scholar

Kerry Boyle

Graduate Student

Vanni Bucci
Nathaniel Campbell
Nathaniel Campbell

Graduate Student

William Chang

Graduate Student

Yanyan Chen
Yanyan Chen

Research Scholar

Katharine Coyte
Laura de Vargas Roditi

Graduate Student

Maxime Deforet

Postdoctoral Research Fellow

Henri Estanbouli
Henri Estanbouli

Laboratory Technician

Lucas Evans

Admin Assistant II

Carlos Carmona Fontaine

Research Fellow

Silja Heilmann

Postdoctoral Research Fellow

Trinasia Kelly
Trinasia Kelly

Administrative Assistant

Wendy Lin
Wendy Lin

Graduate Student

Chloe Lindberg

Laboratory Technician

Jonas Schlueter
Jonas Schlueter

Postdoctoral Research Fellow

Jonathan Sia

Research Fellow

Bradford Taylor
Bradford Taylor

Postdoctoral Research Fellow

Dave van Ditmarsch

Postdoctoral Research Fellow

Jinyuan Yan
Jinyuan Yan

Postdoctoral Research Fellow

Lab Affiliations

Achievements

  • Director's New Innovator Award, National Institutes of Health (2011)
  • Biofilm Young Investigator Award, Center for Biofilm Engineering (2010)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Joao Xavier discloses the following relationships and financial interests:

  • Oficina Design
    Fiduciary Role / Position

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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