Immunology Program

The Jayanta Chaudhuri Lab

Research

Jayanta Chaudhuri, PhD

Professor

Laboratory of Molecular and Cellular Immunology

Recombination, genomic integrity, and heterogeneity in B cells

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Featured News

Kalina Belcheva, Teddy Yewdell, Jayanta Chaudhuri, and Ryan Smolkin standing together in a lab

In the Lab

SKI Research Reveals New Insights into Immune Response to Viral Infections — Including COVID-19

Research from Sloan Kettering Institute immunologists suggests that the body may mount an immune response to respiratory viruses that lasts longer than previously thought. The discovery could impact the timing of COVID-19 vaccinations.

At Work: Immunologist Jayanta Chaudhuri

Immunologist Jayanta Chaudhuri has long been interested in biology, Mendelian genetics, and the story of how life evolved.

Allysia Matthews, with Citymeals-on-Wheels staff donating reusable ice packs

In the Community

Giving Supplies a Second Life, and Making an Environmental Impact in the Process

Memorial Sloan Kettering “green” committees focus on waste reduction and energy efficiency throughout the institution while donating useful supplies to New York–area nonprofits.

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Publications Highlights

Chowdhury, P., Belcheva, K. T., Smolkin, R. M., Cols, M., Fontenot, J. D., Yewdell, W. T., & Chaudhuri, J. (2025). IL-2Rα is dispensable for murine B cell development and humoral response. Journal of Immunology, 214(4), 694–702. https://doi.org/10.1093/jimmun/vkae045

Kim, Y., Manara, F., Grassmann, S., Belcheva, K. T., Reyes, K., Kim, H., Downs-Canner, S., Yewdell, W. T., Sun, J. C., & Chaudhuri, J. (2025). IL-21 shapes the B cell response in a context-dependent manner. Cell Reports, 44(1), 115190. https://doi.org/10.1016/j.celrep.2024.115190

Sharma, R., Smolkin, R. M., Chowdhury, P., Fernandez, K. C., Kim, Y., Cols, M., Alread, W., Yen, W.-F., Hu, W., Wang, Z.-M., Violante, S., Chaligné, R., Li, M. O., Cross, J. R., & Chaudhuri, J. (2023). Distinct metabolic requirements regulate B cell activation and germinal center responses. Nature Immunology, 24(8), 1358–1369. https://doi.org/10.1038/s41590-023-01540-y

Fernandez, K. C., Feeney, L., Smolkin, R. M., Yen, W.-F., Matthews, A. J., Alread, W., Petrini, J. H. J., & Chaudhuri, J. (2022). The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes. eLife, 11, e77073. https://doi.org/10.7554/eLife.77073

Maekawa, K., Yamada, S., Sharma, R., Chaudhuri, J., & Keeney, S. (2022). Triple-helix potential of the mouse genome. Proceedings of the National Academy of Sciences of the United States of America, 119(19), e2203967119. https://doi.org/10.1073/pnas.2203967119

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People

Jayanta Chaudhuri, PhD

Professor

Immunologist Jayanta Chaudhuri studies the mechanisms of immunoglobulin gene diversification.
PhD, Albert Einstein College of Medicine

[email protected]: Email Address
646-888-2357: Office Phone

Members

Jayanta Chaudhuri

Principal Investigator

Stephanie Downs-Canner

Assistant Attending Surgeon

Jennifer Lue

Assistant Attending

Francesca Manara

Postdoctoral Research Fellow

Laura Nicolas Gomariz

Postdoctoral Research Fellow

Maria Maddalena Perra

Postdoctoral Research Fellow

Keith Conrad Fernandez

Graduate Student

Kalina Belcheva

Graduate Student

Vivian Kuan

Graduate Student

Dulguun Baasan

Graduate Student

Kanelly Reyes

Research Technician

Matthew Kantorski

Research Technician

Lorraine Hernandez Delgado

MSK Bridge Scholar

Veronica Shields

Administrative Assistant

Ryan Smolkin

Graduate Student

Youngjun Kim

Graduate Student

Marisa Lazarus

Research Technician

Rahul Sharma

Postdoctoral Research Fellow

William Alread

Research Technician

Priyanka Chowdhury

Graduate Student

William Yewdell

Postdoctoral Research Fellow

Silva Baburyan

Research Technician

Zahra Hudda

Pediatric Hematology-Oncology Fellow

Montserrat Cols Vidal

Lab Manager

Wei-Feng Yen

Graduate Student

Joseph Pucella

Graduate Student

William Terry

Pediatric Hematology-Oncology Fellow

Kayleigh-Herrick Reynolds

Research Technician

Bharat Vaidyanathan

Graduate Student

Lauren J. Dimenna

Graduate Student

Simin Zheng

Graduate Student

Bao Q. Vuong

Postdoctoral Research Fellow

Allysia Matthews

Graduate Student

Urszula Nowak

Graduate Student

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Get in Touch

[email protected]

Lab Head Email
646-888-2357

Office Phone
646-422-0495

Office Fax
646-888-2334

Lab Phone
646-888-2614

Lab Phone

Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Jayanta Chaudhuri discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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