The lab focuses on Pre-Regenerative Biology, which comprises the mechanisms by which tissues detect wounds to initiate healing, inflammation, regeneration, and cancer. We address these mechanisms by quantitative imaging in various model systems including live zebrafish.
We study wound detection by an interdisciplinary approach that merges cell biology, immunology, and biophysics. To quantitatively interrogate mechanism, we combine intravital imaging in transparent zebrafish larvae, molecular and biophysical cell culture approaches, mathematical modeling, genomics, and metabolomics as needed.
Imaging Rapid Wound Detection in Translucent Zebrafish Larvae
How do white blood cells (left side, colored tracks) and epithelial cells (right, green/red fluorescence) rapidly detect wounds sites? We study the underlying mechanisms by imaging in live zebrafish larvae.