Molecular Indexing of Chromatin

Molecular Indexing of Chromatin

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We have incomplete understanding of how chromatin is organized within the nucleus. We believe that new assays are needed, so we are developing a novel approach to capture and map the relative locations of complex chromatin structures and domains within a cell. Our method utilizes a novel approach to uniquely tag molecules that interact in 3D space – including proteins and DNA. Our new method is highly quantitative and can map hundreds of co-incident interactions. In the near future, we aim to provide a quantitative map of chromatin folding and the occupancy of select proteins across the genome.