Molecular Biology Program
The Iestyn Whitehouse Lab
The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on understanding basic mechanisms and use a combination of biochemical, molecular biological and genomics approaches. We like to develop new technology and are particularly interested in the development and application of single molecule technologies such as Nanopore sequencing and single molecule indexing strategies.
High-resolution mapping of DNA replication dynamics in S. cerevisiae. McGuffee S, Smith D, Whitehouse I. Manuscript in preparation.
Intrinsic Coupling of Lagging Strand Synthesis to Chromatin Assembly. Smith D, Whitehouse I. Nature, 2012. In press.
Chromatin remodeling around nucleosome-free regions leads to repression of noncoding RNA transcription. Yadon AN, Van de Mark D, Basom R, Delrow J, Whitehouse I, Tsukiyama T. Mol Cell Biol. 2010 Nov;30(21):5110-22. Epub 2010 Aug 30.
Iestyn Whitehouse, PhD
Interim Director of the Center for Epigenetics Research (CER)
- Molecular biologist Iestyn Whitehouse investigates chromatin structure and the function of ATP-dependent chromatin remodelling enzymes.
- PhD, The University of Dundee
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Iestyn Whitehouse discloses the following relationships and financial interests:
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