Epidemiology & Biostatistics

The Elli Papaemmanouil Lab

Elli Papaemmanouil, PhD

Associate Attending

Associate Professor

Our lab is a collective of clinical, computational, molecular and mathematic research investigators with an interest in studying the role of acquired mutations in cancer development, and how these determine clinical phenotype and response to therapy. Our mission is to execute research that informs and moves clinical practices in oncology forward. We have strong expertise in genome profiling analysis, a proven track record on the development of high-throughput laboratory and analytical pipelines (bioinformatics and statistical), and integrating large and complex genomic datasets. We have formed a strong network of research and clinical collaborations to pursue innovative studies in cancer research.

We like to perform ambitious research, but operate in a fun, collaborative, and team-oriented environment, and we are strongly committed to mentoring young scientists through internal and international internship schemes.

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Research Projects

Featured News

MSK scientists Andrew Kung and Elli Papaemmanuil

New Type of Genetic Testing Aims To Benefit Children and Young Adults With Cancer

By sequencing the entire genome of a tumor, the experimental test will go beyond standard testing for common cancers in adults.

In the Clinic

New Research Shows AML Is Not One Disease, But 11 or More

Learn how researchers plan to use new genetic information about acute myeloid leukemia to tailor treatments.

MSK molecular geneticist Elli Papaemmanouil

Large International Study Pinpoints Impact of TP53 Gene Mutations on Blood Cancer Severity

Having two mutated copies of the TP53 gene — as opposed to a single mutated copy — is associated with worse outcomes in a blood cancer called myelodysplastic syndrome, according to a new study led by researchers at Memorial Sloan Kettering.

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Publications Highlights

Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, Döhner H, Falini B, Garcia-Manero G, Haferlach T, Hellström-Lindberg E, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanouil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Solé F, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola M. Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia. Blood. 2022 Nov 24;140(21):2228-2247. doi: 10.1182/blood.2022015853. PMID: 36130297; PMCID: PMC10488320.

Kinnaman MD, Zaccaria S, Makohon-Moore A, Arnold B, Levine M, Gundem G, Arango Ossa JE, Glodzik D, Rodríguez-Sánchez MI, Bouvier N, Li S, Stockfisch E, Dunigan M, Cobbs C, Bhanot U, You D, Mullen K, Melchor J, Ortiz MV, O’Donohue T, Slotkin E, Wexler LH, Dela Cruz FS, Hameed M, Glade Bender JL, Tap WD, Meyers PA, Papaemmanouil E, Kung AL, Iacobuzio-Donahue CA. Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma. bioRxiv [Preprint]. 2023 Jan 24:2023.01.05.522765. doi: 10.1101/2023.01.05.522765. PMID: 36711976; PMCID: PMC9881990.

Al Assaad M, Gundem G, Liechty B, Sboner A, Medina J, Papaemmanouil E, Sternberg CN, Marks A, Souweidane MM, Greenfield JP, Tran I, Snuderl M, Elemento O, Imielinski M, Pisapia DJ, Mosquera JM. The importance of escalating molecular diagnostics in patients with low-grade pediatric brain cancer. Cold Spring Harb Mol Case Stud. 2023 Aug 31:mcs.a006275. doi: 10.1101/mcs.a006275. Epub ahead of print. PMID: 37652664.

Bolton KL, Chen D, Corona de la Fuente R, Fu Z, Murali R, Köbel M, Tazi Y, Cunningham JM, Chan ICC, Wiley BJ, Moukarzel LA, Winham SJ, Armasu SM, Lester J, Elishaev E, Laslavic A, Kennedy CJ, Piskorz A, Sekowska M, Brand AH, Chiew YE, Pharoah P, Elias KM, Drapkin R, Churchman M, Gourley C, DeFazio A, Karlan B, Brenton JD, Weigelt B, Anglesio MS, Huntsman D, Gayther S, Konner J, Modugno F, Lawrenson K, Goode EL, Papaemmanouil E. Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes. Clin Cancer Res. 2022 Nov 14;28(22):4947-4956. doi: 10.1158/1078-0432.CCR-21-3817. PMID: 35816189; PMCID: PMC9777703.

Diamond B, Ziccheddu B, Maclachlan K, Taylor J, Boyle E, Ossa JA, Jahn J, Affer M, Totiger TM, Coffey D, Chandhok N, Watts J, Cimmino L, Lu SX, Bolli N, Bolton K, Landau H, Park JH, Ganesh K, McPherson A, Sekeres MA, Lesokhin A, Chung DJ, Zhang Y, Ho C, Roshal M, Tyner J, Nimer S, Papaemmanouil E, Usmani S, Morgan G, Landgren O, Maura F. Tracking the evolution of therapy-related myeloid neoplasms using chemotherapy signatures. Blood. 2023 May 11;141(19):2359-2371. doi: 10.1182/blood.2022018244. PMID: 36626250; PMCID: PMC10273163.

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People

Elli Papaemmanouil, PhD

Associate Attending

Associate Professor

Molecular geneticist Elli Elli Papaemmanouil performs systematic interrogations of well-annotated clinical trial cohorts in leukemia and cancer to explore how the compound genetic and clonal architecture in patients' leukemias and tumors dictate clinical phenotype, disease progression, and clinical outcomes.
PhD – University of London, London, England, UK

[email protected]: Email Address
646-608-7645: Office Phone

Members

Anu Amallraja

‪Computational Biologist II

Juan E. Arango-Ossa
Bioinformatics Software Engineer IV

Dylan Domenico
Bioinformatics Software Engineer II

Gunes Gundem
Principal Computational Biologist

Jesus Gutierrez-Abril
Research Associate

Konstantinos Liosis
Bioinformatics Engineer I

Joseph G. McCarter
Senior Computational Biologist II

Noushin Rahnamay Farnoud
Principal Computational Biologist

Sarun Sereewattanawoot
Research Associate

Lab Alumni

Seon Ball

Administrative Assistant II

Elsa Bernard, PhD — Elsa Bernard
Research fellow

Antonin Berthon

Graduate Research Assistant

Maheetha Bharadwaj, Computational Biologist I — Maheetha Bharadwaj
Computational Biologist I

Charlotte Brierley
Graduate Research Assistant

Matthieu Cornet

Graduate Research Assistant

Marc Robert de Massy
Visiting scientists

Andre Deslauriers, Graduate Research Asst — Andre Deslauriers
Graduate Research Assistant

Dominik Glodzik
Associate Manger, Computational Biologist

Pierre F. Guilmin

Graduate Research Assistant

Max Levine
Senior Computational Biologist I

Juan Medina
Bioinformatics Engineer II, Leukemia Genomics

Matahi Moarii, Postdoctoral Fellow — Matahi Moarii
Research Fellow

Yoann Pradat, Graduate Research Asst — Yoann Pradat
Graduate Research Asst

Komal Rathi
Bioinformatics Engineer II, Leukemia Genomics

Kayleigh Rutherford, Computational Biologist II — Kayleigh Rutherford
Computational Biologist II

Maria Sirenko
Postdoctoral Fellow, NYU Langone, New York, NY

Yanis Tazi, Graduate Student, Tri-I Institutional PhD Program — Yanis Tazi
Graduate Student, Tri-I Institutional PhD Program

Yellapantula Venkata, Bioinformatics Engineer II — Yellapantula Venkata
Bioinformatics Engineer II

Yangyu Zhou, Bioinformatics Engineer I — Yangyu Zhou
Bioinformatics Engineer II

Lab Affiliations

Achievements

Josie Robertson Investigator (2015-2020)
European Hematology Association Young Investigator Award
Cancer Research UK Career Development Award

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Get in Touch

[email protected]

Lab Head Email
646-608-7645

Office Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Elli Papaemmanouil discloses the following relationships and financial interests:

Isabl Inc.
Equity; Fiduciary Role / Position; Intellectual Property Rights

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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The Elli Papaemmanouil Lab

Research

Research Projects

Featured News

Publications Highlights

People

Members

Achievements

Open Positions

Bioinformatics Data Scientist

Careers

Molecular genomics, Research Assistant / Senior Research Technician

Get in Touch

Disclosures