Deb S, DeLucia AL, Koff A, Tsui S, and Tegtmeyer P. The adenine-thymine domain of the simian virus 40 core origin directs DNA bending and coordinately regulates DNA replication. Mol. Cell Biol. 6:4578-4584, 1986.
Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR Jr, Roberts JM. Formation and activiation of a cyclin E/CDK2 complex in the G1 phase of the human cell cycle. Science 257:1689 1694, 1992.
Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, and Koff A. p27KIP1, a cyclin-CDK inhibitor, links transforming growth factor- b and contact inhibition to cell cycle arrest. Genes & Dev. 8:9-22, 1994.
Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, and Massague J. Cloning of p27KIP1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78:1-20, 1994.
Bullrich F, MacLachlan TK, Sang N, Druck, T, Veronese ML, Chiorazzi N, Koff A, Heubner K, Croce CM, and Giordano A. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE and a new cdk inhibitor, p27KIP1, to regions involved in human cancer. Cancer Res. 55:1199 1205, 1995.
Fan Z, Lu Y, Wu X, DeBlasio A, Koff A, and Mendelsohn J. Prolonged induction of p21WAF1/CDK2 complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition. J. Cell Biol. 131:235-242, 1995.
Onel K., Koff A, Bennett RL, Unrau P, and Holloman WK. The REC1 gene of Ustilago maydis, which encodes a 3’->5’ exonuclease, couples DNA repair and completion of DNA synthesis to a mitotic checkpoint. Genetics 143:79-89, 1996.
Hoffman ES, Passoni L, Crompton T, Leu TMJ, Schatz DG, Koff A, Owen MJ, and Hayday AC. Productive T-cell receptor b -chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes & Dev. 10:948-962, 1996.
Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman E, Ono M, Khanam D, Hayday AC, Frohman LA, and Koff A. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1. Cell 85:721-732, 1996
Millard SS, Yan JS, Nguyen H, Pagano M, Kiyokawa H, and Koff A. Enhanced ribosomal association of p27kip1 mRNA, a mechanism contributing to accumulation during growth arrest. J. Biol. Chem. 272: 7093-7098, 1997.
Casaccia-Bonnefil P, Tikoo R, Soos, TJ, Kiyokawa H, Friedrich V Jr., Chao MV, and Koff A. Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor, p27Kip1. Genes & Dev. 11: 2335-2346, 1997.
Osman I, Scher H, Zhang ZF, Soos TJ, Hamza R, Eissa S, Khalad H, Koff A, and Cordon-Cardo C. Expression of cyclin D1, but not cyclins E and A, is related to progression in Bilharzial bladder cancer. Clin. Canc. Res. 3: 2247-2251, 1997.
Cordon-Cardo C, Koff A, Drobnjak M, Capodieci P, Osman I, Millard SS, Gaudin PB, Zhang ZF, Massague J, and Scher HI. Distinct altered patterns of p27Kip expression in benign prostatic hyperplasia and prostatic carcinoma. J. Natl. Canc. Inst. 90: 1284-1291, 1998.
Tikoo R, Osterhaout D, Casaccia-Bonnefil P, Seth P, Koff A, and Chao MV. Ectopic expression of p27Kip in oligodendrocyte progenitor cells results in cell cycle growth arrest. J. Neurobiol. 36: 431-440, 1998.
Tong W, Kiyokawa H, Soos TJ, Park MS, Soares VC, Manova K, Pollard JW, and Koff A. The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa->luteal transition. Cell Gro, and Diff. 9: 787-794, 1998.
Beumer TL, Kiyokawa H, Roepers-Gajadien HL, van den Bos LA, Lock TM,Gademan IS, Rutgers DH, Koff A, de Rooij DG. Regulatory role of p27kip1 in the mouse and human testis. Endocrinology 140: 1834-40, 1999.
Kolluri SK, Weib C, Koff A, and Gattlicher M. p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes Dev. 13: 1742-1753, 1999.
Drissi H, Hushka D, Aslam F, Nguyen Q, Buffone E, Koff A, van Wijnen AJ, Lian JB, Stein JL, and Stein GS. The cell cycle regulator p27Kip1 contributes to growth and differentiation of osteoblasts. Cancer Res. 59: 3705-3711, 1999.
Casaccia-Bonnefil P, Hardy RJ, Teng KK, Levine JM, Koff A, and Chao MV. Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development. 126: 4027-4037, 1999.
Chou, JL, Fan Z, DeBlasio T, Koff A, Rosen N, and Mendelsohn J. Constitutive overexpression of cyclin D1 in human breast epithelial cells does not prevent G1 arrest induced by deprivation of epidermal growth factor. Breast Canc. Res. Treat. 55: 267-283, 1999.
Agus DB, Cordon-Cardo C, Fox W, Drobjnak M, Koff A, Golde DW, and Scher HI. Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence. J. Natl. Canc. Inst. 91: 1869-1876, 1999.
Vairo A, Soos TJ, Upton TM, Zalvide J, DeCaprio JA, Ewen ME, Koff A, and Adams JM. Bcl-2 retards cell cycle entry through p27Kip1, pRb relative p130 and altered E2F regulation. Mol Cell Bio 20: 4745-4753, 2000.
Zezula J, Casaccia-Bonnefil P, Ezhevsky SA, Osterhout DJ, Levine JM, Dowdy SF, Chao MV, and Koff A. p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal. EMBO Rep. 2: 27-34, 2001.
Mahoney JA, Odin JA, White SM, Shaffer D, Koff A, Casciola-Rosen L, and Rosen A. The human homolog of the yeast polyubiquitination factor Ufd2p is cleaved by aspase 6 and granzyme B during apoptosis. Biochem. J. 361: 587-595, 2002
Vidal A, Millard SS, Miller JP, and Koff A. Rho activity can alter the translation of p27 mRNA and is important for RasV12 induced transformation in a manner dependent on p27 status. J. Biol. Chem. 277: 16433-16440. 2002.
Nguyen TB, Manova K, Capodieci P, Lindon C, Bottega S, Wang X-Y, Refik-Rogers J, Pines J, Wolgemuth DJ, and Koff A. Characterization and expression of mammalian cyclin B3, a pre-pachytene meiotic cyclin. J. Biol. Chem. 277: 41960-9. 2002
Carneiro C, Jiao MS, Hu M, Shaffer D, Park M, Pandolfi PP, Cordon-Cardo C, and Koff A. p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development. Oncogene 22: 361-369. 2003
Shaffer DR, Viale A, Ishiwata R, Leversha M, Olgac S, Manova K, Satagopan J,Scher H and Koff A. Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate. Proc. Natl. Acad. Sci. USA 210-215, 2005.
Vidal A, Zacharoulis S, Guo W, Shaffer D, Giancotti F, Bramley AH, de la Hoz C,Jensen KK, Kato D, MacDonald DD, Knowles J, Yeh N, Frohman LA, Rafii S, Lyden D and Koff A. p130Rb2 and p27kip1 co-operate to control mobilization of angiogenic progenitors from the bone marrow. Proc. Natl. Acad. Sci. USA 102:6890-6895,2005.
Sakakibara K, Kubota K, Worku B, Ryer EJ, Miller JP, Koff A, Kent KC, Liu B.PDGF-BB regulates p27 expression through ERK-dependent RNA turn-over in vascular smooth muscle cells. J. Biol. Chem. 280:25470-25477, 2005
Feng Z, Plati AR, Cheng QL, Berho M, Banerjee A, Potier M, Jy WC, Koff A, Striker J, Striker GE. Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors. Am. J. Pathol. 167: 355-363, 2005
Kuzushita N, Rogers AB, Monti NA, Whary MT, Park MJ, Aswad BI, Shirin H, Koff A, Eguchi H and Moss SF. p27kip1 deficiency confers susceptibility to gastric carcinogenesis in helicobacter pylori infected mice. Gastroenterology 129:1544- 1546, 2005.
Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A and Nimer SD. The ETS protein MEF is regulated by phosphorylation dependent proteolysis via the protein-ubiquitin ligase SCFskp2. Mol. Cell Biol. 26: 3114-3123, 2006.
Guidi CJ, Mudhasani R, Hoover K, Koff A, Leav I, Imbalzano AN and Jones SN. Functional interaction of the Rb and Ini/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis. Cancer Res. 66: 8076-8082, 2006
Hulit J, Lee RJ, Li Z, Wang C, Katiyar S, Yang J, Quong AA, Wu K, Albanese C, Russell R, Di Vizio D, Koff A, Thummala S, Zhang H, Harrell J, Sun H, Muller WJ, Inghirami G, Lisanti MP and Pestell RG. p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/(beta) catenin signaling. Cancer Res. 66: 8529-8541, 2006.
Yeh N, Miller JP, Gaur T, Capellini TD, Nikolich-Zugich J, de la Hoz C, Selleri L, Bromage TG, van Wijnen AJ, Stein GS, Lian JB, Vidal A and Koff A. Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130. Mol. Cell Biol. 14: 5161-5171, 2007.
Liu Y, Yeh N, Zhu XH, Kasakowski H, Leversha M, Cordon-Cardo C, Ghossein R, Singh B, Holland E and Koff A. An oncogenic role for the cdk inhibitor p21Waf1/Cip1. EMBO J. 26: 4683-4693, 2007.
Liu Y, Elf SE, Miyata Y, Sashida G, Liu Y, Huang G, DiGiandomenico S, Lee JM, DeBlasio A, Menendez S, Antipin J, Reva B, Koff A and Nimer SD. p53 regulates hematopoietic stem cell quiescence.Cell Stem Cell 4: 37-48, 2009.
Liu L, Lee S, Zhang J, Peters SB, Hannah J, Zhang Y, Yin Y, Koff A, Ma L, and Zhou P. Cul4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol Cell 34: 451-60, 2009.
See WL, Miller JP, Squatrito M, Holland E, Resh MD, and Koff A. Defective DNA double-strand break repair underlies enhanced tumorigenesis aggressiveness and chromosomal instability in p27 deficient mice with growth-factor induced oligodendrogliomas. Oncogene 29:1720-31, 2010
Brill E, Gobble R, Angeles C, Lagos-Quintana M, Crago A, Iaxa B, DeCarolis P, Zhang L, Antonescu C, Socci N, Taylor B, Sander C, Koff A, and Singer S. Zic1 overexpression is oncogenic in liposarcoma. Cancer Res. In press