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The Andrew Koff Lab: Publications

Visit PubMed for a full listing of Andrew Koff’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Deb S., DeLucia AL, Baur CP, Koff A, and Tegtmeyer P. Domain structure of the simian virus 40 core origin of replication. Mol. Cell Biol. 6:1663-1670, 1986.

Deb S, DeLucia AL, Koff A, Tsui S, and Tegtmeyer P. The adenine-thymine domain of the simian virus 40 core origin directs DNA bending and coordinately regulates DNA replication. Mol. Cell Biol. 6:4578-4584, 1986.

Deb S, Tsui S, Koff A, DeLucia AL, Parsons R, and Tegtmeyer P. The T-antigen binding domain of the simian virus 40 core origin of replication. J. Virol. 61:2143-2149, 1987.

Koff A, and Tegtmeyer P. Characterization of the major recognition sequences for a herpes simplex virus type I origin-binding protein. J. Virol. 62:4096 4103, 1988.

Koff A, Schwedes JF, and Tegtmeyer P. Herpes simplex virus origin binding protein (UL9) loops and distorts the viral replication origin. J. Virol. 65:3284-3292, 1991.

Koff A, Cross F, Fisher A, Schumacher J, Leguellec K., Philippe M., and Roberts JM. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell 66:1217-1228, 1991.

Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR Jr, Roberts JM. Formation and activiation of a cyclin E/CDK2 complex in the G1 phase of the human cell cycle. Science 257:1689 1694, 1992.

Koff A, Ohtsuki M, Polyak K, Roberts JM, and Massague J. Negative regulation of G1 progression in mammalian cells: Inhibition of the cyclin E associated kinase by TGF-b. Science 260:536-539, 1993.

Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, and Koff A. p27KIP1, a cyclin-CDK inhibitor, links transforming growth factor- b and contact inhibition to cell cycle arrest. Genes & Dev. 8:9-22, 1994.

Firpo E, Koff A, Solomon MJ, and Roberts JM. Inactivation of a Cdk2 inhibitor during Interleukin 2-induced proliferation of human T lymphocytes. Mol. Cell Biol. 14: 4889-4901, 1994.

Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, and Massague J. Cloning of p27KIP1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78:1-20, 1994.

Bullrich F, MacLachlan TK, Sang N, Druck, T, Veronese ML, Chiorazzi N, Koff A, Heubner K, Croce CM, and Giordano A. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE and a new cdk inhibitor, p27KIP1, to regions involved in human cancer. Cancer Res. 55:1199 1205, 1995.

Fan Z, Lu Y, Wu X, DeBlasio A, Koff A, and Mendelsohn J. Prolonged induction of p21WAF1/CDK2 complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition. J. Cell Biol. 131:235-242, 1995.

Wu X, Rubin MS, Fan Z, Soos T, Koff A, and Mendelsohn J. Involvement of p27KIP1 in G1 arrest mediated by anti-epidermal growth factor receptor monoclonal antibody. Oncogene 12:1397-1403, 1996.

Onel K., Koff A, Bennett RL, Unrau P, and Holloman WK. The REC1 gene of Ustilago maydis, which encodes a 3’->5’ exonuclease, couples DNA repair and completion of DNA synthesis to a mitotic checkpoint. Genetics 143:79-89, 1996.

Hoffman ES, Passoni L, Crompton T, Leu TMJ, Schatz DG, Koff A, Owen MJ, and Hayday AC. Productive T-cell receptor b -chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes & Dev. 10:948-962, 1996.

Claudio PP, DeLuca A, Howard CM, Baldi A, Firpo EJ, Koff A, Paggi MG, Giordano, A. Functional analysis of pRb2/p130 interaction with cyclins. Cancer Res. 56: 2003-2008, 1996

Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman E, Ono M, Khanam D, Hayday AC, Frohman LA, and Koff A. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1. Cell 85:721-732, 1996

Luo Y, Marx SO, Kiyokawa H, Koff A, Massague J, and Marks AR. Rapamycin resistance ties to defective regulation of p27Kip1. Mol. Cell Biol. 16; 6744-6751, 1996.

Missero C, Di Cunto F, Kiyokawa H, Koff A, and Dotto GP. The absence of p21Cip1/Waf1 alters keratinocyte growth and differentiation and promotes tumor progression. Genes & Dev. 10; 3065-3075, 1996

Tikoo R, Casaccia-Bonnefil P, Chao MV, and Koff A. Changes in cyclin-dependent kinase 2 and p27Kip accompany glial cell differentiation of Central Glia-4 cells. J.Biol. Chem. 272: 442-447, 1997.

Millard SS, Yan JS, Nguyen H, Pagano M, Kiyokawa H, and Koff A. Enhanced ribosomal association of p27kip1 mRNA, a mechanism contributing to accumulation during growth arrest. J. Biol. Chem. 272: 7093-7098, 1997.

Casaccia-Bonnefil P, Tikoo R, Soos, TJ, Kiyokawa H, Friedrich V Jr., Chao MV, and Koff A. Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor, p27Kip1. Genes & Dev. 11: 2335-2346, 1997.

Osman I, Scher H, Zhang ZF, Soos TJ, Hamza R, Eissa S, Khalad H, Koff A, and Cordon-Cardo C. Expression of cyclin D1, but not cyclins E and A, is related to progression in Bilharzial bladder cancer. Clin. Canc. Res. 3: 2247-2251, 1997.

Cordon-Cardo C, Koff A, Drobnjak M, Capodieci P, Osman I, Millard SS, Gaudin PB, Zhang ZF, Massague J, and Scher HI. Distinct altered patterns of p27Kip expression in benign prostatic hyperplasia and prostatic carcinoma. J. Natl. Canc. Inst. 90: 1284-1291, 1998.

Tikoo R, Osterhaout D, Casaccia-Bonnefil P, Seth P, Koff A, and Chao MV. Ectopic expression of p27Kip in oligodendrocyte progenitor cells results in cell cycle growth arrest. J. Neurobiol. 36: 431-440, 1998.

Tong W, Kiyokawa H, Soos TJ, Park MS, Soares VC, Manova K, Pollard JW, and Koff A. The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa->luteal transition. Cell Gro, and Diff. 9: 787-794, 1998.

Nguyen H, Gitig D, and Koff A. Cell free degradation of the CDK inhibitor p27Kip1 is dependent on CDK2 activity and the proteasome. Mol. Cell Biol. 19: 1190-1201, 1999.

Beumer TL, Kiyokawa H, Roepers-Gajadien HL, van den Bos LA, Lock TM,Gademan IS, Rutgers DH, Koff A, de Rooij DG. Regulatory role of p27kip1 in the mouse and human testis. Endocrinology 140: 1834-40, 1999.

Park MS, Rosai J, Nguyen HT, Capodieci P, Cordon-Cardo C, and Koff A. p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice. Proc. Natl. Acad. Sci. USA 96: 6382-6387, 1999.

Kolluri SK, Weib C, Koff A, and Gattlicher M. p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes Dev. 13: 1742-1753, 1999.

Drissi H, Hushka D, Aslam F, Nguyen Q, Buffone E, Koff A, van Wijnen AJ, Lian JB, Stein JL, and Stein GS. The cell cycle regulator p27Kip1 contributes to growth and differentiation of osteoblasts. Cancer Res. 59: 3705-3711, 1999.

Casaccia-Bonnefil P, Hardy RJ, Teng KK, Levine JM, Koff A, and Chao MV. Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development. 126: 4027-4037, 1999.

Chou, JL, Fan Z, DeBlasio T, Koff A, Rosen N, and Mendelsohn J. Constitutive overexpression of cyclin D1 in human breast epithelial cells does not prevent G1 arrest induced by deprivation of epidermal growth factor. Breast Canc. Res. Treat. 55: 267-283, 1999.

Agus DB, Cordon-Cardo C, Fox W, Drobjnak M, Koff A, Golde DW, and Scher HI. Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence. J. Natl. Canc. Inst. 91: 1869-1876, 1999.

Tsutsui T, Hesabi B, Moons DS, Pandolfi PP, Hansel KS, Koff A, and Kiyokawa H. Targeted disruption of CDK4 delays cell cycle entry with enhanced p27Kip1 activity. Mol. Cell Biol. 19: 7011-7019, 1999.

Vidal A and Koff A. Cell cycle inhibitors: three families united by a single cause. Gene 247: 1-15, 2000.

Vairo A, Soos TJ, Upton TM, Zalvide J, DeCaprio JA, Ewen ME, Koff A, and Adams JM. Bcl-2 retards cell cycle entry through p27Kip1, pRb relative p130 and altered E2F regulation. Mol Cell Bio 20: 4745-4753, 2000.

Millard SS, Vidal A, Markus M, and Koff A. A U-rich element in the 5’UTR of p27mRNA is implicated in basal and induced translational control. Mol. Cell Biol. 20:5947-5959, 2000.

Zezula J, Casaccia-Bonnefil P, Ezhevsky SA, Osterhout DJ, Levine JM, Dowdy SF, Chao MV, and Koff A. p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal. EMBO Rep. 2: 27-34, 2001.

Di Cristofano A, De Acetis M, Koff A, Cordon-Cardo C, and Pandolfi PP. Pten and p27kip1 cooperate in prostate cancer tumor suppression in the mouse.Nat. Genet.27:222-224, 2001.

Cipriano SC, Chen L, Burns KH, Koff A, and Matzuk MM.Inhibin and p27 interact to regulate gonadal tumorigenesis. Mol.Endocrinol. 15: 958-996, 2001.

Mahoney JA, Odin JA, White SM, Shaffer D, Koff A, Casciola-Rosen L, and Rosen A. The human homolog of the yeast polyubiquitination factor Ufd2p is cleaved by aspase 6 and granzyme B during apoptosis. Biochem. J. 361: 587-595, 2002

Vidal A, Millard SS, Miller JP, and Koff A. Rho activity can alter the translation of p27 mRNA and is important for RasV12 induced transformation in a manner dependent on p27 status. J. Biol. Chem. 277: 16433-16440. 2002.

Nguyen TB, Manova K, Capodieci P, Lindon C, Bottega S, Wang X-Y, Refik-Rogers J, Pines J, Wolgemuth DJ, and Koff A. Characterization and expression of mammalian cyclin B3, a pre-pachytene meiotic cyclin. J. Biol. Chem. 277: 41960-9. 2002

Carneiro C, Jiao MS, Hu M, Shaffer D, Park M, Pandolfi PP, Cordon-Cardo C, and Koff A. p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development. Oncogene 22: 361-369. 2003

Blain SW, Scher HI, Cordon-Cardo C, and Koff A. p27 as a target for cancer herapeutics. Cancer Cell 3: 111-115, 2003

Zhu XH, Nguyen H, Halicka DH, Traganos F and Koff A. A non-catalytic requirement for cyclin A-cdk2 in p27 turnover. Mol. Cell Biol. 24: 6058-6066, 2004.

Shaffer DR, Viale A, Ishiwata R, Leversha M, Olgac S, Manova K, Satagopan J,Scher H and Koff A. Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate. Proc. Natl. Acad. Sci. USA 210-215, 2005.

Vidal A, Zacharoulis S, Guo W, Shaffer D, Giancotti F, Bramley AH, de la Hoz C,Jensen KK, Kato D, MacDonald DD, Knowles J, Yeh N, Frohman LA, Rafii S, Lyden D and Koff A. p130Rb2 and p27kip1 co-operate to control mobilization of angiogenic progenitors from the bone marrow. Proc. Natl. Acad. Sci. USA 102:6890-6895,2005.

Sakakibara K, Kubota K, Worku B, Ryer EJ, Miller JP, Koff A, Kent KC, Liu B.PDGF-BB regulates p27 expression through ERK-dependent RNA turn-over in vascular smooth muscle cells. J. Biol. Chem. 280:25470-25477, 2005

Feng Z, Plati AR, Cheng QL, Berho M, Banerjee A, Potier M, Jy WC, Koff A, Striker J, Striker GE. Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors. Am. J. Pathol. 167: 355-363, 2005

Kuzushita N, Rogers AB, Monti NA, Whary MT, Park MJ, Aswad BI, Shirin H, Koff A, Eguchi H and Moss SF. p27kip1 deficiency confers susceptibility to gastric carcinogenesis in helicobacter pylori infected mice. Gastroenterology 129:1544- 1546, 2005.

Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A and Nimer SD. The ETS protein MEF is regulated by phosphorylation dependent proteolysis via the protein-ubiquitin ligase SCFskp2. Mol. Cell Biol. 26: 3114-3123, 2006.

Guidi CJ, Mudhasani R, Hoover K, Koff A, Leav I, Imbalzano AN and Jones SN. Functional interaction of the Rb and Ini/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis. Cancer Res. 66: 8076-8082, 2006

Hulit J, Lee RJ, Li Z, Wang C, Katiyar S, Yang J, Quong AA, Wu K, Albanese C, Russell R, Di Vizio D, Koff A, Thummala S, Zhang H, Harrell J, Sun H, Muller WJ, Inghirami G, Lisanti MP and Pestell RG. p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/(beta) catenin signaling. Cancer Res. 66: 8529-8541, 2006.

Refik-Rogers J, Manova K and Koff A. Misexpression of cyclin B3 leads to aberrant spermatogenesis. Cell Cycle 5: 1966-1973, 2006.

Yeh N, Miller JP, Gaur T, Capellini TD, Nikolich-Zugich J, de la Hoz C, Selleri L, Bromage TG, van Wijnen AJ, Stein GS, Lian JB, Vidal A and Koff A. Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130. Mol. Cell Biol. 14: 5161-5171, 2007.

Liu Y, Yeh N, Zhu XH, Kasakowski H, Leversha M, Cordon-Cardo C, Ghossein R, Singh B, Holland E and Koff A. An oncogenic role for the cdk inhibitor p21Waf1/Cip1. EMBO J. 26: 4683-4693, 2007.

Liu Y, Elf SE, Miyata Y, Sashida G, Liu Y, Huang G, DiGiandomenico S, Lee JM, DeBlasio A, Menendez S, Antipin J, Reva B, Koff A and Nimer SD. p53 regulates hematopoietic stem cell quiescence.Cell Stem Cell 4: 37-48, 2009.

Liu L, Lee S, Zhang J, Peters SB, Hannah J, Zhang Y, Yin Y, Koff A, Ma L, and Zhou P. Cul4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol Cell 34: 451-60, 2009.

See WL, Miller JP, Squatrito M, Holland E, Resh MD, and Koff A. Defective DNA double-strand break repair underlies enhanced tumorigenesis aggressiveness and chromosomal instability in p27 deficient mice with growth-factor induced oligodendrogliomas. Oncogene 29:1720-31, 2010

Brill E, Gobble R, Angeles C, Lagos-Quintana M, Crago A, Iaxa B, DeCarolis P, Zhang L, Antonescu C, Socci N, Taylor B, Sander C, Koff A, and Singer S. Zic1 overexpression is oncogenic in liposarcoma. Cancer Res. In press