The Jayanta Chaudhuri Lab
Laboratory of Molecular and Cellular Immunology
Recombination, genomic integrity, and heterogeneity in B cells
Vuong BQ, Herrick-Reynolds K, Vaidyanathan B, Pucella JN, Ucher AJ, Donghia NM, Gu X, Nicolas L, Nowak U, Rahman N, Strout MP, Mills KD, Stavnezer J, Chaudhuri J. A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. Nat Immunol. 2013; 14: 1183-9.
Matthews AJ, Husain S, Chaudhuri J. Binding of AID to DNA does not correlate with mutator activity. J Immunol. 2014; 193: 252-7.
Pucella JN, Yen WF, Kim MV, van der Veeken J, Luo CT, Socci ND, Naito Y, Iwai, N, Chaudhuri J. miR182 is largely dispensable for adaptive immunity: lack of correlation between expression and function. J Immunol. 2015; 194: 2635-42.
Zheng S, Vuong BQ, Vaidyanathan B, Lin JY, Huang FT, Chaudhuri J. Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA. Cell. 2015; 161: 762-73.
Kunimoto H, McKenney AS, Meydan C, Shank K, Nazir A, Rapaport F, Durham B, Garrett-Bakelman FE, Pronier E, Shih AH, Melnick A, Chaudhuri J, Levine RL. Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells. Blood. 2017; 129:1779-1790.
Jayanta Chaudhuri, PhD
- Immunologist Jayanta Chaudhuri studies the mechanisms of immunoglobulin gene diversification.
- PhD, Albert Einstein College of Medicine
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